Reviewed,
UniProtKB/Swiss-Prot P58710 (GGLO_MOUSE)
Last modified
June 16, 2009.
Version 66.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: L-gulonolactone oxidase Short name=LGO EC=1.1.3.8 Alternative name(s): L-gulono-gamma-lactone oxidase Short name=GLO | ||
| Gene names |
| ||
| Organism | Mus musculus (Mouse) | ||
| Taxonomic identifier | 10090 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus |
Protein attributes
| Sequence length | 440 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Oxidizes L-gulono-1,4-lactone to hydrogen peroxide and L-xylo-hexulonolactone which spontaneously isomerizes to L-ascorbate By similarity. |
| Catalytic activity | L-gulono-1,4-lactone + O2 = L-xylo-hex-2-ulono-1,4-lactone + H2O2. L-xylo-hex-2-ulono-1,4-lactone = L-ascorbate. |
| Cofactor | FAD By similarity. |
| Pathway | |
| Subcellular location | Microsome membrane; Single-pass membrane protein By similarity. Endoplasmic reticulum membrane; Single-pass membrane protein By similarity. |
| Sequence similarities | Belongs to the oxygen-dependent FAD-linked oxidoreductase family. Contains 1 FAD-binding PCMH-type domain. |
Ontologies
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Initiator methionine | 1 | 1 | Removed By similarity | ||||||
| Chain | 2 – 440 | 439 | L-gulonolactone oxidase | PRO_0000128159 | |||||
Regions | |||||||||
| Transmembrane | 251 – 273 | 23 | Potential | ||||||
| Domain | 17 – 187 | 171 | FAD-binding PCMH-type | ||||||
Amino acid modifications | |||||||||
| Modified residue | 54 | 1 | Tele-8alpha-FAD histidine By similarity | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Liver. |
| [2] | Lubec G., Kang S.U. Submitted (APR-2007) to UniProtKB Cited for: PROTEIN SEQUENCE OF 318-324, MASS SPECTROMETRY. Strain: C57BL/6. Tissue: Brain. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| BC019856 mRNA. Translation: AAH19856.1. | |
| IPI | IPI00554830. |
| UniGene | Mm.26207 |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| Ensembl | ENSMUSG00000034450. Mus musculus. [Contig view] |
Organism-specific databases | |
| MGI | MGI:1353434. Gulo. |
Phylogenomic databases | |
| HOGENOM | P58710. |
| HOVERGEN | P58710. |
Enzyme and pathway databases | |
| BRENDA | 1.1.3.8. 244. |
Gene expression databases | |
| ArrayExpress | P58710. |
| Bgee | P58710. |
| CleanEx | MM_GULO. |
| GermOnline | ENSMUSG00000034450. Mus musculus. |
Family and domain databases | |
| InterPro | IPR007173. ALO. IPR016166. FAD-bd_2. IPR016168. FAD-linked_Oxase_FAD-bd_sub2. IPR010031. FAD_lactone_oxidase. IPR006094. Oxid_FAD_bind_N. IPR006093. Oxy_OxRdtase_FAD_BS. [Graphical view] |
| Gene3D | G3DSA:3.30.465.20. FAD-linked_oxidase_FAD-bd_sub2. 1 hit. |
| Pfam | PF04030. ALO. 1 hit. PF01565. FAD_binding_4. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR01678. FAD_lactone_ox. 1 hit. |
| PROSITE | PS51387. FAD_PCMH. 1 hit. PS00862. OX2_COVAL_FAD. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| SOURCE | Search... |
Entry information
| Entry name | GGLO_MOUSE | ||||||||
| Accession | Primary (citable) accession number: P58710 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


