SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P58682

- TLR8_MOUSE

UniProt

P58682 - TLR8_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Toll-like receptor 8
Gene
Tlr8
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B. activation, cytokine secretion and the inflammatory response By similarity.

GO - Molecular functioni

  1. DNA binding Source: UniProtKB
  2. double-stranded RNA binding Source: UniProtKB
  3. drug binding Source: Ensembl
  4. single-stranded RNA binding Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. I-kappaB kinase/NF-kappaB signaling Source: Ensembl
  2. MyD88-dependent toll-like receptor signaling pathway Source: InterPro
  3. cellular response to mechanical stimulus Source: Ensembl
  4. defense response to virus Source: UniProtKB
  5. inflammatory response Source: UniProtKB-KW
  6. innate immune response Source: UniProtKB-KW
  7. microglial cell activation involved in immune response Source: Ensembl
  8. pathogen-associated molecular pattern dependent induction by symbiont of host innate immune response Source: Ensembl
  9. positive regulation of innate immune response Source: UniProtKB
  10. positive regulation of interferon-alpha biosynthetic process Source: UniProtKB
  11. positive regulation of interferon-beta biosynthetic process Source: UniProtKB
  12. positive regulation of interferon-gamma biosynthetic process Source: UniProtKB
  13. positive regulation of interleukin-8 biosynthetic process Source: UniProtKB
  14. regulation of cytokine secretion Source: InterPro
  15. toll-like receptor 8 signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Immunity, Inflammatory response, Innate immunity

Enzyme and pathway databases

ReactomeiREACT_198527. TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling.
REACT_198976. Trafficking and processing of endosomal TLR.

Names & Taxonomyi

Protein namesi
Recommended name:
Toll-like receptor 8
Alternative name(s):
CD_antigen: CD288
Gene namesi
Name:Tlr8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome X

Organism-specific databases

MGIiMGI:2176887. Tlr8.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini24 – 818795Extracellular Reviewed prediction
Add
BLAST
Transmembranei819 – 83921Helical; Reviewed prediction
Add
BLAST
Topological domaini840 – 1032193Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323 Reviewed prediction
Add
BLAST
Chaini24 – 10321009Toll-like receptor 8
PRO_0000034736Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi29 – 291N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi36 ↔ 49 By similarity
Glycosylationi88 – 881N-linked (GlcNAc...) Reviewed prediction
Glycosylationi111 – 1111N-linked (GlcNAc...) Reviewed prediction
Glycosylationi122 – 1221N-linked (GlcNAc...) Reviewed prediction
Glycosylationi160 – 1601N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi177 ↔ 181 By similarity
Glycosylationi182 – 1821N-linked (GlcNAc...) Reviewed prediction
Glycosylationi231 – 2311N-linked (GlcNAc...) Reviewed prediction
Glycosylationi242 – 2421N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi252 ↔ 265 By similarity
Disulfide bondi255 ↔ 262 By similarity
Glycosylationi268 – 2681N-linked (GlcNAc...) Reviewed prediction
Glycosylationi288 – 2881N-linked (GlcNAc...) Reviewed prediction
Glycosylationi304 – 3041N-linked (GlcNAc...) Reviewed prediction
Glycosylationi353 – 3531N-linked (GlcNAc...) Reviewed prediction
Glycosylationi357 – 3571N-linked (GlcNAc...) Reviewed prediction
Glycosylationi411 – 4111N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi470 ↔ 500 By similarity
Glycosylationi502 – 5021N-linked (GlcNAc...) Reviewed prediction
Glycosylationi513 – 5131N-linked (GlcNAc...) Reviewed prediction
Glycosylationi581 – 5811N-linked (GlcNAc...) Reviewed prediction
Glycosylationi671 – 6711N-linked (GlcNAc...) Reviewed prediction
Glycosylationi743 – 7431N-linked (GlcNAc...) Reviewed prediction
Glycosylationi754 – 7541N-linked (GlcNAc...) Reviewed prediction
Glycosylationi783 – 7831N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP58682.
PRIDEiP58682.

PTM databases

PhosphoSiteiP58682.

Expressioni

Gene expression databases

ArrayExpressiP58682.
BgeeiP58682.
CleanExiMM_TLR8.
GenevestigatoriP58682.

Interactioni

Subunit structurei

Homodimer. Interacts with MYD88 via their respective TIR domains By similarity. Interacts with BTK By similarity. Interacts with UNC93B1.1 Publication

Protein-protein interaction databases

MINTiMINT-4996881.

Structurei

3D structure databases

ProteinModelPortaliP58682.
SMRiP58682. Positions 31-808.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati41 – 6121LRR 1
Add
BLAST
Repeati62 – 8524LRR 2
Add
BLAST
Repeati87 – 10923LRR 3
Add
BLAST
Repeati120 – 14324LRR 4
Add
BLAST
Repeati145 – 16521LRR 5
Add
BLAST
Repeati166 – 19429LRR 6
Add
BLAST
Repeati195 – 21824LRR 7
Add
BLAST
Repeati220 – 23920LRR 8
Add
BLAST
Repeati240 – 26728LRR 9
Add
BLAST
Repeati281 – 30424LRR 10
Add
BLAST
Repeati306 – 32924LRR 11
Add
BLAST
Repeati331 – 36030LRR 12
Add
BLAST
Repeati361 – 38424LRR 13
Add
BLAST
Repeati388 – 41124LRR 14
Add
BLAST
Repeati413 – 43624LRR 15
Add
BLAST
Repeati471 – 49424LRR 16
Add
BLAST
Repeati520 – 54324LRR 17
Add
BLAST
Repeati545 – 57228LRR 18
Add
BLAST
Repeati574 – 59825LRR 19
Add
BLAST
Repeati600 – 62122LRR 20
Add
BLAST
Repeati629 – 65224LRR 21
Add
BLAST
Repeati654 – 67724LRR 22
Add
BLAST
Repeati678 – 70124LRR 23
Add
BLAST
Repeati702 – 72524LRR 24
Add
BLAST
Repeati727 – 74923LRR 25
Add
BLAST
Repeati752 – 77625LRR 26
Add
BLAST
Domaini869 – 1016148TIR
Add
BLAST

Sequence similaritiesi

Contains 1 TIR domain.

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG4886.
GeneTreeiENSGT00750000117479.
HOGENOMiHOG000230468.
HOVERGENiHBG018601.
InParanoidiA2AHI9.
KOiK10170.
OMAiPATWFEN.
OrthoDBiEOG7VB2DM.
TreeFamiTF351113.

Family and domain databases

Gene3Di3.40.50.10140. 1 hit.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR026906. LRR_5.
IPR000157. TIR_dom.
IPR027175. TLR8.
[Graphical view]
PANTHERiPTHR24365:SF227. PTHR24365:SF227. 1 hit.
PfamiPF00560. LRR_1. 1 hit.
PF13306. LRR_5. 1 hit.
PF13504. LRR_7. 1 hit.
PF13855. LRR_8. 3 hits.
PF01582. TIR. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 2 hits.
SM00082. LRRCT. 1 hit.
[Graphical view]
SUPFAMiSSF52200. SSF52200. 1 hit.
PROSITEiPS51450. LRR. 22 hits.
PS50104. TIR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P58682-1 [UniParc]FASTAAdd to Basket

« Hide

MENMPPQSWI LTCFCLLSSG TSAIFHKANY SRSYPCDEIR HNSLVIAECN     50
HRQLHEVPQT IGKYVTNIDL SDNAITHITK ESFQKLQNLT KIDLNHNAKQ 100
QHPNENKNGM NITEGALLSL RNLTVLLLED NQLYTIPAGL PESLKELSLI 150
QNNIFQVTKN NTFGLRNLER LYLGWNCYFK CNQTFKVEDG AFKNLIHLKV 200
LSLSFNNLFY VPPKLPSSLR KLFLSNAKIM NITQEDFKGL ENLTLLDLSG 250
NCPRCYNAPF PCTPCKENSS IHIHPLAFQS LTQLLYLNLS STSLRTIPST 300
WFENLSNLKE LHLEFNYLVQ EIASGAFLTK LPSLQILDLS FNFQYKEYLQ 350
FINISSNFSK LRSLKKLHLR GYVFRELKKK HFEHLQSLPN LATINLGINF 400
IEKIDFKAFQ NFSKLDVIYL SGNRIASVLD GTDYSSWRNR LRKPLSTDDD 450
EFDPHVNFYH STKPLIKPQC TAYGKALDLS LNNIFIIGKS QFEGFQDIAC 500
LNLSFNANTQ VFNGTEFSSM PHIKYLDLTN NRLDFDDNNA FSDLHDLEVL 550
DLSHNAHYFS IAGVTHRLGF IQNLINLRVL NLSHNGIYTL TEESELKSIS 600
LKELVFSGNR LDRLWNANDG KYWSIFKSLQ NLIRLDLSYN NLQQIPNGAF 650
LNLPQSLQEL LISGNKLRFF NWTLLQYFPH LHLLDLSRNE LYFLPNCLSK 700
FAHSLETLLL SHNHFSHLPS GFLSEARNLV HLDLSFNTIK MINKSSLQTK 750
MKTNLSILEL HGNYFDCTCD ISDFRSWLDE NLNITIPKLV NVICSNPGDQ 800
KSKSIMSLDL TTCVSDTTAA VLFFLTFLTT SMVMLAALVH HLFYWDVWFI 850
YHMCSAKLKG YRTSSTSQTF YDAYISYDTK DASVTDWVIN ELRYHLEESE 900
DKSVLLCLEE RDWDPGLPII DNLMQSINQS KKTIFVLTKK YAKSWNFKTA 950
FYLALQRLMD ENMDVIIFIL LEPVLQYSQY LRLRQRICKS SILQWPNNPK 1000
AENLFWQSLK NVVLTENDSR YDDLYIDSIR QY 1032
Length:1,032
Mass (Da):119,358
Last modified:July 27, 2011 - v2
Checksum:iCA192552F08E33EA
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti613 – 6131R → H in AAK62677. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY035890 mRNA. Translation: AAK62677.1.
AL731735 Genomic DNA. Translation: CAM14949.1.
BC132054 mRNA. Translation: AAI32055.1.
CCDSiCCDS41209.1.
RefSeqiNP_573475.2. NM_133212.2.
XP_006528780.1. XM_006528717.1.
UniGeneiMm.196676.

Genome annotation databases

EnsembliENSMUST00000049023; ENSMUSP00000036762; ENSMUSG00000040522.
ENSMUST00000112170; ENSMUSP00000107793; ENSMUSG00000040522.
GeneIDi170744.
KEGGimmu:170744.
UCSCiuc009uwy.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY035890 mRNA. Translation: AAK62677.1 .
AL731735 Genomic DNA. Translation: CAM14949.1 .
BC132054 mRNA. Translation: AAI32055.1 .
CCDSi CCDS41209.1.
RefSeqi NP_573475.2. NM_133212.2.
XP_006528780.1. XM_006528717.1.
UniGenei Mm.196676.

3D structure databases

ProteinModelPortali P58682.
SMRi P58682. Positions 31-808.
ModBasei Search...

Protein-protein interaction databases

MINTi MINT-4996881.

PTM databases

PhosphoSitei P58682.

Proteomic databases

PaxDbi P58682.
PRIDEi P58682.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000049023 ; ENSMUSP00000036762 ; ENSMUSG00000040522 .
ENSMUST00000112170 ; ENSMUSP00000107793 ; ENSMUSG00000040522 .
GeneIDi 170744.
KEGGi mmu:170744.
UCSCi uc009uwy.1. mouse.

Organism-specific databases

CTDi 51311.
MGIi MGI:2176887. Tlr8.

Phylogenomic databases

eggNOGi COG4886.
GeneTreei ENSGT00750000117479.
HOGENOMi HOG000230468.
HOVERGENi HBG018601.
InParanoidi A2AHI9.
KOi K10170.
OMAi PATWFEN.
OrthoDBi EOG7VB2DM.
TreeFami TF351113.

Enzyme and pathway databases

Reactomei REACT_198527. TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling.
REACT_198976. Trafficking and processing of endosomal TLR.

Miscellaneous databases

NextBioi 370310.
PROi P58682.
SOURCEi Search...

Gene expression databases

ArrayExpressi P58682.
Bgeei P58682.
CleanExi MM_TLR8.
Genevestigatori P58682.

Family and domain databases

Gene3Di 3.40.50.10140. 1 hit.
InterProi IPR000483. Cys-rich_flank_reg_C.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR026906. LRR_5.
IPR000157. TIR_dom.
IPR027175. TLR8.
[Graphical view ]
PANTHERi PTHR24365:SF227. PTHR24365:SF227. 1 hit.
Pfami PF00560. LRR_1. 1 hit.
PF13306. LRR_5. 1 hit.
PF13504. LRR_7. 1 hit.
PF13855. LRR_8. 3 hits.
PF01582. TIR. 1 hit.
[Graphical view ]
SMARTi SM00369. LRR_TYP. 2 hits.
SM00082. LRRCT. 1 hit.
[Graphical view ]
SUPFAMi SSF52200. SSF52200. 1 hit.
PROSITEi PS51450. LRR. 22 hits.
PS50104. TIR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of murine Toll-like receptor 8."
    Heil F.J., Lipford G.B., Wagner H., Bauer S.M.
    Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
    Tissue: Spleen.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  4. "Unc93B1 biases Toll-like receptor responses to nucleic acid in dendritic cells toward DNA- but against RNA-sensing."
    Fukui R., Saitoh S., Matsumoto F., Kozuka-Hata H., Oyama M., Tabeta K., Beutler B., Miyake K.
    J. Exp. Med. 206:1339-1350(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH UNC93B1.

Entry informationi

Entry nameiTLR8_MOUSE
AccessioniPrimary (citable) accession number: P58682
Secondary accession number(s): A2AHI9, Q91XI7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: July 27, 2011
Last modified: September 3, 2014
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi