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P58756 (SOMA_PANTR) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Somatotropin
Alternative name(s):
Growth hormone
Short name=GH
Short name=GH-N
Growth hormone 1
Pituitary growth hormone
Gene names
Name:GH1
OrganismPan troglodytes (Chimpanzee) [Reference proteome]
Taxonomic identifier9598 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan

Protein attributes

Sequence length217 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues By similarity.

Subcellular location

Secreted.

Sequence similarities

Belongs to the somatotropin/prolactin family.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   LigandMetal-binding
Zinc
   Molecular functionHormone
   PTMDisulfide bond
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionmetal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2626 By similarity
Chain27 – 217191Somatotropin
PRO_0000032996

Sites

Metal binding441Zinc By similarity
Metal binding2001Zinc By similarity

Amino acid modifications

Modified residue1321Phosphoserine By similarity
Disulfide bond79 ↔ 191 By similarity
Disulfide bond208 ↔ 215 By similarity

Sequences

Sequence LengthMass (Da)Tools
P58756 [UniParc].

Last modified March 27, 2002. Version 1.
Checksum: FEA295EDE0518674

FASTA21724,843
        10         20         30         40         50         60 
MAPGSRTSLL LAFGLLCLPW LQEGSAFPTI PLSRLFDNAM LRAHRLHQLA FDTYQEFEEA 

        70         80         90        100        110        120 
YIPKEQKYSF LQNPQTSLCF SESIPTPSNR EETQQKSNLE LLRISLLLIQ SWLEPVQFLR 

       130        140        150        160        170        180 
SVFANSLVYG ASDSNVYDLL KDLEEGIQTL MGRLEDGSPR TGQIFKQTYS KFDTNSHNDD 

       190        200        210 
ALLKNYGLLY CFRKDMDKVE TFLRIVQCRS VEGSCGF 

« Hide

References

[1]"Independent duplication of the growth hormone gene in three Anthropoidean lineages."
Revol A., Esquivel D., Santiago D., Barrera-Saldana H.
Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF374232 Genomic DNA. Translation: AAL72284.1.
RefSeqNP_001184093.1. NM_001197164.1.
UniGenePtr.6157.

3D structure databases

ProteinModelPortalP58756.
SMRP58756. Positions 27-216.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

MINTMINT-1511069.
STRING9598.ENSPTRP00000055878.

Chemistry

DrugBankDB00082. Pegvisomant.
DB00052. Somatropin recombinant.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID454774.
KEGGptr:454774.

Organism-specific databases

CTD2688.

Phylogenomic databases

eggNOGNOG26152.
HOGENOMHOG000068443.
HOVERGENHBG011318.
KOK05438.

Family and domain databases

Gene3D1.20.1250.10. 1 hit.
InterProIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR001400. Somatotropin.
IPR018116. Somatotropin_CS.
[Graphical view]
PANTHERPTHR11417. PTHR11417. 1 hit.
PfamPF00103. Hormone_1. 1 hit.
[Graphical view]
PRINTSPR00836. SOMATOTROPIN.
SUPFAMSSF47266. SSF47266. 1 hit.
PROSITEPS00266. SOMATOTROPIN_1. 1 hit.
PS00338. SOMATOTROPIN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20836350.

Entry information

Entry nameSOMA_PANTR
AccessionPrimary (citable) accession number: P58756
Entry history
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: March 27, 2002
Last modified: March 19, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families