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Protein

Methyl-coenzyme M reductase II subunit gamma

Gene

mrtG

Organism
Methanothermobacter marburgensis (strain ATCC BAA-927 / DSM 2133 / JCM 14651 / NBRC 100331 / OCM 82 / Marburg) (Methanobacterium thermoautotrophicum)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Reduction of methyl-coenzyme M (2-(methylthio) ethanesulfonic acid) with 7-mercaptoheptanoylthreonine phosphate to methane and a heterodisulfide.

Catalytic activityi

Methyl-CoM + CoB = CoM-S-S-CoB + methane.

Pathwayi: methyl-coenzyme M reduction

This protein is involved in step 1 of the subpathway that synthesizes methane from methyl-coenzyme M.
Proteins known to be involved in this subpathway in this organism are:
  1. Methyl-coenzyme M reductase II subunit alpha (mrtA), Methyl-coenzyme M reductase I subunit beta (mcrB), Methyl-coenzyme M reductase II subunit gamma (mrtG), Methyl-coenzyme M reductase I subunit alpha (mcrA), Methyl-coenzyme M reductase subunit beta (mrtB), Methyl-coenzyme M reductase I subunit gamma (mcrG)
This subpathway is part of the pathway methyl-coenzyme M reduction, which is itself part of One-carbon metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes methane from methyl-coenzyme M, the pathway methyl-coenzyme M reduction and in One-carbon metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processMethanogenesis

Enzyme and pathway databases

BioCyciMMAR79929:G1GML-1490-MONOMER
UniPathwayiUPA00646; UER00699

Names & Taxonomyi

Protein namesi
Recommended name:
Methyl-coenzyme M reductase II subunit gamma (EC:2.8.4.1)
Short name:
MCR II gamma
Gene namesi
Name:mrtG
Ordered Locus Names:MTBMA_c15130
OrganismiMethanothermobacter marburgensis (strain ATCC BAA-927 / DSM 2133 / JCM 14651 / NBRC 100331 / OCM 82 / Marburg) (Methanobacterium thermoautotrophicum)
Taxonomic identifieri79929 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanothermobacter
Proteomesi
  • UP000000345 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001474812 – 265Methyl-coenzyme M reductase II subunit gammaAdd BLAST264

Expressioni

Developmental stagei

There are two MCR complexes in this bacteria. MCR II is expressed in the early growth phase. Late growth cells contains mostly MCR I.

Interactioni

Subunit structurei

Hexamer of two alpha, two beta, and two gamma chains.

Protein-protein interaction databases

STRINGi79929.MTBMA_c15130

Structurei

Secondary structure

1265
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi13 – 22Combined sources10
Helixi36 – 43Combined sources8
Beta strandi54 – 56Combined sources3
Helixi59 – 61Combined sources3
Helixi68 – 71Combined sources4
Helixi77 – 80Combined sources4
Beta strandi85 – 92Combined sources8
Turni94 – 96Combined sources3
Helixi101 – 111Combined sources11
Beta strandi116 – 119Combined sources4
Beta strandi124 – 129Combined sources6
Helixi130 – 142Combined sources13
Turni148 – 150Combined sources3
Beta strandi151 – 153Combined sources3
Beta strandi177 – 181Combined sources5
Turni182 – 185Combined sources4
Beta strandi186 – 191Combined sources6
Beta strandi197 – 203Combined sources7
Helixi210 – 216Combined sources7
Helixi227 – 229Combined sources3
Helixi231 – 249Combined sources19
Turni251 – 254Combined sources4
Helixi255 – 262Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5A8RX-ray2.15C/F/I/L1-265[»]
SMRiP58816
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiarCOG04858 Archaea
COG4057 LUCA
HOGENOMiHOG000225820
KOiK00402
OMAiGHRNPGE
OrthoDBiPOG093Z08I2

Family and domain databases

CDDicd00539 MCR_gamma, 1 hit
Gene3Di3.90.320.20, 1 hit
InterProiView protein in InterPro
IPR009024 Me_CoM_Rdtase_Fd-like_fold
IPR003178 Me_CoM_Rdtase_gsu
IPR036994 Me_CoM_Rdtase_gsu_sf
PfamiView protein in Pfam
PF02240 MCR_gamma, 1 hit
PIRSFiPIRSF000264 Meth_CoM_rd_gama, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD005845 Me_CoM_Rdtase_gsu, 1 hit
SUPFAMiSSF55088 SSF55088, 1 hit
TIGRFAMsiTIGR03259 met_CoM_red_gam, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P58816-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYKAQYTPG ETQIAENRRK HMDPDYEFRK LREVSDEDLV KVLGHRNPGE
60 70 80 90 100
SYKSVHPPLD EMDFEEDIVR DMVEPIQGAK EGVRVRYIQF ADSMYNAPAQ
110 120 130 140 150
PYDRARTYMW RYRGVDTGTL SGRQVIEMRE LDLEGVSKEL VETELFDPAT
160 170 180 190 200
TGIRGATVHG HSLRLDENGL MFDALQRYVF DEEKGHVVYV KDQVGRPLDE
210 220 230 240 250
PVDMGQPLGE DELKKITTIY RKDNIAMRDD KEAIEVVENI HTGRTLGGFG
260
MDVFKDDLRK RLGDD
Length:265
Mass (Da):30,535
Last modified:November 30, 2010 - v3
Checksum:iEA917838AE5A3CA9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001710 Genomic DNA Translation: ADL59092.1
PIRiE69017
RefSeqiWP_013296303.1, NC_014408.1

Genome annotation databases

EnsemblBacteriaiADL59092; ADL59092; MTBMA_c15130
GeneIDi9705222
KEGGimmg:MTBMA_c15130
PATRICifig|79929.8.peg.1466

Similar proteinsi

Entry informationi

Entry nameiMCRZ_METTM
AccessioniPrimary (citable) accession number: P58816
Secondary accession number(s): D9PXZ4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: November 30, 2010
Last modified: March 28, 2018
This is version 69 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing
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Main funding by: National Institutes of Health