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P58741

- UPPP2_AGRT5

UniProt

P58741 - UPPP2_AGRT5

Protein

Undecaprenyl-diphosphatase 2

Gene

uppP2

Organism
Agrobacterium tumefaciens (strain C58 / ATCC 33970)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (05 Mar 2002)
      Previous versions | rss
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    Functioni

    Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

    Catalytic activityi

    Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

    GO - Molecular functioni

    1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. dephosphorylation Source: InterPro
    2. peptidoglycan biosynthetic process Source: UniProtKB-KW
    3. regulation of cell shape Source: UniProtKB-KW
    4. response to antibiotic Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Enzyme and pathway databases

    BioCyciAGRO:ATU0998-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Undecaprenyl-diphosphatase 2UniRule annotation (EC:3.6.1.27UniRule annotation)
    Alternative name(s):
    Bacitracin resistance protein 2UniRule annotation
    Undecaprenyl pyrophosphate phosphatase 2UniRule annotation
    Gene namesi
    Name:uppP2UniRule annotation
    Synonyms:bacA2, upk2
    Ordered Locus Names:Atu0998
    ORF Names:AGR_C_1833
    OrganismiAgrobacterium tumefaciens (strain C58 / ATCC 33970)
    Taxonomic identifieri176299 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupAgrobacteriumAgrobacterium tumefaciens complex
    ProteomesiUP000000813: Chromosome circular

    Subcellular locationi

    Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 278278Undecaprenyl-diphosphatase 2PRO_0000151080Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi176299.Atu0998.

    Structurei

    3D structure databases

    ProteinModelPortaliP58741.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei43 – 6321HelicalUniRule annotationAdd
    BLAST
    Transmembranei88 – 10821HelicalUniRule annotationAdd
    BLAST
    Transmembranei119 – 13921HelicalUniRule annotationAdd
    BLAST
    Transmembranei149 – 16921HelicalUniRule annotationAdd
    BLAST
    Transmembranei194 – 21421HelicalUniRule annotationAdd
    BLAST
    Transmembranei226 – 24621HelicalUniRule annotationAdd
    BLAST
    Transmembranei254 – 27421HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UppP family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1968.
    HOGENOMiHOG000218357.
    KOiK06153.
    OMAiSDIMRIA.
    OrthoDBiEOG6QP13M.

    Family and domain databases

    HAMAPiMF_01006. Undec_diphosphatase.
    InterProiIPR003824. UppP.
    [Graphical view]
    PfamiPF02673. BacA. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P58741-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSMGWMEAGF LGLLQGLTEF LPVSSSAHLR IAGEFLPSGA DPGAAFTAIT    50
    QIGTEMAVLV YFWSDIMRIA AAWLRQNLRL GEYNKADARL GWLIIVGSVP 100
    IVFLGLFFKD AIEHSLRNLY ITAVMLIVFG IVLGLADRIG EKRYKLNQLI 150
    WRDGILFGFA QAMALIPGVS RSGGTISAGL LLGYTREAAA RYSFLLAVPA 200
    VFGSGFYQLF KSIGEDNPVG WGQTGLATLI AFIVGYAVIV VFLKLVSTKS 250
    YMPFVWYRVV IGFILLALLG TGVISAGG 278
    Length:278
    Mass (Da):30,075
    Last modified:March 5, 2002 - v1
    Checksum:i819EF0CD1FCF13B8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE007869 Genomic DNA. Translation: AAK86807.1.
    PIRiAF2699.
    F97481.
    RefSeqiNP_354022.1. NC_003062.2.

    Genome annotation databases

    EnsemblBacteriaiAAK86807; AAK86807; Atu0998.
    GeneIDi1133036.
    KEGGiatu:Atu0998.
    PATRICi20811741. VBIAgrTum91616_1012.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE007869 Genomic DNA. Translation: AAK86807.1 .
    PIRi AF2699.
    F97481.
    RefSeqi NP_354022.1. NC_003062.2.

    3D structure databases

    ProteinModelPortali P58741.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 176299.Atu0998.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAK86807 ; AAK86807 ; Atu0998 .
    GeneIDi 1133036.
    KEGGi atu:Atu0998.
    PATRICi 20811741. VBIAgrTum91616_1012.

    Phylogenomic databases

    eggNOGi COG1968.
    HOGENOMi HOG000218357.
    KOi K06153.
    OMAi SDIMRIA.
    OrthoDBi EOG6QP13M.

    Enzyme and pathway databases

    BioCyci AGRO:ATU0998-MONOMER.

    Family and domain databases

    HAMAPi MF_01006. Undec_diphosphatase.
    InterProi IPR003824. UppP.
    [Graphical view ]
    Pfami PF02673. BacA. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00753. undec_PP_bacA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C58 / ATCC 33970.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C58 / ATCC 33970.

    Entry informationi

    Entry nameiUPPP2_AGRT5
    AccessioniPrimary (citable) accession number: P58741
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 5, 2002
    Last sequence update: March 5, 2002
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3