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Protein

Toxin Ptu1

Gene
N/A
Organism
Peirates turpis (Assassin bug)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Binds reversibly and blocks N-type voltage-gated calcium channels (Cav).

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCalcium channel impairing toxin, Ion channel impairing toxin, Neurotoxin, Toxin, Voltage-gated calcium channel impairing toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Toxin Ptu1
OrganismiPeirates turpis (Assassin bug)
Taxonomic identifieri181095 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraParaneopteraHemipteraEuhemipteraHeteropteraPanheteropteraCimicomorphaReduviidaePeiratinaePeirates

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PeptideiPRO_00000448911 – 34Toxin Ptu1Add BLAST34

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi5 ↔ 20
Disulfide bondi12 ↔ 26
Disulfide bondi19 ↔ 33

Keywords - PTMi

Disulfide bond

Structurei

Secondary structure

134
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi4 – 6Combined sources3
Turni13 – 16Combined sources4
Beta strandi19 – 21Combined sources3
Turni28 – 31Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1I26NMR-A1-34[»]
ProteinModelPortaliP58606.
SMRiP58606.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP58606.

Family & Domainsi

Domaini

The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.

Sequence similaritiesi

Belongs to the assassin bug toxin family.Curated

Keywords - Domaini

Knottin

Family and domain databases

InterProiView protein in InterPro
IPR012325. Assassin_bug_toxin.
PfamiView protein in Pfam
PF08117. Toxin_30. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD591704. Assassin_bug_toxin. 1 hit.
PROSITEiView protein in PROSITE
PS60010. ASSASSIN_BUG_TOXIN. 1 hit.

Sequencei

Sequence statusi: Complete.

P58606-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30 
AEKDCIAPGA PCFGTDKPCC NPRAWCSSYA NKCL
Length:34
Mass (Da):3,621
Last modified:January 23, 2002 - v1
Checksum:i6B58A20A9E6B6FFA
GO

Mass spectrometryi

Molecular mass is 3615.1 Da from positions 1 - 34. Determined by MALDI. 1 Publication

Cross-referencesi

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1I26NMR-A1-34[»]
ProteinModelPortaliP58606.
SMRiP58606.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP58606.

Family and domain databases

InterProiView protein in InterPro
IPR012325. Assassin_bug_toxin.
PfamiView protein in Pfam
PF08117. Toxin_30. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD591704. Assassin_bug_toxin. 1 hit.
PROSITEiView protein in PROSITE
PS60010. ASSASSIN_BUG_TOXIN. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPTU1_PEITU
AccessioniPrimary (citable) accession number: P58606
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: January 23, 2002
Last modified: November 2, 2016
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.