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Protein

Toll-like receptor 7

Gene

Tlr7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR7 is a nucleotide-sensing TLR which is activated by single-stranded RNA. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.1 Publication

GO - Molecular functioni

  • double-stranded RNA binding Source: UniProtKB
  • drug binding Source: Ensembl
  • receptor activity Source: GO_Central
  • single-stranded RNA binding Source: UniProtKB
  • siRNA binding Source: UniProtKB
  • transmembrane signaling receptor activity Source: InterPro

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Immunity, Inflammatory response, Innate immunity

Enzyme and pathway databases

ReactomeiR-MMU-1679131. Trafficking and processing of endosomal TLR.
R-MMU-168181. Toll Like Receptor 7/8 (TLR7/8) Cascade.
R-MMU-975110. TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling.
R-MMU-975138. TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation.
R-MMU-975155. MyD88 dependent cascade initiated on endosome.

Names & Taxonomyi

Protein namesi
Recommended name:
Toll-like receptor 7
Gene namesi
Name:Tlr7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:2176882. Tlr7.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini27 – 837ExtracellularSequence analysisAdd BLAST811
Transmembranei838 – 858HelicalSequence analysisAdd BLAST21
Topological domaini859 – 1050CytoplasmicSequence analysisAdd BLAST192

GO - Cellular componenti

  • cytoplasm Source: MGI
  • early phagosome Source: UniProtKB
  • endoplasmic reticulum Source: UniProtKB
  • endoplasmic reticulum membrane Source: UniProtKB-SubCell
  • endosome Source: UniProtKB
  • integral component of plasma membrane Source: GO_Central
  • lysosome Source: UniProtKB
  • plasma membrane Source: MGI
  • receptor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Endoplasmic reticulum, Endosome, Lysosome, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL6085.
GuidetoPHARMACOLOGYi1757.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000003473427 – 1050Toll-like receptor 7Add BLAST1024

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi66N-linked (GlcNAc...)Sequence analysis1
Glycosylationi69N-linked (GlcNAc...)Sequence analysis1
Glycosylationi167N-linked (GlcNAc...)Sequence analysis1
Glycosylationi190N-linked (GlcNAc...)Sequence analysis1
Glycosylationi215N-linked (GlcNAc...)Sequence analysis1
Glycosylationi387N-linked (GlcNAc...)Sequence analysis1
Glycosylationi524N-linked (GlcNAc...)Sequence analysis1
Glycosylationi535N-linked (GlcNAc...)Sequence analysis1
Glycosylationi591N-linked (GlcNAc...)Sequence analysis1
Glycosylationi680N-linked (GlcNAc...)Sequence analysis1
Glycosylationi721N-linked (GlcNAc...)Sequence analysis1
Glycosylationi800N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP58681.
PeptideAtlasiP58681.
PRIDEiP58681.

PTM databases

iPTMnetiP58681.
PhosphoSitePlusiP58681.

Expressioni

Gene expression databases

BgeeiENSMUSG00000044583.
CleanExiMM_TLR7.
ExpressionAtlasiP58681. baseline and differential.
GenevisibleiP58681. MM.

Interactioni

Subunit structurei

Interacts with MYD88 via their respective TIR domains (By similarity). Interacts with UNC93B1. Interacts with SMPDL3B (PubMed:26095358).By similarity2 Publications

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000061853.

Chemistry databases

BindingDBiP58681.

Structurei

3D structure databases

ProteinModelPortaliP58681.
SMRiP58681.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati42 – 64LRR 1Add BLAST23
Repeati65 – 87LRR 2Add BLAST23
Repeati89 – 111LRR 3Add BLAST23
Repeati126 – 149LRR 4Add BLAST24
Repeati151 – 170LRR 5Add BLAST20
Repeati171 – 195LRR 6Add BLAST25
Repeati203 – 226LRR 7Add BLAST24
Repeati228 – 247LRR 8Add BLAST20
Repeati248 – 273LRR 9Add BLAST26
Repeati275 – 289LRR 10Add BLAST15
Repeati290 – 312LRR 11Add BLAST23
Repeati314 – 337LRR 12Add BLAST24
Repeati339 – 364LRR 13Add BLAST26
Repeati369 – 392LRR 14Add BLAST24
Repeati396 – 419LRR 15Add BLAST24
Repeati421 – 443LRR 16Add BLAST23
Repeati493 – 516LRR 17Add BLAST24
Repeati517 – 542LRR 18Add BLAST26
Repeati543 – 565LRR 19Add BLAST23
Repeati567 – 589LRR 20Add BLAST23
Repeati596 – 619LRR 21Add BLAST24
Repeati620 – 645LRR 22Add BLAST26
Repeati650 – 673LRR 23Add BLAST24
Repeati675 – 698LRR 24Add BLAST24
Repeati699 – 722LRR 25Add BLAST24
Repeati724 – 746LRR 26Add BLAST23
Repeati747 – 770LRR 27Add BLAST24
Repeati773 – 796LRR 28Add BLAST24
Domaini890 – 1037TIRPROSITE-ProRule annotationAdd BLAST148

Sequence similaritiesi

Belongs to the Toll-like receptor family.Curated
Contains 28 LRR (leucine-rich) repeats.Curated
Contains 1 TIR domain.PROSITE-ProRule annotation

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4641. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000119006.
HOGENOMiHOG000230468.
HOVERGENiHBG018601.
InParanoidiP58681.
KOiK05404.
OMAiERLANCS.
OrthoDBiEOG091G023M.
PhylomeDBiP58681.
TreeFamiTF325595.

Family and domain databases

Gene3Di3.40.50.10140. 1 hit.
3.80.10.10. 5 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000157. TIR_dom.
IPR026880. TLR7.
[Graphical view]
PANTHERiPTHR24365:SF222. PTHR24365:SF222. 3 hits.
PfamiPF00560. LRR_1. 1 hit.
PF13855. LRR_8. 4 hits.
PF01582. TIR. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 12 hits.
SM00082. LRRCT. 1 hit.
SM00255. TIR. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
SSF52200. SSF52200. 1 hit.
PROSITEiPS51450. LRR. 19 hits.
PS50104. TIR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P58681-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVFSMWTRKR QILIFLNMLL VSRVFGFRWF PKTLPCEVKV NIPEAHVIVD
60 70 80 90 100
CTDKHLTEIP EGIPTNTTNL TLTINHIPSI SPDSFRRLNH LEEIDLRCNC
110 120 130 140 150
VPVLLGSKAN VCTKRLQIRP GSFSGLSDLK ALYLDGNQLL EIPQDLPSSL
160 170 180 190 200
HLLSLEANNI FSITKENLTE LVNIETLYLG QNCYYRNPCN VSYSIEKDAF
210 220 230 240 250
LVMRNLKVLS LKDNNVTAVP TTLPPNLLEL YLYNNIIKKI QENDFNNLNE
260 270 280 290 300
LQVLDLSGNC PRCYNVPYPC TPCENNSPLQ IHDNAFNSLT ELKVLRLHSN
310 320 330 340 350
SLQHVPPTWF KNMRNLQELD LSQNYLAREI EEAKFLHFLP NLVELDFSFN
360 370 380 390 400
YELQVYHASI TLPHSLSSLE NLKILRVKGY VFKELKNSSL SVLHKLPRLE
410 420 430 440 450
VLDLGTNFIK IADLNIFKHF ENLKLIDLSV NKISPSEESR EVGFCPNAQT
460 470 480 490 500
SVDRHGPQVL EALHYFRYDE YARSCRFKNK EPPSFLPLNA DCHIYGQTLD
510 520 530 540 550
LSRNNIFFIK PSDFQHLSFL KCLNLSGNTI GQTLNGSELW PLRELRYLDF
560 570 580 590 600
SNNRLDLLYS TAFEELQSLE VLDLSSNSHY FQAEGITHML NFTKKLRLLD
610 620 630 640 650
KLMMNDNDIS TSASRTMESD SLRILEFRGN HLDVLWRAGD NRYLDFFKNL
660 670 680 690 700
FNLEVLDISR NSLNSLPPEV FEGMPPNLKN LSLAKNGLKS FFWDRLQLLK
710 720 730 740 750
HLEILDLSHN QLTKVPERLA NCSKSLTTLI LKHNQIRQLT KYFLEDALQL
760 770 780 790 800
RYLDISSNKI QVIQKTSFPE NVLNNLEMLV LHHNRFLCNC DAVWFVWWVN
810 820 830 840 850
HTDVTIPYLA TDVTCVGPGA HKGQSVISLD LYTCELDLTN LILFSVSISS
860 870 880 890 900
VLFLMVVMTT SHLFFWDMWY IYYFWKAKIK GYQHLQSMES CYDAFIVYDT
910 920 930 940 950
KNSAVTEWVL QELVAKLEDP REKHFNLCLE ERDWLPGQPV LENLSQSIQL
960 970 980 990 1000
SKKTVFVMTQ KYAKTESFKM AFYLSHQRLL DEKVDVIILI FLEKPLQKSK
1010 1020 1030 1040 1050
FLQLRKRLCR SSVLEWPANP QAHPYFWQCL KNALTTDNHV AYSQMFKETV
Length:1,050
Mass (Da):121,837
Last modified:January 31, 2002 - v1
Checksum:i495B75DEE849D8EE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY035889 mRNA. Translation: AAK62676.1.
CCDSiCCDS30531.1.
CCDS72469.1.
RefSeqiNP_001277684.1. NM_001290755.1.
NP_001277685.1. NM_001290756.1.
NP_001277686.1. NM_001290757.1.
NP_573474.1. NM_133211.4.
XP_011246087.1. XM_011247785.1.
XP_011246088.1. XM_011247786.1.
UniGeneiMm.23979.
Mm.489377.

Genome annotation databases

EnsembliENSMUST00000060719; ENSMUSP00000061853; ENSMUSG00000044583.
ENSMUST00000112161; ENSMUSP00000107787; ENSMUSG00000044583.
ENSMUST00000112164; ENSMUSP00000107789; ENSMUSG00000044583.
GeneIDi170743.
KEGGimmu:170743.
UCSCiuc009uwz.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY035889 mRNA. Translation: AAK62676.1.
CCDSiCCDS30531.1.
CCDS72469.1.
RefSeqiNP_001277684.1. NM_001290755.1.
NP_001277685.1. NM_001290756.1.
NP_001277686.1. NM_001290757.1.
NP_573474.1. NM_133211.4.
XP_011246087.1. XM_011247785.1.
XP_011246088.1. XM_011247786.1.
UniGeneiMm.23979.
Mm.489377.

3D structure databases

ProteinModelPortaliP58681.
SMRiP58681.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000061853.

Chemistry databases

BindingDBiP58681.
ChEMBLiCHEMBL6085.
GuidetoPHARMACOLOGYi1757.

PTM databases

iPTMnetiP58681.
PhosphoSitePlusiP58681.

Proteomic databases

PaxDbiP58681.
PeptideAtlasiP58681.
PRIDEiP58681.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000060719; ENSMUSP00000061853; ENSMUSG00000044583.
ENSMUST00000112161; ENSMUSP00000107787; ENSMUSG00000044583.
ENSMUST00000112164; ENSMUSP00000107789; ENSMUSG00000044583.
GeneIDi170743.
KEGGimmu:170743.
UCSCiuc009uwz.2. mouse.

Organism-specific databases

CTDi51284.
MGIiMGI:2176882. Tlr7.

Phylogenomic databases

eggNOGiKOG4641. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000119006.
HOGENOMiHOG000230468.
HOVERGENiHBG018601.
InParanoidiP58681.
KOiK05404.
OMAiERLANCS.
OrthoDBiEOG091G023M.
PhylomeDBiP58681.
TreeFamiTF325595.

Enzyme and pathway databases

ReactomeiR-MMU-1679131. Trafficking and processing of endosomal TLR.
R-MMU-168181. Toll Like Receptor 7/8 (TLR7/8) Cascade.
R-MMU-975110. TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling.
R-MMU-975138. TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation.
R-MMU-975155. MyD88 dependent cascade initiated on endosome.

Miscellaneous databases

PROiP58681.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000044583.
CleanExiMM_TLR7.
ExpressionAtlasiP58681. baseline and differential.
GenevisibleiP58681. MM.

Family and domain databases

Gene3Di3.40.50.10140. 1 hit.
3.80.10.10. 5 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000157. TIR_dom.
IPR026880. TLR7.
[Graphical view]
PANTHERiPTHR24365:SF222. PTHR24365:SF222. 3 hits.
PfamiPF00560. LRR_1. 1 hit.
PF13855. LRR_8. 4 hits.
PF01582. TIR. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 12 hits.
SM00082. LRRCT. 1 hit.
SM00255. TIR. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
SSF52200. SSF52200. 1 hit.
PROSITEiPS51450. LRR. 19 hits.
PS50104. TIR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTLR7_MOUSE
AccessioniPrimary (citable) accession number: P58681
Secondary accession number(s): Q923I1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: January 31, 2002
Last modified: November 2, 2016
This is version 134 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.