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Protein

FXYD domain-containing ion transport regulator 7

Gene

FXYD7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-5578775. Ion homeostasis.
R-HSA-936837. Ion transport by P-type ATPases.

Names & Taxonomyi

Protein namesi
Recommended name:
FXYD domain-containing ion transport regulator 7
Gene namesi
Name:FXYD7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:4034. FXYD7.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei24 – 4623HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28450.

Polymorphism and mutation databases

BioMutaiFXYD7.
DMDMi20138168.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 8080FXYD domain-containing ion transport regulator 7PRO_0000148190Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei73 – 731PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP58549.
PRIDEiP58549.

PTM databases

PhosphoSiteiP58549.

Expressioni

Gene expression databases

BgeeiP58549.
CleanExiHS_FXYD7.
ExpressionAtlasiP58549. baseline and differential.
GenevisibleiP58549. HS.

Organism-specific databases

HPAiHPA026916.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
APPBP2Q926243EBI-10216171,EBI-743771
SGTAO437655EBI-10216171,EBI-347996

Protein-protein interaction databases

BioGridi119795. 5 interactions.
IntActiP58549. 2 interactions.
STRINGi9606.ENSP00000270310.

Structurei

3D structure databases

ProteinModelPortaliP58549.
SMRiP58549. Positions 10-52.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FXYD family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J7S9. Eukaryota.
ENOG4111ECY. LUCA.
GeneTreeiENSGT00530000064670.
HOGENOMiHOG000112680.
HOVERGENiHBG051679.
InParanoidiP58549.
KOiK13364.
PhylomeDBiP58549.
TreeFamiTF333443.

Family and domain databases

InterProiIPR000272. Ion-transport_regulator_FXYD.
[Graphical view]
PfamiPF02038. ATP1G1_PLM_MAT8. 1 hit.
[Graphical view]
ProDomiPD005989. PD005989. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS01310. FXYD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P58549-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATPTQTPTK APEEPDPFYY DYNTVQTVGM TLATILFLLG ILIVISKKVK
60 70 80
CRKADSRSES PTCKSCKSEL PSSAPGGGGV
Length:80
Mass (Da):8,524
Last modified:January 23, 2002 - v1
Checksum:i130DAC482EFF1939
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC018619 mRNA. Translation: AAH18619.1.
CCDSiCCDS12446.1.
RefSeqiNP_071289.1. NM_022006.1.
UniGeneiHs.134729.

Genome annotation databases

EnsembliENST00000270310; ENSP00000270310; ENSG00000221946.
GeneIDi53822.
KEGGihsa:53822.
UCSCiuc002nye.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC018619 mRNA. Translation: AAH18619.1.
CCDSiCCDS12446.1.
RefSeqiNP_071289.1. NM_022006.1.
UniGeneiHs.134729.

3D structure databases

ProteinModelPortaliP58549.
SMRiP58549. Positions 10-52.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119795. 5 interactions.
IntActiP58549. 2 interactions.
STRINGi9606.ENSP00000270310.

PTM databases

PhosphoSiteiP58549.

Polymorphism and mutation databases

BioMutaiFXYD7.
DMDMi20138168.

Proteomic databases

PaxDbiP58549.
PRIDEiP58549.

Protocols and materials databases

DNASUi53822.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000270310; ENSP00000270310; ENSG00000221946.
GeneIDi53822.
KEGGihsa:53822.
UCSCiuc002nye.2. human.

Organism-specific databases

CTDi53822.
GeneCardsiFXYD7.
HGNCiHGNC:4034. FXYD7.
HPAiHPA026916.
MIMi606684. gene.
neXtProtiNX_P58549.
PharmGKBiPA28450.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J7S9. Eukaryota.
ENOG4111ECY. LUCA.
GeneTreeiENSGT00530000064670.
HOGENOMiHOG000112680.
HOVERGENiHBG051679.
InParanoidiP58549.
KOiK13364.
PhylomeDBiP58549.
TreeFamiTF333443.

Enzyme and pathway databases

ReactomeiR-HSA-5578775. Ion homeostasis.
R-HSA-936837. Ion transport by P-type ATPases.

Miscellaneous databases

GenomeRNAii53822.
PROiP58549.
SOURCEiSearch...

Gene expression databases

BgeeiP58549.
CleanExiHS_FXYD7.
ExpressionAtlasiP58549. baseline and differential.
GenevisibleiP58549. HS.

Family and domain databases

InterProiIPR000272. Ion-transport_regulator_FXYD.
[Graphical view]
PfamiPF02038. ATP1G1_PLM_MAT8. 1 hit.
[Graphical view]
ProDomiPD005989. PD005989. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS01310. FXYD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Uterus.

Entry informationi

Entry nameiFXYD7_HUMAN
AccessioniPrimary (citable) accession number: P58549
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: January 23, 2002
Last modified: June 8, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.