##gff-version 3
P58801	UniProtKB	Chain	1	539	.	.	.	ID=PRO_0000086609;Note=Receptor-interacting serine/threonine-protein kinase 2	
P58801	UniProtKB	Domain	18	294	.	.	.	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159	
P58801	UniProtKB	Domain	431	523	.	.	.	Note=CARD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00046	
P58801	UniProtKB	Region	65	73	.	.	.	Note=Helix alphaC;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O43353	
P58801	UniProtKB	Region	167	193	.	.	.	Note=Activation segment (AS);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O43353	
P58801	UniProtKB	Region	335	368	.	.	.	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
P58801	UniProtKB	Region	519	539	.	.	.	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
P58801	UniProtKB	Compositional bias	337	367	.	.	.	Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
P58801	UniProtKB	Active site	146	146	.	.	.	Note=Proton acceptor;Ontology_term=ECO:0000255,ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000255|PROSITE-ProRule:PRU10027	
P58801	UniProtKB	Binding site	24	32	.	.	.	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159	
P58801	UniProtKB	Binding site	47	47	.	.	.	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159	
P58801	UniProtKB	Modified residue	168	168	.	.	.	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O43353	
P58801	UniProtKB	Modified residue	174	174	.	.	.	Note=Phosphoserine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O43353	
P58801	UniProtKB	Modified residue	176	176	.	.	.	Note=Phosphoserine%3B by autocatalysis;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19473975;Dbxref=PMID:19473975	
P58801	UniProtKB	Modified residue	178	178	.	.	.	Note=Phosphoserine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O43353	
P58801	UniProtKB	Modified residue	180	180	.	.	.	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O43353	
P58801	UniProtKB	Modified residue	362	362	.	.	.	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O43353	
P58801	UniProtKB	Modified residue	392	392	.	.	.	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O43353	
P58801	UniProtKB	Modified residue	411	411	.	.	.	Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:21183079;Dbxref=PMID:21183079	
P58801	UniProtKB	Modified residue	473	473	.	.	.	Note=Phosphotyrosine%3B by autocatalysis;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O43353	
P58801	UniProtKB	Modified residue	526	526	.	.	.	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O43353	
P58801	UniProtKB	Modified residue	538	538	.	.	.	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O43353	
P58801	UniProtKB	Cross-link	209	209	.	.	.	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O43353	
P58801	UniProtKB	Cross-link	502	502	.	.	.	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O43353	
P58801	UniProtKB	Cross-link	537	537	.	.	.	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O43353	
P58801	UniProtKB	Mutagenesis	47	47	.	.	.	Note=Abolishes protein-kinase activity. Does not affect ubiquitination by PELI3. K->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19473975,ECO:0000269|PubMed:23892723;Dbxref=PMID:19473975,PMID:23892723	
P58801	UniProtKB	Mutagenesis	176	176	.	.	.	Note=Mimics phosphorylation%3B does not promote stabilization of RIPK2. S->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19473975;Dbxref=PMID:19473975	
P58801	UniProtKB	Mutagenesis	209	209	.	.	.	Note=Does not prevent polyubiquitination by PELI3. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23892723;Dbxref=PMID:23892723