ID   DALD_YERPE              Reviewed;         463 AA.
AC   P58709; Q0WEJ6;
DT   31-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT   31-JAN-2002, sequence version 1.
DT   16-JUN-2009, entry version 59.
DE   RecName: Full=D-arabinitol 4-dehydrogenase;
DE            EC=1.1.1.11;
GN   Name=dalD; OrderedLocusNames=YPO2325, y2008, YP_2112;
OS   Yersinia pestis.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; Yersinia.
OX   NCBI_TaxID=632;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CO-92 / Biovar Orientalis;
RX   MEDLINE=21470413; PubMed=11586360; DOI=10.1038/35097083;
RA   Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G.,
RA   Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L.,
RA   Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M.,
RA   Chillingworth T., Cronin A., Davies R.M., Davis P., Dougan G.,
RA   Feltwell T., Hamlin N., Holroyd S., Jagels K., Karlyshev A.V.,
RA   Leather S., Moule S., Oyston P.C.F., Quail M.A., Rutherford K.M.,
RA   Simmonds M., Skelton J., Stevens K., Whitehead S., Barrell B.G.;
RT   "Genome sequence of Yersinia pestis, the causative agent of plague.";
RL   Nature 413:523-527(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KIM5 / Biovar Mediaevalis;
RX   MEDLINE=22137863; PubMed=12142430;
RX   DOI=10.1128/JB.184.16.4601-4611.2002;
RA   Deng W., Burland V., Plunkett G. III, Boutin A., Mayhew G.F., Liss P.,
RA   Perna N.T., Rose D.J., Mau B., Zhou S., Schwartz D.C.,
RA   Fetherston J.D., Lindler L.E., Brubaker R.R., Plano G.V.,
RA   Straley S.C., McDonough K.A., Nilles M.L., Matson J.S., Blattner F.R.,
RA   Perry R.D.;
RT   "Genome sequence of Yersinia pestis KIM.";
RL   J. Bacteriol. 184:4601-4611(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=91001 / Biovar Mediaevalis;
RX   PubMed=15368893; DOI=10.1093/dnares/11.3.179;
RA   Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D.,
RA   Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z.,
RA   Jin L., Dai R., Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J.,
RA   Yang H., Wang J., Huang P., Yang R.;
RT   "Complete genome sequence of Yersinia pestis strain 91001, an isolate
RT   avirulent to humans.";
RL   DNA Res. 11:179-197(2004).
CC   -!- CATALYTIC ACTIVITY: D-arabinitol + NAD(+) = D-xylulose + NADH.
CC   -!- PATHWAY: Carbohydrate metabolism; D-arabinitol metabolism.
CC   -!- SIMILARITY: Belongs to the mannitol dehydrogenase family.
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DR   EMBL; AL590842; CAL20953.1; -; Genomic_DNA.
DR   EMBL; AE009952; AAM85574.1; ALT_INIT; Genomic_DNA.
DR   EMBL; AE017042; AAS62321.1; -; Genomic_DNA.
DR   PIR; AF0283; AF0283.
DR   RefSeq; NP_669323.1; -.
DR   RefSeq; NP_993444.1; -.
DR   RefSeq; YP_002347292.1; -.
DR   HSSP; O08355; 1LJ8.
DR   GeneID; 1146955; -.
DR   GeneID; 1175157; -.
DR   GeneID; 2765378; -.
DR   GenomeReviews; AE009952_GR; y2008.
DR   GenomeReviews; AE017042_GR; YP_2112.
DR   GenomeReviews; AL590842_GR; YPO2325.
DR   KEGG; ype:YPO2325; -.
DR   KEGG; ypk:y2008; -.
DR   KEGG; ypm:YP_2112; -.
DR   HOGENOM; P58709; -.
DR   OMA; P58709; IARVLPW.
DR   BioCyc; YPES187410:Y2008-MON; -.
DR   BioCyc; YPES214092:YPO2325-MON; -.
DR   BioCyc; YPES229193:YP2112-MON; -.
DR   BRENDA; 1.1.1.11; 142588.
DR   GO; GO:0050662; F:coenzyme binding; IEA:InterPro.
DR   GO; GO:0047813; F:D-arabinitol 4-dehydrogenase activity; IEA:EC.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR013328; DH_multihelical.
DR   InterPro; IPR013118; Mannitol_DH_C.
DR   InterPro; IPR000669; Mannitol_DH_core.
DR   InterPro; IPR013131; Mannitol_DH_N.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   Gene3D; G3DSA:1.10.1040.10; Opine_DH; 1.
DR   Pfam; PF01232; Mannitol_dh; 1.
DR   Pfam; PF08125; Mannitol_dh_C; 1.
DR   PRINTS; PR00084; MTLDHDRGNASE.
DR   PROSITE; PS00974; MANNITOL_DHGENASE; FALSE_NEG.
PE   3: Inferred from homology;
KW   Complete proteome; NAD; Oxidoreductase.
FT   CHAIN         1    463       D-arabinitol 4-dehydrogenase.
FT                                /FTId=PRO_0000170737.
SQ   SEQUENCE   463 AA;  51985 MW;  D82E8988685B5EDD CRC64;
     MNTDLKSPPA VWLHIGAGSF HRAHQAWYLH RLLASGDDRW TIALANIRDD AIPLLDTLRA
     QHGEYVLETV TPSGERQYEK ITSLRNIIPW DKALDHLVAQ GSKPETRVIS FTVTEGGYYL
     DNQFNLQQDN SDIQADLRGD CRTIYGAISR ILQQRQQDKS GPVTLLNCDN LRHNGERFRH
     GLLEFLALRG QQSLLNWVTS QTRSPNTMVD RITPRPSADI AQRVLEKTGI VDNAPVMGES
     FIQWVIEDDF IAGRPALENV GAEMVTSVLP YEEAKIRILN ASHSCIAWAG SLIGQCYIHE
     STQTDAIRQM AYDYVTQDVI PSLTPSPLDL AHYRDVVLER FSNPYIRDTN QRVAADGFSK
     IPGFITPTLI ECYQRGGVPT ATAMLPALFF VFMESWHQGT LPYEYQDGIL DPAAVHAMFQ
     SSDPAGLFAR DSALFGPLAN DDQFEQLLRQ SINRVSAWVS TNR
//