Reviewed, UniProtKB/Swiss-Prot P58512 (CU067_HUMAN)

Names and origin

Protein names

Recommended name:
    Uncharacterized protein C21orf67

Gene names

Name:

C21orf67

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	204 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Tissue specificity	Not detected in any tissue tested.
Caution	Maps to the wrongly predicted PRED54 locus.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Technical term	Complete proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform A (identifier: P58512-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform B (identifier: P58512-2)

The sequence of this isoform differs from the canonical sequence as follows:
     72-82: LAADLAGDALP → CTSGASAGQKL
     83-204: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 204	204	Uncharacterized protein C21orf67		PRO_0000079526
Natural variations
	Alternative sequence	72 – 82	11	LAADLAGDALP → CTSGASAGQKL in isoform B.		VSP_003829
	Alternative sequence	83 – 204	122	Missing in isoform B.		VSP_003830

Sequences

	Sequence		Length	Mass (Da)
	Isoform A [UniParc]. Last modified January 23, 2002. Version 1. Checksum: F955EC4E414F2340	FASTA	204	21,308
	10 20 30 40 50 60 MGWDCRRTTV ENPSPIRNCV NQEWPEGSSP GLTEGNTGLV RDLRPAHQDR SGTREDPAGQ 70 80 90 100 110 120 ETTAITNPSP SLAADLAGDA LPGCLGAAAH QGPLLDRSSE STLGPQALEL EHCHERGCCR 130 140 150 160 170 180 GCASFSPFPA PRCPSERLGA HSSRWAIRGR SKINPPPWAP ACLPGGFPAC LPAPKSSTDS 190 200 ASSCFKGGRE FSDPLDIPGA GAMG
	Isoform B. Checksum: C503145358575A72	FASTA	82	8,736
	10 20 30 40 50 60 MGWDCRRTTV ENPSPIRNCV NQEWPEGSSP GLTEGNTGLV RDLRPAHQDR SGTREDPAGQ 70 80 ETTAITNPSP SCTSGASAGQ KL

References

[1]

"From PREDs and open reading frames to cDNA isolation: revisiting the human chromosome 21 transcription map." Reymond A., Friedli M., Neergaard Henrichsen C., Chapot F., Deutsch S., Ucla C., Rossier C., Lyle R., Guipponi M., Antonarakis S.E. Genomics 78:46-54(2001) [PubMed: 11707072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B).

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF380178 mRNA. Translation: AAL34496.1. AY040088 mRNA. Translation: AAK74136.1.
IPI	IPI00067917. IPI00219867.
UniGene	Hs.534504
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	P58512.
Proteomic databases
PRIDE	P58512.
Genome annotation databases
Ensembl	ENST00000330551; ENSP00000331610; ENSG00000183250; Homo sapiens. [Genome view]
UCSC	uc002zgj.2. human.
Organism-specific databases
GeneCards	GC21M045181. GC21M045182.
HGNC	HGNC:15707. C21orf67.
PharmGKB	PA25862.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	P58512.
OMA	PSPIRNC.
Gene expression databases
ArrayExpress	P58512.
Bgee	P58512.
CleanEx	HS_C21orf67.
Genevestigator	P58512.
GermOnline	ENSG00000183250. Homo sapiens.
Family and domain databases
ProtoNet	Search...

Entry information

Entry name

CU067_HUMAN

Accession

Primary (citable) accession number: P58512

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 23, 2002
Last sequence update:	January 23, 2002
Last modified:	December 15, 2009
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.