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Protein

Toxin Iob1

Gene
N/A
Organism
Isyndus obscurus (Assassin bug)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Binds reversibly and blocks N-type voltage-gated calcium channels (Cav).By similarity

GO - Molecular functioni

Keywordsi

Molecular functionCalcium channel impairing toxin, Ion channel impairing toxin, Neurotoxin, Toxin, Voltage-gated calcium channel impairing toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Toxin Iob1
OrganismiIsyndus obscurus (Assassin bug)
Taxonomic identifieri184615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraParaneopteraHemipteraHeteropteraPanheteropteraCimicomorphaReduviidaeHarpactorinaeHarpactoriniIsyndus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PeptideiPRO_00000448901 – 36Toxin Iob1Add BLAST36

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi6 ↔ 21By similarity
Disulfide bondi13 ↔ 26By similarity
Disulfide bondi20 ↔ 33By similarity

Keywords - PTMi

Disulfide bond

Structurei

3D structure databases

ProteinModelPortaliP58609.
SMRiP58609.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.By similarity

Sequence similaritiesi

Belongs to the assassin bug toxin family.Curated

Keywords - Domaini

Knottin

Family and domain databases

InterProiView protein in InterPro
IPR012325. Assassin_bug_toxin.
PfamiView protein in Pfam
PF08117. Toxin_30. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD591704. Assassin_bug_toxin. 1 hit.
PROSITEiView protein in PROSITE
PS60010. ASSASSIN_BUG_TOXIN. 1 hit.

Sequencei

Sequence statusi: Complete.

P58609-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30 
GADEDCLPRG SKCLGENKQC CEKTTCMFYA NRCVGI
Length:36
Mass (Da):3,945
Last modified:January 23, 2002 - v1
Checksum:i2DB8C392FA876F3E
GO

Mass spectrometryi

Molecular mass is 3938.5 Da from positions 1 - 36. Determined by MALDI. 1 Publication

Similar proteinsi

Entry informationi

Entry nameiIOB1_ISYOB
AccessioniPrimary (citable) accession number: P58609
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: January 23, 2002
Last modified: November 22, 2017
This is version 56 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families