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Protein

Protein eva-1 homolog C

Gene

EVA1C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Binds heparin.1 Publication

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Lectin

Names & Taxonomyi

Protein namesi
Recommended name:
Protein eva-1 homolog C
Alternative name(s):
Protein FAM176C
SUE21
Gene namesi
Name:EVA1C
Synonyms:C21orf63, C21orf64, FAM176C
ORF Names:PRED34, UNQ2504/PRO5993
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 21

Organism-specific databases

HGNCiHGNC:13239. EVA1C.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini49 – 322274ExtracellularSequence AnalysisAdd
BLAST
Transmembranei323 – 34321HelicalSequence AnalysisAdd
BLAST
Topological domaini344 – 44198CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25858.

Polymorphism and mutation databases

BioMutaiEVA1C.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 4848Sequence AnalysisAdd
BLAST
Chaini49 – 441393Protein eva-1 homolog CPRO_0000017671Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi62 – 621N-linked (GlcNAc...)Sequence Analysis
Glycosylationi165 – 1651N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP58658.
PRIDEiP58658.

PTM databases

PhosphoSiteiP58658.

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiP58658.
CleanExiHS_C21orf63.
ExpressionAtlasiP58658. baseline and differential.
GenevisibleiP58658. HS.

Organism-specific databases

HPAiCAB034174.
HPA015720.
HPA029944.

Interactioni

Protein-protein interaction databases

BioGridi121863. 30 interactions.
IntActiP58658. 1 interaction.
STRINGi9606.ENSP00000300255.

Structurei

3D structure databases

ProteinModelPortaliP58658.
SMRiP58658. Positions 67-264.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini67 – 15993SUEL-type lectin 1PROSITE-ProRule annotationAdd
BLAST
Domaini168 – 26093SUEL-type lectin 2PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi373 – 3797Poly-Glu

Sequence similaritiesi

Belongs to the EVA1 family.Curated
Contains 2 SUEL-type lectin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG287161.
GeneTreeiENSGT00770000120536.
HOGENOMiHOG000293165.
HOVERGENiHBG051238.
InParanoidiP58658.
OMAiYGRRTQE.
OrthoDBiEOG79PJPP.
PhylomeDBiP58658.
TreeFamiTF328177.

Family and domain databases

InterProiIPR000922. Lectin_gal-bd_dom.
[Graphical view]
PfamiPF02140. Gal_Lectin. 2 hits.
[Graphical view]
PROSITEiPS50228. SUEL_LECTIN. 2 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P58658-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLLPGRARQP PTPQPVQHPG LRRQVEPPGQ LLRLFYCTVL VCSKEISALT
60 70 80 90 100
DFSGYLTKLL QNHTTYACDG DYLNLQCPRH STISVQSAFY GQDYQMCSSQ
110 120 130 140 150
KPASQREDSL TCVAATTFQK VLDECQNQRA CHLLVNSRVF GPDLCPGSSK
160 170 180 190 200
YLLVSFKCQP NELKNKTVCE DQELKLHCHE SKFLNIYSAT YGRRTQERDI
210 220 230 240 250
CSSKAERLPP FDCLSYSALQ VLSRRCYGKQ RCKIIVNNHH FGSPCLPGVK
260 270 280 290 300
KYLTVTYACV PKNILTAIDP AIANLKPSLK QKDGEYGINF DPSGSKVLRK
310 320 330 340 350
DGILVSNSLA AFAYIRAHPE RAALLFVSSV CIGLALTLCA LVIRESCAKD
360 370 380 390 400
FRDLQLGREQ LVPGSDKVEE DSEDEEEEED PSESDFPGEL SGFCRTSYPI
410 420 430 440
YSSIEAAELA ERIERREQII QEIWMNSGLD TSLPRNMGQF Y
Length:441
Mass (Da):49,483
Last modified:January 23, 2002 - v1
Checksum:i31B2C9C12915ACD4
GO
Isoform 2 (identifier: P58658-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     54-69: GYLTKLLQNHTTYACD → EGAGRMPEPAGLPPPG
     70-441: Missing.

Show »
Length:69
Mass (Da):7,458
Checksum:iE02ED7CE215B1730
GO
Isoform 3 (identifier: P58658-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     285-287: Missing.

Note: No experimental confirmation available.
Show »
Length:438
Mass (Da):49,134
Checksum:i56E2699893F27979
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti19 – 191P → H in AAH38710 (PubMed:15489334).Curated
Sequence conflicti284 – 2863Missing in AAH38710 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei54 – 6916GYLTK…TYACD → EGAGRMPEPAGLPPPG in isoform 2. 1 PublicationVSP_003103Add
BLAST
Alternative sequencei70 – 441372Missing in isoform 2. 1 PublicationVSP_003104Add
BLAST
Alternative sequencei285 – 2873Missing in isoform 3. 1 PublicationVSP_055198

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF358258 mRNA. Translation: AAL40411.1.
AY040087 mRNA. Translation: AAK74135.1.
AY358787 mRNA. Translation: AAQ89147.1.
AP000269 Genomic DNA. No translation available.
AP000270 Genomic DNA. No translation available.
AP000271 Genomic DNA. No translation available.
AP000272 Genomic DNA. No translation available.
CH471079 Genomic DNA. Translation: EAX09872.1.
BC038710 mRNA. Translation: AAH38710.1.
CCDSiCCDS13614.1. [P58658-1]
CCDS68186.1. [P58658-3]
RefSeqiNP_001273485.1. NM_001286556.1. [P58658-3]
NP_478067.2. NM_058187.4. [P58658-1]
UniGeneiHs.208358.

Genome annotation databases

EnsembliENST00000300255; ENSP00000300255; ENSG00000166979. [P58658-1]
ENST00000382699; ENSP00000372146; ENSG00000166979. [P58658-3]
GeneIDi59271.
KEGGihsa:59271.
UCSCiuc002ypr.1. human. [P58658-1]
uc010glw.1. human.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF358258 mRNA. Translation: AAL40411.1.
AY040087 mRNA. Translation: AAK74135.1.
AY358787 mRNA. Translation: AAQ89147.1.
AP000269 Genomic DNA. No translation available.
AP000270 Genomic DNA. No translation available.
AP000271 Genomic DNA. No translation available.
AP000272 Genomic DNA. No translation available.
CH471079 Genomic DNA. Translation: EAX09872.1.
BC038710 mRNA. Translation: AAH38710.1.
CCDSiCCDS13614.1. [P58658-1]
CCDS68186.1. [P58658-3]
RefSeqiNP_001273485.1. NM_001286556.1. [P58658-3]
NP_478067.2. NM_058187.4. [P58658-1]
UniGeneiHs.208358.

3D structure databases

ProteinModelPortaliP58658.
SMRiP58658. Positions 67-264.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121863. 30 interactions.
IntActiP58658. 1 interaction.
STRINGi9606.ENSP00000300255.

PTM databases

PhosphoSiteiP58658.

Polymorphism and mutation databases

BioMutaiEVA1C.

Proteomic databases

PaxDbiP58658.
PRIDEiP58658.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000300255; ENSP00000300255; ENSG00000166979. [P58658-1]
ENST00000382699; ENSP00000372146; ENSG00000166979. [P58658-3]
GeneIDi59271.
KEGGihsa:59271.
UCSCiuc002ypr.1. human. [P58658-1]
uc010glw.1. human.

Organism-specific databases

CTDi59271.
GeneCardsiGC21P033786.
H-InvDBHIX0027783.
HGNCiHGNC:13239. EVA1C.
HPAiCAB034174.
HPA015720.
HPA029944.
neXtProtiNX_P58658.
PharmGKBiPA25858.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG287161.
GeneTreeiENSGT00770000120536.
HOGENOMiHOG000293165.
HOVERGENiHBG051238.
InParanoidiP58658.
OMAiYGRRTQE.
OrthoDBiEOG79PJPP.
PhylomeDBiP58658.
TreeFamiTF328177.

Miscellaneous databases

GenomeRNAii59271.
NextBioi35462468.
PROiP58658.

Gene expression databases

BgeeiP58658.
CleanExiHS_C21orf63.
ExpressionAtlasiP58658. baseline and differential.
GenevisibleiP58658. HS.

Family and domain databases

InterProiIPR000922. Lectin_gal-bd_dom.
[Graphical view]
PfamiPF02140. Gal_Lectin. 2 hits.
[Graphical view]
PROSITEiPS50228. SUEL_LECTIN. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "From PREDs and open reading frames to cDNA isolation: revisiting the human chromosome 21 transcription map."
    Reymond A., Friedli M., Neergaard Henrichsen C., Chapot F., Deutsch S., Ucla C., Rossier C., Lyle R., Guipponi M., Antonarakis S.E.
    Genomics 78:46-54(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  3. "The DNA sequence of human chromosome 21."
    Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A.
    , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.
    Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Hippocampus.
  6. Cited for: TISSUE SPECIFICITY, FUNCTION.

Entry informationi

Entry nameiEVA1C_HUMAN
AccessioniPrimary (citable) accession number: P58658
Secondary accession number(s): A6ND58, Q8IXZ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: January 23, 2002
Last modified: June 24, 2015
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.