P58557 (YBEY_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative ribonuclease

Gene names

Name:	YBEY
Synonyms:	C21orf57

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	167 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Cofactor	Binds 1 zinc ion By similarity.
Subcellular location	Nucleus Ref.5.
Miscellaneous	A protein of the expected size has been detected by antibody binding and Western blot in at least one of the analyzed tissues or cells (Ref.5). HAMAP-Rule MF_00009
Sequence similarities	Belongs to the endoribonuclease YbeY family.
Sequence caution	The sequence AAK74138.1 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS. The sequence AAK74139.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. The sequence AAK74140.1 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS. The sequence AAK74141.1 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.

Ontologies

Keywords
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing
Ligand	Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	mitochondrion Inferred from electronic annotation. Source: Compara nucleus Inferred from direct assay Ref.5. Source: UniProtKB
Molecular_function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW metalloendopeptidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform A (identifier: P58557-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform B (identifier: P58557-2)

The sequence of this isoform differs from the canonical sequence as follows:
     71-113: Missing.

Isoform C (identifier: P58557-3)

The sequence of this isoform differs from the canonical sequence as follows:
     26-70: Missing.

Isoform D (identifier: P58557-4)

The sequence of this isoform differs from the canonical sequence as follows:
     26-113: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 167	167	Putative ribonuclease HAMAP-Rule MF_00009		PRO_0000102578
Sites
	Metal binding	118	1	Zinc; catalytic By similarity
	Metal binding	122	1	Zinc; catalytic By similarity
	Metal binding	128	1	Zinc; catalytic By similarity
Natural variations
	Alternative sequence	26 – 113	88	Missing in isoform D.		VSP_006722
	Alternative sequence	26 – 70	45	Missing in isoform C.		VSP_006721
	Alternative sequence	71 – 113	43	Missing in isoform B.		VSP_006723

Sequences

	Sequence		Length	Mass (Da)
	Isoform A [UniParc]. Last modified May 10, 2004. Version 2. Checksum: 62C42B31B6BA5F26	FASTA	167	19,298
	10 20 30 40 50 60 MSLVIRNLQR VIPIRRAPLR SKIEIVRRIL GVQKFDLGII CVDNKNIQHI NRIYRDRNVP 70 80 90 100 110 120 TDVLSFPFHE HLKAGEFPQP DFPDDYNLGD IFLGVEYIFH QCKENEDYND VLTVTATHGL 130 140 150 160 CHLLGFTHGT EAEWQQMFQK EKAVLDELGR RTGTRLQPLT RGLFGGS
	Isoform B [UniParc]. Checksum: DCCA3CE5A38A85CE	FASTA	124	14,269
	10 20 30 40 50 60 MSLVIRNLQR VIPIRRAPLR SKIEIVRRIL GVQKFDLGII CVDNKNIQHI NRIYRDRNVP 70 80 90 100 110 120 TDVLSFPFHE VTATHGLCHL LGFTHGTEAE WQQMFQKEKA VLDELGRRTG TRLQPLTRGL FGGS
	Isoform C [UniParc]. Checksum: 2CBE385901D5AA61	FASTA	122	13,966
	10 20 30 40 50 60 MSLVIRNLQR VIPIRRAPLR SKIEIHLKAG EFPQPDFPDD YNLGDIFLGV EYIFHQCKEN 70 80 90 100 110 120 EDYNDVLTVT ATHGLCHLLG FTHGTEAEWQ QMFQKEKAVL DELGRRTGTR LQPLTRGLFG GS
	Isoform D [UniParc]. Checksum: C4EB042CEBEBD619	FASTA	79	8,936
	10 20 30 40 50 60 MSLVIRNLQR VIPIRRAPLR SKIEIVTATH GLCHLLGFTH GTEAEWQQMF QKEKAVLDEL 70 GRRTGTRLQP LTRGLFGGS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"From PREDs and open reading frames to cDNA isolation: revisiting the human chromosome 21 transcription map." Reymond A., Friedli M., Neergaard Henrichsen C., Chapot F., Deutsch S., Ucla C., Rossier C., Lyle R., Guipponi M., Antonarakis S.E. Genomics 78:46-54(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A; B; C AND D).
[2]	"The DNA sequence of human chromosome 21." Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A. , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L. Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[5]	"Antibody-based protein profiling of the human chromosome 21." Uhlen M., Oksvold P., Algenas C., Hamsten C., Fagerberg L., Klevebring D., Lundberg E., Odeberg J., Ponten F., Kondo T., Sivertsson A. Mol. Cell. Proteomics 11:0-0(2012) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION, MISCELLANEOUS.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY040873 mRNA. Translation: AAK74138.1. Sequence problems. AY040874 mRNA. Translation: AAK74139.1. Different initiation. AY040875 mRNA. Translation: AAK74140.1. Sequence problems. AY040876 mRNA. Translation: AAK74141.1. Sequence problems. AP000471 Genomic DNA. No translation available. CH471079 Genomic DNA. Translation: EAX09288.1. CH471079 Genomic DNA. Translation: EAX09290.1. CH471079 Genomic DNA. Translation: EAX09291.1. CH471079 Genomic DNA. Translation: EAX09293.1.
IPI	IPI00067923. IPI00215811. IPI00215812. IPI00215813.
RefSeq	NP_478061.1. NM_058181.1.
UniGene	Hs.474066.
3D structure databases
ProteinModelPortal	P58557.
ModBase	Search...
Protein-protein interaction databases
IntAct	P58557. 2 interactions.
STRING	9606.ENSP00000329614.
Polymorphism databases
DMDM	47117865.
Proteomic databases
PaxDb	P58557.
PRIDE	P58557.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000329319; ENSP00000329614; ENSG00000182362. ENST00000339195; ENSP00000340675; ENSG00000182362. ENST00000397691; ENSP00000380805; ENSG00000182362. ENST00000397692; ENSP00000380806; ENSG00000182362. ENST00000397694; ENSP00000380808; ENSG00000182362. ENST00000397701; ENSP00000380813; ENSG00000182362.
GeneID	54059.
KEGG	hsa:54059.
UCSC	uc002ziv.3. human. uc002ziw.3. human. uc002ziy.3. human. uc010gqh.3. human.
Organism-specific databases
CTD	54059.
GeneCards	GC21P047707.
H-InvDB	HIX0027793.
HGNC	HGNC:1299. YBEY.
HPA	HPA016593. HPA018162.
neXtProt	NX_P58557.
PharmGKB	PA25852.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0319.
HOGENOM	HOG000132869.
HOVERGEN	HBG051234.
InParanoid	P58557.
OMA	HENLKAG.
OrthoDB	EOG4HT8TC.
PhylomeDB	P58557.
Gene expression databases
Bgee	P58557.
CleanEx	HS_C21orf57.
Genevestigator	P58557.
GermOnline	ENSG00000182362. Homo sapiens.
Family and domain databases
Gene3D	3.40.390.30. 1 hit.
HAMAP	MF_00009. Endoribonucl_YbeY.
InterPro	IPR023091. MetalPrtase_cat_dom_prd. IPR020549. UPF0054_CS. IPR002036. UPF0054_metalloprotease_prd. [Graphical view]
Pfam	PF02130. UPF0054. 1 hit. [Graphical view]
TIGRFAMs	TIGR00043. TIGR00043. 1 hit.
PROSITE	PS01306. UPF0054. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	54059.
NextBio	56368.

Entry information

Entry name

YBEY_HUMAN

Accession

Primary (citable) accession number: P58557
Secondary accession number(s): B7WPA9, B7WPF7, D3DSN2

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 23, 2002
Last sequence update:	May 10, 2004
Last modified:	May 1, 2013
This is version 82 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.