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P58546

- MTPN_HUMAN

UniProt

P58546 - MTPN_HUMAN

Protein

Myotrophin

Gene

MTPN

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Promotes dimerization of NF-kappa-B subunits and regulates NF-kappa-B transcription factor activity By similarity. Plays a role in the regulation of the growth of actin filaments. Inhibits the activity of the F-actin-capping protein complex formed by the CAPZA1 and CAPZB heterodimer. Promotes growth of cardiomyocytes, but not cardiomyocyte proliferation. Promotes cardiac muscle hypertrophy.By similarity3 Publications

    GO - Biological processi

    1. catecholamine metabolic process Source: Ensembl
    2. cell growth Source: UniProtKB
    3. cerebellar granule cell differentiation Source: Ensembl
    4. neuron differentiation Source: UniProtKB
    5. positive regulation of cardiac muscle hypertrophy Source: UniProtKB
    6. positive regulation of cell growth Source: UniProtKB
    7. positive regulation of macromolecule biosynthetic process Source: UniProtKB
    8. positive regulation of NF-kappaB transcription factor activity Source: UniProtKB
    9. positive regulation of protein metabolic process Source: UniProtKB
    10. regulation of barbed-end actin filament capping Source: UniProtKB
    11. regulation of striated muscle tissue development Source: UniProtKB
    12. regulation of translation Source: UniProtKB
    13. skeletal muscle tissue regeneration Source: Ensembl
    14. striated muscle cell differentiation Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Myotrophin
    Alternative name(s):
    Protein V-1
    Gene namesi
    Name:MTPN
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:15667. MTPN.

    Subcellular locationi

    Cytoplasm Curated. Nucleus By similarity. Cytoplasmperinuclear region By similarity

    GO - Cellular componenti

    1. axon Source: Ensembl
    2. cytosol Source: UniProtKB
    3. extracellular vesicular exosome Source: UniProt
    4. F-actin capping protein complex Source: UniProtKB
    5. nucleus Source: UniProtKB
    6. perinuclear region of cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31271.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 118117MyotrophinPRO_0000067031Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylcysteine1 Publication
    Modified residuei4 – 41N6-acetyllysine1 Publication
    Modified residuei11 – 111N6-acetyllysine1 Publication
    Modified residuei24 – 241N6-acetyllysine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiP58546.
    PaxDbiP58546.
    PeptideAtlasiP58546.
    PRIDEiP58546.

    2D gel databases

    OGPiP58546.

    PTM databases

    PhosphoSiteiP58546.

    Expressioni

    Tissue specificityi

    Ubiquitous.1 Publication

    Inductioni

    Up-regulated in heart left ventricle of patients with severe coronary artery disease and history of myocardial ischemia. Up-regulated in heart left ventricle of patients with dilated cardiomyopathy.1 Publication

    Gene expression databases

    ArrayExpressiP58546.
    BgeeiP58546.
    CleanExiHS_MTPN.
    GenevestigatoriP58546.

    Organism-specific databases

    HPAiHPA019735.

    Interactioni

    Subunit structurei

    Interacts with RELA By similarity. Interacts with the heterodimer formed by CAPZA1 and CAPZB.By similarity2 Publications

    Protein-protein interaction databases

    BioGridi126455. 15 interactions.
    DIPiDIP-50234N.
    IntActiP58546. 3 interactions.

    Structurei

    Secondary structure

    1
    118
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi3 – 119
    Helixi15 – 239
    Helixi38 – 447
    Helixi48 – 558
    Turni56 – 583
    Helixi71 – 788
    Helixi81 – 899
    Helixi104 – 1074
    Helixi111 – 1177

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3AAAX-ray2.20C1-118[»]
    ProteinModelPortaliP58546.
    SMRiP58546. Positions 2-118.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP58546.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati2 – 3029ANK 1Add
    BLAST
    Repeati34 – 6633ANK 2Add
    BLAST
    Repeati67 – 9933ANK 3Add
    BLAST

    Sequence similaritiesi

    Belongs to the myotrophin family.Curated
    Contains 3 ANK repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    ANK repeat, Repeat

    Phylogenomic databases

    eggNOGiCOG0666.
    HOGENOMiHOG000276399.
    HOVERGENiHBG019067.
    InParanoidiP58546.
    OMAiYEGHVTC.
    OrthoDBiEOG7SBNQP.
    PhylomeDBiP58546.
    TreeFamiTF327387.

    Family and domain databases

    Gene3Di1.25.40.20. 1 hit.
    InterProiIPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    [Graphical view]
    PfamiPF12796. Ank_2. 1 hit.
    [Graphical view]
    PRINTSiPR01415. ANKYRIN.
    SMARTiSM00248. ANK. 2 hits.
    [Graphical view]
    SUPFAMiSSF48403. SSF48403. 1 hit.
    PROSITEiPS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P58546-1 [UniParc]FASTAAdd to Basket

    « Hide

    MCDKEFMWAL KNGDLDEVKD YVAKGEDVNR TLEGGRKPLH YAADCGQLEI    50
    LEFLLLKGAD INAPDKHHIT PLLSAVYEGH VSCVKLLLSK GADKTVKGPD 100
    GLTAFEATDN QAIKALLQ 118
    Length:118
    Mass (Da):12,895
    Last modified:January 23, 2007 - v2
    Checksum:i9097FFDF61D329A2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC015987 Genomic DNA. No translation available.
    BC028093 mRNA. Translation: AAH28093.1.
    CCDSiCCDS5842.1.
    RefSeqiNP_665807.1. NM_145808.3.
    UniGeneiHs.602015.

    Genome annotation databases

    EnsembliENST00000393085; ENSP00000376800; ENSG00000105887.
    GeneIDi136319.
    KEGGihsa:136319.
    UCSCiuc003vte.4. human.

    Polymorphism databases

    DMDMi20138912.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC015987 Genomic DNA. No translation available.
    BC028093 mRNA. Translation: AAH28093.1 .
    CCDSi CCDS5842.1.
    RefSeqi NP_665807.1. NM_145808.3.
    UniGenei Hs.602015.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3AAA X-ray 2.20 C 1-118 [» ]
    ProteinModelPortali P58546.
    SMRi P58546. Positions 2-118.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 126455. 15 interactions.
    DIPi DIP-50234N.
    IntActi P58546. 3 interactions.

    PTM databases

    PhosphoSitei P58546.

    Polymorphism databases

    DMDMi 20138912.

    2D gel databases

    OGPi P58546.

    Proteomic databases

    MaxQBi P58546.
    PaxDbi P58546.
    PeptideAtlasi P58546.
    PRIDEi P58546.

    Protocols and materials databases

    DNASUi 136319.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000393085 ; ENSP00000376800 ; ENSG00000105887 .
    GeneIDi 136319.
    KEGGi hsa:136319.
    UCSCi uc003vte.4. human.

    Organism-specific databases

    CTDi 136319.
    GeneCardsi GC07M135613.
    HGNCi HGNC:15667. MTPN.
    HPAi HPA019735.
    MIMi 606484. gene.
    neXtProti NX_P58546.
    PharmGKBi PA31271.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0666.
    HOGENOMi HOG000276399.
    HOVERGENi HBG019067.
    InParanoidi P58546.
    OMAi YEGHVTC.
    OrthoDBi EOG7SBNQP.
    PhylomeDBi P58546.
    TreeFami TF327387.

    Miscellaneous databases

    ChiTaRSi MTPN. human.
    EvolutionaryTracei P58546.
    GeneWikii MTPN.
    GenomeRNAii 136319.
    NextBioi 83582.
    PROi P58546.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P58546.
    Bgeei P58546.
    CleanExi HS_MTPN.
    Genevestigatori P58546.

    Family and domain databases

    Gene3Di 1.25.40.20. 1 hit.
    InterProi IPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    [Graphical view ]
    Pfami PF12796. Ank_2. 1 hit.
    [Graphical view ]
    PRINTSi PR01415. ANKYRIN.
    SMARTi SM00248. ANK. 2 hits.
    [Graphical view ]
    SUPFAMi SSF48403. SSF48403. 1 hit.
    PROSITEi PS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "cDNA sequence and characterization of the gene that encodes human myotrophin/V-1 protein, a mediator of cardiac hypertrophy."
      Anderson K.M., Berrebi-Bertrand I., Kirkpatrick R.B., McQueney M.S., Underwood D.C., Rouanet S., Chabot-Fletcher M.
      J. Mol. Cell. Cardiol. 31:705-719(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INDUCTION, TISSUE SPECIFICITY.
    2. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung.
    4. "Binding of myotrophin/V-1 to actin-capping protein: implications for how capping protein binds to the filament barbed end."
      Bhattacharya N., Ghosh S., Sept D., Cooper J.A.
      J. Biol. Chem. 281:31021-31030(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, IDENTIFICATION IN AN ACTIN CAPPING COMPLEX, INTERACTION WITH WITH CAPZA1 AND CAPZB.
    5. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT CYS-2; LYS-4; LYS-11 AND LYS-24, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
    6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    7. "Two distinct mechanisms for actin capping protein regulation--steric and allosteric inhibition."
      Takeda S., Minakata S., Koike R., Kawahata I., Narita A., Kitazawa M., Ota M., Yamakuni T., Maeda Y., Nitanai Y.
      PLoS Biol. 8:E1000416-E1000416(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) IN COMPLEX WITH CAPZA1 AND CAPZB, FUNCTION.

    Entry informationi

    Entry nameiMTPN_HUMAN
    AccessioniPrimary (citable) accession number: P58546
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 23, 2002
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 117 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    This protein is produced by a bicistronic gene which also produces the MPD6 protein from a non-overlapping reading frame. MPD6 belongs to a group of cryptic antigens without conventional genomic structure. It is encoded by a cryptic open reading frame located in the 3'-untranslated region of MTPN.

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3