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P58742 (AAAS_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Aladin
Alternative name(s):
Adracalin
Gene names
Name:Aaas
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length546 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Plays a role in the normal development of the peripheral and central nervous system By similarity.

Sequence similarities

Contains 4 WD repeats.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 546545Aladin
PRO_0000050829

Regions

Repeat149 – 18840WD 1
Repeat191 – 23040WD 2
Repeat243 – 28240WD 3
Repeat285 – 32440WD 4
Motif544 – 5463Microbody targeting signal Potential

Amino acid modifications

Modified residue21N-acetylcysteine By similarity
Modified residue331Phosphoserine By similarity
Modified residue4951Phosphoserine Ref.3

Sequences

Sequence LengthMass (Da)Tools
P58742 [UniParc].

Last modified March 27, 2002. Version 1.
Checksum: 5F483AEB8C2E969B

FASTA54659,431
        10         20         30         40         50         60 
MCSLGLFPPP PPRGQVTLYE HNNELVTGNS YESPPPDFRG QWINLPVLHL TKDPLKAPGR 

        70         80         90        100        110        120 
LDHGTRTAFI HHREQVWKRC INVWHDVGLF GVLNEIANSE EEVFEWVKTA CSWALALCGR 

       130        140        150        160        170        180 
ASSLHGSLFP HLSLRSEDLI AEFAQVTNWS SCCLRVFAWH PHTNKFAVAL LDDSIRVYNA 

       190        200        210        220        230        240 
NSTIVPSLKH RLQRNVAALA WKPLSASVLA VACQSCILIW TLDPTSLSTR PSSGCAQVLS 

       250        260        270        280        290        300 
HPGHTPVTSL AWAPNGGWLL SASPVDAVIL VWDVSTETCV PLPWFRGGGV TNLLWSPDGS 

       310        320        330        340        350        360 
KVLATTPSAV FRVWEAQMWT CEAWPTLSGR CQTGCWSPDG NRLLFTVLGE ALIYSLSFPE 

       370        380        390        400        410        420 
RCGTGKGHVG GAKSATIVAD LSETTIQTPD GEERLGGEAH SMVWDPSGER LAVLMKGNPQ 

       430        440        450        460        470        480 
VQDGNPVILL FRTRNSPVFE LLPCGIIQGE PGAQAQLITF HPSFNKGALL SVCWSTGRIT 

       490        500        510        520        530        540 
HIPLYFVNAQ FPRFSPVLGR AQEPPAGGGG SIHEVPLFTE TSPTSAPWDP LPGQSSAQPH 


SPHSHL 

« Hide

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Embryo, Lung, Spleen and Testis.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]"Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.
Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-495, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Embryonic fibroblast.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK034591 mRNA. Translation: BAC28764.1.
AK083537 mRNA. Translation: BAC38945.1.
AK134406 mRNA. Translation: BAE22131.1.
AK165243 mRNA. Translation: BAE38099.1.
AK166118 mRNA. Translation: BAE38581.1.
BC018191 mRNA. Translation: AAH18191.1.
RefSeqNP_700465.2. NM_153416.2.
UniGeneMm.352946.

3D structure databases

ProteinModelPortalP58742.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteP58742.

Proteomic databases

PaxDbP58742.
PRIDEP58742.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000041208; ENSMUSP00000044604; ENSMUSG00000036678.
GeneID223921.
KEGGmmu:223921.
UCSCuc007xvk.2. mouse.

Organism-specific databases

CTD8086.
MGIMGI:2443767. Aaas.

Phylogenomic databases

eggNOGNOG314927.
GeneTreeENSGT00390000009446.
HOGENOMHOG000033741.
HOVERGENHBG026353.
InParanoidP58742.
KOK14320.
OMAGEGKGCV.
OrthoDBEOG7JQBN1.
PhylomeDBP58742.
TreeFamTF324412.

Gene expression databases

ArrayExpressP58742.
BgeeP58742.
GenevestigatorP58742.

Family and domain databases

Gene3D2.130.10.10. 1 hit.
InterProIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamPF00400. WD40. 1 hit.
[Graphical view]
SMARTSM00320. WD40. 4 hits.
[Graphical view]
SUPFAMSSF50978. SSF50978. 2 hits.
PROSITEPS00678. WD_REPEATS_1. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio376966.
PROP58742.
SOURCESearch...

Entry information

Entry nameAAAS_MOUSE
AccessionPrimary (citable) accession number: P58742
Secondary accession number(s): Q544M6
Entry history
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: March 27, 2002
Last modified: April 16, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot