ID   BBLN_MOUSE              Reviewed;          83 AA.
AC   P58686;
DT   31-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT   31-JAN-2002, sequence version 1.
DT   24-JAN-2024, entry version 123.
DE   RecName: Full=Bublin coiled-coil protein {ECO:0000250|UniProtKB:Q9BUW7};
DE   AltName: Full=UPF0184 protein C9orf16 homolog;
GN   Name=Bbln {ECO:0000312|MGI:MGI:1920987};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Embryo;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Brain, and Mammary gland;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   SUBCELLULAR LOCATION.
RX   PubMed=33857431; DOI=10.1016/j.cub.2021.03.069;
RA   Remmelzwaal S., Geisler F., Stucchi R., van der Horst S., Pasolli M.,
RA   Kroll J.R., Jarosinska O.D., Akhmanova A., Richardson C.A., Altelaar M.,
RA   Leube R.E., Ramalho J.J., Boxem M.;
RT   "BBLN-1 is essential for intermediate filament organization and apical
RT   membrane morphology.";
RL   Curr. Biol. 31:2334-2346.e9(2021).
CC   -!- FUNCTION: Essential for intermediate filament organization in
CC       intestinal cells, interacts with intermediate filament and regulates
CC       intestinal lumen morphology. {ECO:0000250|UniProtKB:Q9BUW7}.
CC   -!- SUBCELLULAR LOCATION: Cell junction {ECO:0000269|PubMed:33857431}.
CC       Cytoplasm, cytoskeleton {ECO:0000269|PubMed:33857431}. Note=In the
CC       intestine, localizes subapically and at cell junctions. Interacts with
CC       intermediate filament (IF) proteins and localizes to the IF network in
CC       an IF-dependent manner (By similarity) (PubMed:33857431). In dividing
CC       cells, localizes to interpolar and kinetochore microtubules (By
CC       similarity). {ECO:0000250|UniProtKB:Q9BUW7,
CC       ECO:0000269|PubMed:33857431}.
CC   -!- SIMILARITY: Belongs to the UPF0184 (EST00098) family. {ECO:0000305}.
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DR   EMBL; AK003598; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; BC024615; AAH24615.1; -; mRNA.
DR   EMBL; BC049639; AAH49639.1; -; mRNA.
DR   CCDS; CCDS38103.1; -.
DR   RefSeq; NP_932118.1; NM_198001.2.
DR   AlphaFoldDB; P58686; -.
DR   SMR; P58686; -.
DR   BioGRID; 216222; 2.
DR   STRING; 10090.ENSMUSP00000038970; -.
DR   iPTMnet; P58686; -.
DR   PhosphoSitePlus; P58686; -.
DR   jPOST; P58686; -.
DR   MaxQB; P58686; -.
DR   PaxDb; 10090-ENSMUSP00000038970; -.
DR   PeptideAtlas; P58686; -.
DR   Pumba; P58686; -.
DR   Antibodypedia; 17364; 88 antibodies from 17 providers.
DR   DNASU; 73737; -.
DR   Ensembl; ENSMUST00000048792.5; ENSMUSP00000038970.5; ENSMUSG00000039195.5.
DR   GeneID; 73737; -.
DR   KEGG; mmu:73737; -.
DR   UCSC; uc008jfk.2; mouse.
DR   AGR; MGI:1920987; -.
DR   CTD; 79095; -.
DR   MGI; MGI:1920987; Bbln.
DR   VEuPathDB; HostDB:ENSMUSG00000039195; -.
DR   eggNOG; ENOG502SAFB; Eukaryota.
DR   GeneTree; ENSGT00390000001761; -.
DR   HOGENOM; CLU_167244_0_0_1; -.
DR   InParanoid; P58686; -.
DR   OMA; EEYVAIN; -.
DR   OrthoDB; 2905809at2759; -.
DR   PhylomeDB; P58686; -.
DR   TreeFam; TF324640; -.
DR   BioGRID-ORCS; 73737; 1 hit in 78 CRISPR screens.
DR   PRO; PR:P58686; -.
DR   Proteomes; UP000000589; Chromosome 2.
DR   RNAct; P58686; Protein.
DR   Bgee; ENSMUSG00000039195; Expressed in facial nucleus and 260 other cell types or tissues.
DR   ExpressionAtlas; P58686; baseline and differential.
DR   GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-SubCell.
DR   GO; GO:0030054; C:cell junction; IMP:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005882; C:intermediate filament; IEA:Ensembl.
DR   GO; GO:0005828; C:kinetochore microtubule; IEA:Ensembl.
DR   GO; GO:0120219; C:subapical part of cell; IMP:UniProtKB.
DR   GO; GO:0060090; F:molecular adaptor activity; ISS:UniProtKB.
DR   GO; GO:0045110; P:intermediate filament bundle assembly; ISS:UniProtKB.
DR   InterPro; IPR005374; BBLN_eukaryota.
DR   PANTHER; PTHR34344:SF1; BUBLIN COILED-COIL PROTEIN; 1.
DR   PANTHER; PTHR34344; UPF0184 PROTEIN C9ORF16; 1.
DR   Pfam; PF03670; UPF0184; 1.
DR   Genevisible; P58686; MM.
PE   3: Inferred from homology;
KW   Cell junction; Coiled coil; Cytoplasm; Cytoskeleton; Phosphoprotein;
KW   Reference proteome.
FT   CHAIN           1..83
FT                   /note="Bublin coiled-coil protein"
FT                   /id="PRO_0000195162"
FT   REGION          1..25
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          25..74
FT                   /evidence="ECO:0000255"
FT   MOD_RES         82
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9BUW7"
SQ   SEQUENCE   83 AA;  9055 MW;  4D6D5BA98B72D36D CRC64;
     MSGPNGDLGM PVDAGTEGEN DSFGEAEYAA INSMLDQINS CLDHLEEKND HLHARLQELL
     ESNRQTRLEF QQQLGEAPGD ASP
//