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Protein

Putative D-threonate 4-phosphate dehydrogenase

Gene

pdxA2

Organism
Salmonella typhi
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the NAD-dependent oxidation and subsequent decarboxylation of D-threonate 4-phosphate to produce dihydroxyacetone phosphate (DHAP).By similarity

Catalytic activityi

4-phospho-D-threonate + NAD+ = glycerone phosphate + CO2 + NADH.By similarity

Cofactori

a divalent metal cationBy similarityNote: Binds 1 divalent metal cation per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei139SubstrateBy similarity1
Binding sitei140SubstrateBy similarity1
Metal bindingi169Divalent metal cation; shared with dimeric partnerBy similarity1
Metal bindingi213Divalent metal cation; shared with dimeric partnerBy similarity1
Metal bindingi268Divalent metal cation; shared with dimeric partnerBy similarity1
Binding sitei276SubstrateBy similarity1
Binding sitei285SubstrateBy similarity1
Binding sitei294SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processCarbohydrate metabolism
LigandMetal-binding, NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Putative D-threonate 4-phosphate dehydrogenaseBy similarity (EC:1.1.1.408By similarity)
Gene namesi
Name:pdxA2By similarity
Ordered Locus Names:STY0185, t0168
OrganismiSalmonella typhi
Taxonomic identifieri90370 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000002670 Componenti: Chromosome
  • UP000000541 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001888271 – 327Putative D-threonate 4-phosphate dehydrogenaseAdd BLAST327

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi220341.STY0185.

Structurei

3D structure databases

ProteinModelPortaliP58716.
SMRiP58716.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PdxA family. PdxA2 subfamily.Curated

Phylogenomic databases

eggNOGiENOG4105CEZ. Bacteria.
COG1995. LUCA.
HOGENOMiHOG000221593.
KOiK22024.

Family and domain databases

InterProiView protein in InterPro
IPR005255. PdxA.
PANTHERiPTHR30004. PTHR30004. 1 hit.
PfamiView protein in Pfam
PF04166. PdxA. 1 hit.
TIGRFAMsiTIGR00557. pdxA. 1 hit.

Sequencei

Sequence statusi: Complete.

P58716-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METKTVAITM GDPAGIGPEI IVKALSEDGL NGAPLVVIGC LATLKCLQAK
60 70 80 90 100
GITPNVELRA IERVAEARFA PGIIHVIDEP LAQPEALEAG KVQAQAGDLA
110 120 130 140 150
YRCVKRATEL ALRGDVQAIA TAPLNKEALH LAGHNYPGHT ELLATLTHSR
160 170 180 190 200
DYAMVLYTDK LKVIHVSTHI ALRKFLDTLS TTRVETVIGI ADTFLKRVGY
210 220 230 240 250
VKPRIAVAGV NPHAGENGLF GDEETRILTP AITDARAKGM DVYGPCPPDT
260 270 280 290 300
VFLQAYEGQY DMVVAMYHDQ GHIPLKLLGF YDGVNITAGL PFIRTSADHG
310 320
TAFDIAWTGK AKSESMAVSI KLAMQLA
Length:327
Mass (Da):35,042
Last modified:January 31, 2002 - v1
Checksum:iF7F563DEB5326FEB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL513382 Genomic DNA. Translation: CAD01321.1.
AE014613 Genomic DNA. Translation: AAO67900.1.
RefSeqiNP_454776.1. NC_003198.1.
WP_000448742.1. NZ_NIFP01000004.1.

Genome annotation databases

EnsemblBacteriaiAAO67900; AAO67900; t0168.
CAD01321; CAD01321; CAD01321.
GeneIDi1246679.
KEGGistt:t0168.
sty:STY0185.
PATRICifig|220341.7.peg.188.

Similar proteinsi

Entry informationi

Entry nameiPDXA2_SALTI
AccessioniPrimary (citable) accession number: P58716
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: January 31, 2002
Last modified: November 22, 2017
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families