P58658 (CU063_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Uncharacterized protein C21orf63

Alternative name(s):
SUE21

Gene names

Name:	C21orf63
Synonyms:	C21orf64
ORF Names:	PRED34, UNQ2504/PRO5993

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	441 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Membrane; Single-pass type I membrane protein Potential.
Tissue specificity	Ubiquitous.
Sequence similarities	Contains 2 SUEL-type lectin domains.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing
Domain	Repeat Signal Transmembrane Transmembrane helix
Ligand	Lectin
PTM	Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	sugar binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform A (identifier: P58658-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform B (identifier: P58658-2)

The sequence of this isoform differs from the canonical sequence as follows:
     54-69: GYLTKLLQNHTTYACD → EGAGRMPEPAGLPPPG
     70-441: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 48	48	Potential
	Chain	49 – 441	393	Uncharacterized protein C21orf63		PRO_0000017671
Regions
	Topological domain	49 – 322	274	Extracellular Potential
	Transmembrane	323 – 343	21	Helical; Potential
	Topological domain	344 – 441	98	Cytoplasmic Potential
	Domain	67 – 159	93	SUEL-type lectin 1
	Domain	168 – 260	93	SUEL-type lectin 2
	Compositional bias	373 – 379	7	Poly-Glu
Amino acid modifications
	Modified residue	365	1	Phosphoserine By similarity
	Glycosylation	62	1	N-linked (GlcNAc...) Potential
	Glycosylation	165	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	54 – 69	16	GYLTK…TYACD → EGAGRMPEPAGLPPPG in isoform B.		VSP_003103
	Alternative sequence	70 – 441	372	Missing in isoform B.		VSP_003104
Experimental info
	Sequence conflict	19	1	P → H in AAH38710. Ref.3
	Sequence conflict	284 – 286	3	Missing in AAH38710. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform A [UniParc]. Last modified January 23, 2002. Version 1. Checksum: 31B2C9C12915ACD4	FASTA	441	49,483
	10 20 30 40 50 60 MLLPGRARQP PTPQPVQHPG LRRQVEPPGQ LLRLFYCTVL VCSKEISALT DFSGYLTKLL 70 80 90 100 110 120 QNHTTYACDG DYLNLQCPRH STISVQSAFY GQDYQMCSSQ KPASQREDSL TCVAATTFQK 130 140 150 160 170 180 VLDECQNQRA CHLLVNSRVF GPDLCPGSSK YLLVSFKCQP NELKNKTVCE DQELKLHCHE 190 200 210 220 230 240 SKFLNIYSAT YGRRTQERDI CSSKAERLPP FDCLSYSALQ VLSRRCYGKQ RCKIIVNNHH 250 260 270 280 290 300 FGSPCLPGVK KYLTVTYACV PKNILTAIDP AIANLKPSLK QKDGEYGINF DPSGSKVLRK 310 320 330 340 350 360 DGILVSNSLA AFAYIRAHPE RAALLFVSSV CIGLALTLCA LVIRESCAKD FRDLQLGREQ 370 380 390 400 410 420 LVPGSDKVEE DSEDEEEEED PSESDFPGEL SGFCRTSYPI YSSIEAAELA ERIERREQII 430 440 QEIWMNSGLD TSLPRNMGQF Y
	Isoform B [UniParc]. Checksum: E02ED7CE215B1730	FASTA	69	7,458
	10 20 30 40 50 60 MLLPGRARQP PTPQPVQHPG LRRQVEPPGQ LLRLFYCTVL VCSKEISALT DFSEGAGRMP EPAGLPPPG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"From PREDs and open reading frames to cDNA isolation: revisiting the human chromosome 21 transcription map." Reymond A., Friedli M., Neergaard Henrichsen C., Chapot F., Deutsch S., Ucla C., Rossier C., Lyle R., Guipponi M., Antonarakis S.E. Genomics 78:46-54(2001) [PubMed: 11707072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B).
[2]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed: 12975309] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A).
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A). Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF358258 mRNA. Translation: AAL40411.1. AY040087 mRNA. Translation: AAK74135.1. AY358787 mRNA. Translation: AAQ89147.1. BC038710 mRNA. Translation: AAH38710.1.
IPI	IPI00068068. IPI00219988.
RefSeq	NP_478067.2. NM_058187.3.
UniGene	Hs.208358.
3D structure databases
ProteinModelPortal	P58658.
SMR	P58658. Positions 62-159, 165-263.
ModBase	Search...
Protein-protein interaction databases
IntAct	P58658. 1 interaction.
STRING	P58658.
PTM databases
PhosphoSite	P58658.
Polymorphism databases
DMDM	20137295.
Proteomic databases
PRIDE	P58658.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000300255; ENSP00000300255; ENSG00000166979.
GeneID	59271.
KEGG	hsa:59271.
UCSC	uc002ypr.1. human.
Organism-specific databases
CTD	59271.
GeneCards	GC21P033784.
HGNC	HGNC:13239. C21orf63.
HPA	CAB034174. HPA015720. HPA029944.
neXtProt	NX_P58658.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG13041.
GeneTree	ENSGT00400000022026.
HOGENOM	HBG713790.
HOVERGEN	HBG051238.
InParanoid	P58658.
OMA	YACDGDY.
OrthoDB	EOG4WDDBW.
PhylomeDB	P58658.
Gene expression databases
ArrayExpress	P58658.
Bgee	P58658.
CleanEx	HS_C21orf63.
Genevestigator	P58658.
GermOnline	ENSG00000166979. Homo sapiens.
Family and domain databases
InterPro	IPR000922. Lectin_gal-bd_dom. [Graphical view]
Pfam	PF02140. Gal_Lectin. 2 hits. [Graphical view]
PROSITE	PS50228. SUEL_LECTIN. 2 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	65150.

Entry information

Entry name

CU063_HUMAN

Accession

Primary (citable) accession number: P58658
Secondary accession number(s): Q8IXZ0

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 23, 2002
Last sequence update:	January 23, 2002
Last modified:	January 25, 2012
This is version 81 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.