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Protein

BTB/POZ domain-containing protein 1

Gene

Btbd1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
BTB/POZ domain-containing protein 1
Alternative name(s):
Glucose signal-repressing protein
Gene namesi
Name:Btbd1
Synonyms:Gsrp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1933765. Btbd1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasmic mRNA processing body Source: UniProtKB
  • protein complex Source: MGI
  • SCF ubiquitin ligase complex Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001862091 – 488BTB/POZ domain-containing protein 1Add BLAST488

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei85Omega-N-methylarginineBy similarity1

Keywords - PTMi

Methylation

Proteomic databases

EPDiP58544.
MaxQBiP58544.
PaxDbiP58544.
PeptideAtlasiP58544.
PRIDEiP58544.

PTM databases

iPTMnetiP58544.
PhosphoSitePlusiP58544.

Expressioni

Gene expression databases

BgeeiENSMUSG00000025103.
CleanExiMM_BTBD1.
GenevisibleiP58544. MM.

Interactioni

Subunit structurei

Interacts with topoisomerase 1 and with TRIM5 isoform Delta. Interacts with CUL3 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiP58544. 1 interactor.
STRINGi10090.ENSMUSP00000026093.

Structurei

3D structure databases

ProteinModelPortaliP58544.
SMRiP58544.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini75 – 151BTBPROSITE-ProRule annotationAdd BLAST77

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi20 – 37Poly-ProAdd BLAST18

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2075. Eukaryota.
ENOG410XQ3X. LUCA.
GeneTreeiENSGT00550000074511.
HOGENOMiHOG000293364.
HOVERGENiHBG050743.
InParanoidiP58544.
KOiK10477.
OMAiRIRFNVN.
OrthoDBiEOG091G04LD.
TreeFamiTF106482.

Family and domain databases

InterProiIPR011705. BACK.
IPR000210. BTB/POZ_dom.
IPR012983. PHR.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
PfamiPF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF08005. PHR. 1 hit.
[Graphical view]
SMARTiSM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P58544-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASLGSAAAG EPATGAEAEP GPPAPPPPPP PPPAPSPSAL GPLLPLQREP
60 70 80 90 100
LYNWQATKAS LKERFAFLFN SELLSDVRFV LGKGRGAAAA GGPQRIPAHR
110 120 130 140 150
FVLAAGSAVF DAMFNGGMAT TSAEIELPDV EPAAFLALLR FLYSDEVQIG
160 170 180 190 200
PETVMTTLYT AKKYAVPALE AHCVEFLTKH LRADNAFMLL TQARLFDEPQ
210 220 230 240 250
LASLCLDTID KSTVDAISAE GFTDIDIDTL CAVLERDTLS IRESRLFGAI
260 270 280 290 300
VRWAEAECQR QQLAVTFGNK QKVLGKALSL IRFPLMTIEE FAAGPAQSGI
310 320 330 340 350
LSDREVVNLF LHFTVNPKPR VEYIDRPRCC LRGKECCINR FQQVESRWGY
360 370 380 390 400
SGTSDRIRFT VNRRISVVGF GLYGSIHGPT DYQVNIQIIE YEKKQTLGQN
410 420 430 440 450
DTGFSCDGTA NTFRVMFKEP IEILPNVCYT ACATLKGPDS HYGTKGLKKV
460 470 480
VHETPAASKT VFLFFSSPGN NNGTSIEDGQ IPEIIFYT
Length:488
Mass (Da):53,233
Last modified:July 27, 2011 - v3
Checksum:i0CBDCA93EA10430F
GO

Sequence cautioni

The sequence AAH31192 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti21G → R in BAC40296 (PubMed:16141072).Curated1
Sequence conflicti99H → P in BAC40296 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK088345 mRNA. Translation: BAC40296.1.
BC031192 mRNA. Translation: AAH31192.1. Different initiation.
BC072618 mRNA. Translation: AAH72618.1.
CCDSiCCDS21407.1.
RefSeqiNP_666305.2. NM_146193.2.
UniGeneiMm.439893.

Genome annotation databases

EnsembliENSMUST00000026093; ENSMUSP00000026093; ENSMUSG00000025103.
GeneIDi83962.
KEGGimmu:83962.
UCSCiuc009icn.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK088345 mRNA. Translation: BAC40296.1.
BC031192 mRNA. Translation: AAH31192.1. Different initiation.
BC072618 mRNA. Translation: AAH72618.1.
CCDSiCCDS21407.1.
RefSeqiNP_666305.2. NM_146193.2.
UniGeneiMm.439893.

3D structure databases

ProteinModelPortaliP58544.
SMRiP58544.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP58544. 1 interactor.
STRINGi10090.ENSMUSP00000026093.

PTM databases

iPTMnetiP58544.
PhosphoSitePlusiP58544.

Proteomic databases

EPDiP58544.
MaxQBiP58544.
PaxDbiP58544.
PeptideAtlasiP58544.
PRIDEiP58544.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000026093; ENSMUSP00000026093; ENSMUSG00000025103.
GeneIDi83962.
KEGGimmu:83962.
UCSCiuc009icn.1. mouse.

Organism-specific databases

CTDi53339.
MGIiMGI:1933765. Btbd1.

Phylogenomic databases

eggNOGiKOG2075. Eukaryota.
ENOG410XQ3X. LUCA.
GeneTreeiENSGT00550000074511.
HOGENOMiHOG000293364.
HOVERGENiHBG050743.
InParanoidiP58544.
KOiK10477.
OMAiRIRFNVN.
OrthoDBiEOG091G04LD.
TreeFamiTF106482.

Enzyme and pathway databases

UniPathwayiUPA00143.

Miscellaneous databases

ChiTaRSiBtbd1. mouse.
PROiP58544.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000025103.
CleanExiMM_BTBD1.
GenevisibleiP58544. MM.

Family and domain databases

InterProiIPR011705. BACK.
IPR000210. BTB/POZ_dom.
IPR012983. PHR.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
PfamiPF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF08005. PHR. 1 hit.
[Graphical view]
SMARTiSM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBTBD1_MOUSE
AccessioniPrimary (citable) accession number: P58544
Secondary accession number(s): Q6GQU7, Q8BTZ0, Q8K0J0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: July 27, 2011
Last modified: November 2, 2016
This is version 114 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.