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Protein

Putative ribonuclease

Gene

YBEY

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi118 – 1181Zinc; catalyticBy similarity
Metal bindingi122 – 1221Zinc; catalyticBy similarity
Metal bindingi128 – 1281Zinc; catalyticBy similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. metalloendopeptidase activity Source: InterPro

GO - Biological processi

  1. rRNA processing Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Putative ribonuclease
Gene namesi
Name:YBEY
Synonyms:C21orf57
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 21

Organism-specific databases

HGNCiHGNC:1299. YBEY.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. mitochondrion Source: Ensembl
  2. nucleoplasm Source: HPA
  3. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25852.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 167167Putative ribonucleasePRO_0000102578Add
BLAST

Proteomic databases

MaxQBiP58557.
PaxDbiP58557.
PRIDEiP58557.

Expressioni

Gene expression databases

BgeeiP58557.
CleanExiHS_C21orf57.
GenevestigatoriP58557.

Organism-specific databases

HPAiHPA016593.
HPA018162.

Interactioni

Protein-protein interaction databases

BioGridi119869. 10 interactions.
IntActiP58557. 3 interactions.
STRINGi9606.ENSP00000329614.

Structurei

3D structure databases

ProteinModelPortaliP58557.
SMRiP58557. Positions 19-148.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the endoribonuclease YbeY family.Curated

Phylogenomic databases

eggNOGiCOG0319.
GeneTreeiENSGT00390000007695.
HOGENOMiHOG000132869.
HOVERGENiHBG051234.
InParanoidiP58557.
OMAiHENLKAG.
OrthoDBiEOG7B31PH.
PhylomeDBiP58557.
TreeFamiTF332551.

Family and domain databases

Gene3Di3.40.390.30. 1 hit.
HAMAPiMF_00009. Endoribonucl_YbeY.
InterProiIPR023091. MetalPrtase_cat_dom_prd.
IPR002036. YbeY.
IPR020549. YbeY_CS.
[Graphical view]
PfamiPF02130. UPF0054. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00043. TIGR00043. 1 hit.
PROSITEiPS01306. UPF0054. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform A (identifier: P58557-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSLVIRNLQR VIPIRRAPLR SKIEIVRRIL GVQKFDLGII CVDNKNIQHI
60 70 80 90 100
NRIYRDRNVP TDVLSFPFHE HLKAGEFPQP DFPDDYNLGD IFLGVEYIFH
110 120 130 140 150
QCKENEDYND VLTVTATHGL CHLLGFTHGT EAEWQQMFQK EKAVLDELGR
160
RTGTRLQPLT RGLFGGS
Length:167
Mass (Da):19,298
Last modified:May 10, 2004 - v2
Checksum:i62C42B31B6BA5F26
GO
Isoform B (identifier: P58557-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     71-113: Missing.

Show »
Length:124
Mass (Da):14,269
Checksum:iDCCA3CE5A38A85CE
GO
Isoform C (identifier: P58557-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     26-70: Missing.

Show »
Length:122
Mass (Da):13,966
Checksum:i2CBE385901D5AA61
GO
Isoform D (identifier: P58557-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     26-113: Missing.

Show »
Length:79
Mass (Da):8,936
Checksum:iC4EB042CEBEBD619
GO

Sequence cautioni

The sequence AAK74139.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei26 – 11388Missing in isoform D. 1 PublicationVSP_006722Add
BLAST
Alternative sequencei26 – 7045Missing in isoform C. 1 PublicationVSP_006721Add
BLAST
Alternative sequencei71 – 11343Missing in isoform B. 1 PublicationVSP_006723Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY040873 mRNA. Translation: AAK74138.1. Sequence problems.
AY040874 mRNA. Translation: AAK74139.1. Different initiation.
AY040875 mRNA. Translation: AAK74140.1. Sequence problems.
AY040876 mRNA. Translation: AAK74141.1. Sequence problems.
AP000471 Genomic DNA. No translation available.
CH471079 Genomic DNA. Translation: EAX09288.1.
CH471079 Genomic DNA. Translation: EAX09290.1.
CH471079 Genomic DNA. Translation: EAX09291.1.
CH471079 Genomic DNA. Translation: EAX09293.1.
CCDSiCCDS33591.1. [P58557-1]
RefSeqiNP_478061.1. NM_058181.1. [P58557-1]
XP_005261212.1. XM_005261155.1. [P58557-1]
XP_005261213.1. XM_005261156.1. [P58557-2]
UniGeneiHs.474066.

Genome annotation databases

EnsembliENST00000329319; ENSP00000329614; ENSG00000182362. [P58557-1]
ENST00000339195; ENSP00000340675; ENSG00000182362. [P58557-2]
ENST00000397691; ENSP00000380805; ENSG00000182362. [P58557-1]
ENST00000397692; ENSP00000380806; ENSG00000182362. [P58557-4]
ENST00000397694; ENSP00000380808; ENSG00000182362. [P58557-3]
ENST00000397701; ENSP00000380813; ENSG00000182362. [P58557-1]
GeneIDi54059.
KEGGihsa:54059.
UCSCiuc002ziv.3. human. [P58557-1]
uc002ziw.3. human. [P58557-3]
uc002ziy.3. human. [P58557-2]
uc010gqh.3. human. [P58557-4]

Polymorphism databases

DMDMi47117865.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY040873 mRNA. Translation: AAK74138.1. Sequence problems.
AY040874 mRNA. Translation: AAK74139.1. Different initiation.
AY040875 mRNA. Translation: AAK74140.1. Sequence problems.
AY040876 mRNA. Translation: AAK74141.1. Sequence problems.
AP000471 Genomic DNA. No translation available.
CH471079 Genomic DNA. Translation: EAX09288.1.
CH471079 Genomic DNA. Translation: EAX09290.1.
CH471079 Genomic DNA. Translation: EAX09291.1.
CH471079 Genomic DNA. Translation: EAX09293.1.
CCDSiCCDS33591.1. [P58557-1]
RefSeqiNP_478061.1. NM_058181.1. [P58557-1]
XP_005261212.1. XM_005261155.1. [P58557-1]
XP_005261213.1. XM_005261156.1. [P58557-2]
UniGeneiHs.474066.

3D structure databases

ProteinModelPortaliP58557.
SMRiP58557. Positions 19-148.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119869. 10 interactions.
IntActiP58557. 3 interactions.
STRINGi9606.ENSP00000329614.

Polymorphism databases

DMDMi47117865.

Proteomic databases

MaxQBiP58557.
PaxDbiP58557.
PRIDEiP58557.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000329319; ENSP00000329614; ENSG00000182362. [P58557-1]
ENST00000339195; ENSP00000340675; ENSG00000182362. [P58557-2]
ENST00000397691; ENSP00000380805; ENSG00000182362. [P58557-1]
ENST00000397692; ENSP00000380806; ENSG00000182362. [P58557-4]
ENST00000397694; ENSP00000380808; ENSG00000182362. [P58557-3]
ENST00000397701; ENSP00000380813; ENSG00000182362. [P58557-1]
GeneIDi54059.
KEGGihsa:54059.
UCSCiuc002ziv.3. human. [P58557-1]
uc002ziw.3. human. [P58557-3]
uc002ziy.3. human. [P58557-2]
uc010gqh.3. human. [P58557-4]

Organism-specific databases

CTDi54059.
GeneCardsiGC21P047707.
H-InvDBHIX0027793.
HGNCiHGNC:1299. YBEY.
HPAiHPA016593.
HPA018162.
neXtProtiNX_P58557.
PharmGKBiPA25852.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0319.
GeneTreeiENSGT00390000007695.
HOGENOMiHOG000132869.
HOVERGENiHBG051234.
InParanoidiP58557.
OMAiHENLKAG.
OrthoDBiEOG7B31PH.
PhylomeDBiP58557.
TreeFamiTF332551.

Miscellaneous databases

GenomeRNAii54059.
NextBioi56368.
PROiP58557.

Gene expression databases

BgeeiP58557.
CleanExiHS_C21orf57.
GenevestigatoriP58557.

Family and domain databases

Gene3Di3.40.390.30. 1 hit.
HAMAPiMF_00009. Endoribonucl_YbeY.
InterProiIPR023091. MetalPrtase_cat_dom_prd.
IPR002036. YbeY.
IPR020549. YbeY_CS.
[Graphical view]
PfamiPF02130. UPF0054. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00043. TIGR00043. 1 hit.
PROSITEiPS01306. UPF0054. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "From PREDs and open reading frames to cDNA isolation: revisiting the human chromosome 21 transcription map."
    Reymond A., Friedli M., Neergaard Henrichsen C., Chapot F., Deutsch S., Ucla C., Rossier C., Lyle R., Guipponi M., Antonarakis S.E.
    Genomics 78:46-54(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A; B; C AND D).
  2. "The DNA sequence of human chromosome 21."
    Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A.
    , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.
    Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. Cited for: SUBCELLULAR LOCATION, MISCELLANEOUS.

Entry informationi

Entry nameiYBEY_HUMAN
AccessioniPrimary (citable) accession number: P58557
Secondary accession number(s): B7WPA9, B7WPF7, D3DSN2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: May 10, 2004
Last modified: February 4, 2015
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

A protein of the expected size has been detected by antibody binding and Western blot in at least one of the analyzed tissues or cells.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.