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P58717

- PDXA1_SALTY

UniProt

P58717 - PDXA1_SALTY

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Protein

4-hydroxythreonine-4-phosphate dehydrogenase 1

Gene

pdxA1

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Catalyzes the NAD(P)-dependent oxidation of 4-(phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP).By similarity

Catalytic activityi

4-phosphonooxy-L-threonine + NAD+ = 3-amino-2-oxopropyl phosphate + CO2 + NADH.

Cofactori

Zn2+1 Publication, Mg2+1 Publication, Co2+1 PublicationNote: Binds 1 divalent metal cation per subunit. Can probably use ions such as Zn(2+), Mg(2+) or Co(2+).1 Publication

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei136 – 1361SubstrateBy similarity
Binding sitei137 – 1371SubstrateBy similarity
Metal bindingi166 – 1661Divalent metal cation; shared with dimeric partner
Metal bindingi211 – 2111Divalent metal cation; shared with dimeric partner
Metal bindingi266 – 2661Divalent metal cation; shared with dimeric partner
Binding sitei274 – 2741SubstrateBy similarity
Binding sitei283 – 2831SubstrateBy similarity
Binding sitei292 – 2921SubstrateBy similarity

GO - Molecular functioni

  1. 4-hydroxythreonine-4-phosphate dehydrogenase activity Source: UniProtKB-HAMAP
  2. cobalt ion binding Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP
  4. NAD binding Source: InterPro
  5. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. pyridoxal phosphate biosynthetic process Source: UniProtKB-HAMAP
  2. pyridoxine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Pyridoxine biosynthesis

Keywords - Ligandi

Cobalt, Magnesium, Metal-binding, NAD, NADP, Zinc

Enzyme and pathway databases

BioCyciSENT99287:GCTI-90-MONOMER.
UniPathwayiUPA00244; UER00312.

Names & Taxonomyi

Protein namesi
Recommended name:
4-hydroxythreonine-4-phosphate dehydrogenase 1 (EC:1.1.1.262)
Alternative name(s):
4-(phosphohydroxy)-L-threonine dehydrogenase 1
Gene namesi
Name:pdxA1
Synonyms:pdxA
Ordered Locus Names:STM0091
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000001014: Chromosome

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 3293294-hydroxythreonine-4-phosphate dehydrogenase 1PRO_0000188826Add
BLAST

Proteomic databases

PaxDbiP58717.
PRIDEiP58717.

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

STRINGi99287.STM0091.

Structurei

Secondary structure

1
329
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi6 – 105Combined sources
Helixi18 – 258Combined sources
Beta strandi31 – 388Combined sources
Helixi40 – 4910Combined sources
Beta strandi55 – 584Combined sources
Beta strandi72 – 776Combined sources
Helixi91 – 933Combined sources
Helixi94 – 10916Combined sources
Beta strandi114 – 1185Combined sources
Helixi123 – 1275Combined sources
Turni128 – 1303Combined sources
Helixi136 – 1438Combined sources
Beta strandi150 – 1545Combined sources
Beta strandi159 – 1646Combined sources
Helixi169 – 1713Combined sources
Helixi172 – 1754Combined sources
Helixi178 – 19417Combined sources
Beta strandi202 – 2065Combined sources
Helixi210 – 2167Combined sources
Helixi221 – 2244Combined sources
Helixi226 – 2349Combined sources
Turni235 – 2373Combined sources
Beta strandi239 – 2446Combined sources
Helixi246 – 2494Combined sources
Helixi252 – 2554Combined sources
Beta strandi259 – 2657Combined sources
Helixi266 – 27712Combined sources
Beta strandi282 – 2909Combined sources
Beta strandi292 – 2943Combined sources
Turni301 – 3066Combined sources
Helixi312 – 32716Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1R8KX-ray2.10A/B1-329[»]
ProteinModelPortaliP58717.
SMRiP58717. Positions 3-329.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP58717.

Family & Domainsi

Sequence similaritiesi

Belongs to the PdxA family.Curated

Phylogenomic databases

eggNOGiCOG1995.
HOGENOMiHOG000221592.
KOiK00097.
OMAiDTLFQDK.
OrthoDBiEOG6GN6ZC.
PhylomeDBiP58717.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
HAMAPiMF_00536. PdxA.
InterProiIPR024084. IsoPropMal-DH-like_dom.
IPR005255. PdxA.
[Graphical view]
PfamiPF04166. PdxA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00557. pdxA. 1 hit.

Sequencei

Sequence statusi: Complete.

P58717-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSSAQRVVIT PGEPAGSGPD LVVQLAQRAW PIELVVCADG ALLTERAAML
60 70 80 90 100
GLPLSLLPYS PDVPAAPQPA GTLTLLPVSL RAPAISGQLT VENGPYVVET
110 120 130 140 150
LARACDGCLN GEFAALITGP VHKGVINDAG ISFTGHTEFF EERSQAKKVV
160 170 180 190 200
MMLATEELRV ALATTHLPLR AIADAITPAL LHEVIAILHH DLRTKFGIAE
210 220 230 240 250
PRILVCGLNP HAGEGGHMGT EEIDTIIPVL DELRAQGMKL NGPLPADTLF
260 270 280 290 300
QPKYLDNADA VLAMYHDQGL PVLKYQGFGR GVNITLGLPF IRTSVDHGTA
310 320
LELAGRGKAD VGSFITALNL AIKMIVNTQ
Length:329
Mass (Da):34,779
Last modified:January 31, 2002 - v1
Checksum:i054D9F4E0F34E43B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006468 Genomic DNA. Translation: AAL19055.1.
RefSeqiNP_459096.1. NC_003197.1.

Genome annotation databases

EnsemblBacteriaiAAL19055; AAL19055; STM0091.
GeneIDi1251609.
KEGGistm:STM0091.
PATRICi32378449. VBISalEnt20916_0094.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006468 Genomic DNA. Translation: AAL19055.1 .
RefSeqi NP_459096.1. NC_003197.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1R8K X-ray 2.10 A/B 1-329 [» ]
ProteinModelPortali P58717.
SMRi P58717. Positions 3-329.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 99287.STM0091.

Proteomic databases

PaxDbi P58717.
PRIDEi P58717.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL19055 ; AAL19055 ; STM0091 .
GeneIDi 1251609.
KEGGi stm:STM0091.
PATRICi 32378449. VBISalEnt20916_0094.

Phylogenomic databases

eggNOGi COG1995.
HOGENOMi HOG000221592.
KOi K00097.
OMAi DTLFQDK.
OrthoDBi EOG6GN6ZC.
PhylomeDBi P58717.

Enzyme and pathway databases

UniPathwayi UPA00244 ; UER00312 .
BioCyci SENT99287:GCTI-90-MONOMER.

Miscellaneous databases

EvolutionaryTracei P58717.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
HAMAPi MF_00536. PdxA.
InterProi IPR024084. IsoPropMal-DH-like_dom.
IPR005255. PdxA.
[Graphical view ]
Pfami PF04166. PdxA. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00557. pdxA. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LT2 / SGSC1412 / ATCC 700720.
  2. "Crystal structure of NAD-dependent dehydrogenase/carboxylase of Salmonella typhimurium."
    Midwest center for structural genomics (MCSG)
    Submitted (JAN-2005) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) IN COMPLEX WITH COBALT IONS, COFACTOR, SUBUNIT.

Entry informationi

Entry nameiPDXA1_SALTY
AccessioniPrimary (citable) accession number: P58717
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: January 31, 2002
Last modified: November 26, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The active site is located at the dimer interface.By similarity

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3