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P58718

- PDXA2_SALTY

UniProt

P58718 - PDXA2_SALTY

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Protein

4-hydroxythreonine-4-phosphate dehydrogenase 2

Gene

pdxA2

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Catalyzes the NAD(P)-dependent oxidation of 4-(phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP).By similarity

Catalytic activityi

4-phosphonooxy-L-threonine + NAD+ = 3-amino-2-oxopropyl phosphate + CO2 + NADH.

Cofactori

Binds 1 divalent metal cation per subunit. Can use ions such as zinc, magnesium or cobalt (By similarity).By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei139 – 1391SubstrateBy similarity
Binding sitei140 – 1401SubstrateBy similarity
Metal bindingi169 – 1691Divalent metal cation; shared with dimeric partnerBy similarity
Metal bindingi213 – 2131Divalent metal cation; shared with dimeric partnerBy similarity
Metal bindingi268 – 2681Divalent metal cation; shared with dimeric partnerBy similarity
Binding sitei276 – 2761SubstrateBy similarity
Binding sitei285 – 2851SubstrateBy similarity
Binding sitei294 – 2941SubstrateBy similarity

GO - Molecular functioni

  1. 4-hydroxythreonine-4-phosphate dehydrogenase activity Source: UniProtKB-HAMAP
  2. cobalt ion binding Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP
  4. NAD binding Source: InterPro
  5. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. pyridoxal phosphate biosynthetic process Source: UniProtKB-HAMAP
  2. pyridoxine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Pyridoxine biosynthesis

Keywords - Ligandi

Cobalt, Magnesium, Metal-binding, NAD, NADP, Zinc

Enzyme and pathway databases

BioCyciRETL1328306-WGS:GSTH-6864-MONOMER.
SENT99287:GCTI-162-MONOMER.
UniPathwayiUPA00244; UER00312.

Names & Taxonomyi

Protein namesi
Recommended name:
4-hydroxythreonine-4-phosphate dehydrogenase 2 (EC:1.1.1.262)
Alternative name(s):
4-(phosphohydroxy)-L-threonine dehydrogenase 2
Gene namesi
Name:pdxA2
Ordered Locus Names:STM0163
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000001014: Chromosome

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 3273274-hydroxythreonine-4-phosphate dehydrogenase 2PRO_0000188828Add
BLAST

Proteomic databases

PaxDbiP58718.
PRIDEiP58718.

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

STRINGi99287.STM0163.

Structurei

Secondary structure

1
327
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi6 – 94Combined sources
Turni13 – 164Combined sources
Helixi17 – 259Combined sources
Turni28 – 325Combined sources
Beta strandi34 – 396Combined sources
Helixi41 – 499Combined sources
Beta strandi57 – 637Combined sources
Helixi64 – 663Combined sources
Beta strandi73 – 786Combined sources
Helixi84 – 863Combined sources
Helixi94 – 11219Combined sources
Beta strandi117 – 1215Combined sources
Helixi126 – 1316Combined sources
Helixi139 – 1468Combined sources
Beta strandi153 – 1575Combined sources
Beta strandi162 – 1665Combined sources
Helixi172 – 1787Combined sources
Helixi181 – 19717Combined sources
Beta strandi204 – 2085Combined sources
Helixi212 – 2143Combined sources
Helixi222 – 2265Combined sources
Helixi228 – 2369Combined sources
Turni237 – 2393Combined sources
Beta strandi241 – 2466Combined sources
Helixi248 – 2569Combined sources
Beta strandi261 – 2677Combined sources
Helixi268 – 27710Combined sources
Beta strandi283 – 2886Combined sources
Beta strandi290 – 2989Combined sources
Turni303 – 3097Combined sources
Helixi314 – 32613Combined sources

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2HI1X-ray2.30A/B1-327[»]
ProteinModelPortaliP58718.
SMRiP58718. Positions 2-327.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP58718.

Family & Domainsi

Sequence similaritiesi

Belongs to the PdxA family.Curated

Phylogenomic databases

eggNOGiCOG1995.
HOGENOMiHOG000221593.
KOiK00097.
OMAiISIKLAM.
OrthoDBiEOG6GN6ZC.
PhylomeDBiP58718.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
HAMAPiMF_00536. PdxA.
InterProiIPR024084. IsoPropMal-DH-like_dom.
IPR005255. PdxA.
[Graphical view]
PfamiPF04166. PdxA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00557. pdxA. 1 hit.

Sequencei

Sequence statusi: Complete.

P58718-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
METKTVAITM GDPAGIGPEI IVKALSEDGL NGAPLVVIGC LATLKRLQAK
60 70 80 90 100
GITPNVELRA IERVAEARFA PGIIHVIDEP LAQPEALEAG KVQAQAGDLA
110 120 130 140 150
YRCVKRATEL ALRGDVQAIA TAPLNKEALH LAGHNYPGHT ELLATLTHSR
160 170 180 190 200
DYAMVLYTDK LKVIHVSTHI ALRKFLDTLS TARVETVIGI ADTFLKRVGY
210 220 230 240 250
VKPRIAVAGV NPHAGENGLF GDEETRILTP AITDARAKGM DVYGPCPPDT
260 270 280 290 300
VFLQAYEGQY DMVVAMYHDQ GHIPLKLLGF YDGVNITAGL PFIRTSADHG
310 320
TAFDIAWTGK AKSESMAVSI KLAMQLA
Length:327
Mass (Da):35,065
Last modified:January 31, 2002 - v1
Checksum:i03BB6725F1896440
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE006468 Genomic DNA. Translation: AAL19127.1.
RefSeqiNP_459168.1. NC_003197.1.

Genome annotation databases

EnsemblBacteriaiAAL19127; AAL19127; STM0163.
GeneIDi1251681.
KEGGistm:STM0163.
PATRICi32378607. VBISalEnt20916_0173.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE006468 Genomic DNA. Translation: AAL19127.1 .
RefSeqi NP_459168.1. NC_003197.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2HI1 X-ray 2.30 A/B 1-327 [» ]
ProteinModelPortali P58718.
SMRi P58718. Positions 2-327.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 99287.STM0163.

Proteomic databases

PaxDbi P58718.
PRIDEi P58718.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL19127 ; AAL19127 ; STM0163 .
GeneIDi 1251681.
KEGGi stm:STM0163.
PATRICi 32378607. VBISalEnt20916_0173.

Phylogenomic databases

eggNOGi COG1995.
HOGENOMi HOG000221593.
KOi K00097.
OMAi ISIKLAM.
OrthoDBi EOG6GN6ZC.
PhylomeDBi P58718.

Enzyme and pathway databases

UniPathwayi UPA00244 ; UER00312 .
BioCyci RETL1328306-WGS:GSTH-6864-MONOMER.
SENT99287:GCTI-162-MONOMER.

Miscellaneous databases

EvolutionaryTracei P58718.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
HAMAPi MF_00536. PdxA.
InterProi IPR024084. IsoPropMal-DH-like_dom.
IPR005255. PdxA.
[Graphical view ]
Pfami PF04166. PdxA. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00557. pdxA. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LT2 / SGSC1412 / ATCC 700720.
  2. "The structure of a putative 4-hydroxythreonine-4-phosphate dehydrogenase from Salmonella typhimurium."
    Midwest center for structural genomics (MCSG)
    Submitted (AUG-2006) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS), SUBUNIT.

Entry informationi

Entry nameiPDXA2_SALTY
AccessioniPrimary (citable) accession number: P58718
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: January 31, 2002
Last modified: October 29, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The active site is located at the dimer interface.By similarity

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3