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P58681

- TLR7_MOUSE

UniProt

P58681 - TLR7_MOUSE

Protein

Toll-like receptor 7

Gene

Tlr7

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 115 (01 Oct 2014)
      Sequence version 1 (31 Jan 2002)
      Previous versions | rss
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    Functioni

    Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR7 is a nucleotide-sensing TLR which is activated by single-stranded RNA. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.1 Publication

    GO - Molecular functioni

    1. double-stranded RNA binding Source: UniProtKB
    2. drug binding Source: Ensembl
    3. protein binding Source: UniProtKB
    4. single-stranded RNA binding Source: UniProtKB
    5. siRNA binding Source: UniProtKB
    6. transmembrane signaling receptor activity Source: InterPro

    GO - Biological processi

    1. cellular response to mechanical stimulus Source: Ensembl
    2. defense response to virus Source: UniProtKB
    3. I-kappaB phosphorylation Source: Ensembl
    4. inflammatory response Source: UniProtKB-KW
    5. innate immune response Source: UniProtKB-KW
    6. microglial cell activation involved in immune response Source: Ensembl
    7. MyD88-dependent toll-like receptor signaling pathway Source: InterPro
    8. pathogen-associated molecular pattern dependent induction by symbiont of host innate immune response Source: Ensembl
    9. positive regulation of chemokine production Source: Ensembl
    10. positive regulation of interferon-alpha biosynthetic process Source: UniProtKB
    11. positive regulation of interferon-beta biosynthetic process Source: UniProtKB
    12. positive regulation of interferon-gamma biosynthetic process Source: UniProtKB
    13. positive regulation of interleukin-6 production Source: MGI
    14. positive regulation of interleukin-8 biosynthetic process Source: UniProtKB
    15. positive regulation of interleukin-8 production Source: Ensembl
    16. positive regulation of NF-kappaB import into nucleus Source: Ensembl
    17. toll-like receptor 7 signaling pathway Source: UniProtKB

    Keywords - Molecular functioni

    Receptor

    Keywords - Biological processi

    Immunity, Inflammatory response, Innate immunity

    Enzyme and pathway databases

    ReactomeiREACT_198527. TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling.
    REACT_198976. Trafficking and processing of endosomal TLR.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Toll-like receptor 7
    Gene namesi
    Name:Tlr7
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome X

    Organism-specific databases

    MGIiMGI:2176882. Tlr7.

    Subcellular locationi

    Endoplasmic reticulum membrane 1 Publication; Single-pass type I membrane protein 1 Publication. Endosome 1 Publication. Lysosome 1 Publication. Cytoplasmic vesiclephagosome 1 Publication
    Note: Relocalizes from endoplasmic reticulum to endosome and lysosome upon stimulation with agonist.

    GO - Cellular componenti

    1. early phagosome Source: UniProtKB
    2. endoplasmic reticulum Source: UniProtKB
    3. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    4. endosome Source: UniProtKB
    5. integral component of membrane Source: UniProtKB-KW
    6. lysosome Source: UniProtKB
    7. plasma membrane Source: Ensembl
    8. receptor complex Source: MGI

    Keywords - Cellular componenti

    Cytoplasmic vesicle, Endoplasmic reticulum, Endosome, Lysosome, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2626Sequence AnalysisAdd
    BLAST
    Chaini27 – 10501024Toll-like receptor 7PRO_0000034734Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi66 – 661N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi69 – 691N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi167 – 1671N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi190 – 1901N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi215 – 2151N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi387 – 3871N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi524 – 5241N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi535 – 5351N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi591 – 5911N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi680 – 6801N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi721 – 7211N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi800 – 8001N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiP58681.
    PRIDEiP58681.

    PTM databases

    PhosphoSiteiP58681.

    Expressioni

    Gene expression databases

    ArrayExpressiP58681.
    BgeeiP58681.
    CleanExiMM_TLR7.
    GenevestigatoriP58681.

    Interactioni

    Subunit structurei

    Interacts with MYD88 via their respective TIR domains By similarity. Interacts with UNC93B1.By similarity1 Publication

    Structurei

    3D structure databases

    ProteinModelPortaliP58681.
    SMRiP58681. Positions 32-835, 892-1036.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini27 – 837811ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini859 – 1050192CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei838 – 85821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati42 – 6423LRR 1Add
    BLAST
    Repeati65 – 8723LRR 2Add
    BLAST
    Repeati89 – 11123LRR 3Add
    BLAST
    Repeati126 – 14924LRR 4Add
    BLAST
    Repeati151 – 17020LRR 5Add
    BLAST
    Repeati171 – 19525LRR 6Add
    BLAST
    Repeati203 – 22624LRR 7Add
    BLAST
    Repeati228 – 24720LRR 8Add
    BLAST
    Repeati248 – 27326LRR 9Add
    BLAST
    Repeati275 – 28915LRR 10Add
    BLAST
    Repeati290 – 31223LRR 11Add
    BLAST
    Repeati314 – 33724LRR 12Add
    BLAST
    Repeati339 – 36426LRR 13Add
    BLAST
    Repeati369 – 39224LRR 14Add
    BLAST
    Repeati396 – 41924LRR 15Add
    BLAST
    Repeati421 – 44323LRR 16Add
    BLAST
    Repeati493 – 51624LRR 17Add
    BLAST
    Repeati517 – 54226LRR 18Add
    BLAST
    Repeati543 – 56523LRR 19Add
    BLAST
    Repeati567 – 58923LRR 20Add
    BLAST
    Repeati596 – 61924LRR 21Add
    BLAST
    Repeati620 – 64526LRR 22Add
    BLAST
    Repeati650 – 67324LRR 23Add
    BLAST
    Repeati675 – 69824LRR 24Add
    BLAST
    Repeati699 – 72224LRR 25Add
    BLAST
    Repeati724 – 74623LRR 26Add
    BLAST
    Repeati747 – 77024LRR 27Add
    BLAST
    Repeati773 – 79624LRR 28Add
    BLAST
    Domaini890 – 1037148TIRPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the Toll-like receptor family.Curated
    Contains 28 LRR (leucine-rich) repeats.Curated
    Contains 1 TIR domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG4886.
    HOGENOMiHOG000230468.
    HOVERGENiHBG018601.
    InParanoidiP58681.
    KOiK05404.
    OMAiVWWINRT.
    OrthoDBiEOG7VB2DM.
    PhylomeDBiP58681.
    TreeFamiTF325595.

    Family and domain databases

    Gene3Di3.40.50.10140. 1 hit.
    InterProiIPR000483. Cys-rich_flank_reg_C.
    IPR001611. Leu-rich_rpt.
    IPR003591. Leu-rich_rpt_typical-subtyp.
    IPR000372. LRR-contain_N.
    IPR000157. TIR_dom.
    IPR026880. TLR7.
    [Graphical view]
    PANTHERiPTHR24365:SF222. PTHR24365:SF222. 1 hit.
    PfamiPF00560. LRR_1. 2 hits.
    PF13855. LRR_8. 4 hits.
    PF01582. TIR. 1 hit.
    [Graphical view]
    SMARTiSM00369. LRR_TYP. 3 hits.
    SM00082. LRRCT. 1 hit.
    SM00013. LRRNT. 1 hit.
    [Graphical view]
    SUPFAMiSSF52200. SSF52200. 1 hit.
    PROSITEiPS51450. LRR. 19 hits.
    PS50104. TIR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P58681-1 [UniParc]FASTAAdd to Basket

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    MVFSMWTRKR QILIFLNMLL VSRVFGFRWF PKTLPCEVKV NIPEAHVIVD     50
    CTDKHLTEIP EGIPTNTTNL TLTINHIPSI SPDSFRRLNH LEEIDLRCNC 100
    VPVLLGSKAN VCTKRLQIRP GSFSGLSDLK ALYLDGNQLL EIPQDLPSSL 150
    HLLSLEANNI FSITKENLTE LVNIETLYLG QNCYYRNPCN VSYSIEKDAF 200
    LVMRNLKVLS LKDNNVTAVP TTLPPNLLEL YLYNNIIKKI QENDFNNLNE 250
    LQVLDLSGNC PRCYNVPYPC TPCENNSPLQ IHDNAFNSLT ELKVLRLHSN 300
    SLQHVPPTWF KNMRNLQELD LSQNYLAREI EEAKFLHFLP NLVELDFSFN 350
    YELQVYHASI TLPHSLSSLE NLKILRVKGY VFKELKNSSL SVLHKLPRLE 400
    VLDLGTNFIK IADLNIFKHF ENLKLIDLSV NKISPSEESR EVGFCPNAQT 450
    SVDRHGPQVL EALHYFRYDE YARSCRFKNK EPPSFLPLNA DCHIYGQTLD 500
    LSRNNIFFIK PSDFQHLSFL KCLNLSGNTI GQTLNGSELW PLRELRYLDF 550
    SNNRLDLLYS TAFEELQSLE VLDLSSNSHY FQAEGITHML NFTKKLRLLD 600
    KLMMNDNDIS TSASRTMESD SLRILEFRGN HLDVLWRAGD NRYLDFFKNL 650
    FNLEVLDISR NSLNSLPPEV FEGMPPNLKN LSLAKNGLKS FFWDRLQLLK 700
    HLEILDLSHN QLTKVPERLA NCSKSLTTLI LKHNQIRQLT KYFLEDALQL 750
    RYLDISSNKI QVIQKTSFPE NVLNNLEMLV LHHNRFLCNC DAVWFVWWVN 800
    HTDVTIPYLA TDVTCVGPGA HKGQSVISLD LYTCELDLTN LILFSVSISS 850
    VLFLMVVMTT SHLFFWDMWY IYYFWKAKIK GYQHLQSMES CYDAFIVYDT 900
    KNSAVTEWVL QELVAKLEDP REKHFNLCLE ERDWLPGQPV LENLSQSIQL 950
    SKKTVFVMTQ KYAKTESFKM AFYLSHQRLL DEKVDVIILI FLEKPLQKSK 1000
    FLQLRKRLCR SSVLEWPANP QAHPYFWQCL KNALTTDNHV AYSQMFKETV 1050
    Length:1,050
    Mass (Da):121,837
    Last modified:January 31, 2002 - v1
    Checksum:i495B75DEE849D8EE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY035889 mRNA. Translation: AAK62676.1.
    CCDSiCCDS30531.1.
    CCDS72469.1.
    RefSeqiNP_001277684.1. NM_001290755.1.
    NP_001277685.1. NM_001290756.1.
    NP_001277686.1. NM_001290757.1.
    NP_573474.1. NM_133211.4.
    UniGeneiMm.23979.
    Mm.489377.

    Genome annotation databases

    EnsembliENSMUST00000060719; ENSMUSP00000061853; ENSMUSG00000044583.
    ENSMUST00000112161; ENSMUSP00000107787; ENSMUSG00000044583.
    ENSMUST00000112164; ENSMUSP00000107789; ENSMUSG00000044583.
    GeneIDi170743.
    KEGGimmu:170743.
    UCSCiuc009uwz.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY035889 mRNA. Translation: AAK62676.1 .
    CCDSi CCDS30531.1.
    CCDS72469.1.
    RefSeqi NP_001277684.1. NM_001290755.1.
    NP_001277685.1. NM_001290756.1.
    NP_001277686.1. NM_001290757.1.
    NP_573474.1. NM_133211.4.
    UniGenei Mm.23979.
    Mm.489377.

    3D structure databases

    ProteinModelPortali P58681.
    SMRi P58681. Positions 32-835, 892-1036.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    ChEMBLi CHEMBL6085.

    PTM databases

    PhosphoSitei P58681.

    Proteomic databases

    PaxDbi P58681.
    PRIDEi P58681.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000060719 ; ENSMUSP00000061853 ; ENSMUSG00000044583 .
    ENSMUST00000112161 ; ENSMUSP00000107787 ; ENSMUSG00000044583 .
    ENSMUST00000112164 ; ENSMUSP00000107789 ; ENSMUSG00000044583 .
    GeneIDi 170743.
    KEGGi mmu:170743.
    UCSCi uc009uwz.1. mouse.

    Organism-specific databases

    CTDi 51284.
    MGIi MGI:2176882. Tlr7.

    Phylogenomic databases

    eggNOGi COG4886.
    HOGENOMi HOG000230468.
    HOVERGENi HBG018601.
    InParanoidi P58681.
    KOi K05404.
    OMAi VWWINRT.
    OrthoDBi EOG7VB2DM.
    PhylomeDBi P58681.
    TreeFami TF325595.

    Enzyme and pathway databases

    Reactomei REACT_198527. TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling.
    REACT_198976. Trafficking and processing of endosomal TLR.

    Miscellaneous databases

    NextBioi 370306.
    PROi P58681.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P58681.
    Bgeei P58681.
    CleanExi MM_TLR7.
    Genevestigatori P58681.

    Family and domain databases

    Gene3Di 3.40.50.10140. 1 hit.
    InterProi IPR000483. Cys-rich_flank_reg_C.
    IPR001611. Leu-rich_rpt.
    IPR003591. Leu-rich_rpt_typical-subtyp.
    IPR000372. LRR-contain_N.
    IPR000157. TIR_dom.
    IPR026880. TLR7.
    [Graphical view ]
    PANTHERi PTHR24365:SF222. PTHR24365:SF222. 1 hit.
    Pfami PF00560. LRR_1. 2 hits.
    PF13855. LRR_8. 4 hits.
    PF01582. TIR. 1 hit.
    [Graphical view ]
    SMARTi SM00369. LRR_TYP. 3 hits.
    SM00082. LRRCT. 1 hit.
    SM00013. LRRNT. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52200. SSF52200. 1 hit.
    PROSITEi PS51450. LRR. 19 hits.
    PS50104. TIR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of murine Toll-like receptor 7."
      Heil F.J., Lipford G.B., Wagner H., Bauer S.M.
      Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Macrophage.
    2. "Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA."
      Diebold S.S., Kaisho T., Hemmi H., Akira S., Reis e Sousa C.
      Science 303:1529-1531(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    3. "The interaction between the ER membrane protein UNC93B and TLR3, 7, and 9 is crucial for TLR signaling."
      Brinkmann M.M., Spooner E., Hoebe K., Beutler B., Ploegh H.L., Kim Y.M.
      J. Cell Biol. 177:265-275(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY, INTERACTION WITH UNC93B1.
    4. "UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes."
      Kim Y.M., Brinkmann M.M., Paquet M.E., Ploegh H.L.
      Nature 452:234-238(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiTLR7_MOUSE
    AccessioniPrimary (citable) accession number: P58681
    Secondary accession number(s): Q923I1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 31, 2002
    Last sequence update: January 31, 2002
    Last modified: October 1, 2014
    This is version 115 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3