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Protein

Adenosine deaminase 2

Gene

ADA2

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Adenosine deaminase that may contribute to the degradation of extracellular adenosine, a signaling molecule that controls a variety of cellular responses. Requires elevated adenosine levels for optimal enzyme activity. Binds to cell surfaces via proteoglycans and may play a role in the regulation of cell proliferation and differentiation, independently of its enzyme activity (By similarity).By similarity

Catalytic activityi

Adenosine + H2O = inosine + NH3.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi107Zinc; catalyticBy similarity1
Metal bindingi109Zinc; catalyticBy similarity1
Binding sitei110SubstrateBy similarity1
Binding sitei290SubstrateBy similarity1
Binding sitei323Substrate; via amide nitrogenBy similarity1
Metal bindingi353Zinc; catalyticBy similarity1
Active sitei356Proton donorBy similarity1
Active sitei381Proton acceptorBy similarity1
Metal bindingi438Zinc; catalyticBy similarity1
Binding sitei439SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHeparin-binding, Hydrolase
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Adenosine deaminase 2By similarity (EC:3.5.4.4By similarity)
Alternative name(s):
Cat eye syndrome critical region protein 1
Gene namesi
Name:ADA2By similarity
Synonyms:CECR1
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000000672625 – 510Adenosine deaminase 2Add BLAST486

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi122N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi132 ↔ 156By similarity
Glycosylationi171N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi375N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP58780.
PRIDEiP58780.

Interactioni

Subunit structurei

Homodimer. Interacts with adenosine receptors. Binds heparin (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000027144.

Structurei

3D structure databases

ProteinModelPortaliP58780.
SMRiP58780.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni25 – 95DimerizationBy similarityAdd BLAST71
Regioni122 – 182PRB domainBy similarityAdd BLAST61
Regioni201 – 208Substrate bindingBy similarity8

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi49 – 52Poly-Glu4
Compositional biasi146 – 151Poly-Pro6

Domaini

The PRB domain is involved in receptor binding, and may be responsible for the cytokine-like growth factor activity due to it's sharing of several structural properties with chemokines.By similarity
High-affinity binding to heparin/glycosaminoclycan (GAG) is mediated by a large, highly positively charged surface at the interface of dimer's subunits involving approximately residues 25-40, 386-393, and 419-425.By similarity

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1097. Eukaryota.
COG1816. LUCA.
HOVERGENiHBG050883.
InParanoidiP58780.
KOiK19572.

Family and domain databases

InterProiView protein in InterPro
IPR001365. A/AMP_deaminase_dom.
IPR013659. A_deaminase_N.
IPR006331. ADGF.
IPR032466. Metal_Hydrolase.
PfamiView protein in Pfam
PF00962. A_deaminase. 1 hit.
PF08451. A_deaminase_N. 1 hit.
SUPFAMiSSF51556. SSF51556. 1 hit.
TIGRFAMsiTIGR01431. adm_rel. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P58780-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGWPVLPAL LLAVAMSSFH SATSRDEERN RLLMREKMMQ VGGQLVLQEE
60 70 80 90 100
EERANGRLQA LKEAEMQEAK RTGIFPPSLH FFQAKGLMEK SAVFNILKKM
110 120 130 140 150
PKGAALHVHD FGMVSMDWLV KNATYRPYCY FCLTPKGATQ FKFAHPPPPT
160 170 180 190 200
PKQEECSEWV LLEKFRKGLP NVTEFDNSLL RTFTLMTENP QETYANQDMV
210 220 230 240 250
WKKFKTIFFA ISGLVNYAPV FRDFIFLGLE EFYQDQVLYL ELRAMLYPVY
260 270 280 290 300
ELNGMVHSRE WSVRTYEEVA RTFAKTHPGF IGIKLIYSDH RSKDVSLIKE
310 320 330 340 350
SVQRAMELRA KFPQMVAGFD LVGREDTGHS LYDYKEALMI PASRGVKLPY
360 370 380 390 400
FFHAGETDWQ GTSADRNLLD ALILNSTRIG HGFALSKHPA VWADAWRKDI
410 420 430 440 450
PLEVCPISNQ VLKLVSDLRN HPAAVLMATG YPMVISSDDP AAFGAKGLSY
460 470 480 490 500
DFYEAFMGLG GLTADLRTLK QLAMNSIRYS ALSETEKKVA METWEERWHR
510
FVAELTRGPK
Length:510
Mass (Da):58,190
Last modified:April 16, 2002 - v1
Checksum:i7C9C360E1E65EBBD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF384216 mRNA. Translation: AAL40921.1.
RefSeqiNP_999181.1. NM_214016.2.
UniGeneiSsc.79.

Genome annotation databases

GeneIDi397079.
KEGGissc:397079.

Similar proteinsi

Entry informationi

Entry nameiADA2_PIG
AccessioniPrimary (citable) accession number: P58780
Secondary accession number(s): Q8WND6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: April 16, 2002
Last modified: August 30, 2017
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families