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Protein

Sulfate anion transporter 1

Gene

Slc26a1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

High affinity uptake of sulfate. Accepts oxalate, but not succinate as a cosubstrate. Mediates sulfate and oxalate transport.1 Publication

GO - Molecular functioni

  • anion:anion antiporter activity Source: UniProtKB
  • bicarbonate transmembrane transporter activity Source: GO_Central
  • chloride channel activity Source: GO_Central
  • chloride transmembrane transporter activity Source: UniProtKB
  • oxalate transmembrane transporter activity Source: UniProtKB
  • secondary active sulfate transmembrane transporter activity Source: InterPro
  • sulfate transmembrane transporter activity Source: UniProtKB

GO - Biological processi

  • bicarbonate transport Source: GO_Central
  • chloride transport Source: UniProtKB
  • oxalate transport Source: UniProtKB
  • regulation of intracellular pH Source: GO_Central
  • regulation of membrane potential Source: GO_Central
  • sulfate transport Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Ion channel

Keywords - Biological processi

Anion exchange, Antiport, Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-174362. Transport and synthesis of PAPS.
R-MMU-427601. Multifunctional anion exchangers.

Names & Taxonomyi

Protein namesi
Recommended name:
Sulfate anion transporter 1
Short name:
SAT-1
Alternative name(s):
Solute carrier family 26 member 1
Gene namesi
Name:Slc26a1
Synonyms:Sat1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:2385894. Slc26a1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei68 – 9023HelicalSequence analysisAdd
BLAST
Transmembranei94 – 11623HelicalSequence analysisAdd
BLAST
Transmembranei185 – 20723HelicalSequence analysisAdd
BLAST
Transmembranei260 – 28223HelicalSequence analysisAdd
BLAST
Transmembranei295 – 31420HelicalSequence analysisAdd
BLAST
Transmembranei347 – 36923HelicalSequence analysisAdd
BLAST
Transmembranei382 – 40423HelicalSequence analysisAdd
BLAST
Transmembranei417 – 43923HelicalSequence analysisAdd
BLAST
Transmembranei477 – 49923HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL2176770.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 704704Sulfate anion transporter 1PRO_0000080156Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei13 – 131PhosphothreonineBy similarity
Glycosylationi158 – 1581N-linked (GlcNAc...)Sequence analysis
Glycosylationi163 – 1631N-linked (GlcNAc...)Sequence analysis
Modified residuei587 – 5871PhosphoserineCombined sources
Glycosylationi588 – 5881N-linked (GlcNAc...)Sequence analysis
Modified residuei590 – 5901PhosphoserineBy similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP58735.
PRIDEiP58735.

PTM databases

iPTMnetiP58735.
PhosphoSiteiP58735.

Expressioni

Gene expression databases

BgeeiENSMUSG00000046959.
CleanExiMM_SAT1.
ExpressionAtlasiP58735. baseline and differential.
GenevisibleiP58735. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000051561.

Chemistry

BindingDBiP58735.

Structurei

3D structure databases

ProteinModelPortaliP58735.
SMRiP58735. Positions 72-142, 326-693.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini532 – 690159STASPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 STAS domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0236. Eukaryota.
COG0659. LUCA.
HOGENOMiHOG000006546.
HOVERGENiHBG000639.
InParanoidiP58735.
KOiK14700.
PhylomeDBiP58735.
TreeFamiTF313784.

Family and domain databases

Gene3Di3.30.750.24. 2 hits.
InterProiIPR018045. S04_transporter_CS.
IPR011547. SLC26A/SulP_dom.
IPR001902. SLC26A/SulP_fam.
IPR030331. SLC26A1.
IPR002645. STAS_dom.
[Graphical view]
PANTHERiPTHR11814. PTHR11814. 3 hits.
PTHR11814:SF31. PTHR11814:SF31. 3 hits.
PfamiPF01740. STAS. 1 hit.
PF00916. Sulfate_transp. 1 hit.
[Graphical view]
SUPFAMiSSF52091. SSF52091. 2 hits.
TIGRFAMsiTIGR00815. sulP. 1 hit.
PROSITEiPS01130. SLC26A. 1 hit.
PS50801. STAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P58735-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDASPEPQQK GGTLVLVRRQ PPVSQGLLET LKARLKKSCT CSMPCAQALV
60 70 80 90 100
QGLFPAIHWL PQYRLKEYLA GDVMSGLVIG IILVPQAIAY SLLAGLQPIY
110 120 130 140 150
SLYTSFFANL IYFLMGTSRH VNVGIFSLLC LMVGQVVDRE LQLAGFDPSQ
160 170 180 190 200
DSLGPKNNDS TLNNSATTLI IGLQDCRRDC YAIRVATALT LMAGLYQVLM
210 220 230 240 250
GILRLGFVST YLSQPLLDGF AMGASVTILT SQAKHMLGVQ IPRHQGLGMV
260 270 280 290 300
VHTWLSLLQN VGQANICDVV TSALCLGVLL AAKELSDRYR HRLKVPIPTE
310 320 330 340 350
LFVIVVATIV SHFGQLHTRF DSRVAGNIPT GFVAPQVPDP KIMWRVALDA
360 370 380 390 400
MSLALVGSAF SISLAEMFAR SHGYSVSANQ ELLAVGCCNV LPAFFHCFAT
410 420 430 440 450
SAALSKTLVK IATGCQTQLS SVVSAAVVLL VLLVLAPLFH DLQRCVLACI
460 470 480 490 500
IVVSLRGALR KVKDLPQLWR LSPADALVWV ATAATCVLVS TEAGLLAGVF
510 520 530 540 550
FSLLSLAGRT QRPRAALLAR IGDSTFYEDA AEFEGLLPPP EVRVFRFTGP
560 570 580 590 600
LYYANKDFFL RSLYRLTGLD AGHSATRKDQ GPEVGVSNRS LVDGKDLGSV
610 620 630 640 650
SSGAGLVVPL AFGFHTVVID CAPLLFLDVA GMATLKDLRR DYRALDITLL
660 670 680 690 700
LACCSPSVRD TLRKGGFLGE EQGAENELLF PSVHSAVEAA CARREELLAA

DSAL
Length:704
Mass (Da):75,788
Last modified:March 5, 2002 - v1
Checksum:iA6FA988522A6160A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC032151 mRNA. Translation: AAH32151.1.
BC022130 mRNA. Translation: AAH22130.1.
BC025824 mRNA. Translation: AAH25824.1.
CCDSiCCDS19517.1.
RefSeqiNP_001297621.1. NM_001310692.1.
NP_777359.3. NM_174870.4.
XP_006534974.1. XM_006534911.1.
XP_011247743.1. XM_011249441.1.
XP_011247744.1. XM_011249442.1.
XP_011247745.1. XM_011249443.1.
UniGeneiMm.440571.

Genome annotation databases

EnsembliENSMUST00000051757; ENSMUSP00000051561; ENSMUSG00000046959.
ENSMUST00000163328; ENSMUSP00000131282; ENSMUSG00000046959.
GeneIDi231583.
KEGGimmu:231583.
UCSCiuc008yoy.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC032151 mRNA. Translation: AAH32151.1.
BC022130 mRNA. Translation: AAH22130.1.
BC025824 mRNA. Translation: AAH25824.1.
CCDSiCCDS19517.1.
RefSeqiNP_001297621.1. NM_001310692.1.
NP_777359.3. NM_174870.4.
XP_006534974.1. XM_006534911.1.
XP_011247743.1. XM_011249441.1.
XP_011247744.1. XM_011249442.1.
XP_011247745.1. XM_011249443.1.
UniGeneiMm.440571.

3D structure databases

ProteinModelPortaliP58735.
SMRiP58735. Positions 72-142, 326-693.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000051561.

Chemistry

BindingDBiP58735.
ChEMBLiCHEMBL2176770.

PTM databases

iPTMnetiP58735.
PhosphoSiteiP58735.

Proteomic databases

PaxDbiP58735.
PRIDEiP58735.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000051757; ENSMUSP00000051561; ENSMUSG00000046959.
ENSMUST00000163328; ENSMUSP00000131282; ENSMUSG00000046959.
GeneIDi231583.
KEGGimmu:231583.
UCSCiuc008yoy.3. mouse.

Organism-specific databases

CTDi10861.
MGIiMGI:2385894. Slc26a1.

Phylogenomic databases

eggNOGiKOG0236. Eukaryota.
COG0659. LUCA.
HOGENOMiHOG000006546.
HOVERGENiHBG000639.
InParanoidiP58735.
KOiK14700.
PhylomeDBiP58735.
TreeFamiTF313784.

Enzyme and pathway databases

ReactomeiR-MMU-174362. Transport and synthesis of PAPS.
R-MMU-427601. Multifunctional anion exchangers.

Miscellaneous databases

PROiP58735.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000046959.
CleanExiMM_SAT1.
ExpressionAtlasiP58735. baseline and differential.
GenevisibleiP58735. MM.

Family and domain databases

Gene3Di3.30.750.24. 2 hits.
InterProiIPR018045. S04_transporter_CS.
IPR011547. SLC26A/SulP_dom.
IPR001902. SLC26A/SulP_fam.
IPR030331. SLC26A1.
IPR002645. STAS_dom.
[Graphical view]
PANTHERiPTHR11814. PTHR11814. 3 hits.
PTHR11814:SF31. PTHR11814:SF31. 3 hits.
PfamiPF01740. STAS. 1 hit.
PF00916. Sulfate_transp. 1 hit.
[Graphical view]
SUPFAMiSSF52091. SSF52091. 2 hits.
TIGRFAMsiTIGR00815. sulP. 1 hit.
PROSITEiPS01130. SLC26A. 1 hit.
PS50801. STAS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS26A1_MOUSE
AccessioniPrimary (citable) accession number: P58735
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 5, 2002
Last sequence update: March 5, 2002
Last modified: September 7, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.