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Protein

Myotrophin

Gene

MTPN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Promotes dimerization of NF-kappa-B subunits and regulates NF-kappa-B transcription factor activity (By similarity). Plays a role in the regulation of the growth of actin filaments. Inhibits the activity of the F-actin-capping protein complex formed by the CAPZA1 and CAPZB heterodimer. Promotes growth of cardiomyocytes, but not cardiomyocyte proliferation. Promotes cardiac muscle hypertrophy.By similarity3 Publications

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000105887-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Myotrophin
Alternative name(s):
Protein V-1
Gene namesi
Name:MTPN
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:15667. MTPN.

Subcellular locationi

GO - Cellular componenti

  • axon Source: Ensembl
  • cytosol Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • F-actin capping protein complex Source: UniProtKB
  • nucleus Source: UniProtKB
  • perinuclear region of cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi136319.
OpenTargetsiENSG00000105887.
PharmGKBiPA31271.

Polymorphism and mutation databases

BioMutaiMTPN.
DMDMi20138912.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000670312 – 118MyotrophinAdd BLAST117

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylcysteineBy similarity1
Modified residuei4N6-acetyllysineCombined sources1
Modified residuei11N6-acetyllysineCombined sources1
Modified residuei24N6-acetyllysineCombined sources1
Modified residuei31PhosphothreonineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP58546.
PaxDbiP58546.
PeptideAtlasiP58546.
PRIDEiP58546.
TopDownProteomicsiP58546.

2D gel databases

OGPiP58546.

PTM databases

iPTMnetiP58546.
PhosphoSitePlusiP58546.

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Inductioni

Up-regulated in heart left ventricle of patients with severe coronary artery disease and history of myocardial ischemia. Up-regulated in heart left ventricle of patients with dilated cardiomyopathy.1 Publication

Gene expression databases

BgeeiENSG00000105887.
CleanExiHS_MTPN.
ExpressionAtlasiP58546. baseline and differential.
GenevisibleiP58546. HS.

Organism-specific databases

HPAiHPA019735.

Interactioni

Subunit structurei

Interacts with RELA (By similarity). Interacts with the heterodimer formed by CAPZA1 and CAPZB.By similarity2 Publications

Protein-protein interaction databases

BioGridi126455. 32 interactors.
DIPiDIP-50234N.
IntActiP58546. 14 interactors.
STRINGi9606.ENSP00000376800.

Structurei

Secondary structure

1118
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi3 – 11Combined sources9
Helixi15 – 23Combined sources9
Helixi38 – 44Combined sources7
Helixi48 – 55Combined sources8
Turni56 – 58Combined sources3
Helixi71 – 78Combined sources8
Helixi81 – 89Combined sources9
Helixi104 – 107Combined sources4
Helixi111 – 117Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3AAAX-ray2.20C1-118[»]
ProteinModelPortaliP58546.
SMRiP58546.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP58546.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati2 – 30ANK 1Add BLAST29
Repeati34 – 66ANK 2Add BLAST33
Repeati67 – 99ANK 3Add BLAST33

Sequence similaritiesi

Belongs to the myotrophin family.Curated
Contains 3 ANK repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG4214. Eukaryota.
ENOG4111U90. LUCA.
GeneTreeiENSGT00430000031071.
HOGENOMiHOG000276399.
HOVERGENiHBG019067.
InParanoidiP58546.
OMAiTALIDCT.
OrthoDBiEOG091G0Y4J.
PhylomeDBiP58546.
TreeFamiTF327387.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 2 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P58546-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCDKEFMWAL KNGDLDEVKD YVAKGEDVNR TLEGGRKPLH YAADCGQLEI
60 70 80 90 100
LEFLLLKGAD INAPDKHHIT PLLSAVYEGH VSCVKLLLSK GADKTVKGPD
110
GLTAFEATDN QAIKALLQ
Length:118
Mass (Da):12,895
Last modified:January 23, 2007 - v2
Checksum:i9097FFDF61D329A2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC015987 Genomic DNA. No translation available.
BC028093 mRNA. Translation: AAH28093.1.
CCDSiCCDS5842.1.
RefSeqiNP_665807.1. NM_145808.3.
UniGeneiHs.602015.

Genome annotation databases

EnsembliENST00000393085; ENSP00000376800; ENSG00000105887.
GeneIDi136319.
KEGGihsa:136319.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC015987 Genomic DNA. No translation available.
BC028093 mRNA. Translation: AAH28093.1.
CCDSiCCDS5842.1.
RefSeqiNP_665807.1. NM_145808.3.
UniGeneiHs.602015.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3AAAX-ray2.20C1-118[»]
ProteinModelPortaliP58546.
SMRiP58546.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126455. 32 interactors.
DIPiDIP-50234N.
IntActiP58546. 14 interactors.
STRINGi9606.ENSP00000376800.

PTM databases

iPTMnetiP58546.
PhosphoSitePlusiP58546.

Polymorphism and mutation databases

BioMutaiMTPN.
DMDMi20138912.

2D gel databases

OGPiP58546.

Proteomic databases

EPDiP58546.
PaxDbiP58546.
PeptideAtlasiP58546.
PRIDEiP58546.
TopDownProteomicsiP58546.

Protocols and materials databases

DNASUi136319.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000393085; ENSP00000376800; ENSG00000105887.
GeneIDi136319.
KEGGihsa:136319.

Organism-specific databases

CTDi136319.
DisGeNETi136319.
GeneCardsiMTPN.
HGNCiHGNC:15667. MTPN.
HPAiHPA019735.
MIMi606484. gene.
neXtProtiNX_P58546.
OpenTargetsiENSG00000105887.
PharmGKBiPA31271.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4214. Eukaryota.
ENOG4111U90. LUCA.
GeneTreeiENSGT00430000031071.
HOGENOMiHOG000276399.
HOVERGENiHBG019067.
InParanoidiP58546.
OMAiTALIDCT.
OrthoDBiEOG091G0Y4J.
PhylomeDBiP58546.
TreeFamiTF327387.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000105887-MONOMER.

Miscellaneous databases

ChiTaRSiMTPN. human.
EvolutionaryTraceiP58546.
GeneWikiiMTPN.
GenomeRNAii136319.
PROiP58546.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000105887.
CleanExiHS_MTPN.
ExpressionAtlasiP58546. baseline and differential.
GenevisibleiP58546. HS.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 2 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMTPN_HUMAN
AccessioniPrimary (citable) accession number: P58546
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 136 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

This protein is produced by a bicistronic gene which also produces the MPD6 protein from a non-overlapping reading frame. MPD6 belongs to a group of cryptic antigens without conventional genomic structure. It is encoded by a cryptic open reading frame located in the 3'-untranslated region of MTPN.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.