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P58756

- SOMA_PANTR

UniProt

P58756 - SOMA_PANTR

Protein

Somatotropin

Gene

GH1

Organism
Pan troglodytes (Chimpanzee)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 1 (27 Mar 2002)
      Previous versions | rss
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    Functioni

    Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi44 – 441ZincBy similarity
    Metal bindingi200 – 2001ZincBy similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hormone

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Somatotropin
    Alternative name(s):
    Growth hormone
    Short name:
    GH
    Short name:
    GH-N
    Growth hormone 1
    Pituitary growth hormone
    Gene namesi
    Name:GH1
    OrganismiPan troglodytes (Chimpanzee)
    Taxonomic identifieri9598 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
    ProteomesiUP000002277: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2626By similarityAdd
    BLAST
    Chaini27 – 217191SomatotropinPRO_0000032996Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi79 ↔ 191By similarity
    Modified residuei132 – 1321PhosphoserineBy similarity
    Disulfide bondi208 ↔ 215By similarity

    Keywords - PTMi

    Disulfide bond, Phosphoprotein

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-1511069.
    STRINGi9598.ENSPTRP00000055878.

    Structurei

    3D structure databases

    ProteinModelPortaliP58756.
    SMRiP58756. Positions 27-216.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the somatotropin/prolactin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG26152.
    HOGENOMiHOG000068443.
    HOVERGENiHBG011318.
    KOiK05438.

    Family and domain databases

    Gene3Di1.20.1250.10. 1 hit.
    InterProiIPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR001400. Somatotropin.
    IPR018116. Somatotropin_CS.
    [Graphical view]
    PANTHERiPTHR11417. PTHR11417. 1 hit.
    PfamiPF00103. Hormone_1. 1 hit.
    [Graphical view]
    PRINTSiPR00836. SOMATOTROPIN.
    SUPFAMiSSF47266. SSF47266. 1 hit.
    PROSITEiPS00266. SOMATOTROPIN_1. 1 hit.
    PS00338. SOMATOTROPIN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P58756-1 [UniParc]FASTAAdd to Basket

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    MAPGSRTSLL LAFGLLCLPW LQEGSAFPTI PLSRLFDNAM LRAHRLHQLA    50
    FDTYQEFEEA YIPKEQKYSF LQNPQTSLCF SESIPTPSNR EETQQKSNLE 100
    LLRISLLLIQ SWLEPVQFLR SVFANSLVYG ASDSNVYDLL KDLEEGIQTL 150
    MGRLEDGSPR TGQIFKQTYS KFDTNSHNDD ALLKNYGLLY CFRKDMDKVE 200
    TFLRIVQCRS VEGSCGF 217
    Length:217
    Mass (Da):24,843
    Last modified:March 27, 2002 - v1
    Checksum:iFEA295EDE0518674
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF374232 Genomic DNA. Translation: AAL72284.1.
    RefSeqiNP_001184093.1. NM_001197164.1.
    UniGeneiPtr.6157.

    Genome annotation databases

    GeneIDi454774.
    KEGGiptr:454774.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF374232 Genomic DNA. Translation: AAL72284.1 .
    RefSeqi NP_001184093.1. NM_001197164.1.
    UniGenei Ptr.6157.

    3D structure databases

    ProteinModelPortali P58756.
    SMRi P58756. Positions 27-216.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-1511069.
    STRINGi 9598.ENSPTRP00000055878.

    Chemistry

    DrugBanki DB00082. Pegvisomant.
    DB00052. Somatropin recombinant.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 454774.
    KEGGi ptr:454774.

    Organism-specific databases

    CTDi 2688.

    Phylogenomic databases

    eggNOGi NOG26152.
    HOGENOMi HOG000068443.
    HOVERGENi HBG011318.
    KOi K05438.

    Miscellaneous databases

    NextBioi 20836350.

    Family and domain databases

    Gene3Di 1.20.1250.10. 1 hit.
    InterProi IPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR001400. Somatotropin.
    IPR018116. Somatotropin_CS.
    [Graphical view ]
    PANTHERi PTHR11417. PTHR11417. 1 hit.
    Pfami PF00103. Hormone_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00836. SOMATOTROPIN.
    SUPFAMi SSF47266. SSF47266. 1 hit.
    PROSITEi PS00266. SOMATOTROPIN_1. 1 hit.
    PS00338. SOMATOTROPIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Independent duplication of the growth hormone gene in three Anthropoidean lineages."
      Revol A., Esquivel D., Santiago D., Barrera-Saldana H.
      Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiSOMA_PANTR
    AccessioniPrimary (citable) accession number: P58756
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 27, 2002
    Last sequence update: March 27, 2002
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3