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Protein

Toll-like receptor 8

Gene

Tlr8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B. activation, cytokine secretion and the inflammatory response (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptor
Biological processImmunity, Inflammatory response, Innate immunity

Enzyme and pathway databases

ReactomeiR-MMU-1679131 Trafficking and processing of endosomal TLR
R-MMU-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade
R-MMU-975110 TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
R-MMU-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
R-MMU-975155 MyD88 dependent cascade initiated on endosome

Names & Taxonomyi

Protein namesi
Recommended name:
Toll-like receptor 8
Alternative name(s):
CD_antigen: CD288
Gene namesi
Name:Tlr8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:2176887 Tlr8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini24 – 818ExtracellularSequence analysisAdd BLAST795
Transmembranei819 – 839HelicalSequence analysisAdd BLAST21
Topological domaini840 – 1032CytoplasmicSequence analysisAdd BLAST193

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3137280

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000003473624 – 1032Toll-like receptor 8Add BLAST1009

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi29N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi36 ↔ 49By similarity
Glycosylationi88N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi111N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi122N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi160N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi177 ↔ 181By similarity
Glycosylationi182N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi231N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi242N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi252 ↔ 265By similarity
Disulfide bondi255 ↔ 262By similarity
Glycosylationi268N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi288N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi304N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi353N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi357N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi411N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi470 ↔ 500By similarity
Glycosylationi502N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi513N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi581N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi671N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi743N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi754N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi783N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP58682
PaxDbiP58682
PeptideAtlasiP58682
PRIDEiP58682

PTM databases

iPTMnetiP58682
PhosphoSitePlusiP58682

Expressioni

Gene expression databases

BgeeiENSMUSG00000040522
CleanExiMM_TLR8
ExpressionAtlasiP58682 baseline and differential
GenevisibleiP58682 MM

Interactioni

Subunit structurei

Homodimer. Interacts with MYD88 via their respective TIR domains (By similarity). Interacts with BTK (By similarity). Interacts with UNC93B1. Interacts with SMPDL3B (PubMed:26095358).By similarity2 Publications

GO - Molecular functioni

Protein-protein interaction databases

IntActiP58682, 2 interactors
STRINGi10090.ENSMUSP00000036762

Structurei

3D structure databases

ProteinModelPortaliP58682
SMRiP58682
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati41 – 61LRR 1Add BLAST21
Repeati62 – 85LRR 2Add BLAST24
Repeati87 – 109LRR 3Add BLAST23
Repeati120 – 143LRR 4Add BLAST24
Repeati145 – 165LRR 5Add BLAST21
Repeati166 – 194LRR 6Add BLAST29
Repeati195 – 218LRR 7Add BLAST24
Repeati220 – 239LRR 8Add BLAST20
Repeati240 – 267LRR 9Add BLAST28
Repeati281 – 304LRR 10Add BLAST24
Repeati306 – 329LRR 11Add BLAST24
Repeati331 – 360LRR 12Add BLAST30
Repeati361 – 384LRR 13Add BLAST24
Repeati388 – 411LRR 14Add BLAST24
Repeati413 – 436LRR 15Add BLAST24
Repeati471 – 494LRR 16Add BLAST24
Repeati520 – 543LRR 17Add BLAST24
Repeati545 – 572LRR 18Add BLAST28
Repeati574 – 598LRR 19Add BLAST25
Repeati600 – 621LRR 20Add BLAST22
Repeati629 – 652LRR 21Add BLAST24
Repeati654 – 677LRR 22Add BLAST24
Repeati678 – 701LRR 23Add BLAST24
Repeati702 – 725LRR 24Add BLAST24
Repeati727 – 749LRR 25Add BLAST23
Repeati752 – 776LRR 26Add BLAST25
Domaini869 – 1016TIRPROSITE-ProRule annotationAdd BLAST148

Sequence similaritiesi

Belongs to the Toll-like receptor family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4641 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00760000119006
HOGENOMiHOG000230468
HOVERGENiHBG018601
InParanoidiP58682
KOiK10170
OMAiWPDNPKA
OrthoDBiEOG091G014D
TreeFamiTF351113

Family and domain databases

Gene3Di3.40.50.10140, 1 hit
3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR026906 LRR_5
IPR032675 LRR_dom_sf
IPR000157 TIR_dom
IPR027175 TLR8
IPR035897 Toll_tir_struct_dom_sf
PANTHERiPTHR44312:SF2 PTHR44312:SF2, 1 hit
PfamiView protein in Pfam
PF13306 LRR_5, 1 hit
PF13855 LRR_8, 4 hits
PF01582 TIR, 1 hit
SMARTiView protein in SMART
SM00369 LRR_TYP, 13 hits
SM00255 TIR, 1 hit
SUPFAMiSSF52200 SSF52200, 1 hit
PROSITEiView protein in PROSITE
PS51450 LRR, 22 hits
PS50104 TIR, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P58682-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENMPPQSWI LTCFCLLSSG TSAIFHKANY SRSYPCDEIR HNSLVIAECN
60 70 80 90 100
HRQLHEVPQT IGKYVTNIDL SDNAITHITK ESFQKLQNLT KIDLNHNAKQ
110 120 130 140 150
QHPNENKNGM NITEGALLSL RNLTVLLLED NQLYTIPAGL PESLKELSLI
160 170 180 190 200
QNNIFQVTKN NTFGLRNLER LYLGWNCYFK CNQTFKVEDG AFKNLIHLKV
210 220 230 240 250
LSLSFNNLFY VPPKLPSSLR KLFLSNAKIM NITQEDFKGL ENLTLLDLSG
260 270 280 290 300
NCPRCYNAPF PCTPCKENSS IHIHPLAFQS LTQLLYLNLS STSLRTIPST
310 320 330 340 350
WFENLSNLKE LHLEFNYLVQ EIASGAFLTK LPSLQILDLS FNFQYKEYLQ
360 370 380 390 400
FINISSNFSK LRSLKKLHLR GYVFRELKKK HFEHLQSLPN LATINLGINF
410 420 430 440 450
IEKIDFKAFQ NFSKLDVIYL SGNRIASVLD GTDYSSWRNR LRKPLSTDDD
460 470 480 490 500
EFDPHVNFYH STKPLIKPQC TAYGKALDLS LNNIFIIGKS QFEGFQDIAC
510 520 530 540 550
LNLSFNANTQ VFNGTEFSSM PHIKYLDLTN NRLDFDDNNA FSDLHDLEVL
560 570 580 590 600
DLSHNAHYFS IAGVTHRLGF IQNLINLRVL NLSHNGIYTL TEESELKSIS
610 620 630 640 650
LKELVFSGNR LDRLWNANDG KYWSIFKSLQ NLIRLDLSYN NLQQIPNGAF
660 670 680 690 700
LNLPQSLQEL LISGNKLRFF NWTLLQYFPH LHLLDLSRNE LYFLPNCLSK
710 720 730 740 750
FAHSLETLLL SHNHFSHLPS GFLSEARNLV HLDLSFNTIK MINKSSLQTK
760 770 780 790 800
MKTNLSILEL HGNYFDCTCD ISDFRSWLDE NLNITIPKLV NVICSNPGDQ
810 820 830 840 850
KSKSIMSLDL TTCVSDTTAA VLFFLTFLTT SMVMLAALVH HLFYWDVWFI
860 870 880 890 900
YHMCSAKLKG YRTSSTSQTF YDAYISYDTK DASVTDWVIN ELRYHLEESE
910 920 930 940 950
DKSVLLCLEE RDWDPGLPII DNLMQSINQS KKTIFVLTKK YAKSWNFKTA
960 970 980 990 1000
FYLALQRLMD ENMDVIIFIL LEPVLQYSQY LRLRQRICKS SILQWPNNPK
1010 1020 1030
AENLFWQSLK NVVLTENDSR YDDLYIDSIR QY
Length:1,032
Mass (Da):119,358
Last modified:July 27, 2011 - v2
Checksum:iCA192552F08E33EA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti613R → H in AAK62677 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY035890 mRNA Translation: AAK62677.1
AL731735 Genomic DNA No translation available.
BC132054 mRNA Translation: AAI32055.1
CCDSiCCDS41209.1
RefSeqiNP_001300689.1, NM_001313760.1
NP_001300690.1, NM_001313761.1
NP_573475.2, NM_133212.3
UniGeneiMm.196676

Genome annotation databases

EnsembliENSMUST00000049023; ENSMUSP00000036762; ENSMUSG00000040522
ENSMUST00000112170; ENSMUSP00000107793; ENSMUSG00000040522
GeneIDi170744
KEGGimmu:170744
UCSCiuc009uwy.1 mouse

Similar proteinsi

Entry informationi

Entry nameiTLR8_MOUSE
AccessioniPrimary (citable) accession number: P58682
Secondary accession number(s): A2AHI9, Q91XI7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: July 27, 2011
Last modified: June 20, 2018
This is version 146 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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