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Protein

Caspase recruitment domain-containing protein 10

Gene

Card10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Activates NF-kappa-B via BCL10 and IKK.

GO - Biological processi

  • activation of NF-kappaB-inducing kinase activity Source: UniProtKB
  • regulation of apoptotic process Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Caspase recruitment domain-containing protein 10
Alternative name(s):
Bcl10-interacting MAGUK protein 1
Short name:
Bimp1
Gene namesi
Name:Card10
Synonyms:Bimp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:2146012. Card10.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10211021Caspase recruitment domain-containing protein 10PRO_0000144085Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei18 – 181PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP58660.
PaxDbiP58660.
PRIDEiP58660.

PTM databases

PhosphoSiteiP58660.

Expressioni

Tissue specificityi

Highly expressed in kidney, heart followed by brain, lung, liver, skeletal muscle and testis.

Gene expression databases

BgeeiP58660.
CleanExiMM_CARD10.
ExpressionAtlasiP58660. baseline and differential.

Interactioni

Subunit structurei

CARD10 and BCL10 bind to each other by CARD-CARD interaction. They both participate in a complex with MALT1, where MALT1 binds to BCL10.

Protein-protein interaction databases

BioGridi222934. 2 interactions.
DIPiDIP-60780N.
IntActiP58660. 1 interaction.
MINTiMINT-4089832.
STRINGi10090.ENSMUSP00000129513.

Structurei

3D structure databases

ProteinModelPortaliP58660.
SMRiP58660. Positions 26-115.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini23 – 11593CARDPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili138 – 450313Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi558 – 5658Poly-Ser

Sequence similaritiesi

Contains 1 CARD domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0708. Eukaryota.
COG0194. LUCA.
GeneTreeiENSGT00530000063108.
HOGENOMiHOG000111299.
HOVERGENiHBG050791.
InParanoidiP58660.
PhylomeDBiP58660.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR001315. CARD.
IPR011029. DEATH-like_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00619. CARD. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
PROSITEiPS50209. CARD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P58660-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQGRADAGEA DEEAGAGSGS EAEEDALWER IEGVRHRLTR ALNPAKLTPY
60 70 80 90 100
LRQCRVLDEQ DEEEVLSTYR FPCRANRTGR LIDILRCRGK RGFEAFLEAL
110 120 130 140 150
EFYYPEHFTL LTGQEPAQRC SMILDEEGPE GLTQFLMTEV RRLREARKSQ
160 170 180 190 200
LHREQQLQAR GRALEEERAG LEQRLREQQQ AQERCQRLRE DWEAGSLELL
210 220 230 240 250
RLKDENYMIA MRLAQLSEEK NSAVLRSRDL QLAVDQLKLK VSRLEEECAL
260 270 280 290 300
LRRARGPPPG AEEKEREPDG ADLLSELRAE NQRLTASLQE LQEGLQQEMS
310 320 330 340 350
RPGAAGSERI LLDILEHDWR EAQDSRQELC QKLHAVQGEL QWAEELRDKY
360 370 380 390 400
LQEMEDLRLK HRTLLKDCDL YKHRMATVLA QLEEIEKERD QAIQSRDRIQ
410 420 430 440 450
LQYSQSLIEK DQYRKQVRGL EAERDELLTT VTSLEGTKAM LEAQLQRTQG
460 470 480 490 500
GSCLKACASS HSLCSNLSST WSLSEFPSPL GGPEATGEAG GSEPHTSEEA
510 520 530 540 550
TDSEKEINRL SILPFPPSAG SILRRQREED PEPPKRSFSS MSDITGSVTL
560 570 580 590 600
KPWSPGLSSS SSSDSVWPLG KPEGLLARGC GLDFLNRSLA IRVSGWSPPA
610 620 630 640 650
GLDPQDKSPD SMPGLGDRWS GAVVRRVLSG PGSARTEQKE PRAEGTGLEG
660 670 680 690 700
AGLEAEAQQR TLPWNQSSTL PFLLDSKACH SFHEALDAWA KGPGAEPFYI
710 720 730 740 750
RANFSLPERS DPHALCVKAQ EILRLVDPAH KRRQEWFCTR VDTLTLRDLD
760 770 780 790 800
RGTVPNYQRA QQLLEVQEKY LISSRHRSPR SNLKKRALGL VRPKPAGGTA
810 820 830 840 850
GDSAEQLPAE PCSELERSLK PYSLVRPLLV SALRPVVLLP ECLAPRLIRN
860 870 880 890 900
LLDLPSSRLD FQVCPAESLS GEEQCTSSAP GAPKAWPATA GLGSRIRAIQ
910 920 930 940 950
ESVGKKHCLL ELGARGVREL VHSEVYPIVI HVEVTEKNVR EIRGLLGRPG
960 970 980 990 1000
WRDSELLRQC RGSEQWLWGL PCSWVQVPAH AWGHAEELAK VVRGRILQEQ
1010 1020
ARLVWVERGS SRGGSGSSSE A
Length:1,021
Mass (Da):114,414
Last modified:January 31, 2002 - v1
Checksum:i4811A09BDB8F792C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF363456 mRNA. Translation: AAK60136.1.
BC060203 mRNA. Translation: AAH60203.1.
RefSeqiNP_570929.2. NM_130859.2.
UniGeneiMm.17629.

Genome annotation databases

EnsembliENSMUST00000170584; ENSMUSP00000131003; ENSMUSG00000033170.
GeneIDi105844.
KEGGimmu:105844.
UCSCiuc007wrj.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF363456 mRNA. Translation: AAK60136.1.
BC060203 mRNA. Translation: AAH60203.1.
RefSeqiNP_570929.2. NM_130859.2.
UniGeneiMm.17629.

3D structure databases

ProteinModelPortaliP58660.
SMRiP58660. Positions 26-115.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi222934. 2 interactions.
DIPiDIP-60780N.
IntActiP58660. 1 interaction.
MINTiMINT-4089832.
STRINGi10090.ENSMUSP00000129513.

PTM databases

PhosphoSiteiP58660.

Proteomic databases

MaxQBiP58660.
PaxDbiP58660.
PRIDEiP58660.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000170584; ENSMUSP00000131003; ENSMUSG00000033170.
GeneIDi105844.
KEGGimmu:105844.
UCSCiuc007wrj.1. mouse.

Organism-specific databases

CTDi29775.
MGIiMGI:2146012. Card10.

Phylogenomic databases

eggNOGiKOG0708. Eukaryota.
COG0194. LUCA.
GeneTreeiENSGT00530000063108.
HOGENOMiHOG000111299.
HOVERGENiHBG050791.
InParanoidiP58660.
PhylomeDBiP58660.

Miscellaneous databases

NextBioi357924.
PROiP58660.
SOURCEiSearch...

Gene expression databases

BgeeiP58660.
CleanExiMM_CARD10.
ExpressionAtlasiP58660. baseline and differential.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR001315. CARD.
IPR011029. DEATH-like_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00619. CARD. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
PROSITEiPS50209. CARD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Bimp1, a MAGUK family member linking protein kinase C activation to Bcl10-mediated NF-kappa B induction."
    McAllister-Lucas L.M., Inohara N., Lucas P.C., Ruland J., Benito A., Li Q., Chen S., Chen F.F., Yamaoka S., Verma I.M., Mak T.W., Nunez G.
    J. Biol. Chem. 276:30589-30597(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Brain.
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-18, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Kidney.

Entry informationi

Entry nameiCAR10_MOUSE
AccessioniPrimary (citable) accession number: P58660
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: January 31, 2002
Last modified: January 20, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Supposed to contain a SH3, a PDZ and a guanylate kinase-like domain. But none of these 3 domains are detected by PROSITE, Pfam or SMART.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.