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P58816

- MCRZ_METTM

UniProt

P58816 - MCRZ_METTM

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Protein
Methyl-coenzyme M reductase II subunit gamma
Gene
mrtG, MTBMA_c15130
Organism
Methanothermobacter marburgensis (strain DSM 2133 / 14651 / NBRC 100331 / OCM 82 / Marburg) (Methanobacterium thermoautotrophicum)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Reduction of methyl-coenzyme M (2-(methylthio) ethanesulfonic acid) with 7-mercaptoheptanoylthreonine phosphate to methane and a heterodisulfide.

Catalytic activityi

Methyl-CoM + CoB = CoM-S-S-CoB + methane.

Pathwayi

GO - Molecular functioni

  1. coenzyme-B sulfoethylthiotransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. methanogenesis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Methanogenesis

Enzyme and pathway databases

BioCyciMMAR79929:GH5J-1517-MONOMER.
UniPathwayiUPA00646; UER00699.

Names & Taxonomyi

Protein namesi
Recommended name:
Methyl-coenzyme M reductase II subunit gamma (EC:2.8.4.1)
Short name:
MCR II gamma
Gene namesi
Name:mrtG
Ordered Locus Names:MTBMA_c15130
OrganismiMethanothermobacter marburgensis (strain DSM 2133 / 14651 / NBRC 100331 / OCM 82 / Marburg) (Methanobacterium thermoautotrophicum)
Taxonomic identifieri79929 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanothermobacter
ProteomesiUP000000345: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 265264Methyl-coenzyme M reductase II subunit gamma
PRO_0000147481Add
BLAST

Expressioni

Developmental stagei

There are two MCR complexes in this bacteria. MCR II is expressed in the early growth phase. Late growth cells contains mostly MCR I.

Interactioni

Subunit structurei

Hexamer of two alpha, two beta, and two gamma chains.

Family & Domainsi

Phylogenomic databases

HOGENOMiHOG000225820.
KOiK00402.
OMAiGHRNPGE.

Family and domain databases

Gene3Di3.90.320.20. 1 hit.
InterProiIPR009024. Me_CoM_Rdtase_Fd-like_fold.
IPR003178. Me_CoM_Rdtase_gsu.
[Graphical view]
PfamiPF02240. MCR_gamma. 1 hit.
[Graphical view]
PIRSFiPIRSF000264. Meth_CoM_rd_gama. 1 hit.
SUPFAMiSSF55088. SSF55088. 1 hit.
TIGRFAMsiTIGR03259. met_CoM_red_gam. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P58816-1 [UniParc]FASTAAdd to Basket

« Hide

MSYKAQYTPG ETQIAENRRK HMDPDYEFRK LREVSDEDLV KVLGHRNPGE    50
SYKSVHPPLD EMDFEEDIVR DMVEPIQGAK EGVRVRYIQF ADSMYNAPAQ 100
PYDRARTYMW RYRGVDTGTL SGRQVIEMRE LDLEGVSKEL VETELFDPAT 150
TGIRGATVHG HSLRLDENGL MFDALQRYVF DEEKGHVVYV KDQVGRPLDE 200
PVDMGQPLGE DELKKITTIY RKDNIAMRDD KEAIEVVENI HTGRTLGGFG 250
MDVFKDDLRK RLGDD 265
Length:265
Mass (Da):30,535
Last modified:November 30, 2010 - v3
Checksum:iEA917838AE5A3CA9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001710 Genomic DNA. Translation: ADL59092.1.
PIRiE69017.
RefSeqiYP_003850405.1. NC_014408.1.

Genome annotation databases

EnsemblBacteriaiADL59092; ADL59092; MTBMA_c15130.
GeneIDi9705222.
KEGGimmg:MTBMA_c15130.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001710 Genomic DNA. Translation: ADL59092.1 .
PIRi E69017.
RefSeqi YP_003850405.1. NC_014408.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADL59092 ; ADL59092 ; MTBMA_c15130 .
GeneIDi 9705222.
KEGGi mmg:MTBMA_c15130.

Phylogenomic databases

HOGENOMi HOG000225820.
KOi K00402.
OMAi GHRNPGE.

Enzyme and pathway databases

UniPathwayi UPA00646 ; UER00699 .
BioCyci MMAR79929:GH5J-1517-MONOMER.

Family and domain databases

Gene3Di 3.90.320.20. 1 hit.
InterProi IPR009024. Me_CoM_Rdtase_Fd-like_fold.
IPR003178. Me_CoM_Rdtase_gsu.
[Graphical view ]
Pfami PF02240. MCR_gamma. 1 hit.
[Graphical view ]
PIRSFi PIRSF000264. Meth_CoM_rd_gama. 1 hit.
SUPFAMi SSF55088. SSF55088. 1 hit.
TIGRFAMsi TIGR03259. met_CoM_red_gam. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete genome sequence of Methanothermobacter marburgensis, a methanoarchaeon model organism."
    Liesegang H., Kaster A.K., Wiezer A., Goenrich M., Wollherr A., Seedorf H., Gottschalk G., Thauer R.K.
    J. Bacteriol. 192:5850-5851(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 2133 / 14651 / NBRC 100331 / OCM 82 / Marburg.
  2. "Two genetically distinct methyl-coenzyme M reductases in Methanobacterium thermoautotrophicum strain Marburg and delta H."
    Rospert S., Linder D., Ellermann J., Thauer R.K.
    Eur. J. Biochem. 194:871-877(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-15.
    Strain: DSM 2133 / 14651 / NBRC 100331 / OCM 82 / Marburg.

Entry informationi

Entry nameiMCRZ_METTM
AccessioniPrimary (citable) accession number: P58816
Secondary accession number(s): D9PXZ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: November 30, 2010
Last modified: September 3, 2014
This is version 54 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways

External Data

Dasty 3

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