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P58658 (EVA1C_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein eva-1 homolog C
Alternative name(s):
Protein FAM176C
SUE21
Gene names
Name:EVA1C
Synonyms:C21orf63, C21orf64, FAM176C
ORF Names:PRED34, UNQ2504/PRO5993
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length441 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Binds heparin. Ref.6

Subcellular location

Membrane; Single-pass type I membrane protein Potential.

Tissue specificity

Ubiquitous. Ref.6

Sequence similarities

Belongs to the EVA1 family.

Contains 2 SUEL-type lectin domains.

Ontologies

Keywords
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
   DomainRepeat
Signal
Transmembrane
Transmembrane helix
   LigandLectin
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functioncarbohydrate binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P58658-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P58658-2)

The sequence of this isoform differs from the canonical sequence as follows:
     54-69: GYLTKLLQNHTTYACD → EGAGRMPEPAGLPPPG
     70-441: Missing.
Isoform 3 (identifier: P58658-3)

The sequence of this isoform differs from the canonical sequence as follows:
     285-287: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 4848 Potential
Chain49 – 441393Protein eva-1 homolog C
PRO_0000017671

Regions

Topological domain49 – 322274Extracellular Potential
Transmembrane323 – 34321Helical; Potential
Topological domain344 – 44198Cytoplasmic Potential
Domain67 – 15993SUEL-type lectin 1
Domain168 – 26093SUEL-type lectin 2
Compositional bias373 – 3797Poly-Glu

Amino acid modifications

Glycosylation621N-linked (GlcNAc...) Potential
Glycosylation1651N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence54 – 6916GYLTK…TYACD → EGAGRMPEPAGLPPPG in isoform 2.
VSP_003103
Alternative sequence70 – 441372Missing in isoform 2.
VSP_003104
Alternative sequence285 – 2873Missing in isoform 3.
VSP_055198

Experimental info

Sequence conflict191P → H in AAH38710. Ref.5
Sequence conflict284 – 2863Missing in AAH38710. Ref.5

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified January 23, 2002. Version 1.
Checksum: 31B2C9C12915ACD4

FASTA44149,483
        10         20         30         40         50         60 
MLLPGRARQP PTPQPVQHPG LRRQVEPPGQ LLRLFYCTVL VCSKEISALT DFSGYLTKLL 

        70         80         90        100        110        120 
QNHTTYACDG DYLNLQCPRH STISVQSAFY GQDYQMCSSQ KPASQREDSL TCVAATTFQK 

       130        140        150        160        170        180 
VLDECQNQRA CHLLVNSRVF GPDLCPGSSK YLLVSFKCQP NELKNKTVCE DQELKLHCHE 

       190        200        210        220        230        240 
SKFLNIYSAT YGRRTQERDI CSSKAERLPP FDCLSYSALQ VLSRRCYGKQ RCKIIVNNHH 

       250        260        270        280        290        300 
FGSPCLPGVK KYLTVTYACV PKNILTAIDP AIANLKPSLK QKDGEYGINF DPSGSKVLRK 

       310        320        330        340        350        360 
DGILVSNSLA AFAYIRAHPE RAALLFVSSV CIGLALTLCA LVIRESCAKD FRDLQLGREQ 

       370        380        390        400        410        420 
LVPGSDKVEE DSEDEEEEED PSESDFPGEL SGFCRTSYPI YSSIEAAELA ERIERREQII 

       430        440 
QEIWMNSGLD TSLPRNMGQF Y 

« Hide

Isoform 2 [UniParc].

Checksum: E02ED7CE215B1730
Show »

FASTA697,458
Isoform 3 [UniParc].

Checksum: 56E2699893F27979
Show »

FASTA43849,134

References

« Hide 'large scale' references
[1]"From PREDs and open reading frames to cDNA isolation: revisiting the human chromosome 21 transcription map."
Reymond A., Friedli M., Neergaard Henrichsen C., Chapot F., Deutsch S., Ucla C., Rossier C., Lyle R., Guipponi M., Antonarakis S.E.
Genomics 78:46-54(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
[2]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[3]"The DNA sequence of human chromosome 21."
Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A. expand/collapse author list , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.
Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
Tissue: Hippocampus.
[6]"Human C21orf63 is a heparin-binding protein."
Mitsunaga K., Harada-Itadani J., Shikanai T., Tateno H., Ikehara Y., Hirabayashi J., Narimatsu H., Angata T.
J. Biochem. 146:369-373(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY, FUNCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF358258 mRNA. Translation: AAL40411.1.
AY040087 mRNA. Translation: AAK74135.1.
AY358787 mRNA. Translation: AAQ89147.1.
AP000269 Genomic DNA. No translation available.
AP000270 Genomic DNA. No translation available.
AP000271 Genomic DNA. No translation available.
AP000272 Genomic DNA. No translation available.
CH471079 Genomic DNA. Translation: EAX09872.1.
BC038710 mRNA. Translation: AAH38710.1.
CCDSCCDS13614.1. [P58658-1]
RefSeqNP_001273485.1. NM_001286556.1.
NP_478067.2. NM_058187.4. [P58658-1]
UniGeneHs.208358.

3D structure databases

ProteinModelPortalP58658.
SMRP58658. Positions 67-264.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid121863. 2 interactions.
IntActP58658. 1 interaction.
STRING9606.ENSP00000300255.

PTM databases

PhosphoSiteP58658.

Proteomic databases

PaxDbP58658.
PRIDEP58658.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000300255; ENSP00000300255; ENSG00000166979. [P58658-1]
ENST00000382699; ENSP00000372146; ENSG00000166979.
ENST00000435323; ENSP00000407190; ENSG00000166979.
ENST00000437338; ENSP00000389291; ENSG00000166979.
GeneID59271.
KEGGhsa:59271.
UCSCuc002ypr.1. human. [P58658-1]

Organism-specific databases

CTD59271.
GeneCardsGC21P033786.
H-InvDBHIX0027783.
HGNCHGNC:13239. EVA1C.
HPACAB034174.
HPA015720.
HPA029944.
neXtProtNX_P58658.
PharmGKBPA25858.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG287161.
HOGENOMHOG000293165.
HOVERGENHBG051238.
InParanoidP58658.
OMAYGRRTQE.
OrthoDBEOG79PJPP.
PhylomeDBP58658.
TreeFamTF328177.

Gene expression databases

ArrayExpressP58658.
BgeeP58658.
CleanExHS_C21orf63.
GenevestigatorP58658.

Family and domain databases

InterProIPR000922. Lectin_gal-bd_dom.
[Graphical view]
PfamPF02140. Gal_Lectin. 2 hits.
[Graphical view]
PROSITEPS50228. SUEL_LECTIN. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi59271.
NextBio65150.
PROP58658.

Entry information

Entry nameEVA1C_HUMAN
AccessionPrimary (citable) accession number: P58658
Secondary accession number(s): A6ND58, Q8IXZ0
Entry history
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: January 23, 2002
Last modified: July 9, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 21

Human chromosome 21: entries, gene names and cross-references to MIM