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Protein

Neuron-specific vesicular protein calcyon

Gene

Caly

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Interacts with clathrin light chain A and stimulates clathrin self-assembly and clathrin-mediated endocytosis.1 Publication

Caution

The human ortholog was originally thought to interact with the D1 dopamine receptor (DRD1) and to play a role in potentiating calcium ion-dependent signaling but this work was later retracted.Curated

GO - Molecular functioni

  • clathrin light chain binding Source: UniProtKB
  • dopamine receptor binding Source: RGD

GO - Biological processi

Keywordsi

Biological processEndocytosis

Names & Taxonomyi

Protein namesi
Recommended name:
Neuron-specific vesicular protein calcyon
Gene namesi
Name:Caly
Synonyms:Drd1ip
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi621719 Caly

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 88ExtracellularSequence analysisAdd BLAST88
Transmembranei89 – 109HelicalSequence analysisAdd BLAST21
Topological domaini110 – 226CytoplasmicSequence analysisAdd BLAST117

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001643701 – 226Neuron-specific vesicular protein calcyonAdd BLAST226

Proteomic databases

PaxDbiP58821
PRIDEiP58821

PTM databases

iPTMnetiP58821
PhosphoSitePlusiP58821

Expressioni

Tissue specificityi

Expressed exclusively in neurons (at protein level). In all age groups, expressed at significantly higher levels in the medial prefrontal and orbital frontal cortices of spontaneously hypertensive rats (SHR), a model of attention deficit-hyperactivity disorder, than Wistar Kyoto (WKY) animals. In the motor cortex, dorsal striatum and nucleus accumbens, expression is significantly elevated in SHR only in younger animals.2 Publications

Developmental stagei

Levels decrease significantly with age.1 Publication

Gene expression databases

BgeeiENSRNOG00000018337
GenevisibleiP58821 RN

Interactioni

Subunit structurei

Interacts with CLTA.By similarity

GO - Molecular functioni

  • clathrin light chain binding Source: UniProtKB
  • dopamine receptor binding Source: RGD

Protein-protein interaction databases

BioGridi251406, 1 interactor
STRINGi10116.ENSRNOP00000024766

Family & Domainsi

Sequence similaritiesi

Belongs to the NSG family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKA7 Eukaryota
ENOG41118NY LUCA
GeneTreeiENSGT00390000000483
HOGENOMiHOG000030909
HOVERGENiHBG012403
InParanoidiP58821
KOiK15493
OMAiPAALEMY
PhylomeDBiP58821
TreeFamiTF332232

Family and domain databases

InterProiView protein in InterPro
IPR009431 NSG
PANTHERiPTHR28546 PTHR28546, 1 hit
PfamiView protein in Pfam
PF06387 Calcyon, 1 hit
PIRSFiPIRSF002383 Calcyon, 1 hit

Sequencei

Sequence statusi: Complete.

P58821-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVKLGCSFSG KPGKETGDQD GAAMDSVPLI SPLDVSQLQP SFPDQVVIKT
60 70 80 90 100
QTEYQLTSAD QPKKFADLEG QRLACSHPEE GRRLPTARMI AFAMALLGCV
110 120 130 140 150
LIMYKAIWYD QFTCPDGFLL RHKICTPLTL EMYYTEMDPE RHRSILAAIG
160 170 180 190 200
AYPLSRKHGT EMPAIWGNSY RAGKEEHKGT TPAAMTVSTA AAAAAAEGNE
210 220
PSGKPLDMRE KEDPQKAEDV PSQSPK
Length:226
Mass (Da):24,718
Last modified:May 27, 2002 - v1
Checksum:iCF575AC37A3EF6B5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF303658 mRNA Translation: AAL09318.1
RefSeqiNP_001177328.1, NM_001190399.1
NP_620270.1, NM_138915.1
UniGeneiRn.27756

Genome annotation databases

EnsembliENSRNOT00000024765; ENSRNOP00000024766; ENSRNOG00000018337
ENSRNOT00000089729; ENSRNOP00000069564; ENSRNOG00000018337
GeneIDi192349
KEGGirno:192349
UCSCiRGD:621719 rat

Similar proteinsi

Entry informationi

Entry nameiCALY_RAT
AccessioniPrimary (citable) accession number: P58821
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: May 27, 2002
Last modified: April 25, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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