Reviewed, UniProtKB/Swiss-Prot P58709 (DALD_YERPE)

Names and origin

Protein names

Recommended name:
    D-arabinitol 4-dehydrogenase
    EC=1.1.1.11

Gene names

Name:	dalD
Ordered Locus Names:	YPO2325, y2008, YP_2112

Organism

Yersinia pestis [Complete proteome] [HAMAP]

Taxonomic identifier

632 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Yersinia

Protein attributes

Sequence length	463 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-arabinitol + NAD(+) = D-xylulose + NADH.
Pathway	Carbohydrate metabolism; D-arabinitol metabolism.
Sequence similarities	Belongs to the mannitol dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	D-arabinitol 4-dehydrogenase activity Inferred from electronic annotation. Source: EC coenzyme binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 463	463	D-arabinitol 4-dehydrogenase		PRO_0000170737

Sequences

	Sequence		Length	Mass (Da)
	P58709-1 [UniParc]. Last modified January 31, 2002. Version 1. Checksum: D82E8988685B5EDD	FASTA	463	51,985
	10 20 30 40 50 60 MNTDLKSPPA VWLHIGAGSF HRAHQAWYLH RLLASGDDRW TIALANIRDD AIPLLDTLRA 70 80 90 100 110 120 QHGEYVLETV TPSGERQYEK ITSLRNIIPW DKALDHLVAQ GSKPETRVIS FTVTEGGYYL 130 140 150 160 170 180 DNQFNLQQDN SDIQADLRGD CRTIYGAISR ILQQRQQDKS GPVTLLNCDN LRHNGERFRH 190 200 210 220 230 240 GLLEFLALRG QQSLLNWVTS QTRSPNTMVD RITPRPSADI AQRVLEKTGI VDNAPVMGES 250 260 270 280 290 300 FIQWVIEDDF IAGRPALENV GAEMVTSVLP YEEAKIRILN ASHSCIAWAG SLIGQCYIHE 310 320 330 340 350 360 STQTDAIRQM AYDYVTQDVI PSLTPSPLDL AHYRDVVLER FSNPYIRDTN QRVAADGFSK 370 380 390 400 410 420 IPGFITPTLI ECYQRGGVPT ATAMLPALFF VFMESWHQGT LPYEYQDGIL DPAAVHAMFQ 430 440 450 460 SSDPAGLFAR DSALFGPLAN DDQFEQLLRQ SINRVSAWVS TNR

References

[1]	"Genome sequence of Yersinia pestis, the causative agent of plague." Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G., Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L., Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M., Chillingworth T., Cronin A., Davies R.M. , Davis P., Dougan G., Feltwell T., Hamlin N., Holroyd S., Jagels K., Karlyshev A.V., Leather S., Moule S., Oyston P.C.F., Quail M.A., Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S., Barrell B.G. Nature 413:523-527(2001) [PubMed: 11586360] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CO-92 / Biovar Orientalis.
[2]	"Genome sequence of Yersinia pestis KIM." Deng W., Burland V., Plunkett G. III, Boutin A., Mayhew G.F., Liss P., Perna N.T., Rose D.J., Mau B., Zhou S., Schwartz D.C., Fetherston J.D., Lindler L.E., Brubaker R.R., Plano G.V., Straley S.C., McDonough K.A., Nilles M.L. , Matson J.S., Blattner F.R., Perry R.D. J. Bacteriol. 184:4601-4611(2002) [PubMed: 12142430] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: KIM5 / Biovar Mediaevalis.
[3]	"Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans." Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D., Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L., Dai R. , Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H., Wang J., Huang P., Yang R. DNA Res. 11:179-197(2004) [PubMed: 15368893] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 91001 / Biovar Mediaevalis.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AL590842 Genomic DNA. Translation: CAL20953.1. AE009952 Genomic DNA. Translation: AAM85574.1. Different initiation. AE017042 Genomic DNA. Translation: AAS62321.1.
PIR	AF0283.
RefSeq	NP_669323.1. NP_993444.1.
3D structure databases
HSSP	HSSP built from PDB template 1LJ8 based on UniProtKB O08355.
ModBase	Search...
Genome annotation databases
GeneID	1146955. 2765378.
GenomeReviews	Gene locus y2008 in contig AE009952_GR. Gene locus YP_2112 in contig AE017042_GR. Gene locus YPO2325 in contig AL590842_GR.
KEGG	ype:YPO2325. ypk:y2008. ypm:YP_2112.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	P58709.
Enzyme and pathway databases
BioCyc	YPES187410:Y2008-MON. YPES214092:YPO2325-MON. YPES229193:YP2112-MON.
Family and domain databases
InterPro	IPR013328. DHase_multihelical. IPR013118. Mannitol_DHase_C. IPR000669. Mannitol_DHase_core. IPR013131. Mannitol_DHase_N. IPR016040. NAD(P)-bd. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:1.10.1040.10. Opine_DH. 1 hit.
Pfam	PF01232. Mannitol_dh. 1 hit. PF08125. Mannitol_dh_C. 1 hit. [Graphical view]
PRINTS	PR00084. MTLDHDRGNASE.
PROSITE	PS00974. MANNITOL_DHGENASE. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DALD_YERPE

Accession

Primary (citable) accession number: P58709
Secondary accession number(s): Q0WEJ6

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 31, 2002
Last sequence update:	January 31, 2002
Last modified:	November 25, 2008
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)