Reviewed, UniProtKB/Swiss-Prot P58814 (APGM_PYRFU)

Names and origin

Protein names

Recommended name:
    2,3-bisphosphoglycerate-independent phosphoglycerate mutase
      Short name=Phosphoglyceromutase
      Short name=BPG-independent PGAM
      Short name=aPGAM
    EC=5.4.2.1

Gene names

Name:	apgM
Ordered Locus Names:	PF1959

Organism

Pyrococcus furiosus [Complete proteome] [HAMAP]

Taxonomic identifier

2261 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Pyrococcus

Protein attributes

Sequence length	411 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate. HAMAP MF_01402
Catalytic activity	2-phospho-D-glycerate = 3-phospho-D-glycerate. HAMAP MF_01402
Cofactor	Magnesium Probable.
Enzyme regulation	Inhibited to approximately 20% by EDTA. HAMAP MF_01402
Pathway	Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5. HAMAP MF_01402
Subunit structure	Homotetramer Probable.
Sequence similarities	Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.
Biophysicochemical properties	pH dependence: Optimum pH is 8.0. HAMAP MF_01402

Ontologies

Keywords
Biological process	Glycolysis
Ligand	Magnesium
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity Inferred from electronic annotation. Source: HAMAP magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 411	411	2,3-bisphosphoglycerate-independent phosphoglycerate mutase HAMAP MF_01402		PRO_0000138144

Sequences

	Sequence		Length	Mass (Da)
	P58814-1 [UniParc]. Last modified May 2, 2002. Version 1. Checksum: 870587E630C2B104	FASTA	411	45,314
	10 20 30 40 50 60 MKQRKGVLII LDGLGDRPIK ELGGKTPLEY ANTPTMDYLA KIGILGQQDP IKPGQPAGSD 70 80 90 100 110 120 TAHLSIFGYD PYKSYRGRGY FEALGVGLEL DEDDLAFRVN FATLENGVIT DRRAGRISTE 130 140 150 160 170 180 EAHELAKAIQ ENVDIPVDFI FKGATGHRAV LVLKGMAEGY KVGENDPHEA GKPPHPFTWE 190 200 210 220 230 240 DEASKKVAEI LEEFVKKAHE VLDKHPINEK RRKEGKPVAN YLLIRGAGTY PNIPMKFTEQ 250 260 270 280 290 300 WKVKAAAVVA VALVKGVAKA IGFDVYTPKG ATGEYNTDEM AKARKAVELL KDYDFVFIHF 310 320 330 340 350 360 KPTDAAGHDN NPKLKAELIE RADRMIKYIV DHVDLEDVVI AITGDHSTPC EVMNHSGDPV 370 380 390 400 410 PLLIAGGGVR ADYTEKFGER EAMRGGLGRI RGHDIVPIMM DLMNRTEKFG A

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The complete sequence of the Pyrococcus furiosus genome." Weiss R.B., Dunn D.M., Robb F.T., Brown J.R. Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43587 / DSM 3638 / JCM 8422 / Vc1.
[2]	"Molecular characterization of phosphoglycerate mutase in archaea." van der Oost J., Huynen M.A., Verhees C.H. FEMS Microbiol. Lett. 212:111-120(2002) [PubMed: 12076796] [Abstract] Cited for: CHARACTERIZATION. Strain: ATCC 43587 / DSM 3638 / JCM 8422 / Vc1.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE009950 Genomic DNA. Translation: AAL82083.1.
RefSeq	NP_579688.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1469841.
GenomeReviews	Gene locus PF1959 in contig AE009950_GR.
KEGG	pfu:PF1959.
NMPDR	fig|186497.1.peg.2011.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	P58814.
OMA	ITGDHST.
Enzyme and pathway databases
BRENDA	5.4.2.1. 321.
Family and domain databases
HAMAP	MF_01402. [Tree]
InterPro	IPR004456. APGAM_arc. IPR019304. bisP-indep_Pglycerate_Mutase. IPR006124. Metalloenzyme. [Graphical view]
Pfam	PF01676. Metalloenzyme. 1 hit. PF10143. PhosphMutase. 1 hit. [Graphical view]
PIRSF	PIRSF006392. IPGAM_arch. 1 hit.
ProDom	PD004704. APGAM_DeoB. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00306. apgM. 1 hit.
ProtoNet	Search...

Entry information

Entry name

APGM_PYRFU

Accession

Primary (citable) accession number: P58814

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 2, 2002
Last sequence update:	May 2, 2002
Last modified:	November 3, 2009
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)