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P58742

- AAAS_MOUSE

UniProt

P58742 - AAAS_MOUSE

Protein

Aladin

Gene

Aaas

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (27 Mar 2002)
      Previous versions | rss
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    Functioni

    Plays a role in the normal development of the peripheral and central nervous system.By similarity

    GO - Biological processi

    1. fertilization Source: MGI
    2. learning Source: MGI
    3. mRNA transport Source: UniProtKB-KW
    4. nucleocytoplasmic transport Source: Ensembl
    5. protein transport Source: UniProtKB-KW

    Keywords - Biological processi

    mRNA transport, Protein transport, Translocation, Transport

    Enzyme and pathway databases

    ReactomeiREACT_196650. Nuclear Pore Complex (NPC) Disassembly.
    REACT_204192. Regulation of Glucokinase by Glucokinase Regulatory Protein.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Aladin
    Alternative name(s):
    Adracalin
    Gene namesi
    Name:Aaas
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 15

    Organism-specific databases

    MGIiMGI:2443767. Aaas.

    Subcellular locationi

    Nucleusnuclear pore complex By similarity

    GO - Cellular componenti

    1. centrosome Source: Ensembl
    2. cytoplasm Source: Ensembl
    3. nuclear membrane Source: Ensembl
    4. nuclear pore Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nuclear pore complex, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 546545AladinPRO_0000050829Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylcysteineBy similarity
    Modified residuei33 – 331PhosphoserineBy similarity
    Modified residuei495 – 4951Phosphoserine1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    PaxDbiP58742.
    PRIDEiP58742.

    PTM databases

    PhosphoSiteiP58742.

    Expressioni

    Gene expression databases

    ArrayExpressiP58742.
    BgeeiP58742.
    GenevestigatoriP58742.

    Interactioni

    Subunit structurei

    Interacts with NDC1, the interaction is required for nuclear pore localization.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP58742.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati149 – 18840WD 1Add
    BLAST
    Repeati191 – 23040WD 2Add
    BLAST
    Repeati243 – 28240WD 3Add
    BLAST
    Repeati285 – 32440WD 4Add
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi544 – 5463Microbody targeting signalSequence Analysis

    Sequence similaritiesi

    Contains 4 WD repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, WD repeat

    Phylogenomic databases

    eggNOGiNOG314927.
    GeneTreeiENSGT00390000009446.
    HOGENOMiHOG000033741.
    HOVERGENiHBG026353.
    InParanoidiP58742.
    KOiK14320.
    OMAiGEGKGCV.
    OrthoDBiEOG7JQBN1.
    PhylomeDBiP58742.
    TreeFamiTF324412.

    Family and domain databases

    Gene3Di2.130.10.10. 1 hit.
    InterProiIPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR019775. WD40_repeat_CS.
    IPR017986. WD40_repeat_dom.
    [Graphical view]
    PfamiPF00400. WD40. 1 hit.
    [Graphical view]
    SMARTiSM00320. WD40. 4 hits.
    [Graphical view]
    SUPFAMiSSF50978. SSF50978. 2 hits.
    PROSITEiPS00678. WD_REPEATS_1. 1 hit.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P58742-1 [UniParc]FASTAAdd to Basket

    « Hide

    MCSLGLFPPP PPRGQVTLYE HNNELVTGNS YESPPPDFRG QWINLPVLHL    50
    TKDPLKAPGR LDHGTRTAFI HHREQVWKRC INVWHDVGLF GVLNEIANSE 100
    EEVFEWVKTA CSWALALCGR ASSLHGSLFP HLSLRSEDLI AEFAQVTNWS 150
    SCCLRVFAWH PHTNKFAVAL LDDSIRVYNA NSTIVPSLKH RLQRNVAALA 200
    WKPLSASVLA VACQSCILIW TLDPTSLSTR PSSGCAQVLS HPGHTPVTSL 250
    AWAPNGGWLL SASPVDAVIL VWDVSTETCV PLPWFRGGGV TNLLWSPDGS 300
    KVLATTPSAV FRVWEAQMWT CEAWPTLSGR CQTGCWSPDG NRLLFTVLGE 350
    ALIYSLSFPE RCGTGKGHVG GAKSATIVAD LSETTIQTPD GEERLGGEAH 400
    SMVWDPSGER LAVLMKGNPQ VQDGNPVILL FRTRNSPVFE LLPCGIIQGE 450
    PGAQAQLITF HPSFNKGALL SVCWSTGRIT HIPLYFVNAQ FPRFSPVLGR 500
    AQEPPAGGGG SIHEVPLFTE TSPTSAPWDP LPGQSSAQPH SPHSHL 546
    Length:546
    Mass (Da):59,431
    Last modified:March 27, 2002 - v1
    Checksum:i5F483AEB8C2E969B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK034591 mRNA. Translation: BAC28764.1.
    AK083537 mRNA. Translation: BAC38945.1.
    AK134406 mRNA. Translation: BAE22131.1.
    AK165243 mRNA. Translation: BAE38099.1.
    AK166118 mRNA. Translation: BAE38581.1.
    BC018191 mRNA. Translation: AAH18191.1.
    CCDSiCCDS27880.1.
    RefSeqiNP_700465.2. NM_153416.2.
    UniGeneiMm.352946.

    Genome annotation databases

    EnsembliENSMUST00000041208; ENSMUSP00000044604; ENSMUSG00000036678.
    GeneIDi223921.
    KEGGimmu:223921.
    UCSCiuc007xvk.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK034591 mRNA. Translation: BAC28764.1 .
    AK083537 mRNA. Translation: BAC38945.1 .
    AK134406 mRNA. Translation: BAE22131.1 .
    AK165243 mRNA. Translation: BAE38099.1 .
    AK166118 mRNA. Translation: BAE38581.1 .
    BC018191 mRNA. Translation: AAH18191.1 .
    CCDSi CCDS27880.1.
    RefSeqi NP_700465.2. NM_153416.2.
    UniGenei Mm.352946.

    3D structure databases

    ProteinModelPortali P58742.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei P58742.

    Proteomic databases

    PaxDbi P58742.
    PRIDEi P58742.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000041208 ; ENSMUSP00000044604 ; ENSMUSG00000036678 .
    GeneIDi 223921.
    KEGGi mmu:223921.
    UCSCi uc007xvk.2. mouse.

    Organism-specific databases

    CTDi 8086.
    MGIi MGI:2443767. Aaas.

    Phylogenomic databases

    eggNOGi NOG314927.
    GeneTreei ENSGT00390000009446.
    HOGENOMi HOG000033741.
    HOVERGENi HBG026353.
    InParanoidi P58742.
    KOi K14320.
    OMAi GEGKGCV.
    OrthoDBi EOG7JQBN1.
    PhylomeDBi P58742.
    TreeFami TF324412.

    Enzyme and pathway databases

    Reactomei REACT_196650. Nuclear Pore Complex (NPC) Disassembly.
    REACT_204192. Regulation of Glucokinase by Glucokinase Regulatory Protein.

    Miscellaneous databases

    NextBioi 376966.
    PROi P58742.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P58742.
    Bgeei P58742.
    Genevestigatori P58742.

    Family and domain databases

    Gene3Di 2.130.10.10. 1 hit.
    InterProi IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR019775. WD40_repeat_CS.
    IPR017986. WD40_repeat_dom.
    [Graphical view ]
    Pfami PF00400. WD40. 1 hit.
    [Graphical view ]
    SMARTi SM00320. WD40. 4 hits.
    [Graphical view ]
    SUPFAMi SSF50978. SSF50978. 2 hits.
    PROSITEi PS00678. WD_REPEATS_1. 1 hit.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Embryo, Lung, Spleen and Testis.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
      Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.
      Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-495, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic fibroblast.

    Entry informationi

    Entry nameiAAAS_MOUSE
    AccessioniPrimary (citable) accession number: P58742
    Secondary accession number(s): Q544M6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 27, 2002
    Last sequence update: March 27, 2002
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3