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Protein

Methyl-coenzyme M reductase II subunit gamma

Gene

mrtG

Organism
Methanothermobacter marburgensis (strain ATCC BAA-927 / DSM 2133 / JCM 14651 / NBRC 100331 / OCM 82 / Marburg) (Methanobacterium thermoautotrophicum)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Reduction of methyl-coenzyme M (2-(methylthio) ethanesulfonic acid) with 7-mercaptoheptanoylthreonine phosphate to methane and a heterodisulfide.

Catalytic activityi

Methyl-CoM + CoB = CoM-S-S-CoB + methane.

Pathwayi: methyl-coenzyme M reduction

This protein is involved in step 1 of the subpathway that synthesizes methane from methyl-coenzyme M.
Proteins known to be involved in this subpathway in this organism are:
  1. Methyl-coenzyme M reductase II subunit alpha (mrtA), Methyl-coenzyme M reductase II subunit gamma (mrtG), Methyl-coenzyme M reductase I subunit beta (mcrB), Methyl-coenzyme M reductase I subunit alpha (mcrA), Methyl-coenzyme M reductase I subunit gamma (mcrG)
This subpathway is part of the pathway methyl-coenzyme M reduction, which is itself part of One-carbon metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes methane from methyl-coenzyme M, the pathway methyl-coenzyme M reduction and in One-carbon metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Methanogenesis

Enzyme and pathway databases

UniPathwayiUPA00646; UER00699.

Names & Taxonomyi

Protein namesi
Recommended name:
Methyl-coenzyme M reductase II subunit gamma (EC:2.8.4.1)
Short name:
MCR II gamma
Gene namesi
Name:mrtG
Ordered Locus Names:MTBMA_c15130
OrganismiMethanothermobacter marburgensis (strain ATCC BAA-927 / DSM 2133 / JCM 14651 / NBRC 100331 / OCM 82 / Marburg) (Methanobacterium thermoautotrophicum)
Taxonomic identifieri79929 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanothermobacter
Proteomesi
  • UP000000345 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001474812 – 265Methyl-coenzyme M reductase II subunit gammaAdd BLAST264

Expressioni

Developmental stagei

There are two MCR complexes in this bacteria. MCR II is expressed in the early growth phase. Late growth cells contains mostly MCR I.

Interactioni

Subunit structurei

Hexamer of two alpha, two beta, and two gamma chains.

Protein-protein interaction databases

STRINGi79929.MTBMA_c15130.

Structurei

Secondary structure

1265
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi13 – 22Combined sources10
Helixi36 – 43Combined sources8
Beta strandi54 – 56Combined sources3
Helixi59 – 61Combined sources3
Helixi68 – 71Combined sources4
Helixi77 – 80Combined sources4
Beta strandi85 – 92Combined sources8
Turni94 – 96Combined sources3
Helixi101 – 111Combined sources11
Beta strandi116 – 119Combined sources4
Beta strandi124 – 129Combined sources6
Helixi130 – 142Combined sources13
Turni148 – 150Combined sources3
Beta strandi151 – 153Combined sources3
Beta strandi177 – 181Combined sources5
Turni182 – 185Combined sources4
Beta strandi186 – 191Combined sources6
Beta strandi197 – 203Combined sources7
Helixi210 – 216Combined sources7
Helixi227 – 229Combined sources3
Helixi231 – 249Combined sources19
Turni251 – 254Combined sources4
Helixi255 – 262Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5A8RX-ray2.15C/F/I/L1-265[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiarCOG04858. Archaea.
COG4057. LUCA.
HOGENOMiHOG000225820.
KOiK00402.
OMAiHRNPGES.

Family and domain databases

CDDicd00539. MCR_gamma. 1 hit.
Gene3Di3.90.320.20. 1 hit.
InterProiIPR009024. Me_CoM_Rdtase_Fd-like_fold.
IPR003178. Me_CoM_Rdtase_gsu.
[Graphical view]
PfamiPF02240. MCR_gamma. 1 hit.
[Graphical view]
PIRSFiPIRSF000264. Meth_CoM_rd_gama. 1 hit.
ProDomiPD005845. Me_CoM_Rdtase_gsu. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF55088. SSF55088. 1 hit.
TIGRFAMsiTIGR03259. met_CoM_red_gam. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P58816-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYKAQYTPG ETQIAENRRK HMDPDYEFRK LREVSDEDLV KVLGHRNPGE
60 70 80 90 100
SYKSVHPPLD EMDFEEDIVR DMVEPIQGAK EGVRVRYIQF ADSMYNAPAQ
110 120 130 140 150
PYDRARTYMW RYRGVDTGTL SGRQVIEMRE LDLEGVSKEL VETELFDPAT
160 170 180 190 200
TGIRGATVHG HSLRLDENGL MFDALQRYVF DEEKGHVVYV KDQVGRPLDE
210 220 230 240 250
PVDMGQPLGE DELKKITTIY RKDNIAMRDD KEAIEVVENI HTGRTLGGFG
260
MDVFKDDLRK RLGDD
Length:265
Mass (Da):30,535
Last modified:November 30, 2010 - v3
Checksum:iEA917838AE5A3CA9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001710 Genomic DNA. Translation: ADL59092.1.
PIRiE69017.
RefSeqiWP_013296303.1. NC_014408.1.

Genome annotation databases

EnsemblBacteriaiADL59092; ADL59092; MTBMA_c15130.
GeneIDi9705222.
KEGGimmg:MTBMA_c15130.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001710 Genomic DNA. Translation: ADL59092.1.
PIRiE69017.
RefSeqiWP_013296303.1. NC_014408.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5A8RX-ray2.15C/F/I/L1-265[»]
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi79929.MTBMA_c15130.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADL59092; ADL59092; MTBMA_c15130.
GeneIDi9705222.
KEGGimmg:MTBMA_c15130.

Phylogenomic databases

eggNOGiarCOG04858. Archaea.
COG4057. LUCA.
HOGENOMiHOG000225820.
KOiK00402.
OMAiHRNPGES.

Enzyme and pathway databases

UniPathwayiUPA00646; UER00699.

Family and domain databases

CDDicd00539. MCR_gamma. 1 hit.
Gene3Di3.90.320.20. 1 hit.
InterProiIPR009024. Me_CoM_Rdtase_Fd-like_fold.
IPR003178. Me_CoM_Rdtase_gsu.
[Graphical view]
PfamiPF02240. MCR_gamma. 1 hit.
[Graphical view]
PIRSFiPIRSF000264. Meth_CoM_rd_gama. 1 hit.
ProDomiPD005845. Me_CoM_Rdtase_gsu. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF55088. SSF55088. 1 hit.
TIGRFAMsiTIGR03259. met_CoM_red_gam. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMCRZ_METTM
AccessioniPrimary (citable) accession number: P58816
Secondary accession number(s): D9PXZ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: November 30, 2010
Last modified: November 30, 2016
This is version 63 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.