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Protein

Putative ribonuclease

Gene

YBEY

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi118Zinc; catalyticBy similarity1
Metal bindingi122Zinc; catalyticBy similarity1
Metal bindingi128Zinc; catalyticBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Putative ribonuclease
Gene namesi
Name:YBEY
Synonyms:C21orf57
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

HGNCiHGNC:1299. YBEY.

Subcellular locationi

GO - Cellular componenti

  • mitochondrion Source: Ensembl
  • nucleoplasm Source: HPA
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi54059.
OpenTargetsiENSG00000182362.
PharmGKBiPA25852.

Polymorphism and mutation databases

BioMutaiYBEY.
DMDMi47117865.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001025781 – 167Putative ribonucleaseAdd BLAST167

Proteomic databases

EPDiP58557.
MaxQBiP58557.
PaxDbiP58557.
PeptideAtlasiP58557.
PRIDEiP58557.
TopDownProteomicsiP58557-1. [P58557-1]
P58557-3. [P58557-3]

Expressioni

Gene expression databases

BgeeiENSG00000182362.
CleanExiHS_C21orf57.
GenevisibleiP58557. HS.

Organism-specific databases

HPAiHPA016593.
HPA018162.

Interactioni

Protein-protein interaction databases

BioGridi119869. 67 interactors.
IntActiP58557. 3 interactors.
STRINGi9606.ENSP00000329614.

Structurei

3D structure databases

ProteinModelPortaliP58557.
SMRiP58557.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the endoribonuclease YbeY family.Curated

Phylogenomic databases

eggNOGiENOG410IRPH. Eukaryota.
COG0319. LUCA.
GeneTreeiENSGT00390000007695.
HOGENOMiHOG000132869.
HOVERGENiHBG051234.
InParanoidiP58557.
OMAiHENLKAG.
OrthoDBiEOG091G148Y.
PhylomeDBiP58557.
TreeFamiTF332551.

Family and domain databases

Gene3Di3.40.390.30. 1 hit.
HAMAPiMF_00009. Endoribonucl_YbeY. 1 hit.
InterProiIPR023091. MetalPrtase_cat_dom_prd.
IPR002036. YbeY.
IPR020549. YbeY_CS.
[Graphical view]
PfamiPF02130. UPF0054. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00043. TIGR00043. 1 hit.
PROSITEiPS01306. UPF0054. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform A (identifier: P58557-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSLVIRNLQR VIPIRRAPLR SKIEIVRRIL GVQKFDLGII CVDNKNIQHI
60 70 80 90 100
NRIYRDRNVP TDVLSFPFHE HLKAGEFPQP DFPDDYNLGD IFLGVEYIFH
110 120 130 140 150
QCKENEDYND VLTVTATHGL CHLLGFTHGT EAEWQQMFQK EKAVLDELGR
160
RTGTRLQPLT RGLFGGS
Length:167
Mass (Da):19,298
Last modified:May 10, 2004 - v2
Checksum:i62C42B31B6BA5F26
GO
Isoform B (identifier: P58557-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     71-113: Missing.

Show »
Length:124
Mass (Da):14,269
Checksum:iDCCA3CE5A38A85CE
GO
Isoform C (identifier: P58557-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     26-70: Missing.

Show »
Length:122
Mass (Da):13,966
Checksum:i2CBE385901D5AA61
GO
Isoform D (identifier: P58557-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     26-113: Missing.

Show »
Length:79
Mass (Da):8,936
Checksum:iC4EB042CEBEBD619
GO

Sequence cautioni

The sequence AAK74138 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated
The sequence AAK74139 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAK74140 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated
The sequence AAK74141 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00672226 – 113Missing in isoform D. 1 PublicationAdd BLAST88
Alternative sequenceiVSP_00672126 – 70Missing in isoform C. 1 PublicationAdd BLAST45
Alternative sequenceiVSP_00672371 – 113Missing in isoform B. 1 PublicationAdd BLAST43

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY040873 mRNA. Translation: AAK74138.1. Sequence problems.
AY040874 mRNA. Translation: AAK74139.1. Different initiation.
AY040875 mRNA. Translation: AAK74140.1. Sequence problems.
AY040876 mRNA. Translation: AAK74141.1. Sequence problems.
AP000471 Genomic DNA. No translation available.
CH471079 Genomic DNA. Translation: EAX09288.1.
CH471079 Genomic DNA. Translation: EAX09290.1.
CH471079 Genomic DNA. Translation: EAX09291.1.
CH471079 Genomic DNA. Translation: EAX09293.1.
CCDSiCCDS33591.1. [P58557-1]
CCDS82685.1. [P58557-3]
CCDS82686.1. [P58557-4]
CCDS82687.1. [P58557-2]
RefSeqiNP_001300951.1. NM_001314022.1. [P58557-2]
NP_001300952.1. NM_001314023.1. [P58557-3]
NP_001300953.1. NM_001314024.1. [P58557-4]
NP_001300954.1. NM_001314025.1. [P58557-1]
NP_001300955.1. NM_001314026.1.
NP_478061.1. NM_058181.2. [P58557-1]
UniGeneiHs.474066.

Genome annotation databases

EnsembliENST00000329319; ENSP00000329614; ENSG00000182362. [P58557-1]
ENST00000339195; ENSP00000340675; ENSG00000182362. [P58557-2]
ENST00000397691; ENSP00000380805; ENSG00000182362. [P58557-1]
ENST00000397692; ENSP00000380806; ENSG00000182362. [P58557-4]
ENST00000397694; ENSP00000380808; ENSG00000182362. [P58557-3]
ENST00000397701; ENSP00000380813; ENSG00000182362. [P58557-1]
GeneIDi54059.
KEGGihsa:54059.
UCSCiuc002ziv.4. human. [P58557-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY040873 mRNA. Translation: AAK74138.1. Sequence problems.
AY040874 mRNA. Translation: AAK74139.1. Different initiation.
AY040875 mRNA. Translation: AAK74140.1. Sequence problems.
AY040876 mRNA. Translation: AAK74141.1. Sequence problems.
AP000471 Genomic DNA. No translation available.
CH471079 Genomic DNA. Translation: EAX09288.1.
CH471079 Genomic DNA. Translation: EAX09290.1.
CH471079 Genomic DNA. Translation: EAX09291.1.
CH471079 Genomic DNA. Translation: EAX09293.1.
CCDSiCCDS33591.1. [P58557-1]
CCDS82685.1. [P58557-3]
CCDS82686.1. [P58557-4]
CCDS82687.1. [P58557-2]
RefSeqiNP_001300951.1. NM_001314022.1. [P58557-2]
NP_001300952.1. NM_001314023.1. [P58557-3]
NP_001300953.1. NM_001314024.1. [P58557-4]
NP_001300954.1. NM_001314025.1. [P58557-1]
NP_001300955.1. NM_001314026.1.
NP_478061.1. NM_058181.2. [P58557-1]
UniGeneiHs.474066.

3D structure databases

ProteinModelPortaliP58557.
SMRiP58557.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119869. 67 interactors.
IntActiP58557. 3 interactors.
STRINGi9606.ENSP00000329614.

Polymorphism and mutation databases

BioMutaiYBEY.
DMDMi47117865.

Proteomic databases

EPDiP58557.
MaxQBiP58557.
PaxDbiP58557.
PeptideAtlasiP58557.
PRIDEiP58557.
TopDownProteomicsiP58557-1. [P58557-1]
P58557-3. [P58557-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000329319; ENSP00000329614; ENSG00000182362. [P58557-1]
ENST00000339195; ENSP00000340675; ENSG00000182362. [P58557-2]
ENST00000397691; ENSP00000380805; ENSG00000182362. [P58557-1]
ENST00000397692; ENSP00000380806; ENSG00000182362. [P58557-4]
ENST00000397694; ENSP00000380808; ENSG00000182362. [P58557-3]
ENST00000397701; ENSP00000380813; ENSG00000182362. [P58557-1]
GeneIDi54059.
KEGGihsa:54059.
UCSCiuc002ziv.4. human. [P58557-1]

Organism-specific databases

CTDi54059.
DisGeNETi54059.
GeneCardsiYBEY.
H-InvDBHIX0027793.
HGNCiHGNC:1299. YBEY.
HPAiHPA016593.
HPA018162.
neXtProtiNX_P58557.
OpenTargetsiENSG00000182362.
PharmGKBiPA25852.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IRPH. Eukaryota.
COG0319. LUCA.
GeneTreeiENSGT00390000007695.
HOGENOMiHOG000132869.
HOVERGENiHBG051234.
InParanoidiP58557.
OMAiHENLKAG.
OrthoDBiEOG091G148Y.
PhylomeDBiP58557.
TreeFamiTF332551.

Miscellaneous databases

GenomeRNAii54059.
PROiP58557.

Gene expression databases

BgeeiENSG00000182362.
CleanExiHS_C21orf57.
GenevisibleiP58557. HS.

Family and domain databases

Gene3Di3.40.390.30. 1 hit.
HAMAPiMF_00009. Endoribonucl_YbeY. 1 hit.
InterProiIPR023091. MetalPrtase_cat_dom_prd.
IPR002036. YbeY.
IPR020549. YbeY_CS.
[Graphical view]
PfamiPF02130. UPF0054. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00043. TIGR00043. 1 hit.
PROSITEiPS01306. UPF0054. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiYBEY_HUMAN
AccessioniPrimary (citable) accession number: P58557
Secondary accession number(s): B7WPA9, B7WPF7, D3DSN2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: May 10, 2004
Last modified: November 2, 2016
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

A protein of the expected size has been detected by antibody binding and Western blot in at least one of the analyzed tissues or cells.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.