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Protein

Glutamate mutase sigma subunit

Gene

glmS

Organism
Escherichia coli O157:H7
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the carbon skeleton rearrangement of L-glutamate to L-threo-3-methylaspartate ((2S,3S)-3-methylaspartate).UniRule annotation

Catalytic activityi

L-threo-3-methylaspartate = L-glutamate.UniRule annotation

Cofactori

adenosylcob(III)alaminUniRule annotation

Pathwayi: L-glutamate degradation via mesaconate pathway

This protein is involved in step 1 of the subpathway that synthesizes acetate and pyruvate from L-glutamate.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. Glutamate mutase epsilon subunit (glmE), Glutamate mutase sigma subunit (glmS)
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. no protein annotated in this organism
This subpathway is part of the pathway L-glutamate degradation via mesaconate pathway, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetate and pyruvate from L-glutamate, the pathway L-glutamate degradation via mesaconate pathway and in Amino-acid degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi16Cobalt (cobalamin axial ligand)UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
LigandCobalamin, Cobalt, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00561; UER00617

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate mutase sigma subunitUniRule annotation (EC:5.4.99.1UniRule annotation)
Alternative name(s):
Glutamate mutase S chainUniRule annotation
Glutamate mutase small subunitUniRule annotation
Methylaspartate mutaseUniRule annotation
Gene namesi
Name:glmSUniRule annotation
Ordered Locus Names:Z0895, ECs0764
OrganismiEscherichia coli O157:H7
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000558 Componenti: Chromosome
  • UP000002519 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002164461 – 149Glutamate mutase sigma subunitAdd BLAST149

Interactioni

Subunit structurei

Heterotetramer composed of 2 epsilon subunits (GlmE) and 2 sigma subunits (GlmS). GlmE exists as a homodimer and GlmS as a monomer.UniRule annotation

Protein-protein interaction databases

STRINGi155864.Z0895

Structurei

3D structure databases

ProteinModelPortaliP58620
SMRiP58620
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 140B12-bindingUniRule annotationAdd BLAST138

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni13 – 17Adenosylcobalamin bindingUniRule annotation5
Regioni61 – 63Adenosylcobalamin bindingUniRule annotation3
Regioni93 – 97Adenosylcobalamin bindingUniRule annotation5

Sequence similaritiesi

Belongs to the methylaspartate mutase GlmS subunit family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107WFU Bacteria
COG2185 LUCA
HOGENOMiHOG000011065
KOiK01846
OMAiGHGEMDC

Family and domain databases

CDDicd02072 Glm_B12_BD, 1 hit
HAMAPiMF_00526 Me_Asp_mutase_S, 1 hit
InterProiView protein in InterPro
IPR006158 Cobalamin-bd
IPR036724 Cobalamin-bd_sf
IPR006394 GlmS
PfamiView protein in Pfam
PF02310 B12-binding, 1 hit
SUPFAMiSSF52242 SSF52242, 1 hit
TIGRFAMsiTIGR01501 MthylAspMutase, 1 hit
PROSITEiView protein in PROSITE
PS51332 B12_BINDING, 1 hit

Sequencei

Sequence statusi: Complete.

P58620-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKATLVIGV IGADCHAVGN KVLDRVFSNH DFRVINLGVM VSQDEYIDAA
60 70 80 90 100
IETGADAIVV SSIYGHGDID CLGMRERCIE RGLGDILLYV GGNLVVGKHD
110 120 130 140
FADVETKFKE MGFDRVFAPS HDLEDVCQLM AHDINQRHDV DTRILEEAI
Length:149
Mass (Da):16,430
Last modified:January 23, 2002 - v1
Checksum:iB785DAE49F27D9D0
GO

Sequence cautioni

The sequence AAG55064 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA Translation: AAG55064.1 Different initiation.
BA000007 Genomic DNA Translation: BAB34187.1
PIRiD85575
D90724
RefSeqiNP_308791.1, NC_002695.1
WP_000710390.1, NZ_NOKN01000002.1

Genome annotation databases

EnsemblBacteriaiAAG55064; AAG55064; Z0895
BAB34187; BAB34187; BAB34187
GeneIDi917503
KEGGiece:Z0895
ecs:ECs0764
PATRICifig|386585.9.peg.883

Similar proteinsi

Entry informationi

Entry nameiGMSS_ECO57
AccessioniPrimary (citable) accession number: P58620
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: January 23, 2002
Last modified: April 25, 2018
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health