P58512 (CU067_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Uncharacterized protein C21orf67

Gene names

Name:	C21orf67
Synonyms:	C21orf69

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	204 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Tissue specificity	Not detected in any tissue tested.
Sequence caution	The sequence AAK60445.1 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	endoplasmic reticulum Inferred from direct assay. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P58512-1)

Also known as: A;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Note: No experimental confirmation available.

Isoform 2 (identifier: P58512-2)

Also known as: B;

The sequence of this isoform differs from the canonical sequence as follows:
     72-82: LAADLAGDALP → CTSGASAGQKL
     83-204: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: P58512-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-22: MGWDCRRTTVENPSPIRNCVNQ → MARNRLIAASTSRTRAILPPQPLEK
     165-204: GGFPACLPAP...LDIPGAGAMG → GFPVSWRTRM...NNPGCLCVPS

Note: No experimental confirmation available. Gene prediction based on EST data.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 204	204	Uncharacterized protein C21orf67		PRO_0000079526
Natural variations
	Alternative sequence	1 – 22	22	MGWDC…NCVNQ → MARNRLIAASTSRTRAILPP QPLEK in isoform 3.		VSP_039828
	Alternative sequence	72 – 82	11	LAADLAGDALP → CTSGASAGQKL in isoform 2.		VSP_003829
	Alternative sequence	83 – 204	122	Missing in isoform 2.		VSP_003830
	Alternative sequence	165 – 204	40	GGFPA…AGAMG → GFPVSWRTRMRAFHLSLPGG AQLLTYLVKVLKRRTWRRNV DNNPGCLCVPS in isoform 3.		VSP_039829
Experimental info
	Sequence conflict	158	1	W → R in AAK60445. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (A) [UniParc]. Last modified January 23, 2002. Version 1. Checksum: F955EC4E414F2340	FASTA	204	21,308
	10 20 30 40 50 60 MGWDCRRTTV ENPSPIRNCV NQEWPEGSSP GLTEGNTGLV RDLRPAHQDR SGTREDPAGQ 70 80 90 100 110 120 ETTAITNPSP SLAADLAGDA LPGCLGAAAH QGPLLDRSSE STLGPQALEL EHCHERGCCR 130 140 150 160 170 180 GCASFSPFPA PRCPSERLGA HSSRWAIRGR SKINPPPWAP ACLPGGFPAC LPAPKSSTDS 190 200 ASSCFKGGRE FSDPLDIPGA GAMG
	Isoform 2 (B) [UniParc]. Checksum: C503145358575A72	FASTA	82	8,736
	10 20 30 40 50 60 MGWDCRRTTV ENPSPIRNCV NQEWPEGSSP GLTEGNTGLV RDLRPAHQDR SGTREDPAGQ 70 80 ETTAITNPSP SCTSGASAGQ KL
	Isoform 3 [UniParc]. Checksum: 8FD82D114E6699AE	FASTA	218	23,504
	10 20 30 40 50 60 MARNRLIAAS TSRTRAILPP QPLEKEWPEG SSPGLTEGNT GLVRDLRPAH QDRSGTREDP 70 80 90 100 110 120 AGQETTAITN PSPSLAADLA GDALPGCLGA AAHQGPLLDR SSESTLGPQA LELEHCHERG 130 140 150 160 170 180 CCRGCASFSP FPAPRCPSER LGAHSSRWAI RGRSKINPPP WAPACLPGFP VSWRTRMRAF 190 200 210 HLSLPGGAQL LTYLVKVLKR RTWRRNVDNN PGCLCVPS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"From PREDs and open reading frames to cDNA isolation: revisiting the human chromosome 21 transcription map." Reymond A., Friedli M., Neergaard Henrichsen C., Chapot F., Deutsch S., Ucla C., Rossier C., Lyle R., Guipponi M., Antonarakis S.E. Genomics 78:46-54(2001) [PubMed: 11707072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), NUCLEOTIDE SEQUENCE [MRNA] OF 152-204 (ISOFORM 3).
[2]	"The DNA sequence of human chromosome 21." Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A. , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L. Nature 405:311-319(2000) [PubMed: 10830953] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF380178 mRNA. Translation: AAL34496.1. AY035381 mRNA. Translation: AAK60445.1. Sequence problems. AY040088 mRNA. Translation: AAK74136.1. AL844908 Genomic DNA. No translation available.
IPI	IPI00067917. IPI00219867. IPI00926843.
UniGene	Hs.534504.
3D structure databases
ProteinModelPortal	P58512.
ModBase	Search...
Protein-protein interaction databases
STRING	P58512.
Polymorphism databases
DMDM	20137274.
Proteomic databases
PRIDE	P58512.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000330551; ENSP00000331610; ENSG00000183250.
UCSC	uc002zgj.2. human.
Organism-specific databases
GeneCards	GC21M046352.
HGNC	HGNC:15707. C21orf67.
neXtProt	NX_P58512.
GenAtlas	Search...
Phylogenomic databases
GeneTree	ENSGT00390000018577.
OMA	PSPIRNC.
Gene expression databases
ArrayExpress	P58512.
Bgee	P58512.
CleanEx	HS_C21orf67.
Genevestigator	P58512.
GermOnline	ENSG00000183250. Homo sapiens.
Family and domain databases
ProtoNet	Search...

Entry information

Entry name

CU067_HUMAN

Accession

Primary (citable) accession number: P58512
Secondary accession number(s): P58556, Q495D3, Q495D5

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 23, 2002
Last sequence update:	January 23, 2002
Last modified:	January 25, 2012
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.