Reviewed, UniProtKB/Swiss-Prot P58557 (CU057_HUMAN)

Names and origin

Protein names

Recommended name:
    Putative metalloprotease C21orf57
    EC=3.4.24.-

Gene names

Name:

C21orf57

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	167 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	May have metalloprotease activity Potential.
Cofactor	Binds 1 zinc ion By similarity.
Sequence similarities	Belongs to the UPF0054 family.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Ligand	Metal-binding Zinc
Molecular function	Hydrolase Metalloprotease Protease
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	metallopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform A (identifier: P58557-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform B (identifier: P58557-2)

The sequence of this isoform differs from the canonical sequence as follows:
     71-113: Missing.

Isoform C (identifier: P58557-3)

The sequence of this isoform differs from the canonical sequence as follows:
     26-70: Missing.

Isoform D (identifier: P58557-4)

The sequence of this isoform differs from the canonical sequence as follows:
     26-113: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 167	167	Putative metalloprotease C21orf57		PRO_0000102578
Sites
	Metal binding	118	1	Zinc; catalytic By similarity
	Metal binding	122	1	Zinc; catalytic By similarity
	Metal binding	128	1	Zinc; catalytic By similarity
Natural variations
	Alternative sequence	26 – 113	88	Missing in isoform D.		VSP_006722
	Alternative sequence	26 – 70	45	Missing in isoform C.		VSP_006721
	Alternative sequence	71 – 113	43	Missing in isoform B.		VSP_006723

Sequences

	Sequence		Length	Mass (Da)
	Isoform A [UniParc]. Last modified May 10, 2004. Version 2. Checksum: 62C42B31B6BA5F26	FASTA	167	19,298
	10 20 30 40 50 60 MSLVIRNLQR VIPIRRAPLR SKIEIVRRIL GVQKFDLGII CVDNKNIQHI NRIYRDRNVP 70 80 90 100 110 120 TDVLSFPFHE HLKAGEFPQP DFPDDYNLGD IFLGVEYIFH QCKENEDYND VLTVTATHGL 130 140 150 160 CHLLGFTHGT EAEWQQMFQK EKAVLDELGR RTGTRLQPLT RGLFGGS
	Isoform B. Checksum: DCCA3CE5A38A85CE	FASTA	124	14,269
	10 20 30 40 50 60 MSLVIRNLQR VIPIRRAPLR SKIEIVRRIL GVQKFDLGII CVDNKNIQHI NRIYRDRNVP 70 80 90 100 110 120 TDVLSFPFHE VTATHGLCHL LGFTHGTEAE WQQMFQKEKA VLDELGRRTG TRLQPLTRGL FGGS
	Isoform C. Checksum: 2CBE385901D5AA61	FASTA	122	13,966
	10 20 30 40 50 60 MSLVIRNLQR VIPIRRAPLR SKIEIHLKAG EFPQPDFPDD YNLGDIFLGV EYIFHQCKEN 70 80 90 100 110 120 EDYNDVLTVT ATHGLCHLLG FTHGTEAEWQ QMFQKEKAVL DELGRRTGTR LQPLTRGLFG GS
	Isoform D. Checksum: C4EB042CEBEBD619	FASTA	79	8,936
	10 20 30 40 50 60 MSLVIRNLQR VIPIRRAPLR SKIEIVTATH GLCHLLGFTH GTEAEWQQMF QKEKAVLDEL 70 GRRTGTRLQP LTRGLFGGS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"From PREDs and open reading frames to cDNA isolation: revisiting the human chromosome 21 transcription map." Reymond A., Friedli M., Neergaard Henrichsen C., Chapot F., Deutsch S., Ucla C., Rossier C., Lyle R., Guipponi M., Antonarakis S.E. Genomics 78:46-54(2001) [PubMed: 11707072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A; B; C AND D).
[2]	"The DNA sequence of human chromosome 21." Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A. , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L. Nature 405:311-319(2000) [PubMed: 10830953] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AY040873 mRNA. Translation: AAK74138.1. Different initiation. AY040874 mRNA. Translation: AAK74139.1. Different initiation. AY040875 mRNA. Translation: AAK74140.1. Different initiation. AY040876 mRNA. Translation: AAK74141.1. Different initiation. AP000471 Genomic DNA. No translation available. CH471079 Genomic DNA. Translation: EAX09290.1. CH471079 Genomic DNA. Translation: EAX09293.1.
IPI	IPI00067923. IPI00215811. IPI00215812. IPI00215813.
RefSeq	NP_478061.1.
UniGene	Hs.474066
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	P58557. 2 interactions.
STRING	P58557.
Proteomic databases
PRIDE	P58557.
Genome annotation databases
Ensembl	ENST00000329319; ENSP00000329614; ENSG00000182362; Homo sapiens. [Genome view] ENST00000397691; ENSP00000380805; ENSG00000182362; Homo sapiens. [Genome view] ENST00000397701; ENSP00000380813; ENSG00000182362; Homo sapiens. [Genome view]
GeneID	54059.
NMPDR	fig|9606.3.peg.21142.
UCSC	uc002ziv.1. human. uc002ziw.1. human. uc002ziy.1. human. uc010gqh.1. human.
Organism-specific databases
CTD	54059.
GeneCards	GC21P046530.
HGNC	HGNC:1299. C21orf57.
HPA	HPA016593. HPA018162.
PharmGKB	PA25852.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	HBG714978.
HOVERGEN	P58557.
InParanoid	P58557.
OMA	DLGIICV.
OrthoDB	EOG95QKZZ.
Gene expression databases
ArrayExpress	P58557.
Bgee	P58557.
CleanEx	HS_C21orf57.
Genevestigator	P58557.
GermOnline	ENSG00000182362. Homo sapiens.
Family and domain databases
InterPro	IPR002036. UPF0054. IPR020549. UPF0054_CS. [Graphical view]
Pfam	PF02130. UPF0054. 1 hit. [Graphical view]
PROSITE	PS01306. UPF0054. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	56368.

Entry information

Entry name

CU057_HUMAN

Accession

Primary (citable) accession number: P58557
Secondary accession number(s): B7WPA9, B7WPF7

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 23, 2002
Last sequence update:	May 10, 2004
Last modified:	December 15, 2009
This is version 56 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.