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Protein

FXYD domain-containing ion transport regulator 7

Gene

FXYD7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel
Biological processIon transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-5578775. Ion homeostasis.
R-HSA-936837. Ion transport by P-type ATPases.

Names & Taxonomyi

Protein namesi
Recommended name:
FXYD domain-containing ion transport regulator 7
Gene namesi
Name:FXYD7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:4034. FXYD7.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei24 – 46HelicalSequence analysisAdd BLAST23

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000221946.
PharmGKBiPA28450.

Polymorphism and mutation databases

BioMutaiFXYD7.
DMDMi20138168.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001481901 – 80FXYD domain-containing ion transport regulator 7Add BLAST80

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei73PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP58549.
PaxDbiP58549.
PeptideAtlasiP58549.
PRIDEiP58549.

PTM databases

PhosphoSitePlusiP58549.

Expressioni

Gene expression databases

BgeeiENSG00000221946.
CleanExiHS_FXYD7.
ExpressionAtlasiP58549. baseline and differential.
GenevisibleiP58549. HS.

Organism-specific databases

HPAiHPA026916.

Interactioni

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi119795. 5 interactors.
IntActiP58549. 2 interactors.
STRINGi9606.ENSP00000270310.

Structurei

3D structure databases

ProteinModelPortaliP58549.
SMRiP58549.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FXYD family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J7S9. Eukaryota.
ENOG4111ECY. LUCA.
GeneTreeiENSGT00530000064670.
HOGENOMiHOG000112680.
HOVERGENiHBG051679.
InParanoidiP58549.
KOiK13364.
PhylomeDBiP58549.
TreeFamiTF333443.

Family and domain databases

InterProiView protein in InterPro
IPR000272. Ion-transport_regulator_FXYD.
PfamiView protein in Pfam
PF02038. ATP1G1_PLM_MAT8. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD005989. PD005989. 1 hit.
PROSITEiView protein in PROSITE
PS01310. FXYD. 1 hit.

Sequencei

Sequence statusi: Complete.

P58549-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATPTQTPTK APEEPDPFYY DYNTVQTVGM TLATILFLLG ILIVISKKVK
60 70 80
CRKADSRSES PTCKSCKSEL PSSAPGGGGV
Length:80
Mass (Da):8,524
Last modified:January 23, 2002 - v1
Checksum:i130DAC482EFF1939
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC018619 mRNA. Translation: AAH18619.1.
CCDSiCCDS12446.1.
RefSeqiNP_071289.1. NM_022006.1.
UniGeneiHs.134729.

Genome annotation databases

EnsembliENST00000270310; ENSP00000270310; ENSG00000221946.
GeneIDi53822.
KEGGihsa:53822.
UCSCiuc002nye.2. human.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiFXYD7_HUMAN
AccessioniPrimary (citable) accession number: P58549
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: January 23, 2002
Last modified: May 10, 2017
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families