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P58816

- MCRZ_METTM

UniProt

P58816 - MCRZ_METTM

Protein

Methyl-coenzyme M reductase II subunit gamma

Gene

mrtG

Organism
Methanothermobacter marburgensis (strain DSM 2133 / 14651 / NBRC 100331 / OCM 82 / Marburg) (Methanobacterium thermoautotrophicum)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 3 (30 Nov 2010)
      Previous versions | rss
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    Functioni

    Reduction of methyl-coenzyme M (2-(methylthio) ethanesulfonic acid) with 7-mercaptoheptanoylthreonine phosphate to methane and a heterodisulfide.

    Catalytic activityi

    Methyl-CoM + CoB = CoM-S-S-CoB + methane.

    Pathwayi

    GO - Molecular functioni

    1. coenzyme-B sulfoethylthiotransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. methanogenesis Source: UniProtKB-KW

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Methanogenesis

    Enzyme and pathway databases

    BioCyciMMAR79929:GH5J-1517-MONOMER.
    UniPathwayiUPA00646; UER00699.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Methyl-coenzyme M reductase II subunit gamma (EC:2.8.4.1)
    Short name:
    MCR II gamma
    Gene namesi
    Name:mrtG
    Ordered Locus Names:MTBMA_c15130
    OrganismiMethanothermobacter marburgensis (strain DSM 2133 / 14651 / NBRC 100331 / OCM 82 / Marburg) (Methanobacterium thermoautotrophicum)
    Taxonomic identifieri79929 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanothermobacter
    ProteomesiUP000000345: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 265264Methyl-coenzyme M reductase II subunit gammaPRO_0000147481Add
    BLAST

    Expressioni

    Developmental stagei

    There are two MCR complexes in this bacteria. MCR II is expressed in the early growth phase. Late growth cells contains mostly MCR I.

    Interactioni

    Subunit structurei

    Hexamer of two alpha, two beta, and two gamma chains.

    Family & Domainsi

    Phylogenomic databases

    HOGENOMiHOG000225820.
    KOiK00402.
    OMAiGHRNPGE.

    Family and domain databases

    Gene3Di3.90.320.20. 1 hit.
    InterProiIPR009024. Me_CoM_Rdtase_Fd-like_fold.
    IPR003178. Me_CoM_Rdtase_gsu.
    [Graphical view]
    PfamiPF02240. MCR_gamma. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000264. Meth_CoM_rd_gama. 1 hit.
    SUPFAMiSSF55088. SSF55088. 1 hit.
    TIGRFAMsiTIGR03259. met_CoM_red_gam. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P58816-1 [UniParc]FASTAAdd to Basket

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    MSYKAQYTPG ETQIAENRRK HMDPDYEFRK LREVSDEDLV KVLGHRNPGE    50
    SYKSVHPPLD EMDFEEDIVR DMVEPIQGAK EGVRVRYIQF ADSMYNAPAQ 100
    PYDRARTYMW RYRGVDTGTL SGRQVIEMRE LDLEGVSKEL VETELFDPAT 150
    TGIRGATVHG HSLRLDENGL MFDALQRYVF DEEKGHVVYV KDQVGRPLDE 200
    PVDMGQPLGE DELKKITTIY RKDNIAMRDD KEAIEVVENI HTGRTLGGFG 250
    MDVFKDDLRK RLGDD 265
    Length:265
    Mass (Da):30,535
    Last modified:November 30, 2010 - v3
    Checksum:iEA917838AE5A3CA9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001710 Genomic DNA. Translation: ADL59092.1.
    PIRiE69017.
    RefSeqiYP_003850405.1. NC_014408.1.

    Genome annotation databases

    EnsemblBacteriaiADL59092; ADL59092; MTBMA_c15130.
    GeneIDi9705222.
    KEGGimmg:MTBMA_c15130.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001710 Genomic DNA. Translation: ADL59092.1 .
    PIRi E69017.
    RefSeqi YP_003850405.1. NC_014408.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADL59092 ; ADL59092 ; MTBMA_c15130 .
    GeneIDi 9705222.
    KEGGi mmg:MTBMA_c15130.

    Phylogenomic databases

    HOGENOMi HOG000225820.
    KOi K00402.
    OMAi GHRNPGE.

    Enzyme and pathway databases

    UniPathwayi UPA00646 ; UER00699 .
    BioCyci MMAR79929:GH5J-1517-MONOMER.

    Family and domain databases

    Gene3Di 3.90.320.20. 1 hit.
    InterProi IPR009024. Me_CoM_Rdtase_Fd-like_fold.
    IPR003178. Me_CoM_Rdtase_gsu.
    [Graphical view ]
    Pfami PF02240. MCR_gamma. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000264. Meth_CoM_rd_gama. 1 hit.
    SUPFAMi SSF55088. SSF55088. 1 hit.
    TIGRFAMsi TIGR03259. met_CoM_red_gam. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of Methanothermobacter marburgensis, a methanoarchaeon model organism."
      Liesegang H., Kaster A.K., Wiezer A., Goenrich M., Wollherr A., Seedorf H., Gottschalk G., Thauer R.K.
      J. Bacteriol. 192:5850-5851(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 2133 / 14651 / NBRC 100331 / OCM 82 / Marburg.
    2. "Two genetically distinct methyl-coenzyme M reductases in Methanobacterium thermoautotrophicum strain Marburg and delta H."
      Rospert S., Linder D., Ellermann J., Thauer R.K.
      Eur. J. Biochem. 194:871-877(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-15.
      Strain: DSM 2133 / 14651 / NBRC 100331 / OCM 82 / Marburg.

    Entry informationi

    Entry nameiMCRZ_METTM
    AccessioniPrimary (citable) accession number: P58816
    Secondary accession number(s): D9PXZ4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 10, 2002
    Last sequence update: November 30, 2010
    Last modified: October 1, 2014
    This is version 55 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways

    External Data

    Dasty 3