Reviewed, UniProtKB/Swiss-Prot P58652 (COBC_SALTI)

Names and origin

Protein names

Recommended name:
    Alpha-ribazole phosphatase
    EC=3.1.3.73
Alternative name(s):
    Alpha-ribazole-5'-phosphate phosphatase

Gene names

Name:	cobC
Ordered Locus Names:	STY0694, t2224

Organism

Salmonella typhi [Complete proteome] [HAMAP]

Taxonomic identifier

90370 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Salmonella

Protein attributes

Sequence length	202 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Converts N1-(5-phospho-alpha-D-ribosyl)-5,6-dimethylbenzimidazole into N1-alpha-D-ribosyl-5,6-dimethylbenzimidazole; involved in the assembly of the nucleotide loop of cobalamin By similarity.
Catalytic activity	Alpha-ribazole 5'-phosphate + H2O = alpha-ribazole + phosphate.
Pathway	Nucleoside biosynthesis; alpha-ribazole biosynthesis; alpha-ribazole from 5,6-dimethylbenzimidazole: step 2/2.
Sequence similarities	Belongs to the phosphoglycerate mutase family.

Ontologies

Keywords
Biological process	Cobalamin biosynthesis
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cobalamin biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	alpha-ribazole phosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 202	202	Alpha-ribazole phosphatase		PRO_0000179955
Sites
	Active site	8	1	Tele-phosphohistidine intermediate By similarity
	Site	57	1	Interaction with carboxyl group of phosphoglycerates By similarity
Experimental info
	Sequence conflict	85	1	V → G in AAO69827. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P58652-1 [UniParc]. Last modified January 23, 2002. Version 1. Checksum: 8FEA0F235C5C148A	FASTA	202	23,109
	10 20 30 40 50 60 MRLWLVRHGE TEANVAGLYS GHAPTPLTEK GIGQAKTLHT LLRHAPFDRV LCSELERARH 70 80 90 100 110 120 TARLVLEGRD TPQHILPELN EMYFVDWEMR HHRDLTHEDA ESYAAWCTDW QNAVPTNGEG 130 140 150 160 170 180 FQAFTRRVER FISRLGAFSD CQNLLIVSHQ GVLSLLIARL LAMPAASLWH FRVEQGCWST 190 200 IDICEGFATL KVLNSRAVWR PE

References

[1]

"Complete genome sequence of a multiple drug resistant Salmonella enterica serovar Typhi CT18." Parkhill J., Dougan G., James K.D., Thomson N.R., Pickard D., Wain J., Churcher C.M., Mungall K.L., Bentley S.D., Holden M.T.G., Sebaihia M., Baker S., Basham D., Brooks K., Chillingworth T., Connerton P., Cronin A., Davis P. , Davies R.M., Dowd L., White N., Farrar J., Feltwell T., Hamlin N., Haque A., Hien T.T., Holroyd S., Jagels K., Krogh A., Larsen T.S., Leather S., Moule S., O'Gaora P., Parry C., Quail M.A., Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S., Barrell B.G. Nature 413:848-852(2001) [PubMed: 11677608] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CT18.

[2]

"Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and CT18." Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V., Kodoyianni V., Schwartz D.C., Blattner F.R. J. Bacteriol. 185:2330-2337(2003) [PubMed: 12644504] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700931 / Ty2.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AL627267 Genomic DNA. Translation: CAD05120.1. AE014613 Genomic DNA. Translation: AAO69827.1.
RefSeq	NP_455219.1. NP_805967.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1067291. 1247152.
GenomeReviews	Gene locus t2224 in contig AE014613_GR. Gene locus STY0694 in contig AL513382_GR.
KEGG	stt:t2224. sty:STY0694.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	P58652.
OMA	P58652. HTARRVL.
Enzyme and pathway databases
BioCyc	SENT209261:T2224-MON. SENT220341:STY0694-MON.
BRENDA	3.1.3.73. 3716.
Family and domain databases
InterPro	IPR001345. PG/BPGM_mutase. IPR013078. PG_mutase. IPR017578. Ribazole_CobC. [Graphical view]
Pfam	PF00300. PGAM. 1 hit. [Graphical view]
TIGRFAMs	TIGR03162. ribazole_cobC. 1 hit.
PROSITE	PS00175. PG_MUTASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

COBC_SALTI

Accession

Primary (citable) accession number: P58652

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 23, 2002
Last sequence update:	January 23, 2002
Last modified:	June 16, 2009
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)