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P58743

- S26A5_HUMAN

UniProt

P58743 - S26A5_HUMAN

Protein

Prestin

Gene

SLC26A5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 1 (27 Mar 2002)
      Previous versions | rss
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    Functioni

    Motor protein that converts auditory stimuli to length changes in outer hair cells and mediates sound amplification in the mammalian hearing organ. Prestin is a bidirectional voltage-to-force converter, it can operate at microsecond rates. It uses cytoplasmic anions as extrinsic voltage sensors, probably chloride and bicarbonate. After binding to a site with millimolar affinity, these anions are translocated across the membrane in response to changes in the transmembrane voltage. They move towards the extracellular surface following hyperpolarization, and towards the cytoplasmic side in response to depolarization. As a consequence, this translocation triggers conformational changes in the protein that ultimately alter its surface area in the plane of the plasma membrane. The area decreases when the anion is near the cytoplasmic face of the membrane (short state), and increases when the ion has crossed the membrane to the outer surface (long state). So, it acts as an incomplete transporter. It swings anions across the membrane, but does not allow these anions to dissociate and escape to the extracellular space. Salicylate, an inhibitor of outer hair cell motility, acts as competitive antagonist at the prestin anion-binding site By similarity.By similarity

    GO - Molecular functioni

    1. secondary active sulfate transmembrane transporter activity Source: InterPro

    GO - Biological processi

    1. regulation of cell shape Source: UniProtKB-KW
    2. regulation of membrane potential Source: Ensembl
    3. sensory perception of sound Source: UniProtKB

    Keywords - Molecular functioni

    Motor protein

    Keywords - Biological processi

    Cell shape, Hearing

    Protein family/group databases

    TCDBi2.A.53.2.19. the sulfate permease (sulp) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Prestin
    Alternative name(s):
    Solute carrier family 26 member 5
    Gene namesi
    Name:SLC26A5
    Synonyms:PRES
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:9359. SLC26A5.

    Subcellular locationi

    Cell membrane By similarity; Multi-pass membrane protein By similarity
    Note: Lateral wall of outer hair cells.By similarity

    GO - Cellular componenti

    1. basolateral plasma membrane Source: Ensembl
    2. integral component of membrane Source: UniProtKB-KW
    3. lateral plasma membrane Source: Ensembl

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Deafness, autosomal recessive, 61 (DFNB61) [MIM:613865]: A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.

    Keywords - Diseasei

    Deafness, Non-syndromic deafness

    Organism-specific databases

    MIMi613865. phenotype.
    Orphaneti90636. Autosomal recessive nonsyndromic sensorineural deafness type DFNB.
    PharmGKBiPA33731.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 744744PrestinPRO_0000080167Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi163 – 1631N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi166 – 1661N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiP58743.
    PRIDEiP58743.

    PTM databases

    PhosphoSiteiP58743.

    Expressioni

    Gene expression databases

    BgeeiP58743.
    CleanExiHS_SLC26A5.
    GenevestigatoriP58743.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000304783.

    Structurei

    3D structure databases

    ProteinModelPortaliP58743.
    SMRiP58743. Positions 505-718.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 7979CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini101 – 1022ExtracellularSequence Analysis
    Topological domaini124 – 1318CytoplasmicSequence Analysis
    Topological domaini153 – 18331ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini205 – 2117CytoplasmicSequence Analysis
    Topological domaini233 – 25321ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini275 – 28612CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini308 – 33427ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini356 – 37419CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini396 – 41116ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini433 – 4419CytoplasmicSequence Analysis
    Topological domaini463 – 47917ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini501 – 744244CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei80 – 10021Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei103 – 12321Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei132 – 15221Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei184 – 20421Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei212 – 23221Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei254 – 27421Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei287 – 30721Helical; Name=7Sequence AnalysisAdd
    BLAST
    Transmembranei335 – 35521Helical; Name=8Sequence AnalysisAdd
    BLAST
    Transmembranei375 – 39521Helical; Name=9Sequence AnalysisAdd
    BLAST
    Transmembranei412 – 43221Helical; Name=10Sequence AnalysisAdd
    BLAST
    Transmembranei442 – 46221Helical; Name=11Sequence AnalysisAdd
    BLAST
    Transmembranei480 – 50021Helical; Name=12Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini525 – 713189STASPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 STAS domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0659.
    HOGENOMiHOG000006546.
    HOVERGENiHBG000639.
    KOiK14703.
    OrthoDBiEOG76T9QT.
    PhylomeDBiP58743.
    TreeFamiTF313784.

    Family and domain databases

    Gene3Di3.30.750.24. 2 hits.
    InterProiIPR018045. S04_transporter_CS.
    IPR002645. STAS_dom.
    IPR001902. SulP_transpt.
    IPR011547. Sulph_transpt.
    [Graphical view]
    PfamiPF01740. STAS. 1 hit.
    PF00916. Sulfate_transp. 1 hit.
    [Graphical view]
    SUPFAMiSSF52091. SSF52091. 2 hits.
    TIGRFAMsiTIGR00815. sulP. 1 hit.
    PROSITEiPS01130. SLC26A. 1 hit.
    PS50801. STAS. 1 hit.
    [Graphical view]

    Sequences (6)i

    Sequence statusi: Complete.

    This entry describes 6 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P58743-1) [UniParc]FASTAAdd to Basket

    Also known as: SLC26A5a

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDHAEENEIL AATQRYYVER PIFSHPVLQE RLHTKDKVPD SIADKLKQAF    50
    TCTPKKIRNI IYMFLPITKW LPAYKFKEYV LGDLVSGIST GVLQLPQGLA 100
    FAMLAAVPPI FGLYSSFYPV IMYCFLGTSR HISIGPFAVI SLMIGGVAVR 150
    LVPDDIVIPG GVNATNGTEA RDALRVKVAM SVTLLSGIIQ FCLGVCRFGF 200
    VAIYLTEPLV RGFTTAAAVH VFTSMLKYLF GVKTKRYSGI FSVVYSTVAV 250
    LQNVKNLNVC SLGVGLMVFG LLLGGKEFNE RFKEKLPAPI PLEFFAVVMG 300
    TGISAGFNLK ESYNVDVVGT LPLGLLPPAN PDTSLFHLVY VDAIAIAIVG 350
    FSVTISMAKT LANKHGYQVD GNQELIALGL CNSIGSLFQT FSISCSLSRS 400
    LVQEGTGGKT QLAGCLASLM ILLVILATGF LFESLPQAVL SAIVIVNLKG 450
    MFMQFSDLPF FWRTSKIELT IWLTTFVSSL FLGLDYGLIT AVIIALLTVI 500
    YRTQSPSYKV LGKLPETDVY IDIDAYEEVK EIPGIKIFQI NAPIYYANSD 550
    LYSNALKRKT GVNPAVIMGA RRKAMRKYAK EVGNANMANA TVVKADAEVD 600
    GEDATKPEEE DGEVKYPPIV IKSTFPEEMQ RFMPPGDNVH TVILDFTQVN 650
    FIDSVGVKTL AGIVKEYGDV GIYVYLAGCS AQVVNDLTRN RFFENPALWE 700
    LLFHSIHDAV LGSQLREALA EQEASAPPSQ EDLEPNATPA TPEA 744
    Length:744
    Mass (Da):81,264
    Last modified:March 27, 2002 - v1
    Checksum:i9E64BE6DB2DC065E
    GO
    Isoform 2 (identifier: P58743-2) [UniParc]FASTAAdd to Basket

    Also known as: SLC26A5b

    The sequence of this isoform differs from the canonical sequence as follows:
         682-685: QVVN → FIQR
         686-744: Missing.

    Show »
    Length:685
    Mass (Da):74,844
    Checksum:iEF5682F6B068BEAE
    GO
    Isoform 3 (identifier: P58743-3) [UniParc]FASTAAdd to Basket

    Also known as: SLC26A5c

    The sequence of this isoform differs from the canonical sequence as follows:
         506-516: PSYKVLGKLPE → FHTEMTRRWRP
         517-744: Missing.

    Show »
    Length:516
    Mass (Da):56,458
    Checksum:iB12E4F7437574ED6
    GO
    Isoform 4 (identifier: P58743-4) [UniParc]FASTAAdd to Basket

    Also known as: SLC26A5d

    The sequence of this isoform differs from the canonical sequence as follows:
         325-335: LLPPANPDTSL → FHTEMTRRWRP
         336-744: Missing.

    Show »
    Length:335
    Mass (Da):36,949
    Checksum:i49BD1BF137784071
    GO
    Isoform 5 (identifier: P58743-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         438-469: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:712
    Mass (Da):77,579
    Checksum:iDFC2F97FD6F18EC1
    GO
    Isoform 6 (identifier: P58743-6) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         438-469: Missing.
         595-595: A → ATQ

    Show »
    Length:714
    Mass (Da):77,809
    Checksum:i0D1EB01E3E0578A4
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei325 – 33511LLPPANPDTSL → FHTEMTRRWRP in isoform 4. 1 PublicationVSP_010190Add
    BLAST
    Alternative sequencei336 – 744409Missing in isoform 4. 1 PublicationVSP_010191Add
    BLAST
    Alternative sequencei438 – 46932Missing in isoform 5 and isoform 6. 2 PublicationsVSP_043153Add
    BLAST
    Alternative sequencei506 – 51611PSYKVLGKLPE → FHTEMTRRWRP in isoform 3. 1 PublicationVSP_010192Add
    BLAST
    Alternative sequencei517 – 744228Missing in isoform 3. 1 PublicationVSP_010193Add
    BLAST
    Alternative sequencei595 – 5951A → ATQ in isoform 6. 1 PublicationVSP_047640
    Alternative sequencei682 – 6854QVVN → FIQR in isoform 2. 1 PublicationVSP_010194
    Alternative sequencei686 – 74459Missing in isoform 2. 1 PublicationVSP_010195Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF523354 mRNA. Translation: AAP31417.1.
    AY256823 mRNA. Translation: AAP31532.1.
    AY256824 mRNA. Translation: AAP31533.1.
    AY256825 mRNA. Translation: AAP31534.1.
    AY289134 mRNA. Translation: AAP43686.1.
    AC004668 Genomic DNA. No translation available.
    AC005064 Genomic DNA. No translation available.
    AC093701 Genomic DNA. No translation available.
    BC100833 mRNA. Translation: AAI00834.1.
    CCDSiCCDS43629.1. [P58743-3]
    CCDS43630.1. [P58743-2]
    CCDS55150.1. [P58743-5]
    CCDS5732.1. [P58743-4]
    CCDS5733.1. [P58743-1]
    RefSeqiNP_001161434.1. NM_001167962.1. [P58743-5]
    NP_945350.1. NM_198999.2. [P58743-1]
    NP_996766.1. NM_206883.2. [P58743-2]
    NP_996767.1. NM_206884.2. [P58743-3]
    NP_996768.1. NM_206885.2. [P58743-4]
    UniGeneiHs.585146.

    Genome annotation databases

    EnsembliENST00000306312; ENSP00000304783; ENSG00000170615. [P58743-1]
    ENST00000339444; ENSP00000342396; ENSG00000170615. [P58743-2]
    ENST00000356767; ENSP00000349210; ENSG00000170615. [P58743-4]
    ENST00000393723; ENSP00000377324; ENSG00000170615. [P58743-6]
    ENST00000393730; ENSP00000377331; ENSG00000170615. [P58743-5]
    ENST00000393735; ENSP00000377336; ENSG00000170615. [P58743-3]
    ENST00000432958; ENSP00000389733; ENSG00000170615. [P58743-5]
    GeneIDi375611.
    KEGGihsa:375611.
    UCSCiuc003vbt.2. human. [P58743-2]
    uc003vbu.2. human. [P58743-3]
    uc003vbv.2. human. [P58743-4]
    uc003vbx.3. human. [P58743-5]
    uc003vbz.3. human. [P58743-1]

    Polymorphism databases

    DMDMi20139418.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Web resourcesi

    Protein Spotlight

    Pump up the volume - Issue 22 of May 2002

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF523354 mRNA. Translation: AAP31417.1 .
    AY256823 mRNA. Translation: AAP31532.1 .
    AY256824 mRNA. Translation: AAP31533.1 .
    AY256825 mRNA. Translation: AAP31534.1 .
    AY289134 mRNA. Translation: AAP43686.1 .
    AC004668 Genomic DNA. No translation available.
    AC005064 Genomic DNA. No translation available.
    AC093701 Genomic DNA. No translation available.
    BC100833 mRNA. Translation: AAI00834.1 .
    CCDSi CCDS43629.1. [P58743-3 ]
    CCDS43630.1. [P58743-2 ]
    CCDS55150.1. [P58743-5 ]
    CCDS5732.1. [P58743-4 ]
    CCDS5733.1. [P58743-1 ]
    RefSeqi NP_001161434.1. NM_001167962.1. [P58743-5 ]
    NP_945350.1. NM_198999.2. [P58743-1 ]
    NP_996766.1. NM_206883.2. [P58743-2 ]
    NP_996767.1. NM_206884.2. [P58743-3 ]
    NP_996768.1. NM_206885.2. [P58743-4 ]
    UniGenei Hs.585146.

    3D structure databases

    ProteinModelPortali P58743.
    SMRi P58743. Positions 505-718.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000304783.

    Protein family/group databases

    TCDBi 2.A.53.2.19. the sulfate permease (sulp) family.

    PTM databases

    PhosphoSitei P58743.

    Polymorphism databases

    DMDMi 20139418.

    Proteomic databases

    PaxDbi P58743.
    PRIDEi P58743.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000306312 ; ENSP00000304783 ; ENSG00000170615 . [P58743-1 ]
    ENST00000339444 ; ENSP00000342396 ; ENSG00000170615 . [P58743-2 ]
    ENST00000356767 ; ENSP00000349210 ; ENSG00000170615 . [P58743-4 ]
    ENST00000393723 ; ENSP00000377324 ; ENSG00000170615 . [P58743-6 ]
    ENST00000393730 ; ENSP00000377331 ; ENSG00000170615 . [P58743-5 ]
    ENST00000393735 ; ENSP00000377336 ; ENSG00000170615 . [P58743-3 ]
    ENST00000432958 ; ENSP00000389733 ; ENSG00000170615 . [P58743-5 ]
    GeneIDi 375611.
    KEGGi hsa:375611.
    UCSCi uc003vbt.2. human. [P58743-2 ]
    uc003vbu.2. human. [P58743-3 ]
    uc003vbv.2. human. [P58743-4 ]
    uc003vbx.3. human. [P58743-5 ]
    uc003vbz.3. human. [P58743-1 ]

    Organism-specific databases

    CTDi 375611.
    GeneCardsi GC07M102993.
    HGNCi HGNC:9359. SLC26A5.
    MIMi 604943. gene.
    613865. phenotype.
    neXtProti NX_P58743.
    Orphaneti 90636. Autosomal recessive nonsyndromic sensorineural deafness type DFNB.
    PharmGKBi PA33731.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0659.
    HOGENOMi HOG000006546.
    HOVERGENi HBG000639.
    KOi K14703.
    OrthoDBi EOG76T9QT.
    PhylomeDBi P58743.
    TreeFami TF313784.

    Miscellaneous databases

    GeneWikii Prestin.
    GenomeRNAii 375611.
    NextBioi 100545.
    PROi P58743.
    SOURCEi Search...

    Gene expression databases

    Bgeei P58743.
    CleanExi HS_SLC26A5.
    Genevestigatori P58743.

    Family and domain databases

    Gene3Di 3.30.750.24. 2 hits.
    InterProi IPR018045. S04_transporter_CS.
    IPR002645. STAS_dom.
    IPR001902. SulP_transpt.
    IPR011547. Sulph_transpt.
    [Graphical view ]
    Pfami PF01740. STAS. 1 hit.
    PF00916. Sulfate_transp. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52091. SSF52091. 2 hits.
    TIGRFAMsi TIGR00815. sulP. 1 hit.
    PROSITEi PS01130. SLC26A. 1 hit.
    PS50801. STAS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3 AND 4), INVOLVEMENT IN DFNB61.
      Tissue: Organ of Corti.
    2. "Sequence of an alternatively spliced isoform of prestin (SLC26A5e)."
      Mount D.B.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 6).
    3. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).

    Entry informationi

    Entry nameiS26A5_HUMAN
    AccessioniPrimary (citable) accession number: P58743
    Secondary accession number(s): Q496J2
    , Q7Z7F3, Q86UF8, Q86UF9, Q86UG0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 27, 2002
    Last sequence update: March 27, 2002
    Last modified: October 1, 2014
    This is version 108 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. Protein Spotlight
      Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3