P58546 (MTPN_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Myotrophin

Alternative name(s):
Protein V-1

Gene names

Name:

MTPN

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	118 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Potential role in cerebellar morphogenesis. May function in differentiation of cerebellar neurons, particularly of granule cells. Seems to be associated with cardiac hypertrophy.
Subcellular location	Cytoplasm By similarity.
Tissue specificity	Ubiquitous. Ref.1
Miscellaneous	This protein is produced by a bicistronic gene which also produces the MPD6 protein from a non-overlapping reading frame. MPD6 belongs to a group of cryptic antigens without conventional genomic structure. It is encoded by a cryptic open reading frame located in the 3'-untranslated region of MTPN.
Sequence similarities	Belongs to the myotrophin family. Contains 3 ANK repeats.

Ontologies

Keywords
Cellular component	Cytoplasm
Domain	ANK repeat Repeat
PTM	Acetylation
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cell growth Non-traceable author statement. Source: UniProtKB regulation of striated muscle tissue development Non-traceable author statement. Source: UniProtKB regulation of translation Non-traceable author statement. Source: UniProtKB
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Initiator methionine

1

1

Removed By similarity

Chain

2 – 118

117

Myotrophin

PRO_0000067031

Regions

Repeat

2 – 30

29

ANK 1

Repeat

34 – 66

33

ANK 2

Repeat

67 – 99

33

ANK 3

Amino acid modifications

Modified residue

2

1

N-acetylcysteine Ref.4

Modified residue

4

1

N6-acetyllysine Ref.4

Modified residue

11

1

N6-acetyllysine Ref.4

Modified residue

24

1

N6-acetyllysine Ref.4

Modified residue

97

1

N6-acetyllysine Ref.4

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

118

Helix Strand Turn

Details...

Helix

3 – 11

9

Helix

15 – 23

9

Helix

38 – 44

7

Helix

48 – 55

8

Helix

71 – 77

7

Helix

81 – 89

9

Helix

104 – 107

4

Helix

111 – 117

7

Sequences

	Sequence		Length	Mass (Da)
	P58546 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: 9097FFDF61D329A2	FASTA	118	12,895
	10 20 30 40 50 60 MCDKEFMWAL KNGDLDEVKD YVAKGEDVNR TLEGGRKPLH YAADCGQLEI LEFLLLKGAD 70 80 90 100 110 INAPDKHHIT PLLSAVYEGH VSCVKLLLSK GADKTVKGPD GLTAFEATDN QAIKALLQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"cDNA sequence and characterization of the gene that encodes human myotrophin/V-1 protein, a mediator of cardiac hypertrophy." Anderson K.M., Berrebi-Bertrand I., Kirkpatrick R.B., McQueney M.S., Underwood D.C., Rouanet S., Chabot-Fletcher M. J. Mol. Cell. Cardiol. 31:705-719(1999) [PubMed: 10329199] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[2]	"The DNA sequence of human chromosome 7." Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K. Nature 424:157-164(2003) [PubMed: 12853948] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung.
[4]	"Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed: 19608861] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT CYS-2; LYS-4; LYS-11; LYS-24 AND LYS-97, MASS SPECTROMETRY.
[5]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AC015987 Genomic DNA. No translation available.
BC028093 mRNA. Translation: AAH28093.1.

IPI

IPI00924816.

RefSeq

NP_665807.1. NM_145808.3.

UniGene

Hs.602015.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3AAA	X-ray	2.20	C	1-118	[»]

ProteinModelPortal

P58546.

SMR

P58546. Positions 2-118.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-50234N.

IntAct

P58546. 3 interactions.

STRING

P58546.

PTM databases

PhosphoSite

P58546.

Polymorphism databases

DMDM

20138912.

2D gel databases

OGP

P58546.

Proteomic databases

PeptideAtlas

P58546.

PRIDE

P58546.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000356707; ENSP00000349140; ENSG00000105887.
ENST00000393085; ENSP00000376800; ENSG00000105887.

GeneID

136319.

KEGG

hsa:136319.

UCSC

uc003vte.2. human.

Organism-specific databases

CTD

136319.

GeneCards

GC07M135613.

H-InvDB

HIX0007116.

HGNC

HGNC:15667. MTPN.

HPA

HPA019735.

MIM

606484. gene.

neXtProt

NX_P58546.

PharmGKB

PA31271.

GenAtlas

Search...

Phylogenomic databases

eggNOG

prNOG20033.

HOGENOM

HBG595165.

HOVERGEN

HBG019067.

InParanoid

P58546.

OMA

NATDKHG.

OrthoDB

EOG470TJP.

PhylomeDB

P58546.

Gene expression databases

ArrayExpress

P58546.

Bgee

P58546.

CleanEx

HS_MTPN.

Genevestigator

P58546.

Family and domain databases

InterPro

IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]

Gene3D

G3DSA:1.25.40.20. ANK. 1 hit.

Pfam

PF12796. Ank_2. 1 hit.
[Graphical view]

PRINTS

PR01415. ANKYRIN.

SMART

SM00248. ANK. 2 hits.
[Graphical view]

SUPFAM

SSF48403. ANK. 1 hit.

PROSITE

PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
[Graphical view]

ProtoNet

Search...

Other

NextBio

83582.

SOURCE

Search...

Entry information

Entry name

MTPN_HUMAN

Accession

Primary (citable) accession number: P58546

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 23, 2002
Last sequence update:	January 23, 2007
Last modified:	December 14, 2011
This is version 96 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.