Reviewed, UniProtKB/Swiss-Prot P58812 (APGM_METAC)

Names and origin

Protein names

Recommended name:
    2,3-bisphosphoglycerate-independent phosphoglycerate mutase
      Short name=Phosphoglyceromutase
      Short name=BPG-independent PGAM
      Short name=aPGAM
    EC=5.4.2.1

Gene names

Name:	apgM
Ordered Locus Names:	MA_0132

Organism

Methanosarcina acetivorans [Complete proteome] [HAMAP]

Taxonomic identifier

2214 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanomicrobia › Methanosarcinales › Methanosarcinaceae › Methanosarcina

Protein attributes

Sequence length	397 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate By similarity.
Catalytic activity	2-phospho-D-glycerate = 3-phospho-D-glycerate. HAMAP MF_01402
Pathway	Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5. HAMAP MF_01402
Sequence similarities	Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.

Ontologies

Keywords
Biological process	Glycolysis
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity Inferred from electronic annotation. Source: HAMAP metal ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 397	397	2,3-bisphosphoglycerate-independent phosphoglycerate mutase HAMAP MF_01402		PRO_0000138133

Sequences

	Sequence		Length	Mass (Da)
	P58812-1 [UniParc]. Last modified May 2, 2002. Version 1. Checksum: 619F1075EB8F6115	FASTA	397	42,900
	10 20 30 40 50 60 MKYAVLIGDG MADYPIEELG SRTILQAART PAMDSIAARG KTGLAKTVPE GFPPGSDVAN 70 80 90 100 110 120 MSIFGYDPAI YYSGRAPLEA ASMGVALAAD DVAFRCNLIT IENGKIKDYS AGHISSDEAE 130 140 150 160 170 180 ILIDTLDSEL RTEKVRFYPG ISYRHLIVAG NDLGAETECT PPHDITGERK DDYLPRGKDG 190 200 210 220 230 240 EFFSGLIEAS TVVLELHPVN LKRVQEGKNP ANSIWVWGQG YAPKFKTFQE LYGKSGAIIS 250 260 270 280 290 300 AVDLLKGIGI YAGLDVIEVP GATGYLDTNY EGKASAAIEA LKTRDLVFVH VEAPDEAGHE 310 320 330 340 350 360 GSLEKKMKAI EDFDSRIVSP ILKHAEASDE TFTILVLPDH PTPISVKTHT RDPIPFAIYR 370 380 390 TDAADPDGVE YFDEESVKNG SMGLVKASDL IGMLVKV

References

[1]

"The genome of Methanosarcina acetivorans reveals extensive metabolic and physiological diversity." Galagan J.E., Nusbaum C., Roy A., Endrizzi M.G., Macdonald P., FitzHugh W., Calvo S., Engels R., Smirnov S., Atnoor D., Brown A., Allen N., Naylor J., Stange-Thomann N., DeArellano K., Johnson R., Linton L., McEwan P. , McKernan K., Talamas J., Tirrell A., Ye W., Zimmer A., Barber R.D., Cann I., Graham D.E., Grahame D.A., Guss A.M., Hedderich R., Ingram-Smith C., Kuettner H.C., Krzycki J.A., Leigh J.A., Li W., Liu J., Mukhopadhyay B., Reeve J.N., Smith K., Springer T.A., Umayam L.A., White O., White R.H., de Macario E.C., Ferry J.G., Jarrell K.F., Jing H., Macario A.J.L., Paulsen I.T., Pritchett M., Sowers K.R., Swanson R.V., Zinder S.H., Lander E., Metcalf W.W., Birren B. Genome Res. 12:532-542(2002) [PubMed: 11932238] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 35395 / DSM 2834 / JCM 12185 / C2A.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE010299 Genomic DNA. Translation: AAM03586.1.
RefSeq	NP_615106.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1472024.
GenomeReviews	Gene locus MA_0132 in contig AE010299_GR.
KEGG	mac:MA0132.
NMPDR	fig|188937.1.peg.132.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	P58812.
OMA	GATGYLD.
Enzyme and pathway databases
BioCyc	MACE188937:MA0132-MON.
BRENDA	5.4.2.1. 275708.
Family and domain databases
HAMAP	MF_01402. [Tree]
InterPro	IPR004456. APGAM_arc. IPR019304. bisP-indep_Pglycerate_Mutase. IPR013371. Homoserine_kin_put. IPR006124. Metalloenzyme. [Graphical view]
Pfam	PF01676. Metalloenzyme. 1 hit. PF10143. PhosphMutase. 1 hit. [Graphical view]
PIRSF	PIRSF006392. IPGAM_arch. 1 hit.
ProDom	PD004704. APGAM_DeoB. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00306. apgM. 1 hit. TIGR02535. hyp_Hser_kinase. 1 hit.
ProtoNet	Search...

Entry information

Entry name

APGM_METAC

Accession

Primary (citable) accession number: P58812

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 2, 2002
Last sequence update:	May 2, 2002
Last modified:	November 3, 2009
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)