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P58743

- S26A5_HUMAN

UniProt

P58743 - S26A5_HUMAN

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Protein

Prestin

Gene

SLC26A5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Motor protein that converts auditory stimuli to length changes in outer hair cells and mediates sound amplification in the mammalian hearing organ. Prestin is a bidirectional voltage-to-force converter, it can operate at microsecond rates. It uses cytoplasmic anions as extrinsic voltage sensors, probably chloride and bicarbonate. After binding to a site with millimolar affinity, these anions are translocated across the membrane in response to changes in the transmembrane voltage. They move towards the extracellular surface following hyperpolarization, and towards the cytoplasmic side in response to depolarization. As a consequence, this translocation triggers conformational changes in the protein that ultimately alter its surface area in the plane of the plasma membrane. The area decreases when the anion is near the cytoplasmic face of the membrane (short state), and increases when the ion has crossed the membrane to the outer surface (long state). So, it acts as an incomplete transporter. It swings anions across the membrane, but does not allow these anions to dissociate and escape to the extracellular space. Salicylate, an inhibitor of outer hair cell motility, acts as competitive antagonist at the prestin anion-binding site (By similarity).By similarity

GO - Molecular functioni

  1. secondary active sulfate transmembrane transporter activity Source: InterPro

GO - Biological processi

  1. regulation of cell shape Source: UniProtKB-KW
  2. regulation of membrane potential Source: Ensembl
  3. sensory perception of sound Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Keywords - Biological processi

Cell shape, Hearing

Protein family/group databases

TCDBi2.A.53.2.19. the sulfate permease (sulp) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Prestin
Alternative name(s):
Solute carrier family 26 member 5
Gene namesi
Name:SLC26A5
Synonyms:PRES
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:9359. SLC26A5.

Subcellular locationi

Cell membrane By similarity; Multi-pass membrane protein By similarity
Note: Lateral wall of outer hair cells.By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 7979CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei80 – 10021Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini101 – 1022ExtracellularSequence Analysis
Transmembranei103 – 12321Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini124 – 1318CytoplasmicSequence Analysis
Transmembranei132 – 15221Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini153 – 18331ExtracellularSequence AnalysisAdd
BLAST
Transmembranei184 – 20421Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini205 – 2117CytoplasmicSequence Analysis
Transmembranei212 – 23221Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini233 – 25321ExtracellularSequence AnalysisAdd
BLAST
Transmembranei254 – 27421Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini275 – 28612CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei287 – 30721Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini308 – 33427ExtracellularSequence AnalysisAdd
BLAST
Transmembranei335 – 35521Helical; Name=8Sequence AnalysisAdd
BLAST
Topological domaini356 – 37419CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei375 – 39521Helical; Name=9Sequence AnalysisAdd
BLAST
Topological domaini396 – 41116ExtracellularSequence AnalysisAdd
BLAST
Transmembranei412 – 43221Helical; Name=10Sequence AnalysisAdd
BLAST
Topological domaini433 – 4419CytoplasmicSequence Analysis
Transmembranei442 – 46221Helical; Name=11Sequence AnalysisAdd
BLAST
Topological domaini463 – 47917ExtracellularSequence AnalysisAdd
BLAST
Transmembranei480 – 50021Helical; Name=12Sequence AnalysisAdd
BLAST
Topological domaini501 – 744244CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. basolateral plasma membrane Source: Ensembl
  2. integral component of membrane Source: UniProtKB-KW
  3. lateral plasma membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Deafness, autosomal recessive, 61 (DFNB61) [MIM:613865]: A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.1 Publication
Note: The disease is caused by mutations affecting the gene represented in this entry.

Keywords - Diseasei

Deafness, Non-syndromic deafness

Organism-specific databases

MIMi613865. phenotype.
Orphaneti90636. Autosomal recessive non-syndromic sensorineural deafness type DFNB.
PharmGKBiPA33731.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 744744PrestinPRO_0000080167Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi163 – 1631N-linked (GlcNAc...)Sequence Analysis
Glycosylationi166 – 1661N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP58743.
PRIDEiP58743.

PTM databases

PhosphoSiteiP58743.

Expressioni

Gene expression databases

BgeeiP58743.
CleanExiHS_SLC26A5.
ExpressionAtlasiP58743. baseline.
GenevestigatoriP58743.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000304783.

Structurei

3D structure databases

ProteinModelPortaliP58743.
SMRiP58743. Positions 505-555, 638-718.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini525 – 713189STASPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 STAS domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0659.
GeneTreeiENSGT00760000119026.
HOGENOMiHOG000006546.
HOVERGENiHBG000639.
InParanoidiP58743.
KOiK14703.
OrthoDBiEOG76T9QT.
PhylomeDBiP58743.
TreeFamiTF313784.

Family and domain databases

Gene3Di3.30.750.24. 2 hits.
InterProiIPR018045. S04_transporter_CS.
IPR002645. STAS_dom.
IPR001902. SulP_transpt.
IPR011547. Sulph_transpt.
[Graphical view]
PfamiPF01740. STAS. 1 hit.
PF00916. Sulfate_transp. 1 hit.
[Graphical view]
SUPFAMiSSF52091. SSF52091. 2 hits.
TIGRFAMsiTIGR00815. sulP. 1 hit.
PROSITEiPS01130. SLC26A. 1 hit.
PS50801. STAS. 1 hit.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P58743-1) [UniParc]FASTAAdd to Basket

Also known as: SLC26A5a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDHAEENEIL AATQRYYVER PIFSHPVLQE RLHTKDKVPD SIADKLKQAF
60 70 80 90 100
TCTPKKIRNI IYMFLPITKW LPAYKFKEYV LGDLVSGIST GVLQLPQGLA
110 120 130 140 150
FAMLAAVPPI FGLYSSFYPV IMYCFLGTSR HISIGPFAVI SLMIGGVAVR
160 170 180 190 200
LVPDDIVIPG GVNATNGTEA RDALRVKVAM SVTLLSGIIQ FCLGVCRFGF
210 220 230 240 250
VAIYLTEPLV RGFTTAAAVH VFTSMLKYLF GVKTKRYSGI FSVVYSTVAV
260 270 280 290 300
LQNVKNLNVC SLGVGLMVFG LLLGGKEFNE RFKEKLPAPI PLEFFAVVMG
310 320 330 340 350
TGISAGFNLK ESYNVDVVGT LPLGLLPPAN PDTSLFHLVY VDAIAIAIVG
360 370 380 390 400
FSVTISMAKT LANKHGYQVD GNQELIALGL CNSIGSLFQT FSISCSLSRS
410 420 430 440 450
LVQEGTGGKT QLAGCLASLM ILLVILATGF LFESLPQAVL SAIVIVNLKG
460 470 480 490 500
MFMQFSDLPF FWRTSKIELT IWLTTFVSSL FLGLDYGLIT AVIIALLTVI
510 520 530 540 550
YRTQSPSYKV LGKLPETDVY IDIDAYEEVK EIPGIKIFQI NAPIYYANSD
560 570 580 590 600
LYSNALKRKT GVNPAVIMGA RRKAMRKYAK EVGNANMANA TVVKADAEVD
610 620 630 640 650
GEDATKPEEE DGEVKYPPIV IKSTFPEEMQ RFMPPGDNVH TVILDFTQVN
660 670 680 690 700
FIDSVGVKTL AGIVKEYGDV GIYVYLAGCS AQVVNDLTRN RFFENPALWE
710 720 730 740
LLFHSIHDAV LGSQLREALA EQEASAPPSQ EDLEPNATPA TPEA
Length:744
Mass (Da):81,264
Last modified:March 27, 2002 - v1
Checksum:i9E64BE6DB2DC065E
GO
Isoform 2 (identifier: P58743-2) [UniParc]FASTAAdd to Basket

Also known as: SLC26A5b

The sequence of this isoform differs from the canonical sequence as follows:
     682-685: QVVN → FIQR
     686-744: Missing.

Show »
Length:685
Mass (Da):74,844
Checksum:iEF5682F6B068BEAE
GO
Isoform 3 (identifier: P58743-3) [UniParc]FASTAAdd to Basket

Also known as: SLC26A5c

The sequence of this isoform differs from the canonical sequence as follows:
     506-516: PSYKVLGKLPE → FHTEMTRRWRP
     517-744: Missing.

Show »
Length:516
Mass (Da):56,458
Checksum:iB12E4F7437574ED6
GO
Isoform 4 (identifier: P58743-4) [UniParc]FASTAAdd to Basket

Also known as: SLC26A5d

The sequence of this isoform differs from the canonical sequence as follows:
     325-335: LLPPANPDTSL → FHTEMTRRWRP
     336-744: Missing.

Show »
Length:335
Mass (Da):36,949
Checksum:i49BD1BF137784071
GO
Isoform 5 (identifier: P58743-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     438-469: Missing.

Note: No experimental confirmation available.

Show »
Length:712
Mass (Da):77,579
Checksum:iDFC2F97FD6F18EC1
GO
Isoform 6 (identifier: P58743-6) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     438-469: Missing.
     595-595: A → ATQ

Show »
Length:714
Mass (Da):77,809
Checksum:i0D1EB01E3E0578A4
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei325 – 33511LLPPANPDTSL → FHTEMTRRWRP in isoform 4. 1 PublicationVSP_010190Add
BLAST
Alternative sequencei336 – 744409Missing in isoform 4. 1 PublicationVSP_010191Add
BLAST
Alternative sequencei438 – 46932Missing in isoform 5 and isoform 6. 2 PublicationsVSP_043153Add
BLAST
Alternative sequencei506 – 51611PSYKVLGKLPE → FHTEMTRRWRP in isoform 3. 1 PublicationVSP_010192Add
BLAST
Alternative sequencei517 – 744228Missing in isoform 3. 1 PublicationVSP_010193Add
BLAST
Alternative sequencei595 – 5951A → ATQ in isoform 6. 1 PublicationVSP_047640
Alternative sequencei682 – 6854QVVN → FIQR in isoform 2. 1 PublicationVSP_010194
Alternative sequencei686 – 74459Missing in isoform 2. 1 PublicationVSP_010195Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF523354 mRNA. Translation: AAP31417.1.
AY256823 mRNA. Translation: AAP31532.1.
AY256824 mRNA. Translation: AAP31533.1.
AY256825 mRNA. Translation: AAP31534.1.
AY289134 mRNA. Translation: AAP43686.1.
AC004668 Genomic DNA. No translation available.
AC005064 Genomic DNA. No translation available.
AC093701 Genomic DNA. No translation available.
BC100833 mRNA. Translation: AAI00834.1.
CCDSiCCDS43629.1. [P58743-3]
CCDS43630.1. [P58743-2]
CCDS55150.1. [P58743-5]
CCDS5732.1. [P58743-4]
CCDS5733.1. [P58743-1]
RefSeqiNP_001161434.1. NM_001167962.1. [P58743-5]
NP_945350.1. NM_198999.2. [P58743-1]
NP_996766.1. NM_206883.2. [P58743-2]
NP_996767.1. NM_206884.2. [P58743-3]
NP_996768.1. NM_206885.2. [P58743-4]
UniGeneiHs.585146.

Genome annotation databases

EnsembliENST00000306312; ENSP00000304783; ENSG00000170615. [P58743-1]
ENST00000339444; ENSP00000342396; ENSG00000170615. [P58743-2]
ENST00000356767; ENSP00000349210; ENSG00000170615. [P58743-4]
ENST00000393723; ENSP00000377324; ENSG00000170615. [P58743-6]
ENST00000393730; ENSP00000377331; ENSG00000170615. [P58743-5]
ENST00000393735; ENSP00000377336; ENSG00000170615. [P58743-3]
ENST00000432958; ENSP00000389733; ENSG00000170615. [P58743-5]
GeneIDi375611.
KEGGihsa:375611.
UCSCiuc003vbt.2. human. [P58743-2]
uc003vbu.2. human. [P58743-3]
uc003vbv.2. human. [P58743-4]
uc003vbx.3. human. [P58743-5]
uc003vbz.3. human. [P58743-1]

Polymorphism databases

DMDMi20139418.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Web resourcesi

Protein Spotlight

Pump up the volume - Issue 22 of May 2002

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF523354 mRNA. Translation: AAP31417.1 .
AY256823 mRNA. Translation: AAP31532.1 .
AY256824 mRNA. Translation: AAP31533.1 .
AY256825 mRNA. Translation: AAP31534.1 .
AY289134 mRNA. Translation: AAP43686.1 .
AC004668 Genomic DNA. No translation available.
AC005064 Genomic DNA. No translation available.
AC093701 Genomic DNA. No translation available.
BC100833 mRNA. Translation: AAI00834.1 .
CCDSi CCDS43629.1. [P58743-3 ]
CCDS43630.1. [P58743-2 ]
CCDS55150.1. [P58743-5 ]
CCDS5732.1. [P58743-4 ]
CCDS5733.1. [P58743-1 ]
RefSeqi NP_001161434.1. NM_001167962.1. [P58743-5 ]
NP_945350.1. NM_198999.2. [P58743-1 ]
NP_996766.1. NM_206883.2. [P58743-2 ]
NP_996767.1. NM_206884.2. [P58743-3 ]
NP_996768.1. NM_206885.2. [P58743-4 ]
UniGenei Hs.585146.

3D structure databases

ProteinModelPortali P58743.
SMRi P58743. Positions 505-555, 638-718.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000304783.

Protein family/group databases

TCDBi 2.A.53.2.19. the sulfate permease (sulp) family.

PTM databases

PhosphoSitei P58743.

Polymorphism databases

DMDMi 20139418.

Proteomic databases

PaxDbi P58743.
PRIDEi P58743.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000306312 ; ENSP00000304783 ; ENSG00000170615 . [P58743-1 ]
ENST00000339444 ; ENSP00000342396 ; ENSG00000170615 . [P58743-2 ]
ENST00000356767 ; ENSP00000349210 ; ENSG00000170615 . [P58743-4 ]
ENST00000393723 ; ENSP00000377324 ; ENSG00000170615 . [P58743-6 ]
ENST00000393730 ; ENSP00000377331 ; ENSG00000170615 . [P58743-5 ]
ENST00000393735 ; ENSP00000377336 ; ENSG00000170615 . [P58743-3 ]
ENST00000432958 ; ENSP00000389733 ; ENSG00000170615 . [P58743-5 ]
GeneIDi 375611.
KEGGi hsa:375611.
UCSCi uc003vbt.2. human. [P58743-2 ]
uc003vbu.2. human. [P58743-3 ]
uc003vbv.2. human. [P58743-4 ]
uc003vbx.3. human. [P58743-5 ]
uc003vbz.3. human. [P58743-1 ]

Organism-specific databases

CTDi 375611.
GeneCardsi GC07M102993.
HGNCi HGNC:9359. SLC26A5.
MIMi 604943. gene.
613865. phenotype.
neXtProti NX_P58743.
Orphaneti 90636. Autosomal recessive non-syndromic sensorineural deafness type DFNB.
PharmGKBi PA33731.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0659.
GeneTreei ENSGT00760000119026.
HOGENOMi HOG000006546.
HOVERGENi HBG000639.
InParanoidi P58743.
KOi K14703.
OrthoDBi EOG76T9QT.
PhylomeDBi P58743.
TreeFami TF313784.

Miscellaneous databases

GeneWikii Prestin.
GenomeRNAii 375611.
NextBioi 100545.
PROi P58743.
SOURCEi Search...

Gene expression databases

Bgeei P58743.
CleanExi HS_SLC26A5.
ExpressionAtlasi P58743. baseline.
Genevestigatori P58743.

Family and domain databases

Gene3Di 3.30.750.24. 2 hits.
InterProi IPR018045. S04_transporter_CS.
IPR002645. STAS_dom.
IPR001902. SulP_transpt.
IPR011547. Sulph_transpt.
[Graphical view ]
Pfami PF01740. STAS. 1 hit.
PF00916. Sulfate_transp. 1 hit.
[Graphical view ]
SUPFAMi SSF52091. SSF52091. 2 hits.
TIGRFAMsi TIGR00815. sulP. 1 hit.
PROSITEi PS01130. SLC26A. 1 hit.
PS50801. STAS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3 AND 4), INVOLVEMENT IN DFNB61.
    Tissue: Organ of Corti.
  2. "Sequence of an alternatively spliced isoform of prestin (SLC26A5e)."
    Mount D.B.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 6).
  3. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).

Entry informationi

Entry nameiS26A5_HUMAN
AccessioniPrimary (citable) accession number: P58743
Secondary accession number(s): Q496J2
, Q7Z7F3, Q86UF8, Q86UF9, Q86UG0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: March 27, 2002
Last modified: October 29, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3