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P58557

- YBEY_HUMAN

UniProt

P58557 - YBEY_HUMAN

Protein

Putative ribonuclease

Gene

YBEY

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Cofactori

    Binds 1 zinc ion.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi118 – 1181Zinc; catalyticBy similarity
    Metal bindingi122 – 1221Zinc; catalyticBy similarity
    Metal bindingi128 – 1281Zinc; catalyticBy similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. metalloendopeptidase activity Source: InterPro

    GO - Biological processi

    1. rRNA processing Source: InterPro

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative ribonuclease
    Gene namesi
    Name:YBEY
    Synonyms:C21orf57
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 21

    Organism-specific databases

    HGNCiHGNC:1299. YBEY.

    Subcellular locationi

    Nucleus 1 Publication

    GO - Cellular componenti

    1. mitochondrion Source: Ensembl
    2. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA25852.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 167167Putative ribonucleasePRO_0000102578Add
    BLAST

    Proteomic databases

    MaxQBiP58557.
    PaxDbiP58557.
    PRIDEiP58557.

    Expressioni

    Gene expression databases

    BgeeiP58557.
    CleanExiHS_C21orf57.
    GenevestigatoriP58557.

    Organism-specific databases

    HPAiHPA016593.
    HPA018162.

    Interactioni

    Protein-protein interaction databases

    BioGridi119869. 1 interaction.
    IntActiP58557. 3 interactions.
    STRINGi9606.ENSP00000329614.

    Structurei

    3D structure databases

    ProteinModelPortaliP58557.
    SMRiP58557. Positions 19-148.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the endoribonuclease YbeY family.Curated

    Phylogenomic databases

    eggNOGiCOG0319.
    HOGENOMiHOG000132869.
    HOVERGENiHBG051234.
    InParanoidiP58557.
    OMAiAHGICHL.
    OrthoDBiEOG7B31PH.
    PhylomeDBiP58557.
    TreeFamiTF332551.

    Family and domain databases

    Gene3Di3.40.390.30. 1 hit.
    HAMAPiMF_00009. Endoribonucl_YbeY.
    InterProiIPR023091. MetalPrtase_cat_dom_prd.
    IPR002036. YbeY.
    IPR020549. YbeY_CS.
    [Graphical view]
    PfamiPF02130. UPF0054. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00043. TIGR00043. 1 hit.
    PROSITEiPS01306. UPF0054. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform A (identifier: P58557-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSLVIRNLQR VIPIRRAPLR SKIEIVRRIL GVQKFDLGII CVDNKNIQHI    50
    NRIYRDRNVP TDVLSFPFHE HLKAGEFPQP DFPDDYNLGD IFLGVEYIFH 100
    QCKENEDYND VLTVTATHGL CHLLGFTHGT EAEWQQMFQK EKAVLDELGR 150
    RTGTRLQPLT RGLFGGS 167
    Length:167
    Mass (Da):19,298
    Last modified:May 10, 2004 - v2
    Checksum:i62C42B31B6BA5F26
    GO
    Isoform B (identifier: P58557-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         71-113: Missing.

    Show »
    Length:124
    Mass (Da):14,269
    Checksum:iDCCA3CE5A38A85CE
    GO
    Isoform C (identifier: P58557-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         26-70: Missing.

    Show »
    Length:122
    Mass (Da):13,966
    Checksum:i2CBE385901D5AA61
    GO
    Isoform D (identifier: P58557-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         26-113: Missing.

    Show »
    Length:79
    Mass (Da):8,936
    Checksum:iC4EB042CEBEBD619
    GO

    Sequence cautioni

    The sequence AAK74139.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei26 – 11388Missing in isoform D. 1 PublicationVSP_006722Add
    BLAST
    Alternative sequencei26 – 7045Missing in isoform C. 1 PublicationVSP_006721Add
    BLAST
    Alternative sequencei71 – 11343Missing in isoform B. 1 PublicationVSP_006723Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY040873 mRNA. Translation: AAK74138.1. Sequence problems.
    AY040874 mRNA. Translation: AAK74139.1. Different initiation.
    AY040875 mRNA. Translation: AAK74140.1. Sequence problems.
    AY040876 mRNA. Translation: AAK74141.1. Sequence problems.
    AP000471 Genomic DNA. No translation available.
    CH471079 Genomic DNA. Translation: EAX09288.1.
    CH471079 Genomic DNA. Translation: EAX09290.1.
    CH471079 Genomic DNA. Translation: EAX09291.1.
    CH471079 Genomic DNA. Translation: EAX09293.1.
    CCDSiCCDS33591.1. [P58557-1]
    RefSeqiNP_478061.1. NM_058181.1. [P58557-1]
    XP_005261212.1. XM_005261155.1. [P58557-1]
    XP_005261213.1. XM_005261156.1. [P58557-2]
    UniGeneiHs.474066.

    Genome annotation databases

    EnsembliENST00000329319; ENSP00000329614; ENSG00000182362. [P58557-1]
    ENST00000339195; ENSP00000340675; ENSG00000182362. [P58557-2]
    ENST00000397691; ENSP00000380805; ENSG00000182362. [P58557-1]
    ENST00000397692; ENSP00000380806; ENSG00000182362. [P58557-4]
    ENST00000397694; ENSP00000380808; ENSG00000182362. [P58557-3]
    ENST00000397701; ENSP00000380813; ENSG00000182362. [P58557-1]
    GeneIDi54059.
    KEGGihsa:54059.
    UCSCiuc002ziv.3. human. [P58557-1]
    uc002ziw.3. human. [P58557-3]
    uc002ziy.3. human. [P58557-2]
    uc010gqh.3. human. [P58557-4]

    Polymorphism databases

    DMDMi47117865.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY040873 mRNA. Translation: AAK74138.1 . Sequence problems.
    AY040874 mRNA. Translation: AAK74139.1 . Different initiation.
    AY040875 mRNA. Translation: AAK74140.1 . Sequence problems.
    AY040876 mRNA. Translation: AAK74141.1 . Sequence problems.
    AP000471 Genomic DNA. No translation available.
    CH471079 Genomic DNA. Translation: EAX09288.1 .
    CH471079 Genomic DNA. Translation: EAX09290.1 .
    CH471079 Genomic DNA. Translation: EAX09291.1 .
    CH471079 Genomic DNA. Translation: EAX09293.1 .
    CCDSi CCDS33591.1. [P58557-1 ]
    RefSeqi NP_478061.1. NM_058181.1. [P58557-1 ]
    XP_005261212.1. XM_005261155.1. [P58557-1 ]
    XP_005261213.1. XM_005261156.1. [P58557-2 ]
    UniGenei Hs.474066.

    3D structure databases

    ProteinModelPortali P58557.
    SMRi P58557. Positions 19-148.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119869. 1 interaction.
    IntActi P58557. 3 interactions.
    STRINGi 9606.ENSP00000329614.

    Polymorphism databases

    DMDMi 47117865.

    Proteomic databases

    MaxQBi P58557.
    PaxDbi P58557.
    PRIDEi P58557.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000329319 ; ENSP00000329614 ; ENSG00000182362 . [P58557-1 ]
    ENST00000339195 ; ENSP00000340675 ; ENSG00000182362 . [P58557-2 ]
    ENST00000397691 ; ENSP00000380805 ; ENSG00000182362 . [P58557-1 ]
    ENST00000397692 ; ENSP00000380806 ; ENSG00000182362 . [P58557-4 ]
    ENST00000397694 ; ENSP00000380808 ; ENSG00000182362 . [P58557-3 ]
    ENST00000397701 ; ENSP00000380813 ; ENSG00000182362 . [P58557-1 ]
    GeneIDi 54059.
    KEGGi hsa:54059.
    UCSCi uc002ziv.3. human. [P58557-1 ]
    uc002ziw.3. human. [P58557-3 ]
    uc002ziy.3. human. [P58557-2 ]
    uc010gqh.3. human. [P58557-4 ]

    Organism-specific databases

    CTDi 54059.
    GeneCardsi GC21P047707.
    H-InvDB HIX0027793.
    HGNCi HGNC:1299. YBEY.
    HPAi HPA016593.
    HPA018162.
    neXtProti NX_P58557.
    PharmGKBi PA25852.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0319.
    HOGENOMi HOG000132869.
    HOVERGENi HBG051234.
    InParanoidi P58557.
    OMAi AHGICHL.
    OrthoDBi EOG7B31PH.
    PhylomeDBi P58557.
    TreeFami TF332551.

    Miscellaneous databases

    GenomeRNAii 54059.
    NextBioi 56368.
    PROi P58557.

    Gene expression databases

    Bgeei P58557.
    CleanExi HS_C21orf57.
    Genevestigatori P58557.

    Family and domain databases

    Gene3Di 3.40.390.30. 1 hit.
    HAMAPi MF_00009. Endoribonucl_YbeY.
    InterProi IPR023091. MetalPrtase_cat_dom_prd.
    IPR002036. YbeY.
    IPR020549. YbeY_CS.
    [Graphical view ]
    Pfami PF02130. UPF0054. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00043. TIGR00043. 1 hit.
    PROSITEi PS01306. UPF0054. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "From PREDs and open reading frames to cDNA isolation: revisiting the human chromosome 21 transcription map."
      Reymond A., Friedli M., Neergaard Henrichsen C., Chapot F., Deutsch S., Ucla C., Rossier C., Lyle R., Guipponi M., Antonarakis S.E.
      Genomics 78:46-54(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A; B; C AND D).
    2. "The DNA sequence of human chromosome 21."
      Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A.
      , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.
      Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    5. Cited for: SUBCELLULAR LOCATION, MISCELLANEOUS.

    Entry informationi

    Entry nameiYBEY_HUMAN
    AccessioniPrimary (citable) accession number: P58557
    Secondary accession number(s): B7WPA9, B7WPF7, D3DSN2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 23, 2002
    Last sequence update: May 10, 2004
    Last modified: October 1, 2014
    This is version 92 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    A protein of the expected size has been detected by antibody binding and Western blot in at least one of the analyzed tissues or cells.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 21
      Human chromosome 21: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3