P58741 (UPPP2_AGRT5) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Undecaprenyl-diphosphatase 2
EC=3.6.1.27

Alternative name(s):
Bacitracin resistance protein 2
Undecaprenyl pyrophosphate phosphatase 2

Gene names

Name:	uppP2
Synonyms:	bacA2, upk2
Ordered Locus Names:	Atu0998
ORF Names:	AGR_C_1833

Organism

Agrobacterium tumefaciens (strain C58 / ATCC 33970)

Taxonomic identifier

176299 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Rhizobiaceae › Rhizobium/Agrobacterium group › Agrobacterium

Protein attributes

Sequence length	278 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP MF_01006
Catalytic activity	Undecaprenyl diphosphate + H2O = undecaprenyl phosphate + phosphate. HAMAP MF_01006
Subcellular location	Cell inner membrane; Multi-pass membrane protein By similarity HAMAP MF_01006.
Miscellaneous	Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available. HAMAP MF_01006
Sequence similarities	Belongs to the UppP family.

Ontologies

Keywords
Biological process	Antibiotic resistance Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cellular cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW dephosphorylation Inferred from electronic annotation. Source: InterPro peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW response to antibiotic Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	undecaprenyl-diphosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 278	278	Undecaprenyl-diphosphatase 2 HAMAP MF_01006		PRO_0000151080
Regions
	Transmembrane	43 – 63	21	Helical; Potential
	Transmembrane	88 – 108	21	Helical; Potential
	Transmembrane	119 – 139	21	Helical; Potential
	Transmembrane	149 – 169	21	Helical; Potential
	Transmembrane	194 – 214	21	Helical; Potential
	Transmembrane	226 – 246	21	Helical; Potential
	Transmembrane	254 – 274	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	P58741 [UniParc]. Last modified March 5, 2002. Version 1. Checksum: 819EF0CD1FCF13B8	FASTA	278	30,075
	10 20 30 40 50 60 MSMGWMEAGF LGLLQGLTEF LPVSSSAHLR IAGEFLPSGA DPGAAFTAIT QIGTEMAVLV 70 80 90 100 110 120 YFWSDIMRIA AAWLRQNLRL GEYNKADARL GWLIIVGSVP IVFLGLFFKD AIEHSLRNLY 130 140 150 160 170 180 ITAVMLIVFG IVLGLADRIG EKRYKLNQLI WRDGILFGFA QAMALIPGVS RSGGTISAGL 190 200 210 220 230 240 LLGYTREAAA RYSFLLAVPA VFGSGFYQLF KSIGEDNPVG WGQTGLATLI AFIVGYAVIV 250 260 270 VFLKLVSTKS YMPFVWYRVV IGFILLALLG TGVISAGG

References

[1]

"The genome of the natural genetic engineer Agrobacterium tumefaciens C58." Wood D.W., Setubal J.C., Kaul R., Monks D.E., Kitajima J.P., Okura V.K., Zhou Y., Chen L., Wood G.E., Almeida N.F. Jr., Woo L., Chen Y., Paulsen I.T., Eisen J.A., Karp P.D., Bovee D. Sr., Chapman P., Clendenning J. , Deatherage G., Gillet W., Grant C., Kutyavin T., Levy R., Li M.-J., McClelland E., Palmieri A., Raymond C., Rouse G., Saenphimmachak C., Wu Z., Romero P., Gordon D., Zhang S., Yoo H., Tao Y., Biddle P., Jung M., Krespan W., Perry M., Gordon-Kamm B., Liao L., Kim S., Hendrick C., Zhao Z.-Y., Dolan M., Chumley F., Tingey S.V., Tomb J.-F., Gordon M.P., Olson M.V., Nester E.W. Science 294:2317-2323(2001) [PubMed: 11743193] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C58 / ATCC 33970.

[2]

"Genome sequence of the plant pathogen and biotechnology agent Agrobacterium tumefaciens C58." Goodner B., Hinkle G., Gattung S., Miller N., Blanchard M., Qurollo B., Goldman B.S., Cao Y., Askenazi M., Halling C., Mullin L., Houmiel K., Gordon J., Vaudin M., Iartchouk O., Epp A., Liu F., Wollam C. , Allinger M., Doughty D., Scott C., Lappas C., Markelz B., Flanagan C., Crowell C., Gurson J., Lomo C., Sear C., Strub G., Cielo C., Slater S. Science 294:2323-2328(2001) [PubMed: 11743194] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C58 / ATCC 33970.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE007869 Genomic DNA. Translation: AAK86807.1.
PIR	AF2699. F97481.
RefSeq	NP_354022.1. NC_003062.2.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	P58741.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1133036.
GenomeReviews	Gene locus Atu0998 in contig AE007869_GR.
KEGG	atu:Atu0998.
PATRIC	20811741. VBIAgrTum91616_1012.
Phylogenomic databases
eggNOG	COG1968.
HOGENOM	HBG391969.
OMA	IRTGARN.
PhylomeDB	P58741.
ProtClustDB	PRK12554.
Enzyme and pathway databases
BioCyc	ATUM176299-1:ATU0998-MONOMER.
Family and domain databases
HAMAP	MF_01006. Undec_diphosphatase. [Tree]
InterPro	IPR003824. Bacitracin-R_BacA. [Graphical view]
KO	K06153.
Pfam	PF02673. BacA. 1 hit. [Graphical view]
TIGRFAMs	TIGR00753. Undec_PP_bacA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

UPPP2_AGRT5

Accession

Primary (citable) accession number: P58741

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 5, 2002
Last sequence update:	March 5, 2002
Last modified:	January 25, 2012
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program