Reviewed,
UniProtKB/Swiss-Prot P58744 (DKGA_SALTI)
Last modified
June 16, 2009.
Version 51.
History...
Clusters with 100%,
90%,
50% identity |
Documents (1) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Putative 2,5-diketo-D-gluconic acid reductase A Short name=2,5-DKG reductase A Short name=2,5-DKGR A Short name=25DKGR-A EC=1.1.1.274 Alternative name(s): AKR5C | ||||
| Gene names |
| ||||
| Organism | Salmonella typhi [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 90370 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Salmonella |
Protein attributes
| Sequence length | 275 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Uncertain. |
General annotation (Comments)
| Function | Catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG) By similarity. |
| Catalytic activity | 2-dehydro-D-gluconate + NADP+ = 2,5-didehydro-D-gluconate + NADPH. |
| Subunit structure | Monomer By similarity. |
| Subcellular location | Cytoplasm By similarity. |
| Miscellaneous | 2-keto-L-gulonic acid is a key intermediate in the production of L-ascorbic acid (vitamin C). |
| Sequence similarities | Belongs to the aldo/keto reductase family. |
| Caution | Could be the product of a pseudogene. |
| Sequence caution | The sequence AE014613 differs from that shown. Reason: Erroneous termination at position 175. Translated as Trp. The sequence AL627277 differs from that shown. Reason: Erroneous termination at position 175. Translated as Trp. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Ascorbate biosynthesis |
| Cellular component | Cytoplasm |
| Ligand | NADP |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | L-ascorbic acid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reductionInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | 2,5-didehydrogluconate reductase activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 275 | 275 | Putative 2,5-diketo-D-gluconic acid reductase A | PRO_0000124601 | |||||
Regions | |||||||||
| Nucleotide binding | 187 – 241 | 55 | NADP By similarity | ||||||
Sites | |||||||||
| Active site | 51 | 1 | Proton donor By similarity | ||||||
| Binding site | 107 | 1 | Substrate By similarity | ||||||
Sequences
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References
| [1] | "Complete genome sequence of a multiple drug resistant Salmonella enterica serovar Typhi CT18." Parkhill J., Dougan G., James K.D., Thomson N.R., Pickard D., Wain J., Churcher C.M., Mungall K.L., Bentley S.D., Holden M.T.G., Sebaihia M., Baker S., Basham D., Brooks K., Chillingworth T., Connerton P., Cronin A., Davis P. Barrell B.G.Nature 413:848-852(2001) [PubMed: 11677608] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CT18. |
| [2] | "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and CT18." Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V., Kodoyianni V., Schwartz D.C., Blattner F.R. J. Bacteriol. 185:2330-2337(2003) [PubMed: 12644504] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700931 / Ty2. |
Cross-references
Sequence databases | |
|---|---|
| AL627277 Genomic DNA. No translation available. AE014613 Genomic DNA. No translation available. | |
3D structure databases | |
| HSSP | HSSP built from PDB template 1HW6 based on UniProtKB P06632. |
| SMR | P58744. Positions 1-275. |
| ModBase | Search... |
Genome annotation databases | |
| GenomeReviews | Gene locus STY3338 in contig AE014613_GR. Gene locus STY3338 in contig AL513382_GR. |
| KEGG | stt:t3085. sty:STY3338. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | P58744. |
Enzyme and pathway databases | |
| BRENDA | 1.1.1.274. 3716. |
Family and domain databases | |
| InterPro | IPR001395. Aldo/ket_red. IPR018170. Aldo/ket_reductase_CS. [Graphical view] |
| PANTHER | PTHR11732. Aldo/ket_red. 1 hit. |
| Pfam | PF00248. Aldo_ket_red. 1 hit. [Graphical view] |
| ProDom | PD000288. Aldo/ket_red. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| PROSITE | PS00798. ALDOKETO_REDUCTASE_1. 1 hit. PS00062. ALDOKETO_REDUCTASE_2. 1 hit. PS00063. ALDOKETO_REDUCTASE_3. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | DKGA_SALTI | ||||||||
| Accession | Primary (citable) accession number: P58744 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||

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