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P58639

- PYRF_NOSS1

UniProt

P58639 - PYRF_NOSS1

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Protein

Orotidine 5'-phosphate decarboxylase

Gene
pyrF, alr2983
Organism
Nostoc sp. (strain PCC 7120 / UTEX 2576)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP) By similarity.UniRule annotation

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei11 – 111Substrate By similarity
Binding sitei32 – 321Substrate By similarity
Active sitei61 – 611Proton donor By similarity
Binding sitei123 – 1231Substrate By similarity
Binding sitei185 – 1851Substrate By similarity
Binding sitei194 – 1941Substrate By similarity
Binding sitei214 – 2141Substrate; via amide nitrogen By similarity
Binding sitei215 – 2151Substrate By similarity

GO - Molecular functioni

  1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
  2. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Pyrimidine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00070; UER00120.

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylase (EC:4.1.1.23)
Alternative name(s):
OMP decarboxylase
Short name:
OMPDCase
Short name:
OMPdecase
Gene namesi
Name:pyrF
Ordered Locus Names:alr2983
OrganismiNostoc sp. (strain PCC 7120 / UTEX 2576)
Taxonomic identifieri103690 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaNostocalesNostocaceaeNostoc
ProteomesiUP000002483: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 238238Orotidine 5'-phosphate decarboxylaseUniRule annotationPRO_0000134521Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi103690.alr2983.

Structurei

3D structure databases

ProteinModelPortaliP58639.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni59 – 6810Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0284.
HOGENOMiHOG000226070.
KOiK01591.
OMAiDIPNTMR.
OrthoDBiEOG6N6815.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01200_B. OMPdecase_type1_B.
InterProiIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR01740. pyrF. 1 hit.
PROSITEiPS00156. OMPDECASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P58639-1 [UniParc]FASTAAdd to Basket

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MSNDKIIVAL DVPDTESAIA LIDKLESVTF WKVGLELFTS SGPRILEVLK    50
SRQKRIFLDL KFHDIPNTVA GACRAAAGYG VDLMTIHATS GRDALKAAKE 100
AVEEGAAQAG VKPPKLIAVT VLTSISARQL ALDLKIPSEL PEYALDMALM 150
AQEMGLDGAV CSPQEVAHLR QICGDDFVLV CPGVRPTWAE AGDQKRSLTP 200
SQAIQAGADY LVIGRPITAA AEPELAWKRI SQELTTVV 238
Length:238
Mass (Da):25,472
Last modified:January 23, 2002 - v1
Checksum:iF1794F1AF47FAF0E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000019 Genomic DNA. Translation: BAB74682.1.
PIRiAH2178.
RefSeqiNP_487023.1. NC_003272.1.
WP_010997134.1. NC_003272.1.

Genome annotation databases

EnsemblBacteriaiBAB74682; BAB74682; BAB74682.
GeneIDi1106581.
KEGGiana:alr2983.
PATRICi22776276. VBINosSp37423_3598.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000019 Genomic DNA. Translation: BAB74682.1 .
PIRi AH2178.
RefSeqi NP_487023.1. NC_003272.1.
WP_010997134.1. NC_003272.1.

3D structure databases

ProteinModelPortali P58639.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 103690.alr2983.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB74682 ; BAB74682 ; BAB74682 .
GeneIDi 1106581.
KEGGi ana:alr2983.
PATRICi 22776276. VBINosSp37423_3598.

Phylogenomic databases

eggNOGi COG0284.
HOGENOMi HOG000226070.
KOi K01591.
OMAi DIPNTMR.
OrthoDBi EOG6N6815.

Enzyme and pathway databases

UniPathwayi UPA00070 ; UER00120 .

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_01200_B. OMPdecase_type1_B.
InterProi IPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00215. OMPdecase. 1 hit.
[Graphical view ]
SMARTi SM00934. OMPdecase. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 1 hit.
TIGRFAMsi TIGR01740. pyrF. 1 hit.
PROSITEi PS00156. OMPDECASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 7120 / UTEX 2576.

Entry informationi

Entry nameiPYRF_NOSS1
AccessioniPrimary (citable) accession number: P58639
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: January 23, 2002
Last modified: September 3, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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