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P58718

- PDXA2_SALTY

UniProt

P58718 - PDXA2_SALTY

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Protein
4-hydroxythreonine-4-phosphate dehydrogenase 2
Gene
pdxA2, STM0163
Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the NAD(P)-dependent oxidation of 4-(phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) By similarity.UniRule annotation

Catalytic activityi

4-phosphonooxy-L-threonine + NAD+ = 3-amino-2-oxopropyl phosphate + CO2 + NADH.UniRule annotation

Cofactori

Binds 1 divalent metal cation per subunit. Can use ions such as zinc, magnesium or cobalt By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei139 – 1391Substrate By similarity
Binding sitei140 – 1401Substrate By similarity
Metal bindingi169 – 1691Divalent metal cation; shared with dimeric partner By similarity
Metal bindingi213 – 2131Divalent metal cation; shared with dimeric partner By similarity
Metal bindingi268 – 2681Divalent metal cation; shared with dimeric partner By similarity
Binding sitei276 – 2761Substrate By similarity
Binding sitei285 – 2851Substrate By similarity
Binding sitei294 – 2941Substrate By similarity

GO - Molecular functioni

  1. 4-hydroxythreonine-4-phosphate dehydrogenase activity Source: UniProtKB-HAMAP
  2. NAD binding Source: InterPro
  3. cobalt ion binding Source: UniProtKB-HAMAP
  4. magnesium ion binding Source: UniProtKB-HAMAP
  5. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. pyridoxal phosphate biosynthetic process Source: UniProtKB-HAMAP
  2. pyridoxine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Pyridoxine biosynthesis

Keywords - Ligandi

Cobalt, Magnesium, Metal-binding, NAD, NADP, Zinc

Enzyme and pathway databases

BioCyciRETL1328306-WGS:GSTH-6864-MONOMER.
SENT99287:GCTI-162-MONOMER.
UniPathwayiUPA00244; UER00312.

Names & Taxonomyi

Protein namesi
Recommended name:
4-hydroxythreonine-4-phosphate dehydrogenase 2 (EC:1.1.1.262)
Alternative name(s):
4-(phosphohydroxy)-L-threonine dehydrogenase 2
Gene namesi
Name:pdxA2
Ordered Locus Names:STM0163
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000001014: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 3273274-hydroxythreonine-4-phosphate dehydrogenase 2UniRule annotation
PRO_0000188828Add
BLAST

Proteomic databases

PaxDbiP58718.
PRIDEiP58718.

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

STRINGi99287.STM0163.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi6 – 94
Turni13 – 164
Helixi17 – 259
Turni28 – 325
Beta strandi34 – 396
Helixi41 – 499
Beta strandi57 – 637
Helixi64 – 663
Beta strandi73 – 786
Helixi84 – 863
Helixi94 – 11219
Beta strandi117 – 1215
Helixi126 – 1316
Helixi139 – 1468
Beta strandi153 – 1575
Beta strandi162 – 1665
Helixi172 – 1787
Helixi181 – 19717
Beta strandi204 – 2085
Helixi212 – 2143
Helixi222 – 2265
Helixi228 – 2369
Turni237 – 2393
Beta strandi241 – 2466
Helixi248 – 2569
Beta strandi261 – 2677
Helixi268 – 27710
Beta strandi283 – 2886
Beta strandi290 – 2989
Turni303 – 3097
Helixi314 – 32613

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2HI1X-ray2.30A/B1-327[»]
ProteinModelPortaliP58718.
SMRiP58718. Positions 2-327.

Miscellaneous databases

EvolutionaryTraceiP58718.

Family & Domainsi

Sequence similaritiesi

Belongs to the PdxA family.

Phylogenomic databases

eggNOGiCOG1995.
HOGENOMiHOG000221593.
KOiK00097.
OMAiISIKLAM.
OrthoDBiEOG6GN6ZC.
PhylomeDBiP58718.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
HAMAPiMF_00536. PdxA.
InterProiIPR024084. IsoPropMal-DH-like_dom.
IPR005255. PdxA.
[Graphical view]
PfamiPF04166. PdxA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00557. pdxA. 1 hit.

Sequencei

Sequence statusi: Complete.

P58718-1 [UniParc]FASTAAdd to Basket

« Hide

METKTVAITM GDPAGIGPEI IVKALSEDGL NGAPLVVIGC LATLKRLQAK    50
GITPNVELRA IERVAEARFA PGIIHVIDEP LAQPEALEAG KVQAQAGDLA 100
YRCVKRATEL ALRGDVQAIA TAPLNKEALH LAGHNYPGHT ELLATLTHSR 150
DYAMVLYTDK LKVIHVSTHI ALRKFLDTLS TARVETVIGI ADTFLKRVGY 200
VKPRIAVAGV NPHAGENGLF GDEETRILTP AITDARAKGM DVYGPCPPDT 250
VFLQAYEGQY DMVVAMYHDQ GHIPLKLLGF YDGVNITAGL PFIRTSADHG 300
TAFDIAWTGK AKSESMAVSI KLAMQLA 327
Length:327
Mass (Da):35,065
Last modified:January 31, 2002 - v1
Checksum:i03BB6725F1896440
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE006468 Genomic DNA. Translation: AAL19127.1.
RefSeqiNP_459168.1. NC_003197.1.

Genome annotation databases

EnsemblBacteriaiAAL19127; AAL19127; STM0163.
GeneIDi1251681.
KEGGistm:STM0163.
PATRICi32378607. VBISalEnt20916_0173.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE006468 Genomic DNA. Translation: AAL19127.1 .
RefSeqi NP_459168.1. NC_003197.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2HI1 X-ray 2.30 A/B 1-327 [» ]
ProteinModelPortali P58718.
SMRi P58718. Positions 2-327.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 99287.STM0163.

Proteomic databases

PaxDbi P58718.
PRIDEi P58718.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL19127 ; AAL19127 ; STM0163 .
GeneIDi 1251681.
KEGGi stm:STM0163.
PATRICi 32378607. VBISalEnt20916_0173.

Phylogenomic databases

eggNOGi COG1995.
HOGENOMi HOG000221593.
KOi K00097.
OMAi ISIKLAM.
OrthoDBi EOG6GN6ZC.
PhylomeDBi P58718.

Enzyme and pathway databases

UniPathwayi UPA00244 ; UER00312 .
BioCyci RETL1328306-WGS:GSTH-6864-MONOMER.
SENT99287:GCTI-162-MONOMER.

Miscellaneous databases

EvolutionaryTracei P58718.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
HAMAPi MF_00536. PdxA.
InterProi IPR024084. IsoPropMal-DH-like_dom.
IPR005255. PdxA.
[Graphical view ]
Pfami PF04166. PdxA. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00557. pdxA. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LT2 / SGSC1412 / ATCC 700720.
  2. "The structure of a putative 4-hydroxythreonine-4-phosphate dehydrogenase from Salmonella typhimurium."
    Midwest center for structural genomics (MCSG)
    Submitted (AUG-2006) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS), SUBUNIT.

Entry informationi

Entry nameiPDXA2_SALTY
AccessioniPrimary (citable) accession number: P58718
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: January 31, 2002
Last modified: July 9, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The active site is located at the dimer interface By similarity.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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