Reviewed, UniProtKB/Swiss-Prot P58661 (AAT_SALTY)

Names and origin

Protein names

Recommended name:
    Aspartate aminotransferase
      Short name=AspAT
    EC=2.6.1.1
Alternative name(s):
    Transaminase A

Gene names

Name:	aspC
Ordered Locus Names:	STM0998

Organism

Salmonella typhimurium [Complete proteome] [HAMAP]

Taxonomic identifier

90371 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Salmonella

Protein attributes

Sequence length	396 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.
Cofactor	Pyridoxal phosphate By similarity.
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm.
Sequence similarities	Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Pyridoxal phosphate
Molecular function	Aminotransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	biosynthetic process Inferred from electronic annotation. Source: InterPro cellular amino acid metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	L-aspartate:2-oxoglutarate aminotransferase activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 396	396	Aspartate aminotransferase		PRO_0000123840
Sites
	Active site	374	1
Amino acid modifications
	Modified residue	246	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	P58661-1 [UniParc]. Last modified January 31, 2002. Version 1. Checksum: 960940D0148D02FB	FASTA	396	43,521
	10 20 30 40 50 60 MFENITAAPA DPILGLADLF RADDRPGKIN LGIGVYKDET GKTPVLTSVK KAEQYLLENE 70 80 90 100 110 120 TTKNYLGIDG IPEFARCTQE LLFGKGSALI NDKRARTAQT PGGTGALRIA ADFLAKNTPV 130 140 150 160 170 180 KRVWVSNPSW PNHKSVFNAA GLEVREYAYY DAENHTLDFE ALQASLSEAQ AGDVVLFHGC 190 200 210 220 230 240 CHNPTGIDPT LEQWQVLAEL SVEKGWLPLF DFAYQGFARG LEEDAEGLRA FAALHKELIV 250 260 270 280 290 300 ASSYSKNFGL YNERVGACTL VAADAETVDR AFSQMKSAIR ANYSNPPAHG ASIVATILSN 310 320 330 340 350 360 DALRAIWEQE LTDMRQRIQR MRQLFVNTLQ EKGANRDFSF IIKQNGMFSF SGLTKDQVLR 370 380 390 LREEFGVYAV ASGRVNVAGM TPDNMAPLCE AIVAVL

References

[1]

"Complete genome sequence of Salmonella enterica serovar Typhimurium LT2." McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P., Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D., Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E. , Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R., Wilson R.K. Nature 413:852-856(2001) [PubMed: 11677609] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: LT2 / SGSC1412 / ATCC 700720.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE006468 Genomic DNA. Translation: AAL19932.1.
RefSeq	NP_459973.1.
3D structure databases
HSSP	HSSP built from PDB template 1ART based on UniProtKB P00509.
SMR	P58661. Positions 1-396.
ModBase	Search...
Proteomic databases
PRIDE	P58661.
Genome annotation databases
GeneID	1252516.
GenomeReviews	Gene locus STM0998 in contig AE006468_GR.
KEGG	stm:STM0998.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	P58661.
OMA	IASSYSK.
Enzyme and pathway databases
BioCyc	STYP99287:STM0998-MON.
BRENDA	2.6.1.1. 2.
Family and domain databases
InterPro	IPR004839. Aminotransferase_I/II. IPR000796. Asp_trans. IPR004838. NHTrfase_class1_PyrdxlP-BS. IPR015421. PyrdxlP-dep_Trfase_major_sub1. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
PANTHER	PTHR11879. Asp_trans. 1 hit.
Pfam	PF00155. Aminotran_1_2. 1 hit. [Graphical view]
PRINTS	PR00799. TRANSAMINASE.
PROSITE	PS00105. AA_TRANSFER_CLASS_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AAT_SALTY

Accession

Primary (citable) accession number: P58661

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 31, 2002
Last sequence update:	January 31, 2002
Last modified:	November 3, 2009
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)