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Protein

Prestin

Gene

SLC26A5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Motor protein that converts auditory stimuli to length changes in outer hair cells and mediates sound amplification in the mammalian hearing organ. Prestin is a bidirectional voltage-to-force converter, it can operate at microsecond rates. It uses cytoplasmic anions as extrinsic voltage sensors, probably chloride and bicarbonate. After binding to a site with millimolar affinity, these anions are translocated across the membrane in response to changes in the transmembrane voltage. They move towards the extracellular surface following hyperpolarization, and towards the cytoplasmic side in response to depolarization. As a consequence, this translocation triggers conformational changes in the protein that ultimately alter its surface area in the plane of the plasma membrane. The area decreases when the anion is near the cytoplasmic face of the membrane (short state), and increases when the ion has crossed the membrane to the outer surface (long state). So, it acts as an incomplete transporter. It swings anions across the membrane, but does not allow these anions to dissociate and escape to the extracellular space. Salicylate, an inhibitor of outer hair cell motility, acts as competitive antagonist at the prestin anion-binding site (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Keywords - Biological processi

Cell shape, Hearing

Enzyme and pathway databases

BioCyciZFISH:ENSG00000170615-MONOMER.

Protein family/group databases

TCDBi2.A.53.2.19. the sulfate permease (sulp) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Prestin
Alternative name(s):
Solute carrier family 26 member 5
Gene namesi
Name:SLC26A5
Synonyms:PRES
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:9359. SLC26A5.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 79CytoplasmicSequence analysisAdd BLAST79
Transmembranei80 – 100Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini101 – 102ExtracellularSequence analysis2
Transmembranei103 – 123Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini124 – 131CytoplasmicSequence analysis8
Transmembranei132 – 152Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini153 – 183ExtracellularSequence analysisAdd BLAST31
Transmembranei184 – 204Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini205 – 211CytoplasmicSequence analysis7
Transmembranei212 – 232Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini233 – 253ExtracellularSequence analysisAdd BLAST21
Transmembranei254 – 274Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini275 – 286CytoplasmicSequence analysisAdd BLAST12
Transmembranei287 – 307Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini308 – 334ExtracellularSequence analysisAdd BLAST27
Transmembranei335 – 355Helical; Name=8Sequence analysisAdd BLAST21
Topological domaini356 – 374CytoplasmicSequence analysisAdd BLAST19
Transmembranei375 – 395Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini396 – 411ExtracellularSequence analysisAdd BLAST16
Transmembranei412 – 432Helical; Name=10Sequence analysisAdd BLAST21
Topological domaini433 – 441CytoplasmicSequence analysis9
Transmembranei442 – 462Helical; Name=11Sequence analysisAdd BLAST21
Topological domaini463 – 479ExtracellularSequence analysisAdd BLAST17
Transmembranei480 – 500Helical; Name=12Sequence analysisAdd BLAST21
Topological domaini501 – 744CytoplasmicSequence analysisAdd BLAST244

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Deafness, autosomal recessive, 61 (DFNB61)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
See also OMIM:613865

Keywords - Diseasei

Deafness, Non-syndromic deafness

Organism-specific databases

DisGeNETi375611.
MalaCardsiSLC26A5.
MIMi613865. phenotype.
OpenTargetsiENSG00000170615.
Orphaneti90636. Autosomal recessive non-syndromic sensorineural deafness type DFNB.
PharmGKBiPA33731.

Polymorphism and mutation databases

BioMutaiSLC26A5.
DMDMi20139418.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000801671 – 744PrestinAdd BLAST744

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi163N-linked (GlcNAc...)Sequence analysis1
Glycosylationi166N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP58743.
PeptideAtlasiP58743.
PRIDEiP58743.

PTM databases

iPTMnetiP58743.
PhosphoSitePlusiP58743.

Expressioni

Gene expression databases

BgeeiENSG00000170615.
CleanExiHS_SLC26A5.
ExpressionAtlasiP58743. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000304783.

Structurei

3D structure databases

ProteinModelPortaliP58743.
SMRiP58743.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini525 – 713STASPROSITE-ProRule annotationAdd BLAST189

Sequence similaritiesi

Contains 1 STAS domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0236. Eukaryota.
COG0659. LUCA.
GeneTreeiENSGT00760000119026.
HOGENOMiHOG000006546.
HOVERGENiHBG000639.
InParanoidiP58743.
KOiK14703.
PhylomeDBiP58743.
TreeFamiTF313784.

Family and domain databases

Gene3Di3.30.750.24. 2 hits.
InterProiIPR030282. Prestin.
IPR018045. S04_transporter_CS.
IPR011547. SLC26A/SulP_dom.
IPR001902. SLC26A/SulP_fam.
IPR002645. STAS_dom.
[Graphical view]
PANTHERiPTHR11814. PTHR11814. 2 hits.
PTHR11814:SF32. PTHR11814:SF32. 2 hits.
PfamiPF01740. STAS. 1 hit.
PF00916. Sulfate_transp. 1 hit.
[Graphical view]
SUPFAMiSSF52091. SSF52091. 2 hits.
TIGRFAMsiTIGR00815. sulP. 1 hit.
PROSITEiPS01130. SLC26A. 1 hit.
PS50801. STAS. 1 hit.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P58743-1) [UniParc]FASTAAdd to basket
Also known as: SLC26A5a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDHAEENEIL AATQRYYVER PIFSHPVLQE RLHTKDKVPD SIADKLKQAF
60 70 80 90 100
TCTPKKIRNI IYMFLPITKW LPAYKFKEYV LGDLVSGIST GVLQLPQGLA
110 120 130 140 150
FAMLAAVPPI FGLYSSFYPV IMYCFLGTSR HISIGPFAVI SLMIGGVAVR
160 170 180 190 200
LVPDDIVIPG GVNATNGTEA RDALRVKVAM SVTLLSGIIQ FCLGVCRFGF
210 220 230 240 250
VAIYLTEPLV RGFTTAAAVH VFTSMLKYLF GVKTKRYSGI FSVVYSTVAV
260 270 280 290 300
LQNVKNLNVC SLGVGLMVFG LLLGGKEFNE RFKEKLPAPI PLEFFAVVMG
310 320 330 340 350
TGISAGFNLK ESYNVDVVGT LPLGLLPPAN PDTSLFHLVY VDAIAIAIVG
360 370 380 390 400
FSVTISMAKT LANKHGYQVD GNQELIALGL CNSIGSLFQT FSISCSLSRS
410 420 430 440 450
LVQEGTGGKT QLAGCLASLM ILLVILATGF LFESLPQAVL SAIVIVNLKG
460 470 480 490 500
MFMQFSDLPF FWRTSKIELT IWLTTFVSSL FLGLDYGLIT AVIIALLTVI
510 520 530 540 550
YRTQSPSYKV LGKLPETDVY IDIDAYEEVK EIPGIKIFQI NAPIYYANSD
560 570 580 590 600
LYSNALKRKT GVNPAVIMGA RRKAMRKYAK EVGNANMANA TVVKADAEVD
610 620 630 640 650
GEDATKPEEE DGEVKYPPIV IKSTFPEEMQ RFMPPGDNVH TVILDFTQVN
660 670 680 690 700
FIDSVGVKTL AGIVKEYGDV GIYVYLAGCS AQVVNDLTRN RFFENPALWE
710 720 730 740
LLFHSIHDAV LGSQLREALA EQEASAPPSQ EDLEPNATPA TPEA
Length:744
Mass (Da):81,264
Last modified:March 27, 2002 - v1
Checksum:i9E64BE6DB2DC065E
GO
Isoform 2 (identifier: P58743-2) [UniParc]FASTAAdd to basket
Also known as: SLC26A5b

The sequence of this isoform differs from the canonical sequence as follows:
     682-685: QVVN → FIQR
     686-744: Missing.

Show »
Length:685
Mass (Da):74,844
Checksum:iEF5682F6B068BEAE
GO
Isoform 3 (identifier: P58743-3) [UniParc]FASTAAdd to basket
Also known as: SLC26A5c

The sequence of this isoform differs from the canonical sequence as follows:
     506-516: PSYKVLGKLPE → FHTEMTRRWRP
     517-744: Missing.

Show »
Length:516
Mass (Da):56,458
Checksum:iB12E4F7437574ED6
GO
Isoform 4 (identifier: P58743-4) [UniParc]FASTAAdd to basket
Also known as: SLC26A5d

The sequence of this isoform differs from the canonical sequence as follows:
     325-335: LLPPANPDTSL → FHTEMTRRWRP
     336-744: Missing.

Show »
Length:335
Mass (Da):36,949
Checksum:i49BD1BF137784071
GO
Isoform 5 (identifier: P58743-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     438-469: Missing.

Note: No experimental confirmation available.
Show »
Length:712
Mass (Da):77,579
Checksum:iDFC2F97FD6F18EC1
GO
Isoform 6 (identifier: P58743-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     438-469: Missing.
     595-595: A → ATQ

Show »
Length:714
Mass (Da):77,809
Checksum:i0D1EB01E3E0578A4
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_010190325 – 335LLPPANPDTSL → FHTEMTRRWRP in isoform 4. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_010191336 – 744Missing in isoform 4. 1 PublicationAdd BLAST409
Alternative sequenceiVSP_043153438 – 469Missing in isoform 5 and isoform 6. 2 PublicationsAdd BLAST32
Alternative sequenceiVSP_010192506 – 516PSYKVLGKLPE → FHTEMTRRWRP in isoform 3. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_010193517 – 744Missing in isoform 3. 1 PublicationAdd BLAST228
Alternative sequenceiVSP_047640595A → ATQ in isoform 6. 1 Publication1
Alternative sequenceiVSP_010194682 – 685QVVN → FIQR in isoform 2. 1 Publication4
Alternative sequenceiVSP_010195686 – 744Missing in isoform 2. 1 PublicationAdd BLAST59

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF523354 mRNA. Translation: AAP31417.1.
AY256823 mRNA. Translation: AAP31532.1.
AY256824 mRNA. Translation: AAP31533.1.
AY256825 mRNA. Translation: AAP31534.1.
AY289134 mRNA. Translation: AAP43686.1.
AC004668 Genomic DNA. No translation available.
AC005064 Genomic DNA. No translation available.
AC093701 Genomic DNA. No translation available.
BC100833 mRNA. Translation: AAI00834.1.
CCDSiCCDS43629.1. [P58743-3]
CCDS43630.1. [P58743-2]
CCDS55150.1. [P58743-5]
CCDS5732.1. [P58743-4]
CCDS5733.1. [P58743-1]
RefSeqiNP_001161434.1. NM_001167962.1. [P58743-5]
NP_001308716.1. NM_001321787.1.
NP_945350.1. NM_198999.2. [P58743-1]
NP_996766.1. NM_206883.2. [P58743-2]
NP_996767.1. NM_206884.2. [P58743-3]
NP_996768.1. NM_206885.2. [P58743-4]
XP_011514472.1. XM_011516170.2. [P58743-1]
UniGeneiHs.585146.

Genome annotation databases

EnsembliENST00000306312; ENSP00000304783; ENSG00000170615. [P58743-1]
ENST00000339444; ENSP00000342396; ENSG00000170615. [P58743-2]
ENST00000356767; ENSP00000349210; ENSG00000170615. [P58743-4]
ENST00000393723; ENSP00000377324; ENSG00000170615. [P58743-6]
ENST00000393730; ENSP00000377331; ENSG00000170615. [P58743-5]
ENST00000393735; ENSP00000377336; ENSG00000170615. [P58743-3]
ENST00000432958; ENSP00000389733; ENSG00000170615. [P58743-5]
GeneIDi375611.
KEGGihsa:375611.
UCSCiuc003vbt.3. human. [P58743-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Web resourcesi

Protein Spotlight

Pump up the volume - Issue 22 of May 2002

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF523354 mRNA. Translation: AAP31417.1.
AY256823 mRNA. Translation: AAP31532.1.
AY256824 mRNA. Translation: AAP31533.1.
AY256825 mRNA. Translation: AAP31534.1.
AY289134 mRNA. Translation: AAP43686.1.
AC004668 Genomic DNA. No translation available.
AC005064 Genomic DNA. No translation available.
AC093701 Genomic DNA. No translation available.
BC100833 mRNA. Translation: AAI00834.1.
CCDSiCCDS43629.1. [P58743-3]
CCDS43630.1. [P58743-2]
CCDS55150.1. [P58743-5]
CCDS5732.1. [P58743-4]
CCDS5733.1. [P58743-1]
RefSeqiNP_001161434.1. NM_001167962.1. [P58743-5]
NP_001308716.1. NM_001321787.1.
NP_945350.1. NM_198999.2. [P58743-1]
NP_996766.1. NM_206883.2. [P58743-2]
NP_996767.1. NM_206884.2. [P58743-3]
NP_996768.1. NM_206885.2. [P58743-4]
XP_011514472.1. XM_011516170.2. [P58743-1]
UniGeneiHs.585146.

3D structure databases

ProteinModelPortaliP58743.
SMRiP58743.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000304783.

Protein family/group databases

TCDBi2.A.53.2.19. the sulfate permease (sulp) family.

PTM databases

iPTMnetiP58743.
PhosphoSitePlusiP58743.

Polymorphism and mutation databases

BioMutaiSLC26A5.
DMDMi20139418.

Proteomic databases

PaxDbiP58743.
PeptideAtlasiP58743.
PRIDEiP58743.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000306312; ENSP00000304783; ENSG00000170615. [P58743-1]
ENST00000339444; ENSP00000342396; ENSG00000170615. [P58743-2]
ENST00000356767; ENSP00000349210; ENSG00000170615. [P58743-4]
ENST00000393723; ENSP00000377324; ENSG00000170615. [P58743-6]
ENST00000393730; ENSP00000377331; ENSG00000170615. [P58743-5]
ENST00000393735; ENSP00000377336; ENSG00000170615. [P58743-3]
ENST00000432958; ENSP00000389733; ENSG00000170615. [P58743-5]
GeneIDi375611.
KEGGihsa:375611.
UCSCiuc003vbt.3. human. [P58743-1]

Organism-specific databases

CTDi375611.
DisGeNETi375611.
GeneCardsiSLC26A5.
HGNCiHGNC:9359. SLC26A5.
MalaCardsiSLC26A5.
MIMi604943. gene.
613865. phenotype.
neXtProtiNX_P58743.
OpenTargetsiENSG00000170615.
Orphaneti90636. Autosomal recessive non-syndromic sensorineural deafness type DFNB.
PharmGKBiPA33731.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0236. Eukaryota.
COG0659. LUCA.
GeneTreeiENSGT00760000119026.
HOGENOMiHOG000006546.
HOVERGENiHBG000639.
InParanoidiP58743.
KOiK14703.
PhylomeDBiP58743.
TreeFamiTF313784.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000170615-MONOMER.

Miscellaneous databases

GeneWikiiPrestin.
GenomeRNAii375611.
PROiP58743.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000170615.
CleanExiHS_SLC26A5.
ExpressionAtlasiP58743. baseline and differential.

Family and domain databases

Gene3Di3.30.750.24. 2 hits.
InterProiIPR030282. Prestin.
IPR018045. S04_transporter_CS.
IPR011547. SLC26A/SulP_dom.
IPR001902. SLC26A/SulP_fam.
IPR002645. STAS_dom.
[Graphical view]
PANTHERiPTHR11814. PTHR11814. 2 hits.
PTHR11814:SF32. PTHR11814:SF32. 2 hits.
PfamiPF01740. STAS. 1 hit.
PF00916. Sulfate_transp. 1 hit.
[Graphical view]
SUPFAMiSSF52091. SSF52091. 2 hits.
TIGRFAMsiTIGR00815. sulP. 1 hit.
PROSITEiPS01130. SLC26A. 1 hit.
PS50801. STAS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS26A5_HUMAN
AccessioniPrimary (citable) accession number: P58743
Secondary accession number(s): Q496J2
, Q7Z7F3, Q86UF8, Q86UF9, Q86UG0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: March 27, 2002
Last modified: November 2, 2016
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.