Reviewed, UniProtKB/Swiss-Prot P58558 (FENR_ANASP)

Names and origin

Protein names

Recommended name:
    Ferredoxin--NADP reductase
      Short name=FNR
    EC=1.18.1.2

Gene names

Name:	petH
Ordered Locus Names:	all4121

Organism

Anabaena sp. (strain PCC 7120) [Complete proteome] [HAMAP]

Taxonomic identifier

103690 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Nostocales › Nostocaceae › Nostoc

Protein attributes

Sequence length	440 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	2 reduced ferredoxin + NADP+ + H+ = 2 oxidized ferredoxin + NADPH.
Cofactor	FAD.
Subcellular location	Cellular thylakoid membrane; Peripheral membrane protein; Cytoplasmic side By similarity. Note: May be bound to the thylakoid membrane or anchored to the thylakoid-bound phycobilisomes By similarity.
Sequence similarities	Belongs to the ferredoxin--NADP reductase type 1 family. Contains 1 cpcD-like domain. Contains 1 FAD-binding FR-type domain.

Ontologies

Keywords
Cellular component	Membrane Phycobilisome Thylakoid
Ligand	FAD Flavoprotein NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	internal side of plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell phycobilisome Inferred from electronic annotation. Source: UniProtKB-KW thylakoid membrane Inferred from electronic annotation. Source: InterPro
Molecular function	FAD binding Inferred from electronic annotation. Source: InterPro NADP or NADPH binding Inferred from electronic annotation. Source: InterPro electron carrier activity Inferred from electronic annotation. Source: InterPro ferredoxin-NADP+ reductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 440	440	Ferredoxin--NADP reductase		PRO_0000167633
Regions
	Domain	17 – 75	59	CpcD-like
	Domain	155 – 279	125	FAD-binding FR-type
	Nucleotide binding	214 – 217	4	FAD By similarity
	Nucleotide binding	235 – 237	3	FAD By similarity
	Nucleotide binding	253 – 255	3	FAD By similarity
	Nucleotide binding	330 – 331	2	NADP By similarity
	Nucleotide binding	360 – 361	2	NADP By similarity
	Nucleotide binding	370 – 374	5	NADP By similarity
	Nucleotide binding	399 – 400	2	NADP By similarity
Sites
	Binding site	217	1	NADP By similarity
	Binding site	237	1	NADP By similarity
	Binding site	241	1	FAD By similarity
	Binding site	294	1	FAD By similarity
	Binding site	294	1	NADP; via amide nitrogen By similarity
	Binding site	438	1	NADP By similarity

Sequences

	Sequence		Length	Mass (Da)
	P58558-1 [UniParc]. Last modified January 23, 2002. Version 1. Checksum: BB07AA1B99295C98	FASTA	440	48,838
	10 20 30 40 50 60 MSNQGAFDGA ANVESGSRVF VYEVVGMRQN EETDQTNYPI RKSGSVFIRV PYNRMNQEMQ 70 80 90 100 110 120 RITRLGGKIV SIQTVSALQQ LNGRTTIATV TDASSEIAKS EGNGKATPVK TDSGAKGFAK 130 140 150 160 170 180 PPAEEQLKKK DNKGNTMTQA KAKHADVPVN LYRPNAPFIG KVISNEPLVK EGGIGIVQHI 190 200 210 220 230 240 KFDLTGGNLK YIEGQSIGII PPGVDKNGKP EKLRLYSIAS TRHGDDVDDK TISLCVRQLE 250 260 270 280 290 300 YKHPESGETV YGVCSTYLTH IEPGSEVKIT GPVGKEMLLP DDPEANVIML ATGTGIAPMR 310 320 330 340 350 360 TYLWRMFKDA ERAANPEYQF KGFSWLVFGV PTTPNILYKE ELEEIQQKYP DNFRLTYAIS 370 380 390 400 410 420 REQKNPQGGR MYIQDRVAEH ADELWQLIKN EKTHTYICGL RGMEEGIDAA LSAAAAKEGV 430 440 TWSDYQKDLK KAGRWHVETY

References

[1]

"Complete genomic sequence of the filamentous nitrogen-fixing cyanobacterium Anabaena sp. strain PCC 7120." Kaneko T., Nakamura Y., Wolk C.P., Kuritz T., Sasamoto S., Watanabe A., Iriguchi M., Ishikawa A., Kawashima K., Kimura T., Kishida Y., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakazaki N., Shimpo S., Sugimoto M. , Takazawa M., Yamada M., Yasuda M., Tabata S. DNA Res. 8:205-213(2001) [PubMed: 11759840] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	BA000019 Genomic DNA. Translation: BAB75820.1.
PIR	AB2321.
RefSeq	NP_488161.1.
3D structure databases
HSSP	HSSP built from PDB template 1EWY based on UniProtKB P21890.
SMR	P58558. Positions 146-440.
ModBase	Search...
Protein-protein interaction databases
STRING	P58558.
Genome annotation databases
GeneID	1107723.
GenomeReviews	Gene locus all4121 in contig BA000019_GR.
KEGG	ana:all4121.
NMPDR	fig|103690.1.peg.4428.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	P58558.
OMA	GRMYIQD.
Enzyme and pathway databases
BioCyc	NSP103690:ALL4121-MON.
Family and domain databases
InterPro	IPR017927. Fd_Rdtase_FAD-bd. IPR001709. Flavoprot_Pyr_Nucl_cyt_Rdtase. IPR012146. Frd-NADP+_RD. IPR015701. FRD_Red. IPR001433. OxRdtase_FAD/NAD_bd. IPR008213. Phycobilisome_lnk_CpcD-like. [Graphical view]
PANTHER	PTHR19384:SF1. FRD_Red. 1 hit.
Pfam	PF01383. CpcD. 1 hit. PF00175. NAD_binding_1. 1 hit. [Graphical view]
PIRSF	PIRSF000361. Frd-NADP+_RD. 1 hit.
PRINTS	PR00371. FPNCR.
PROSITE	PS51441. CPCD_LIKE. 1 hit. PS51384. FAD_FR. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FENR_ANASP

Accession

Primary (citable) accession number: P58558

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 23, 2002
Last sequence update:	January 23, 2002
Last modified:	November 3, 2009
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)