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P58652 (COBC_SALTI) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Alpha-ribazole phosphatase

EC=3.1.3.73
Alternative name(s):
Adenosylcobalamin phosphatase
Alpha-ribazole-5'-phosphate phosphatase
Gene names
Name:cobC
Ordered Locus Names:STY0694, t2224
OrganismSalmonella typhi [Complete proteome] [HAMAP]
Taxonomic identifier90370 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella

Protein attributes

Sequence length202 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Converts N1-(5-phospho-alpha-D-ribosyl)-5,6-dimethylbenzimidazole into N1-alpha-D-ribosyl-5,6-dimethylbenzimidazole. Also catalyzes the conversion of adenosylcobalamin 5'-phosphate to adenosylcobalamin (vitamin B12); involved in the assembly of the nucleotide loop of cobalamin By similarity.

Catalytic activity

Adenosylcobalamin 5'-phosphate + H2O = coenzyme B12 + phosphate.

Alpha-ribazole 5'-phosphate + H2O = alpha-ribazole + phosphate.

Pathway

Nucleoside biosynthesis; alpha-ribazole biosynthesis; alpha-ribazole from 5,6-dimethylbenzimidazole: step 2/2.

Sequence similarities

Belongs to the phosphoglycerate mutase family.

Ontologies

Keywords
   Biological processCobalamin biosynthesis
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processcobalamin biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionalpha-ribazole phosphatase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 202202Alpha-ribazole phosphatase
PRO_0000179955

Sites

Active site81Tele-phosphohistidine intermediate By similarity
Site571Interaction with carboxyl group of phosphoglycerates By similarity

Experimental info

Sequence conflict851V → G in AAO69827. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P58652 [UniParc].

Last modified January 23, 2002. Version 1.
Checksum: 8FEA0F235C5C148A

FASTA20223,109
        10         20         30         40         50         60 
MRLWLVRHGE TEANVAGLYS GHAPTPLTEK GIGQAKTLHT LLRHAPFDRV LCSELERARH 

        70         80         90        100        110        120 
TARLVLEGRD TPQHILPELN EMYFVDWEMR HHRDLTHEDA ESYAAWCTDW QNAVPTNGEG 

       130        140        150        160        170        180 
FQAFTRRVER FISRLGAFSD CQNLLIVSHQ GVLSLLIARL LAMPAASLWH FRVEQGCWST 

       190        200 
IDICEGFATL KVLNSRAVWR PE 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL627267 Genomic DNA. Translation: CAD05120.1.
AE014613 Genomic DNA. Translation: AAO69827.1.
RefSeqNP_455219.1. NC_003198.1.

3D structure databases

ProteinModelPortalP58652.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1247152.
GenomeReviewsGene locus t2224 in contig AE014613_GR.
Gene locus STY0694 in contig AL513382_GR.
KEGGstt:t2224.
sty:STY0694.
PATRIC18539235. VBISalEnt120419_0698.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG658938.
OMAENGIGQA.
ProtClustDBPRK15004.

Enzyme and pathway databases

BioCycSENT209261:T2224-MONOMER.
SENT220341:STY0694-MONOMER.

Family and domain databases

InterProIPR013078. His_Pase_superF_clade-1.
IPR001345. PG/BPGM_mutase_AS.
IPR017578. Ribazole_CobC.
[Graphical view]
KOK02226.
PfamPF00300. His_Phos_1. 1 hit.
[Graphical view]
SMARTSM00855. PGAM. 1 hit.
[Graphical view]
TIGRFAMsTIGR03162. Ribazole_cobC. 1 hit.
PROSITEPS00175. PG_MUTASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOBC_SALTI
AccessionPrimary (citable) accession number: P58652
Entry history
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: January 23, 2002
Last modified: January 25, 2012
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families