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Protein

Protein eva-1 homolog C

Gene

EVA1C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Binds heparin.1 Publication

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Lectin

Enzyme and pathway databases

BioCyciZFISH:ENSG00000166979-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein eva-1 homolog C
Alternative name(s):
Protein FAM176C
SUE21
Gene namesi
Name:EVA1C
Synonyms:C21orf63, C21orf64, FAM176C
ORF Names:PRED34, UNQ2504/PRO5993
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

HGNCiHGNC:13239. EVA1C.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini49 – 322ExtracellularSequence analysisAdd BLAST274
Transmembranei323 – 343HelicalSequence analysisAdd BLAST21
Topological domaini344 – 441CytoplasmicSequence analysisAdd BLAST98

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi59271.
OpenTargetsiENSG00000166979.
PharmGKBiPA25858.

Polymorphism and mutation databases

BioMutaiEVA1C.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 48Sequence analysisAdd BLAST48
ChainiPRO_000001767149 – 441Protein eva-1 homolog CAdd BLAST393

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi62N-linked (GlcNAc...)Sequence analysis1
Glycosylationi165N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiP58658.
PaxDbiP58658.
PeptideAtlasiP58658.
PRIDEiP58658.

PTM databases

iPTMnetiP58658.
PhosphoSitePlusiP58658.

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiENSG00000166979.
CleanExiHS_C21orf63.
ExpressionAtlasiP58658. baseline and differential.
GenevisibleiP58658. HS.

Organism-specific databases

HPAiCAB034174.
HPA015720.
HPA029944.

Interactioni

Protein-protein interaction databases

BioGridi121863. 37 interactors.
IntActiP58658. 1 interactor.
STRINGi9606.ENSP00000300255.

Structurei

3D structure databases

ProteinModelPortaliP58658.
SMRiP58658.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini67 – 159SUEL-type lectin 1PROSITE-ProRule annotationAdd BLAST93
Domaini168 – 260SUEL-type lectin 2PROSITE-ProRule annotationAdd BLAST93

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi373 – 379Poly-Glu7

Sequence similaritiesi

Belongs to the EVA1 family.Curated
Contains 2 SUEL-type lectin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4729. Eukaryota.
ENOG4111BWI. LUCA.
GeneTreeiENSGT00860000133784.
HOGENOMiHOG000293165.
HOVERGENiHBG051238.
InParanoidiP58658.
OMAiYGRRTQE.
OrthoDBiEOG091G0BAI.
PhylomeDBiP58658.
TreeFamiTF328177.

Family and domain databases

InterProiIPR000922. Lectin_gal-bd_dom.
[Graphical view]
PfamiPF02140. Gal_Lectin. 2 hits.
[Graphical view]
PROSITEiPS50228. SUEL_LECTIN. 2 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P58658-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLLPGRARQP PTPQPVQHPG LRRQVEPPGQ LLRLFYCTVL VCSKEISALT
60 70 80 90 100
DFSGYLTKLL QNHTTYACDG DYLNLQCPRH STISVQSAFY GQDYQMCSSQ
110 120 130 140 150
KPASQREDSL TCVAATTFQK VLDECQNQRA CHLLVNSRVF GPDLCPGSSK
160 170 180 190 200
YLLVSFKCQP NELKNKTVCE DQELKLHCHE SKFLNIYSAT YGRRTQERDI
210 220 230 240 250
CSSKAERLPP FDCLSYSALQ VLSRRCYGKQ RCKIIVNNHH FGSPCLPGVK
260 270 280 290 300
KYLTVTYACV PKNILTAIDP AIANLKPSLK QKDGEYGINF DPSGSKVLRK
310 320 330 340 350
DGILVSNSLA AFAYIRAHPE RAALLFVSSV CIGLALTLCA LVIRESCAKD
360 370 380 390 400
FRDLQLGREQ LVPGSDKVEE DSEDEEEEED PSESDFPGEL SGFCRTSYPI
410 420 430 440
YSSIEAAELA ERIERREQII QEIWMNSGLD TSLPRNMGQF Y
Length:441
Mass (Da):49,483
Last modified:January 23, 2002 - v1
Checksum:i31B2C9C12915ACD4
GO
Isoform 2 (identifier: P58658-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     54-69: GYLTKLLQNHTTYACD → EGAGRMPEPAGLPPPG
     70-441: Missing.

Show »
Length:69
Mass (Da):7,458
Checksum:iE02ED7CE215B1730
GO
Isoform 3 (identifier: P58658-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     285-287: Missing.

Note: No experimental confirmation available.
Show »
Length:438
Mass (Da):49,134
Checksum:i56E2699893F27979
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti19P → H in AAH38710 (PubMed:15489334).Curated1
Sequence conflicti284 – 286Missing in AAH38710 (PubMed:15489334).Curated3

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00310354 – 69GYLTK…TYACD → EGAGRMPEPAGLPPPG in isoform 2. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_00310470 – 441Missing in isoform 2. 1 PublicationAdd BLAST372
Alternative sequenceiVSP_055198285 – 287Missing in isoform 3. 1 Publication3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF358258 mRNA. Translation: AAL40411.1.
AY040087 mRNA. Translation: AAK74135.1.
AY358787 mRNA. Translation: AAQ89147.1.
AP000269 Genomic DNA. No translation available.
AP000270 Genomic DNA. No translation available.
AP000271 Genomic DNA. No translation available.
AP000272 Genomic DNA. No translation available.
CH471079 Genomic DNA. Translation: EAX09872.1.
BC038710 mRNA. Translation: AAH38710.1.
CCDSiCCDS13614.1. [P58658-1]
CCDS68186.1. [P58658-3]
RefSeqiNP_001273485.1. NM_001286556.1. [P58658-3]
NP_478067.2. NM_058187.4. [P58658-1]
UniGeneiHs.208358.

Genome annotation databases

EnsembliENST00000300255; ENSP00000300255; ENSG00000166979. [P58658-1]
ENST00000382699; ENSP00000372146; ENSG00000166979. [P58658-3]
GeneIDi59271.
KEGGihsa:59271.
UCSCiuc002ypr.3. human. [P58658-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF358258 mRNA. Translation: AAL40411.1.
AY040087 mRNA. Translation: AAK74135.1.
AY358787 mRNA. Translation: AAQ89147.1.
AP000269 Genomic DNA. No translation available.
AP000270 Genomic DNA. No translation available.
AP000271 Genomic DNA. No translation available.
AP000272 Genomic DNA. No translation available.
CH471079 Genomic DNA. Translation: EAX09872.1.
BC038710 mRNA. Translation: AAH38710.1.
CCDSiCCDS13614.1. [P58658-1]
CCDS68186.1. [P58658-3]
RefSeqiNP_001273485.1. NM_001286556.1. [P58658-3]
NP_478067.2. NM_058187.4. [P58658-1]
UniGeneiHs.208358.

3D structure databases

ProteinModelPortaliP58658.
SMRiP58658.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121863. 37 interactors.
IntActiP58658. 1 interactor.
STRINGi9606.ENSP00000300255.

PTM databases

iPTMnetiP58658.
PhosphoSitePlusiP58658.

Polymorphism and mutation databases

BioMutaiEVA1C.

Proteomic databases

EPDiP58658.
PaxDbiP58658.
PeptideAtlasiP58658.
PRIDEiP58658.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000300255; ENSP00000300255; ENSG00000166979. [P58658-1]
ENST00000382699; ENSP00000372146; ENSG00000166979. [P58658-3]
GeneIDi59271.
KEGGihsa:59271.
UCSCiuc002ypr.3. human. [P58658-1]

Organism-specific databases

CTDi59271.
DisGeNETi59271.
GeneCardsiEVA1C.
H-InvDBHIX0027783.
HGNCiHGNC:13239. EVA1C.
HPAiCAB034174.
HPA015720.
HPA029944.
neXtProtiNX_P58658.
OpenTargetsiENSG00000166979.
PharmGKBiPA25858.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4729. Eukaryota.
ENOG4111BWI. LUCA.
GeneTreeiENSGT00860000133784.
HOGENOMiHOG000293165.
HOVERGENiHBG051238.
InParanoidiP58658.
OMAiYGRRTQE.
OrthoDBiEOG091G0BAI.
PhylomeDBiP58658.
TreeFamiTF328177.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000166979-MONOMER.

Miscellaneous databases

GenomeRNAii59271.
PROiP58658.

Gene expression databases

BgeeiENSG00000166979.
CleanExiHS_C21orf63.
ExpressionAtlasiP58658. baseline and differential.
GenevisibleiP58658. HS.

Family and domain databases

InterProiIPR000922. Lectin_gal-bd_dom.
[Graphical view]
PfamiPF02140. Gal_Lectin. 2 hits.
[Graphical view]
PROSITEiPS50228. SUEL_LECTIN. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEVA1C_HUMAN
AccessioniPrimary (citable) accession number: P58658
Secondary accession number(s): A6ND58, Q8IXZ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: January 23, 2002
Last modified: November 30, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.