Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P58557 (YBEY_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative ribonuclease
Gene names
Name:YBEY
Synonyms:C21orf57
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length167 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Cofactor

Binds 1 zinc ion By similarity. HAMAP-Rule MF_00009

Subcellular location

Nucleus Ref.5.

Miscellaneous

A protein of the expected size has been detected by antibody binding and Western blot in at least one of the analyzed tissues or cells (Ref.5).

Sequence similarities

Belongs to the endoribonuclease YbeY family.

Sequence caution

The sequence AAK74138.1 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.

The sequence AAK74139.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

The sequence AAK74140.1 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.

The sequence AAK74141.1 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.

Ontologies

Keywords
   Cellular componentNucleus
   Coding sequence diversityAlternative splicing
   LigandMetal-binding
Zinc
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processrRNA processing

Inferred from electronic annotation. Source: InterPro

   Cellular_componentmitochondrion

Inferred from electronic annotation. Source: Ensembl

nucleus

Inferred from direct assay Ref.5. Source: UniProtKB

   Molecular_functionmetal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

metalloendopeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform A (identifier: P58557-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform B (identifier: P58557-2)

The sequence of this isoform differs from the canonical sequence as follows:
     71-113: Missing.
Isoform C (identifier: P58557-3)

The sequence of this isoform differs from the canonical sequence as follows:
     26-70: Missing.
Isoform D (identifier: P58557-4)

The sequence of this isoform differs from the canonical sequence as follows:
     26-113: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 167167Putative ribonuclease HAMAP-Rule MF_00009
PRO_0000102578

Sites

Metal binding1181Zinc; catalytic By similarity
Metal binding1221Zinc; catalytic By similarity
Metal binding1281Zinc; catalytic By similarity

Natural variations

Alternative sequence26 – 11388Missing in isoform D.
VSP_006722
Alternative sequence26 – 7045Missing in isoform C.
VSP_006721
Alternative sequence71 – 11343Missing in isoform B.
VSP_006723

Sequences

Sequence LengthMass (Da)Tools
Isoform A [UniParc].

Last modified May 10, 2004. Version 2.
Checksum: 62C42B31B6BA5F26

FASTA16719,298
        10         20         30         40         50         60 
MSLVIRNLQR VIPIRRAPLR SKIEIVRRIL GVQKFDLGII CVDNKNIQHI NRIYRDRNVP 

        70         80         90        100        110        120 
TDVLSFPFHE HLKAGEFPQP DFPDDYNLGD IFLGVEYIFH QCKENEDYND VLTVTATHGL 

       130        140        150        160 
CHLLGFTHGT EAEWQQMFQK EKAVLDELGR RTGTRLQPLT RGLFGGS 

« Hide

Isoform B [UniParc].

Checksum: DCCA3CE5A38A85CE
Show »

FASTA12414,269
Isoform C [UniParc].

Checksum: 2CBE385901D5AA61
Show »

FASTA12213,966
Isoform D [UniParc].

Checksum: C4EB042CEBEBD619
Show »

FASTA798,936

References

« Hide 'large scale' references
[1]"From PREDs and open reading frames to cDNA isolation: revisiting the human chromosome 21 transcription map."
Reymond A., Friedli M., Neergaard Henrichsen C., Chapot F., Deutsch S., Ucla C., Rossier C., Lyle R., Guipponi M., Antonarakis S.E.
Genomics 78:46-54(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A; B; C AND D).
[2]"The DNA sequence of human chromosome 21."
Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A. expand/collapse author list , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.
Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[5]"Antibody-based protein profiling of the human chromosome 21."
Uhlen M., Oksvold P., Algenas C., Hamsten C., Fagerberg L., Klevebring D., Lundberg E., Odeberg J., Ponten F., Kondo T., Sivertsson A.
Mol. Cell. Proteomics 11:0-0(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION, MISCELLANEOUS.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY040873 mRNA. Translation: AAK74138.1. Sequence problems.
AY040874 mRNA. Translation: AAK74139.1. Different initiation.
AY040875 mRNA. Translation: AAK74140.1. Sequence problems.
AY040876 mRNA. Translation: AAK74141.1. Sequence problems.
AP000471 Genomic DNA. No translation available.
CH471079 Genomic DNA. Translation: EAX09288.1.
CH471079 Genomic DNA. Translation: EAX09290.1.
CH471079 Genomic DNA. Translation: EAX09291.1.
CH471079 Genomic DNA. Translation: EAX09293.1.
RefSeqNP_478061.1. NM_058181.1.
XP_005261212.1. XM_005261155.1.
XP_005261213.1. XM_005261156.1.
UniGeneHs.474066.

3D structure databases

ProteinModelPortalP58557.
SMRP58557. Positions 19-148.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid119869. 1 interaction.
IntActP58557. 3 interactions.
STRING9606.ENSP00000329614.

Polymorphism databases

DMDM47117865.

Proteomic databases

PaxDbP58557.
PRIDEP58557.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000329319; ENSP00000329614; ENSG00000182362. [P58557-1]
ENST00000339195; ENSP00000340675; ENSG00000182362. [P58557-2]
ENST00000397691; ENSP00000380805; ENSG00000182362. [P58557-1]
ENST00000397692; ENSP00000380806; ENSG00000182362. [P58557-4]
ENST00000397694; ENSP00000380808; ENSG00000182362. [P58557-3]
ENST00000397701; ENSP00000380813; ENSG00000182362. [P58557-1]
GeneID54059.
KEGGhsa:54059.
UCSCuc002ziv.3. human. [P58557-1]
uc002ziw.3. human. [P58557-3]
uc002ziy.3. human. [P58557-2]
uc010gqh.3. human. [P58557-4]

Organism-specific databases

CTD54059.
GeneCardsGC21P047707.
H-InvDBHIX0027793.
HGNCHGNC:1299. YBEY.
HPAHPA016593.
HPA018162.
neXtProtNX_P58557.
PharmGKBPA25852.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0319.
HOGENOMHOG000132869.
HOVERGENHBG051234.
InParanoidP58557.
OMAHENLKAG.
OrthoDBEOG7B31PH.
PhylomeDBP58557.
TreeFamTF332551.

Gene expression databases

BgeeP58557.
CleanExHS_C21orf57.
GenevestigatorP58557.

Family and domain databases

Gene3D3.40.390.30. 1 hit.
HAMAPMF_00009. Endoribonucl_YbeY.
InterProIPR023091. MetalPrtase_cat_dom_prd.
IPR002036. YbeY.
IPR020549. YbeY_CS.
[Graphical view]
PfamPF02130. UPF0054. 1 hit.
[Graphical view]
TIGRFAMsTIGR00043. TIGR00043. 1 hit.
PROSITEPS01306. UPF0054. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi54059.
NextBio56368.
PROP58557.

Entry information

Entry nameYBEY_HUMAN
AccessionPrimary (citable) accession number: P58557
Secondary accession number(s): B7WPA9, B7WPF7, D3DSN2
Entry history
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: May 10, 2004
Last modified: March 19, 2014
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 21

Human chromosome 21: entries, gene names and cross-references to MIM