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Reviewed, UniProtKB/Swiss-Prot P58652 (COBC_SALTI)

Last modified June 16, 2009. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Alpha-ribazole phosphatase
    EC=3.1.3.73
Alternative name(s):
    Alpha-ribazole-5'-phosphate phosphatase
Gene names
Name: cobC
Ordered Locus Names: STY0694, t2224
OrganismSalmonella typhi [Complete proteome] [HAMAP]
Taxonomic identifier90370 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella

Protein attributes

Sequence length202 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Function

Converts N1-(5-phospho-alpha-D-ribosyl)-5,6-dimethylbenzimidazole into N1-alpha-D-ribosyl-5,6-dimethylbenzimidazole; involved in the assembly of the nucleotide loop of cobalamin By similarity.

Catalytic activity

Alpha-ribazole 5'-phosphate + H2O = alpha-ribazole + phosphate.

Pathway

Nucleoside biosynthesis; alpha-ribazole biosynthesis; alpha-ribazole from 5,6-dimethylbenzimidazole: step 2/2.

Sequence similarities

Belongs to the phosphoglycerate mutase family.

Ontologies

Keywords
   Biological processCobalamin biosynthesis
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processcobalamin biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionalpha-ribazole phosphatase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 202202Alpha-ribazole phosphatase
PRO_0000179955

Sites

Active site81Tele-phosphohistidine intermediate By similarity
Site571Interaction with carboxyl group of phosphoglycerates By similarity

Experimental info

Sequence conflict851V → G in AAO69827. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P58652-1 [UniParc].

Last modified January 23, 2002. Version 1.
Checksum: 8FEA0F235C5C148A

FASTA20223,109
        10         20         30         40         50         60 
MRLWLVRHGE TEANVAGLYS GHAPTPLTEK GIGQAKTLHT LLRHAPFDRV LCSELERARH 

        70         80         90        100        110        120 
TARLVLEGRD TPQHILPELN EMYFVDWEMR HHRDLTHEDA ESYAAWCTDW QNAVPTNGEG 

       130        140        150        160        170        180 
FQAFTRRVER FISRLGAFSD CQNLLIVSHQ GVLSLLIARL LAMPAASLWH FRVEQGCWST 

       190        200 
IDICEGFATL KVLNSRAVWR PE 

« Hide

References

Cross-references

Sequence databases

AL627267 Genomic DNA. Translation: CAD05120.1.
AE014613 Genomic DNA. Translation: AAO69827.1.
RefSeqNP_455219.1.
NP_805967.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID1067291.
1247152.
GenomeReviewsGene locus t2224 in contig AE014613_GR.
Gene locus STY0694 in contig AL513382_GR.
KEGGstt:t2224.
sty:STY0694.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMP58652.
OMAP58652. HTARRVL.

Enzyme and pathway databases

BioCycSENT209261:T2224-MON.
SENT220341:STY0694-MON.
BRENDA3.1.3.73. 3716.

Family and domain databases

InterProIPR001345. PG/BPGM_mutase.
IPR013078. PG_mutase.
IPR017578. Ribazole_CobC.
[Graphical view]
PfamPF00300. PGAM. 1 hit.
[Graphical view]
TIGRFAMsTIGR03162. ribazole_cobC. 1 hit.
PROSITEPS00175. PG_MUTASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOBC_SALTI
AccessionPrimary (citable) accession number: P58652
Entry history
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: January 23, 2002
Last modified: June 16, 2009
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents