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Protein

BTB/POZ domain-containing protein 1

Gene

Btbd1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Seems to regulate expression levels and/or subnuclear distribution of TOP1, via an unknown mechanism (PubMed:15486563, PubMed:17462629). May play a role in mesenchymal differentiation where it promotes myogenic differentiation and suppresses adipogenesis (PubMed:15486563, PubMed:17462629).By similarity2 Publications

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processDifferentiation, Myogenesis, Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-MMU-8951664 Neddylation
R-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation
UniPathwayiUPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
BTB/POZ domain-containing protein 1
Alternative name(s):
Glucose signal-repressing protein
Gene namesi
Name:Btbd1
Synonyms:Gsrp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1933765 Btbd1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi1 – 108Missing : Fails to induce myogenic differentiation in C2C12 cells. 1 PublicationAdd BLAST108

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001862091 – 488BTB/POZ domain-containing protein 1Add BLAST488

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei85Omega-N-methylarginineBy similarity1

Keywords - PTMi

Methylation

Proteomic databases

EPDiP58544
MaxQBiP58544
PaxDbiP58544
PeptideAtlasiP58544
PRIDEiP58544

PTM databases

iPTMnetiP58544
PhosphoSitePlusiP58544

Expressioni

Tissue specificityi

Strongly expressed in heart and skeletal muscle. Weakly expressed in myoblast C2C12 cells, but strongly up-regulated upon their differentiation into myotubes.1 Publication

Gene expression databases

BgeeiENSMUSG00000025103
CleanExiMM_BTBD1
GenevisibleiP58544 MM

Interactioni

Subunit structurei

Interacts (via C-terminus) with TOP1. Interacts with TRIM5 isoform Delta. Interacts with CUL3.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi219989, 1 interactor
IntActiP58544, 1 interactor
MINTiP58544
STRINGi10090.ENSMUSP00000026093

Structurei

3D structure databases

ProteinModelPortaliP58544
SMRiP58544
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini75 – 151BTBPROSITE-ProRule annotationAdd BLAST77
Domaini190 – 290BACKSequence analysisAdd BLAST101

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi20 – 50Pro-richPROSITE-ProRule annotationAdd BLAST31

Phylogenomic databases

eggNOGiKOG2075 Eukaryota
ENOG410XQ3X LUCA
GeneTreeiENSGT00550000074511
HOGENOMiHOG000293364
HOVERGENiHBG050743
InParanoidiP58544
KOiK10477
OMAiRIRFNVN
OrthoDBiEOG091G04LD
TreeFamiTF106482

Family and domain databases

Gene3Di2.60.120.820, 1 hit
InterProiView protein in InterPro
IPR011705 BACK
IPR000210 BTB/POZ_dom
IPR012983 PHR
IPR038648 PHR_sf
IPR011333 SKP1/BTB/POZ_sf
PfamiView protein in Pfam
PF07707 BACK, 1 hit
PF00651 BTB, 1 hit
PF08005 PHR, 1 hit
SMARTiView protein in SMART
SM00875 BACK, 1 hit
SM00225 BTB, 1 hit
SUPFAMiSSF54695 SSF54695, 1 hit
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit

Sequencei

Sequence statusi: Complete.

P58544-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASLGSAAAG EPATGAEAEP GPPAPPPPPP PPPAPSPSAL GPLLPLQREP
60 70 80 90 100
LYNWQATKAS LKERFAFLFN SELLSDVRFV LGKGRGAAAA GGPQRIPAHR
110 120 130 140 150
FVLAAGSAVF DAMFNGGMAT TSAEIELPDV EPAAFLALLR FLYSDEVQIG
160 170 180 190 200
PETVMTTLYT AKKYAVPALE AHCVEFLTKH LRADNAFMLL TQARLFDEPQ
210 220 230 240 250
LASLCLDTID KSTVDAISAE GFTDIDIDTL CAVLERDTLS IRESRLFGAI
260 270 280 290 300
VRWAEAECQR QQLAVTFGNK QKVLGKALSL IRFPLMTIEE FAAGPAQSGI
310 320 330 340 350
LSDREVVNLF LHFTVNPKPR VEYIDRPRCC LRGKECCINR FQQVESRWGY
360 370 380 390 400
SGTSDRIRFT VNRRISVVGF GLYGSIHGPT DYQVNIQIIE YEKKQTLGQN
410 420 430 440 450
DTGFSCDGTA NTFRVMFKEP IEILPNVCYT ACATLKGPDS HYGTKGLKKV
460 470 480
VHETPAASKT VFLFFSSPGN NNGTSIEDGQ IPEIIFYT
Length:488
Mass (Da):53,233
Last modified:July 27, 2011 - v3
Checksum:i0CBDCA93EA10430F
GO

Sequence cautioni

The sequence AAH31192 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti21G → R in BAC40296 (PubMed:16141072).Curated1
Sequence conflicti99H → P in BAC40296 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK088345 mRNA Translation: BAC40296.1
BC031192 mRNA Translation: AAH31192.1 Different initiation.
BC072618 mRNA Translation: AAH72618.1
CCDSiCCDS21407.1
RefSeqiNP_666305.2, NM_146193.2
UniGeneiMm.439893

Genome annotation databases

EnsembliENSMUST00000026093; ENSMUSP00000026093; ENSMUSG00000025103
GeneIDi83962
KEGGimmu:83962
UCSCiuc009icn.1 mouse

Similar proteinsi

Entry informationi

Entry nameiBTBD1_MOUSE
AccessioniPrimary (citable) accession number: P58544
Secondary accession number(s): Q6GQU7, Q8BTZ0, Q8K0J0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: July 27, 2011
Last modified: June 20, 2018
This is version 125 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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