P58543 (ARAB_YERPE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ribulokinase
EC=2.7.1.16

Gene names

Name:	araB
Ordered Locus Names:	YPO2254, y2095, YP_2050

Organism

Yersinia pestis

Taxonomic identifier

632 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Yersinia

Protein attributes

Sequence length	563 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + L(or D)-ribulose = ADP + L(or D)-ribulose 5-phosphate. HAMAP MF_00520
Pathway	Carbohydrate degradation; L-arabinose degradation via L-ribulose; D-xylulose 5-phosphate from L-arabinose (bacterial route): step 2/3. HAMAP MF_00520
Sequence similarities	Belongs to the ribulokinase family.
Sequence caution	The sequence AAM85658.1 differs from that shown. Reason: Erroneous initiation. The sequence AAS62264.1 differs from that shown. Reason: Erroneous initiation. The sequence CAL20881.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Arabinose catabolism Carbohydrate metabolism
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	L-arabinose catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ribulokinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 563	563	Ribulokinase HAMAP MF_00520		PRO_0000198377

Sequences

	Sequence		Length	Mass (Da)
	P58543 [UniParc]. Last modified January 23, 2002. Version 1. Checksum: 88EF1E0B00A5414E	FASTA	563	61,833
	10 20 30 40 50 60 MISADGAIAL GLDFGSDSVR VLAVDCQHGT EIDTEVVYYP RWKKGLYCQA AQNQFRHHPL 70 80 90 100 110 120 DYIEAMEQAI RQMVKRLSEE QRQHIVGIGV DSTGSTPAPI DEQGQVLALR PDFADNPNAM 130 140 150 160 170 180 FVLWKDHTAI EEAEEINRLC RSGEFADYSR YIGGVYSSEW FWAKILHVTR ADVAVREAAV 190 200 210 220 230 240 SWIELCDWVP ALLSGTTAPQ DIQRGRCSAG HKSLWHPSWG GLPPRAFLAA LDTSLVNDLD 250 260 270 280 290 300 YPMFTDTYTA ERPVGQITAE WAERLGLPTT VILSGGAFDC HMGAVGAGAQ PYTLVKVIGT 310 320 330 340 350 360 STCDILIADD QRVGDRAIAG ICGQVEGSVL PGWIGMEAGQ SAFGDMYAWF SNLLSWPLHQ 370 380 390 400 410 420 AALTQPEWQP QLKQIESNLL ASLTRAWAQN PSLDHLPVVL DWFNGRRTPN ANQRLKGVIT 430 440 450 460 470 480 DLNLGTDAPT LFGGFIAATA FGARAIMECF EQQDIPIDNV LALGGIARKS PVIMQVCADV 490 500 510 520 530 540 MNRPLQIVAS DQCCALGAAI FAAVAAGAHD DVPTAQRHMA CNIERTLIPD PVQVVRYQQL 550 560 YQRYQQWCHT AEPHYAPVTK VIH

References

[1]	"Genome sequence of Yersinia pestis, the causative agent of plague." Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G., Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L., Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M., Chillingworth T., Cronin A., Davies R.M. , Davis P., Dougan G., Feltwell T., Hamlin N., Holroyd S., Jagels K., Karlyshev A.V., Leather S., Moule S., Oyston P.C.F., Quail M.A., Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S., Barrell B.G. Nature 413:523-527(2001) [PubMed: 11586360] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CO-92 / Biovar Orientalis.
[2]	"Genome sequence of Yersinia pestis KIM." Deng W., Burland V., Plunkett G. III, Boutin A., Mayhew G.F., Liss P., Perna N.T., Rose D.J., Mau B., Zhou S., Schwartz D.C., Fetherston J.D., Lindler L.E., Brubaker R.R., Plano G.V., Straley S.C., McDonough K.A., Nilles M.L. , Matson J.S., Blattner F.R., Perry R.D. J. Bacteriol. 184:4601-4611(2002) [PubMed: 12142430] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: KIM5 / Biovar Mediaevalis.
[3]	"Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans." Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D., Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L., Dai R. , Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H., Wang J., Huang P., Yang R. DNA Res. 11:179-197(2004) [PubMed: 15368893] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 91001 / Biovar Mediaevalis.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL590842 Genomic DNA. Translation: CAL20881.1. Different initiation. AE009952 Genomic DNA. Translation: AAM85658.1. Different initiation. AE017042 Genomic DNA. Translation: AAS62264.1. Different initiation.
PIR	AF0274.
RefSeq	NP_669407.1. NC_004088.1. NP_993387.1. NC_005810.1. YP_002347221.1. NC_003143.1.
3D structure databases
ProteinModelPortal	P58543.
ModBase	Search...
Protein-protein interaction databases
IntAct	P58543. 6 interactions.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1147042. 1175085. 2763639.
GenomeReviews	Gene locus y2095 in contig AE009952_GR. Gene locus YP_2050 in contig AE017042_GR. Gene locus YPO2254 in contig AL590842_GR.
KEGG	ype:YPO2254. ypk:y2095. ypm:YP_2050.
Phylogenomic databases
HOGENOM	HBG312681.
OMA	NGRRTPD.
ProtClustDB	PRK04123.
Enzyme and pathway databases
BioCyc	YPES187410:Y2095-MONOMER. YPES214092:YPO2254-MONOMER.
Family and domain databases
HAMAP	MF_00520. Ribulokinase. [Tree]
InterPro	IPR000577. Carb_kinase_FGGY. IPR018485. Carb_kinase_FGGY_C. IPR018484. Carb_kinase_FGGY_N. IPR005929. L_ribulokin. [Graphical view]
KO	K00853.
PANTHER	PTHR10196. FGGY_kin. 1 hit.
Pfam	PF02782. FGGY_C. 1 hit. PF00370. FGGY_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR01234. L-ribulokinase. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ARAB_YERPE

Accession

Primary (citable) accession number: P58543
Secondary accession number(s): Q0WER7

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 23, 2002
Last sequence update:	January 23, 2002
Last modified:	November 16, 2011
This is version 71 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program