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P58643

- PYRF_SALTI

UniProt

P58643 - PYRF_SALTI

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Protein
Orotidine 5'-phosphate decarboxylase
Gene
pyrF, STY1344, t1620
Organism
Salmonella typhi
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP) By similarity.UniRule annotation

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei22 – 221Substrate By similarity
Binding sitei44 – 441Substrate By similarity
Active sitei73 – 731Proton donor By similarity
Binding sitei131 – 1311Substrate By similarity
Binding sitei192 – 1921Substrate By similarity
Binding sitei201 – 2011Substrate By similarity
Binding sitei221 – 2211Substrate; via amide nitrogen By similarity
Binding sitei222 – 2221Substrate By similarity

GO - Molecular functioni

  1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
  2. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Pyrimidine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00070; UER00120.

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylase (EC:4.1.1.23)
Alternative name(s):
OMP decarboxylase
Short name:
OMPDCase
Short name:
OMPdecase
Gene namesi
Name:pyrF
Ordered Locus Names:STY1344, t1620
OrganismiSalmonella typhi
Taxonomic identifieri90370 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000000541: Chromosome, UP000002670: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 245245Orotidine 5'-phosphate decarboxylaseUniRule annotation
PRO_0000134570Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi220341.STY1344.

Structurei

3D structure databases

ProteinModelPortaliP58643.
SMRiP58643. Positions 12-243.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni71 – 8010Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000226071.
KOiK01591.
OMAiRPITQSA.
OrthoDBiEOG6N6815.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01200_B. OMPdecase_type1_B.
InterProiIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR01740. pyrF. 1 hit.
PROSITEiPS00156. OMPDECASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P58643-1 [UniParc]FASTAAdd to Basket

« Hide

MTFTASSSSC AITESPVVVA LDYHERDKAL AFVDKIDPRD CRLKVGKEMF    50
TLFGPQLVRD LQQRGFDVFL DLKFHDIPNT TARAVAAAAD LGVWMVNVHA 100
SGGARMMAAA RDALAPFSKD APLLIAVTVL TSMGTSDLHD LGVTLSPAEH 150
AERLARLTQQ CGLDGVVCSA QEAVRFKQAF GAAFKLVTPG IRPAGSEAGD 200
QRRIMTPEQA LSAGVDYMVI GRPVTQSVDP AQTLKDINAS LKREA 245
Length:245
Mass (Da):26,256
Last modified:January 23, 2002 - v1
Checksum:i81596122D76E7C45
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL513382 Genomic DNA. Translation: CAD08424.1.
AE014613 Genomic DNA. Translation: AAO69247.1.
RefSeqiNP_455790.1. NC_003198.1.
NP_805398.1. NC_004631.1.

Genome annotation databases

EnsemblBacteriaiAAO69247; AAO69247; t1620.
CAD08424; CAD08424; CAD08424.
GeneIDi1247743.
KEGGisty:STY1344.
PATRICi18540575. VBISalEnt120419_1353.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL513382 Genomic DNA. Translation: CAD08424.1 .
AE014613 Genomic DNA. Translation: AAO69247.1 .
RefSeqi NP_455790.1. NC_003198.1.
NP_805398.1. NC_004631.1.

3D structure databases

ProteinModelPortali P58643.
SMRi P58643. Positions 12-243.
ModBasei Search...

Protein-protein interaction databases

STRINGi 220341.STY1344.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO69247 ; AAO69247 ; t1620 .
CAD08424 ; CAD08424 ; CAD08424 .
GeneIDi 1247743.
KEGGi sty:STY1344.
PATRICi 18540575. VBISalEnt120419_1353.

Phylogenomic databases

HOGENOMi HOG000226071.
KOi K01591.
OMAi RPITQSA.
OrthoDBi EOG6N6815.

Enzyme and pathway databases

UniPathwayi UPA00070 ; UER00120 .

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_01200_B. OMPdecase_type1_B.
InterProi IPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00215. OMPdecase. 1 hit.
[Graphical view ]
SMARTi SM00934. OMPdecase. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 1 hit.
TIGRFAMsi TIGR01740. pyrF. 1 hit.
PROSITEi PS00156. OMPDECASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CT18.
  2. "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and CT18."
    Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V., Kodoyianni V., Schwartz D.C., Blattner F.R.
    J. Bacteriol. 185:2330-2337(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700931 / Ty2.

Entry informationi

Entry nameiPYRF_SALTI
AccessioniPrimary (citable) accession number: P58643
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: January 23, 2002
Last modified: May 14, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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