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P58742

- AAAS_MOUSE

UniProt

P58742 - AAAS_MOUSE

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Protein

Aladin

Gene
Aaas
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Plays a role in the normal development of the peripheral and central nervous system By similarity.

GO - Biological processi

  1. fertilization Source: MGI
  2. learning Source: MGI
  3. nucleocytoplasmic transport Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

mRNA transport, Protein transport, Translocation, Transport

Enzyme and pathway databases

ReactomeiREACT_196650. Nuclear Pore Complex (NPC) Disassembly.
REACT_204192. Regulation of Glucokinase by Glucokinase Regulatory Protein.

Names & Taxonomyi

Protein namesi
Recommended name:
Aladin
Alternative name(s):
Adracalin
Gene namesi
Name:Aaas
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 15

Organism-specific databases

MGIiMGI:2443767. Aaas.

Subcellular locationi

Nucleusnuclear pore complex By similarity

GO - Cellular componenti

  1. centrosome Source: Ensembl
  2. cytoplasm Source: Ensembl
  3. nuclear membrane Source: Ensembl
  4. nuclear pore Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Nuclear pore complex, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 546545AladinPRO_0000050829Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylcysteine By similarity
Modified residuei33 – 331Phosphoserine By similarity
Modified residuei495 – 4951Phosphoserine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP58742.
PRIDEiP58742.

PTM databases

PhosphoSiteiP58742.

Expressioni

Gene expression databases

ArrayExpressiP58742.
BgeeiP58742.
GenevestigatoriP58742.

Interactioni

Subunit structurei

Interacts with NDC1, the interaction is required for nuclear pore localization By similarity.

Structurei

3D structure databases

ProteinModelPortaliP58742.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati149 – 18840WD 1Add
BLAST
Repeati191 – 23040WD 2Add
BLAST
Repeati243 – 28240WD 3Add
BLAST
Repeati285 – 32440WD 4Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi544 – 5463Microbody targeting signal Reviewed prediction

Sequence similaritiesi

Contains 4 WD repeats.

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiNOG314927.
GeneTreeiENSGT00390000009446.
HOGENOMiHOG000033741.
HOVERGENiHBG026353.
InParanoidiP58742.
KOiK14320.
OMAiGEGKGCV.
OrthoDBiEOG7JQBN1.
PhylomeDBiP58742.
TreeFamiTF324412.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 1 hit.
[Graphical view]
SMARTiSM00320. WD40. 4 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P58742-1 [UniParc]FASTAAdd to Basket

« Hide

MCSLGLFPPP PPRGQVTLYE HNNELVTGNS YESPPPDFRG QWINLPVLHL    50
TKDPLKAPGR LDHGTRTAFI HHREQVWKRC INVWHDVGLF GVLNEIANSE 100
EEVFEWVKTA CSWALALCGR ASSLHGSLFP HLSLRSEDLI AEFAQVTNWS 150
SCCLRVFAWH PHTNKFAVAL LDDSIRVYNA NSTIVPSLKH RLQRNVAALA 200
WKPLSASVLA VACQSCILIW TLDPTSLSTR PSSGCAQVLS HPGHTPVTSL 250
AWAPNGGWLL SASPVDAVIL VWDVSTETCV PLPWFRGGGV TNLLWSPDGS 300
KVLATTPSAV FRVWEAQMWT CEAWPTLSGR CQTGCWSPDG NRLLFTVLGE 350
ALIYSLSFPE RCGTGKGHVG GAKSATIVAD LSETTIQTPD GEERLGGEAH 400
SMVWDPSGER LAVLMKGNPQ VQDGNPVILL FRTRNSPVFE LLPCGIIQGE 450
PGAQAQLITF HPSFNKGALL SVCWSTGRIT HIPLYFVNAQ FPRFSPVLGR 500
AQEPPAGGGG SIHEVPLFTE TSPTSAPWDP LPGQSSAQPH SPHSHL 546
Length:546
Mass (Da):59,431
Last modified:March 27, 2002 - v1
Checksum:i5F483AEB8C2E969B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK034591 mRNA. Translation: BAC28764.1.
AK083537 mRNA. Translation: BAC38945.1.
AK134406 mRNA. Translation: BAE22131.1.
AK165243 mRNA. Translation: BAE38099.1.
AK166118 mRNA. Translation: BAE38581.1.
BC018191 mRNA. Translation: AAH18191.1.
CCDSiCCDS27880.1.
RefSeqiNP_700465.2. NM_153416.2.
UniGeneiMm.352946.

Genome annotation databases

EnsembliENSMUST00000041208; ENSMUSP00000044604; ENSMUSG00000036678.
GeneIDi223921.
KEGGimmu:223921.
UCSCiuc007xvk.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK034591 mRNA. Translation: BAC28764.1 .
AK083537 mRNA. Translation: BAC38945.1 .
AK134406 mRNA. Translation: BAE22131.1 .
AK165243 mRNA. Translation: BAE38099.1 .
AK166118 mRNA. Translation: BAE38581.1 .
BC018191 mRNA. Translation: AAH18191.1 .
CCDSi CCDS27880.1.
RefSeqi NP_700465.2. NM_153416.2.
UniGenei Mm.352946.

3D structure databases

ProteinModelPortali P58742.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei P58742.

Proteomic databases

PaxDbi P58742.
PRIDEi P58742.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000041208 ; ENSMUSP00000044604 ; ENSMUSG00000036678 .
GeneIDi 223921.
KEGGi mmu:223921.
UCSCi uc007xvk.2. mouse.

Organism-specific databases

CTDi 8086.
MGIi MGI:2443767. Aaas.

Phylogenomic databases

eggNOGi NOG314927.
GeneTreei ENSGT00390000009446.
HOGENOMi HOG000033741.
HOVERGENi HBG026353.
InParanoidi P58742.
KOi K14320.
OMAi GEGKGCV.
OrthoDBi EOG7JQBN1.
PhylomeDBi P58742.
TreeFami TF324412.

Enzyme and pathway databases

Reactomei REACT_196650. Nuclear Pore Complex (NPC) Disassembly.
REACT_204192. Regulation of Glucokinase by Glucokinase Regulatory Protein.

Miscellaneous databases

NextBioi 376966.
PROi P58742.
SOURCEi Search...

Gene expression databases

ArrayExpressi P58742.
Bgeei P58742.
Genevestigatori P58742.

Family and domain databases

Gene3Di 2.130.10.10. 1 hit.
InterProi IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view ]
Pfami PF00400. WD40. 1 hit.
[Graphical view ]
SMARTi SM00320. WD40. 4 hits.
[Graphical view ]
SUPFAMi SSF50978. SSF50978. 2 hits.
PROSITEi PS00678. WD_REPEATS_1. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo, Lung, Spleen and Testis.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
    Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.
    Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-495, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiAAAS_MOUSE
AccessioniPrimary (citable) accession number: P58742
Secondary accession number(s): Q544M6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: March 27, 2002
Last modified: September 3, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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