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P58642 (PYRF_RALSO) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Orotidine 5'-phosphate decarboxylase

EC=4.1.1.23
Alternative name(s):
OMP decarboxylase
Short name=OMPDCase
Short name=OMPdecase
Gene names
Name:pyrF
Ordered Locus Names:RSc2773
ORF Names:RS00074
OrganismRalstonia solanacearum (strain GMI1000) (Pseudomonas solanacearum) [Complete proteome] [HAMAP]
Taxonomic identifier267608 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeRalstonia

Protein attributes

Sequence length271 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Orotidine 5'-phosphate = UMP + CO2. HAMAP-Rule MF_01200

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2. HAMAP-Rule MF_01200

Sequence similarities

Belongs to the OMP decarboxylase family. Type 2 subfamily.

Sequence caution

The sequence CAD16480.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processPyrimidine biosynthesis
   Molecular functionDecarboxylase
Lyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_process'de novo' UMP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

'de novo' pyrimidine nucleobase biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functionorotidine-5'-phosphate decarboxylase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 271271Orotidine 5'-phosphate decarboxylase HAMAP-Rule MF_01200
PRO_0000134633

Sites

Active site951Proton donor By similarity

Sequences

Sequence LengthMass (Da)Tools
P58642 [UniParc].

Last modified January 23, 2002. Version 1.
Checksum: 4441A0067094001E

FASTA27129,344
        10         20         30         40         50         60 
MRFTEQLAAA WQRNNSLLCV GLDPDPARLP ASLTTSGGAI FSFCRAIVDA TADLVCAFKP 

        70         80         90        100        110        120 
QIAYFASQRA EDQLEQLIAY IHEAYPGIPV ILDAKRGDIG STAEHYAKEA FERYQADAVT 

       130        140        150        160        170        180 
VSPYMGFDSM QPYLVHPDKG VIVLCRTSNA GGSDVQFLET NGRPVYQVVA ERARDAWNTS 

       190        200        210        220        230        240 
GQMGLVVGAT FPQEIRRVRE IVGDMPLLIP GIGVQGGDIE ATVRAGRTAD GTGMMINSSR 

       250        260        270 
AILYASSDSD FADAARGVAQ ATRDQINQYR N 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL646052 Genomic DNA. Translation: CAD16480.1. Different initiation.
RefSeqNP_520894.1. NC_003295.1.

3D structure databases

ProteinModelPortalP58642.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING267608.RSc2773.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAD16480; CAD16480; RSc2773.
GeneID1221620.
KEGGrso:RSc2773.
PATRIC20264259. VBIRalSol70888_2821.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0284.
HOGENOMHOG000245747.
KOK01591.
OMACRTSNAG.
OrthoDBEOG6DZF33.

Enzyme and pathway databases

BioCycRSOL267608:GCVU-2815-MONOMER.
UniPathwayUPA00070; UER00120.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
HAMAPMF_01215. OMPdecase_type2.
InterProIPR013785. Aldolase_TIM.
IPR018089. OMPdecase_AS.
IPR011995. OMPdecase_type-2.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMSSF51366. SSF51366. 1 hit.
TIGRFAMsTIGR02127. pyrF_sub2. 1 hit.
PROSITEPS00156. OMPDECASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePYRF_RALSO
AccessionPrimary (citable) accession number: P58642
Entry history
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: January 23, 2002
Last modified: May 14, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways