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P58756

- SOMA_PANTR

UniProt

P58756 - SOMA_PANTR

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Protein
Somatotropin
Gene
GH1
Organism
Pan troglodytes (Chimpanzee)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi44 – 441Zinc By similarity
Metal bindingi200 – 2001Zinc By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hormone

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Somatotropin
Alternative name(s):
Growth hormone
Short name:
GH
Short name:
GH-N
Growth hormone 1
Pituitary growth hormone
Gene namesi
Name:GH1
OrganismiPan troglodytes (Chimpanzee)
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
ProteomesiUP000002277: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626 By similarity
Add
BLAST
Chaini27 – 217191Somatotropin
PRO_0000032996Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi79 ↔ 191 By similarity
Modified residuei132 – 1321Phosphoserine By similarity
Disulfide bondi208 ↔ 215 By similarity

Keywords - PTMi

Disulfide bond, Phosphoprotein

Interactioni

Protein-protein interaction databases

MINTiMINT-1511069.
STRINGi9598.ENSPTRP00000055878.

Structurei

3D structure databases

ProteinModelPortaliP58756.
SMRiP58756. Positions 27-216.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG26152.
HOGENOMiHOG000068443.
HOVERGENiHBG011318.
KOiK05438.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR001400. Somatotropin.
IPR018116. Somatotropin_CS.
[Graphical view]
PANTHERiPTHR11417. PTHR11417. 1 hit.
PfamiPF00103. Hormone_1. 1 hit.
[Graphical view]
PRINTSiPR00836. SOMATOTROPIN.
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00266. SOMATOTROPIN_1. 1 hit.
PS00338. SOMATOTROPIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P58756-1 [UniParc]FASTAAdd to Basket

« Hide

MAPGSRTSLL LAFGLLCLPW LQEGSAFPTI PLSRLFDNAM LRAHRLHQLA    50
FDTYQEFEEA YIPKEQKYSF LQNPQTSLCF SESIPTPSNR EETQQKSNLE 100
LLRISLLLIQ SWLEPVQFLR SVFANSLVYG ASDSNVYDLL KDLEEGIQTL 150
MGRLEDGSPR TGQIFKQTYS KFDTNSHNDD ALLKNYGLLY CFRKDMDKVE 200
TFLRIVQCRS VEGSCGF 217
Length:217
Mass (Da):24,843
Last modified:March 27, 2002 - v1
Checksum:iFEA295EDE0518674
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF374232 Genomic DNA. Translation: AAL72284.1.
RefSeqiNP_001184093.1. NM_001197164.1.
UniGeneiPtr.6157.

Genome annotation databases

GeneIDi454774.
KEGGiptr:454774.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF374232 Genomic DNA. Translation: AAL72284.1 .
RefSeqi NP_001184093.1. NM_001197164.1.
UniGenei Ptr.6157.

3D structure databases

ProteinModelPortali P58756.
SMRi P58756. Positions 27-216.
ModBasei Search...

Protein-protein interaction databases

MINTi MINT-1511069.
STRINGi 9598.ENSPTRP00000055878.

Chemistry

DrugBanki DB00082. Pegvisomant.
DB00052. Somatropin recombinant.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 454774.
KEGGi ptr:454774.

Organism-specific databases

CTDi 2688.

Phylogenomic databases

eggNOGi NOG26152.
HOGENOMi HOG000068443.
HOVERGENi HBG011318.
KOi K05438.

Miscellaneous databases

NextBioi 20836350.

Family and domain databases

Gene3Di 1.20.1250.10. 1 hit.
InterProi IPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR001400. Somatotropin.
IPR018116. Somatotropin_CS.
[Graphical view ]
PANTHERi PTHR11417. PTHR11417. 1 hit.
Pfami PF00103. Hormone_1. 1 hit.
[Graphical view ]
PRINTSi PR00836. SOMATOTROPIN.
SUPFAMi SSF47266. SSF47266. 1 hit.
PROSITEi PS00266. SOMATOTROPIN_1. 1 hit.
PS00338. SOMATOTROPIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Independent duplication of the growth hormone gene in three Anthropoidean lineages."
    Revol A., Esquivel D., Santiago D., Barrera-Saldana H.
    Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiSOMA_PANTR
AccessioniPrimary (citable) accession number: P58756
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: March 27, 2002
Last modified: March 19, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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