P58756 (SOMA_PANTR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Somatotropin

Alternative name(s):
Growth hormone
Short name=GH
Short name=GH-N
Growth hormone 1
Pituitary growth hormone

Gene names

Name:

GH1

Organism

Pan troglodytes (Chimpanzee) [Reference proteome]

Taxonomic identifier

9598 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Pan

Protein attributes

Sequence length	217 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues By similarity.
Subcellular location	Secreted.
Sequence similarities	Belongs to the somatotropin/prolactin family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Ligand	Metal-binding Zinc
Molecular function	Hormone
PTM	Disulfide bond Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 26	26	By similarity
	Chain	27 – 217	191	Somatotropin		PRO_0000032996
Sites
	Metal binding	44	1	Zinc By similarity
	Metal binding	200	1	Zinc By similarity
Amino acid modifications
	Modified residue	132	1	Phosphoserine By similarity
	Modified residue	176	1	Phosphoserine By similarity
	Disulfide bond	79 ↔ 191		By similarity
	Disulfide bond	208 ↔ 215		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P58756 [UniParc]. Last modified March 27, 2002. Version 1. Checksum: FEA295EDE0518674	FASTA	217	24,843
	10 20 30 40 50 60 MAPGSRTSLL LAFGLLCLPW LQEGSAFPTI PLSRLFDNAM LRAHRLHQLA FDTYQEFEEA 70 80 90 100 110 120 YIPKEQKYSF LQNPQTSLCF SESIPTPSNR EETQQKSNLE LLRISLLLIQ SWLEPVQFLR 130 140 150 160 170 180 SVFANSLVYG ASDSNVYDLL KDLEEGIQTL MGRLEDGSPR TGQIFKQTYS KFDTNSHNDD 190 200 210 ALLKNYGLLY CFRKDMDKVE TFLRIVQCRS VEGSCGF

References

[1]	"Independent duplication of the growth hormone gene in three Anthropoidean lineages." Revol A., Esquivel D., Santiago D., Barrera-Saldana H. Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF374232 Genomic DNA. Translation: AAL72284.1.
RefSeq	NP_001184093.1. NM_001197164.1.
UniGene	Ptr.6157.
3D structure databases
ProteinModelPortal	P58756.
SMR	P58756. Positions 27-216.
ModBase	Search...
Protein-protein interaction databases
STRING	9598.ENSPTRP00000055878.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	454774.
KEGG	ptr:454774.
Organism-specific databases
CTD	2688.
Phylogenomic databases
eggNOG	NOG26152.
HOGENOM	HOG000068443.
HOVERGEN	HBG011318.
KO	K05438.
Family and domain databases
Gene3D	1.20.1250.10. 1 hit.
InterPro	IPR009079. 4_helix_cytokine-like_core. IPR012351. 4_helix_cytokine_core. IPR001400. Somatotropin. IPR018116. Somatotropin_CS. [Graphical view]
PANTHER	PTHR11417. PTHR11417. 1 hit.
Pfam	PF00103. Hormone_1. 1 hit. [Graphical view]
PRINTS	PR00836. SOMATOTROPIN.
SUPFAM	SSF47266. 4_helix_cytokine. 1 hit.
PROSITE	PS00266. SOMATOTROPIN_1. 1 hit. PS00338. SOMATOTROPIN_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
DrugBank	DB00082. Pegvisomant. DB00052. Somatropin recombinant.
NextBio	20836350.

Entry information

Entry name

SOMA_PANTR

Accession

Primary (citable) accession number: P58756

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 27, 2002
Last sequence update:	March 27, 2002
Last modified:	April 3, 2013
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program