ID   EVA1C_HUMAN             Reviewed;         441 AA.
AC   P58658; A6ND58; Q8IXZ0;
DT   23-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2002, sequence version 1.
DT   24-JAN-2024, entry version 166.
DE   RecName: Full=Protein eva-1 homolog C;
DE   AltName: Full=Protein FAM176C;
DE   AltName: Full=SUE21;
DE   Flags: Precursor;
GN   Name=EVA1C; Synonyms=C21orf63, C21orf64, FAM176C;
GN   ORFNames=PRED34, UNQ2504/PRO5993;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
RX   PubMed=11707072; DOI=10.1006/geno.2001.6640;
RA   Reymond A., Friedli M., Neergaard Henrichsen C., Chapot F., Deutsch S.,
RA   Ucla C., Rossier C., Lyle R., Guipponi M., Antonarakis S.E.;
RT   "From PREDs and open reading frames to cDNA isolation: revisiting the human
RT   chromosome 21 transcription map.";
RL   Genomics 78:46-54(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX   PubMed=12975309; DOI=10.1101/gr.1293003;
RA   Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA   Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA   Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA   Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA   Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA   Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA   Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA   Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT   "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT   identify novel human secreted and transmembrane proteins: a bioinformatics
RT   assessment.";
RL   Genome Res. 13:2265-2270(2003).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=10830953; DOI=10.1038/35012518;
RA   Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S.,
RA   Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M.,
RA   Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A., Menzel U.,
RA   Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A.,
RA   Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J.,
RA   Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K.,
RA   Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G.,
RA   Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J.,
RA   Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S.,
RA   Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K.,
RA   Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.;
RT   "The DNA sequence of human chromosome 21.";
RL   Nature 405:311-319(2000).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC   TISSUE=Hippocampus;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [6]
RP   TISSUE SPECIFICITY, AND FUNCTION.
RX   PubMed=19470522; DOI=10.1093/jb/mvp079;
RA   Mitsunaga K., Harada-Itadani J., Shikanai T., Tateno H., Ikehara Y.,
RA   Hirabayashi J., Narimatsu H., Angata T.;
RT   "Human C21orf63 is a heparin-binding protein.";
RL   J. Biochem. 146:369-373(2009).
CC   -!- FUNCTION: Binds heparin. {ECO:0000269|PubMed:19470522}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=1;
CC         IsoId=P58658-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=P58658-2; Sequence=VSP_003103, VSP_003104;
CC       Name=3;
CC         IsoId=P58658-3; Sequence=VSP_055198;
CC   -!- TISSUE SPECIFICITY: Ubiquitous. {ECO:0000269|PubMed:19470522}.
CC   -!- SIMILARITY: Belongs to the EVA1 family. {ECO:0000305}.
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DR   EMBL; AF358258; AAL40411.1; -; mRNA.
DR   EMBL; AY040087; AAK74135.1; -; mRNA.
DR   EMBL; AY358787; AAQ89147.1; -; mRNA.
DR   EMBL; AP000269; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AP000270; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AP000271; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AP000272; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471079; EAX09872.1; -; Genomic_DNA.
DR   EMBL; BC038710; AAH38710.1; -; mRNA.
DR   CCDS; CCDS13614.1; -. [P58658-1]
DR   CCDS; CCDS68186.1; -. [P58658-3]
DR   RefSeq; NP_001273485.1; NM_001286556.1. [P58658-3]
DR   RefSeq; NP_478067.2; NM_058187.4. [P58658-1]
DR   AlphaFoldDB; P58658; -.
DR   SMR; P58658; -.
DR   BioGRID; 121863; 74.
DR   IntAct; P58658; 29.
DR   STRING; 9606.ENSP00000300255; -.
DR   GlyCosmos; P58658; 2 sites, No reported glycans.
DR   GlyGen; P58658; 2 sites.
DR   iPTMnet; P58658; -.
DR   PhosphoSitePlus; P58658; -.
DR   BioMuta; EVA1C; -.
DR   EPD; P58658; -.
DR   MassIVE; P58658; -.
DR   PaxDb; 9606-ENSP00000300255; -.
DR   PeptideAtlas; P58658; -.
DR   ProteomicsDB; 57094; -. [P58658-1]
DR   ProteomicsDB; 882; -.
DR   Antibodypedia; 2587; 69 antibodies from 13 providers.
DR   DNASU; 59271; -.
DR   Ensembl; ENST00000300255.7; ENSP00000300255.2; ENSG00000166979.13. [P58658-1]
DR   Ensembl; ENST00000382699.7; ENSP00000372146.3; ENSG00000166979.13. [P58658-3]
DR   GeneID; 59271; -.
DR   KEGG; hsa:59271; -.
DR   MANE-Select; ENST00000300255.7; ENSP00000300255.2; NM_058187.5; NP_478067.2.
DR   UCSC; uc002ypr.3; human. [P58658-1]
DR   AGR; HGNC:13239; -.
DR   CTD; 59271; -.
DR   DisGeNET; 59271; -.
DR   GeneCards; EVA1C; -.
DR   HGNC; HGNC:13239; EVA1C.
DR   HPA; ENSG00000166979; Low tissue specificity.
DR   neXtProt; NX_P58658; -.
DR   OpenTargets; ENSG00000166979; -.
DR   PharmGKB; PA25858; -.
DR   VEuPathDB; HostDB:ENSG00000166979; -.
DR   eggNOG; KOG4729; Eukaryota.
DR   GeneTree; ENSGT00940000162103; -.
DR   HOGENOM; CLU_050537_0_1_1; -.
DR   InParanoid; P58658; -.
DR   OMA; LWTRRMN; -.
DR   OrthoDB; 56324at2759; -.
DR   PhylomeDB; P58658; -.
DR   TreeFam; TF328177; -.
DR   PathwayCommons; P58658; -.
DR   SignaLink; P58658; -.
DR   BioGRID-ORCS; 59271; 8 hits in 1134 CRISPR screens.
DR   ChiTaRS; EVA1C; human.
DR   GenomeRNAi; 59271; -.
DR   Pharos; P58658; Tbio.
DR   PRO; PR:P58658; -.
DR   Proteomes; UP000005640; Chromosome 21.
DR   RNAct; P58658; Protein.
DR   Bgee; ENSG00000166979; Expressed in olfactory segment of nasal mucosa and 167 other cell types or tissues.
DR   ExpressionAtlas; P58658; baseline and differential.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR   GO; GO:0008201; F:heparin binding; IMP:UniProtKB.
DR   CDD; cd22828; Gal_Rha_Lectin_EVA1_EVA1C_rpt1; 1.
DR   CDD; cd22829; Gal_Rha_Lectin_EVA1_EVA1C_rpt2; 1.
DR   Gene3D; 2.60.120.740; -; 2.
DR   InterPro; IPR039500; EVA1_dom.
DR   InterPro; IPR000922; Lectin_gal-bd_dom.
DR   InterPro; IPR043159; Lectin_gal-bd_sf.
DR   PANTHER; PTHR46780; PROTEIN EVA-1; 1.
DR   PANTHER; PTHR46780:SF4; PROTEIN EVA-1 HOMOLOG C; 1.
DR   Pfam; PF14851; FAM176; 1.
DR   Pfam; PF02140; Gal_Lectin; 2.
DR   PROSITE; PS50228; SUEL_LECTIN; 2.
DR   Genevisible; P58658; HS.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Glycoprotein; Lectin; Membrane; Reference proteome;
KW   Repeat; Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..48
FT                   /evidence="ECO:0000255"
FT   CHAIN           49..441
FT                   /note="Protein eva-1 homolog C"
FT                   /id="PRO_0000017671"
FT   TOPO_DOM        49..322
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        323..343
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        344..441
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          67..159
FT                   /note="SUEL-type lectin 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00260"
FT   DOMAIN          168..260
FT                   /note="SUEL-type lectin 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00260"
FT   REGION          1..23
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          362..390
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        368..385
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        62
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        165
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   VAR_SEQ         54..69
FT                   /note="GYLTKLLQNHTTYACD -> EGAGRMPEPAGLPPPG (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:11707072"
FT                   /id="VSP_003103"
FT   VAR_SEQ         70..441
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:11707072"
FT                   /id="VSP_003104"
FT   VAR_SEQ         285..287
FT                   /note="Missing (in isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_055198"
FT   CONFLICT        19
FT                   /note="P -> H (in Ref. 5; AAH38710)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        284..286
FT                   /note="Missing (in Ref. 5; AAH38710)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   441 AA;  49483 MW;  31B2C9C12915ACD4 CRC64;
     MLLPGRARQP PTPQPVQHPG LRRQVEPPGQ LLRLFYCTVL VCSKEISALT DFSGYLTKLL
     QNHTTYACDG DYLNLQCPRH STISVQSAFY GQDYQMCSSQ KPASQREDSL TCVAATTFQK
     VLDECQNQRA CHLLVNSRVF GPDLCPGSSK YLLVSFKCQP NELKNKTVCE DQELKLHCHE
     SKFLNIYSAT YGRRTQERDI CSSKAERLPP FDCLSYSALQ VLSRRCYGKQ RCKIIVNNHH
     FGSPCLPGVK KYLTVTYACV PKNILTAIDP AIANLKPSLK QKDGEYGINF DPSGSKVLRK
     DGILVSNSLA AFAYIRAHPE RAALLFVSSV CIGLALTLCA LVIRESCAKD FRDLQLGREQ
     LVPGSDKVEE DSEDEEEEED PSESDFPGEL SGFCRTSYPI YSSIEAAELA ERIERREQII
     QEIWMNSGLD TSLPRNMGQF Y
//