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Protein

Conantokin-R

Gene
N/A
Organism
Conus radiatus (Rayed cone)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Conantokins inhibit N-methyl-D-aspartate (NMDA) receptors. This toxin is potent in the following order of preference: NR2B approximately NR2A/GRIN2A > NR2C/GRIN2C >> NR2D/GRIN2D. Induces sleep-like symptoms in young mice. Is a highly potent anticonvulsant compound.1 Publication

Miscellaneous

Exists in two forms, due to cis-trans isomerization at 106-Tyr-Pro-107.
Stabilized by divalent cations. Calcium, magnesium or zinc.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei85Significant for the subtype selectivity between NR2B/GRIN2B and NR2D/GRIN2D (potent for NR2B/GRIN2B but not for NR2D/GRIN2D)1
Metal bindingi91Divalent metal cation; via 4-carboxyglutamate1
Metal bindingi95Divalent metal cation; via 4-carboxyglutamate1

GO - Molecular functioni

Keywordsi

Molecular functionIon channel impairing toxin, Ionotropic glutamate receptor inhibitor, Neurotoxin, Postsynaptic neurotoxin, Toxin
LigandMetal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Conantokin-R
Short name:
Con-R
OrganismiConus radiatus (Rayed cone)
Taxonomic identifieri61198 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaHypsogastropodaNeogastropodaConoideaConidaeConus

Organism-specific databases

ConoServeri1375. Conantokin-R precursor.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi85 – 86VA → YS: No change in potency for NR2B/GRIN2B; 3-fold increase in potency for NR2D/GRIN2D. 1 Publication2
Mutagenesisi85V → I: Little decrease in potency for NR2B; little decrease in potency for NR2A. 2 Publications1
Mutagenesisi85V → L: No change in potency for NR2B; No change in potency for NR2A. 2 Publications1
Mutagenesisi85V → Y: Little increase in potency for NR2B; little increase in potency for NR2A. 2 Publications1
Mutagenesisi85V → Y: No change in potency for NR2B/GRIN2B; 3-fold increase in potency for NR2D/GRIN2D. 2 Publications1
Mutagenesisi88 – 90MAA → FI: Important decrease in potency for NR2B/GRIN2B; complete loss in potency for NR2D/GRIN2D. 1 Publication3

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
PropeptideiPRO_000003506425 – 801 PublicationAdd BLAST56
PeptideiPRO_000003506581 – 107Conantokin-RAdd BLAST27

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei834-carboxyglutamate1 Publication1
Modified residuei844-carboxyglutamate1 Publication1
Modified residuei914-carboxyglutamate1 Publication1
Modified residuei954-carboxyglutamate1 Publication1
Disulfide bondi101 ↔ 105

Keywords - PTMi

Disulfide bond, Gamma-carboxyglutamic acid

Expressioni

Tissue specificityi

Expressed by the venom duct.Curated

Structurei

3D structure databases

ProteinModelPortaliP58806.
SMRiP58806.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The cysteine framework is C-C.Curated

Sequence similaritiesi

Belongs to the conotoxin B superfamily.Curated

Keywords - Domaini

Signal

Family and domain databases

InterProiView protein in InterPro
IPR005918. Conantokin_CS.
PfamiView protein in Pfam
PF10550. Toxin_36. 1 hit.
PROSITEiView protein in PROSITE
PS60025. CONANTOKIN. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P58806-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQLYTYLYLL VSLVTFYLIL GTGTLGHGGA LTERRSTDAT ALKPEPVLLQ
60 70 80 90 100
KSSARSTDDN GNDRLTQMKR ILKKRGNKAR GEEEVAKMAA ELARENIAKG

CKVNCYP
Length:107
Mass (Da):11,834
Last modified:April 26, 2005 - v2
Checksum:i8C9BD6E9C83C4B78
GO

Mass spectrometryi

Molecular mass is 3098 Da from positions 81 - 107. 1 Publication

Similar proteinsi

Entry informationi

Entry nameiCKR_CONRA
AccessioniPrimary (citable) accession number: P58806
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: April 26, 2005
Last modified: November 22, 2017
This is version 61 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families