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P58658

- EVA1C_HUMAN

UniProt

P58658 - EVA1C_HUMAN

Protein

Protein eva-1 homolog C

Gene

EVA1C

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 1 (23 Jan 2002)
      Previous versions | rss
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    Functioni

    Binds heparin.1 Publication

    GO - Molecular functioni

    1. carbohydrate binding Source: InterPro

    Keywords - Ligandi

    Lectin

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein eva-1 homolog C
    Alternative name(s):
    Protein FAM176C
    SUE21
    Gene namesi
    Name:EVA1C
    Synonyms:C21orf63, C21orf64, FAM176C
    ORF Names:PRED34, UNQ2504/PRO5993
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 21

    Organism-specific databases

    HGNCiHGNC:13239. EVA1C.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA25858.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 4848Sequence AnalysisAdd
    BLAST
    Chaini49 – 441393Protein eva-1 homolog CPRO_0000017671Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi62 – 621N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi165 – 1651N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiP58658.
    PRIDEiP58658.

    PTM databases

    PhosphoSiteiP58658.

    Expressioni

    Tissue specificityi

    Ubiquitous.1 Publication

    Gene expression databases

    ArrayExpressiP58658.
    BgeeiP58658.
    CleanExiHS_C21orf63.
    GenevestigatoriP58658.

    Organism-specific databases

    HPAiCAB034174.
    HPA015720.
    HPA029944.

    Interactioni

    Protein-protein interaction databases

    BioGridi121863. 2 interactions.
    IntActiP58658. 1 interaction.
    STRINGi9606.ENSP00000300255.

    Structurei

    3D structure databases

    ProteinModelPortaliP58658.
    SMRiP58658. Positions 67-264.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini49 – 322274ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini344 – 44198CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei323 – 34321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini67 – 15993SUEL-type lectin 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini168 – 26093SUEL-type lectin 2PROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi373 – 3797Poly-Glu

    Sequence similaritiesi

    Belongs to the EVA1 family.Curated
    Contains 2 SUEL-type lectin domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG287161.
    HOGENOMiHOG000293165.
    HOVERGENiHBG051238.
    InParanoidiP58658.
    OMAiYGRRTQE.
    OrthoDBiEOG79PJPP.
    PhylomeDBiP58658.
    TreeFamiTF328177.

    Family and domain databases

    InterProiIPR000922. Lectin_gal-bd_dom.
    [Graphical view]
    PfamiPF02140. Gal_Lectin. 2 hits.
    [Graphical view]
    PROSITEiPS50228. SUEL_LECTIN. 2 hits.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P58658-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLLPGRARQP PTPQPVQHPG LRRQVEPPGQ LLRLFYCTVL VCSKEISALT    50
    DFSGYLTKLL QNHTTYACDG DYLNLQCPRH STISVQSAFY GQDYQMCSSQ 100
    KPASQREDSL TCVAATTFQK VLDECQNQRA CHLLVNSRVF GPDLCPGSSK 150
    YLLVSFKCQP NELKNKTVCE DQELKLHCHE SKFLNIYSAT YGRRTQERDI 200
    CSSKAERLPP FDCLSYSALQ VLSRRCYGKQ RCKIIVNNHH FGSPCLPGVK 250
    KYLTVTYACV PKNILTAIDP AIANLKPSLK QKDGEYGINF DPSGSKVLRK 300
    DGILVSNSLA AFAYIRAHPE RAALLFVSSV CIGLALTLCA LVIRESCAKD 350
    FRDLQLGREQ LVPGSDKVEE DSEDEEEEED PSESDFPGEL SGFCRTSYPI 400
    YSSIEAAELA ERIERREQII QEIWMNSGLD TSLPRNMGQF Y 441
    Length:441
    Mass (Da):49,483
    Last modified:January 23, 2002 - v1
    Checksum:i31B2C9C12915ACD4
    GO
    Isoform 2 (identifier: P58658-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         54-69: GYLTKLLQNHTTYACD → EGAGRMPEPAGLPPPG
         70-441: Missing.

    Show »
    Length:69
    Mass (Da):7,458
    Checksum:iE02ED7CE215B1730
    GO
    Isoform 3 (identifier: P58658-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         285-287: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:438
    Mass (Da):49,134
    Checksum:i56E2699893F27979
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti19 – 191P → H in AAH38710. (PubMed:15489334)Curated
    Sequence conflicti284 – 2863Missing in AAH38710. (PubMed:15489334)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei54 – 6916GYLTK…TYACD → EGAGRMPEPAGLPPPG in isoform 2. 1 PublicationVSP_003103Add
    BLAST
    Alternative sequencei70 – 441372Missing in isoform 2. 1 PublicationVSP_003104Add
    BLAST
    Alternative sequencei285 – 2873Missing in isoform 3. 1 PublicationVSP_055198

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF358258 mRNA. Translation: AAL40411.1.
    AY040087 mRNA. Translation: AAK74135.1.
    AY358787 mRNA. Translation: AAQ89147.1.
    AP000269 Genomic DNA. No translation available.
    AP000270 Genomic DNA. No translation available.
    AP000271 Genomic DNA. No translation available.
    AP000272 Genomic DNA. No translation available.
    CH471079 Genomic DNA. Translation: EAX09872.1.
    BC038710 mRNA. Translation: AAH38710.1.
    CCDSiCCDS13614.1. [P58658-1]
    CCDS68186.1. [P58658-3]
    RefSeqiNP_001273485.1. NM_001286556.1.
    NP_478067.2. NM_058187.4. [P58658-1]
    UniGeneiHs.208358.

    Genome annotation databases

    EnsembliENST00000300255; ENSP00000300255; ENSG00000166979. [P58658-1]
    ENST00000382699; ENSP00000372146; ENSG00000166979. [P58658-3]
    ENST00000435323; ENSP00000407190; ENSG00000166979.
    ENST00000437338; ENSP00000389291; ENSG00000166979.
    GeneIDi59271.
    KEGGihsa:59271.
    UCSCiuc002ypr.1. human. [P58658-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF358258 mRNA. Translation: AAL40411.1 .
    AY040087 mRNA. Translation: AAK74135.1 .
    AY358787 mRNA. Translation: AAQ89147.1 .
    AP000269 Genomic DNA. No translation available.
    AP000270 Genomic DNA. No translation available.
    AP000271 Genomic DNA. No translation available.
    AP000272 Genomic DNA. No translation available.
    CH471079 Genomic DNA. Translation: EAX09872.1 .
    BC038710 mRNA. Translation: AAH38710.1 .
    CCDSi CCDS13614.1. [P58658-1 ]
    CCDS68186.1. [P58658-3 ]
    RefSeqi NP_001273485.1. NM_001286556.1.
    NP_478067.2. NM_058187.4. [P58658-1 ]
    UniGenei Hs.208358.

    3D structure databases

    ProteinModelPortali P58658.
    SMRi P58658. Positions 67-264.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121863. 2 interactions.
    IntActi P58658. 1 interaction.
    STRINGi 9606.ENSP00000300255.

    PTM databases

    PhosphoSitei P58658.

    Proteomic databases

    PaxDbi P58658.
    PRIDEi P58658.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000300255 ; ENSP00000300255 ; ENSG00000166979 . [P58658-1 ]
    ENST00000382699 ; ENSP00000372146 ; ENSG00000166979 . [P58658-3 ]
    ENST00000435323 ; ENSP00000407190 ; ENSG00000166979 .
    ENST00000437338 ; ENSP00000389291 ; ENSG00000166979 .
    GeneIDi 59271.
    KEGGi hsa:59271.
    UCSCi uc002ypr.1. human. [P58658-1 ]

    Organism-specific databases

    CTDi 59271.
    GeneCardsi GC21P033786.
    H-InvDB HIX0027783.
    HGNCi HGNC:13239. EVA1C.
    HPAi CAB034174.
    HPA015720.
    HPA029944.
    neXtProti NX_P58658.
    PharmGKBi PA25858.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG287161.
    HOGENOMi HOG000293165.
    HOVERGENi HBG051238.
    InParanoidi P58658.
    OMAi YGRRTQE.
    OrthoDBi EOG79PJPP.
    PhylomeDBi P58658.
    TreeFami TF328177.

    Miscellaneous databases

    GenomeRNAii 59271.
    NextBioi 35462468.
    PROi P58658.

    Gene expression databases

    ArrayExpressi P58658.
    Bgeei P58658.
    CleanExi HS_C21orf63.
    Genevestigatori P58658.

    Family and domain databases

    InterProi IPR000922. Lectin_gal-bd_dom.
    [Graphical view ]
    Pfami PF02140. Gal_Lectin. 2 hits.
    [Graphical view ]
    PROSITEi PS50228. SUEL_LECTIN. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "From PREDs and open reading frames to cDNA isolation: revisiting the human chromosome 21 transcription map."
      Reymond A., Friedli M., Neergaard Henrichsen C., Chapot F., Deutsch S., Ucla C., Rossier C., Lyle R., Guipponi M., Antonarakis S.E.
      Genomics 78:46-54(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    3. "The DNA sequence of human chromosome 21."
      Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A.
      , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.
      Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Hippocampus.
    6. Cited for: TISSUE SPECIFICITY, FUNCTION.

    Entry informationi

    Entry nameiEVA1C_HUMAN
    AccessioniPrimary (citable) accession number: P58658
    Secondary accession number(s): A6ND58, Q8IXZ0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 23, 2002
    Last sequence update: January 23, 2002
    Last modified: October 1, 2014
    This is version 104 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 21
      Human chromosome 21: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3