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P58618 (GLK_SALTI) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glucokinase

EC=2.7.1.2
Alternative name(s):
Glucose kinase
Gene names
Name:glk
Ordered Locus Names:STY2644, t0454
OrganismSalmonella typhi [Complete proteome] [HAMAP]
Taxonomic identifier90370 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella

Protein attributes

Sequence length321 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + D-glucose = ADP + D-glucose 6-phosphate. HAMAP-Rule MF_00524

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00524.

Sequence similarities

Belongs to the bacterial glucokinase family.

Ontologies

Keywords
   Biological processGlycolysis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processglycolytic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

glucokinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 321321Glucokinase HAMAP-Rule MF_00524
PRO_0000215137

Regions

Nucleotide binding8 – 136ATP Potential

Sequences

Sequence LengthMass (Da)Tools
P58618 [UniParc].

Last modified January 23, 2002. Version 1.
Checksum: 015608C77989388A

FASTA32134,565
        10         20         30         40         50         60 
MTKYALVGDV GGTNARLALC DIASGEISQA KTYSGLDYPS LEAVVRVYLD EHGVSVEDGC 

        70         80         90        100        110        120 
IAIACPITGD WVAMTNHTWA FSIAEMKKNL GFSHLEIIND FTAVSMAIPM LKKEHLIQFG 

       130        140        150        160        170        180 
GGEPVDGKPI AVYGAGTGLG VAHLVHVDKR WISLPGEGGH VDFAPNSEEE AMILEILRAE 

       190        200        210        220        230        240 
IGHVSAERVL SGPGLVNLYR AIVKSDNRLP ENLRPKDITE RALADSCIDC RRALSLFCVI 

       250        260        270        280        290        300 
MGRFGGDLAL TMGTFGGVYI AGGIVPRFLE FFKASGFRGG FEDKGRFKDY VHGIPVYLIV 

       310        320 
HDNPGLLGSG AHLRQTLGHI L 

« Hide

References

[1]"Complete genome sequence of a multiple drug resistant Salmonella enterica serovar Typhi CT18."
Parkhill J., Dougan G., James K.D., Thomson N.R., Pickard D., Wain J., Churcher C.M., Mungall K.L., Bentley S.D., Holden M.T.G., Sebaihia M., Baker S., Basham D., Brooks K., Chillingworth T., Connerton P., Cronin A., Davis P. expand/collapse author list , Davies R.M., Dowd L., White N., Farrar J., Feltwell T., Hamlin N., Haque A., Hien T.T., Holroyd S., Jagels K., Krogh A., Larsen T.S., Leather S., Moule S., O'Gaora P., Parry C., Quail M.A., Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S., Barrell B.G.
Nature 413:848-852(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CT18.
[2]"Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and CT18."
Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V., Kodoyianni V., Schwartz D.C., Blattner F.R.
J. Bacteriol. 185:2330-2337(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700931 / Ty2.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL513382 Genomic DNA. Translation: CAD07641.1.
AE014613 Genomic DNA. Translation: AAO68166.1.
RefSeqNP_456946.1. NC_003198.1.
NP_804317.1. NC_004631.1.

3D structure databases

ProteinModelPortalP58618.
SMRP58618. Positions 2-321.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING220341.STY2644.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAO68166; AAO68166; t0454.
CAD07641; CAD07641; CAD07641.
GeneID1248964.
KEGGsty:STY2644.
PATRIC18543266. VBISalEnt120419_2680.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000274469.
KOK00845.
OMADWVEMTN.
OrthoDBEOG64BQ47.

Family and domain databases

HAMAPMF_00524. Glucokinase.
InterProIPR003836. Glucokinase.
[Graphical view]
PfamPF02685. Glucokinase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00749. glk. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGLK_SALTI
AccessionPrimary (citable) accession number: P58618
Entry history
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: January 23, 2002
Last modified: June 11, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families