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Protein

Small integral membrane protein 11A

Gene

SMIM11A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Small integral membrane protein 11AImported
Gene namesi
Name:SMIM11AImported
Synonyms:C21orf51, FAM165B, SMIM11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

HGNCiHGNC:1293. SMIM11A.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei10 – 3223HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162387008.

Polymorphism and mutation databases

BioMutaiSMIM11.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 5858Small integral membrane protein 11APRO_0000079517Add
BLAST

Proteomic databases

EPDiP58511.
MaxQBiP58511.
PaxDbiP58511.
PRIDEiP58511.
TopDownProteomicsiP58511.

PTM databases

iPTMnetiP58511.
PhosphoSiteiP58511.

Expressioni

Tissue specificityi

Expressed in heart, spleen, liver, stomach, muscle, lung, testis, skin, PBL and bone marrow.

Gene expression databases

BgeeiP58511.
CleanExiHS_FAM165B.
ExpressionAtlasiP58511. baseline and differential.
GenevisibleiP58511. HS.

Organism-specific databases

HPAiHPA051321.

Interactioni

Protein-protein interaction databases

BioGridi119872. 2 interactions.
STRINGi9606.ENSP00000382231.

Structurei

3D structure databases

ProteinModelPortaliP58511.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili29 – 5830Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the SMIM11 family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J75V. Eukaryota.
ENOG410Z6JA. LUCA.
GeneTreeiENSGT00620000089398.
ENSGT00640000091610.
HOGENOMiHOG000060330.
HOVERGENiHBG107872.
InParanoidiP58511.
OMAiKVYQRKR.
OrthoDBiEOG715Q7C.
PhylomeDBiP58511.
TreeFamiTF330784.

Family and domain databases

InterProiIPR028023. SMIM11A/B.
[Graphical view]
PfamiPF14981. FAM165. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P58511-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNWKVLEHVP LLLYILAAKT LILCLTFAGV KMYQRKRLEA KQQKLEAERK

KQSEKKDN
Length:58
Mass (Da):6,886
Last modified:January 23, 2002 - v1
Checksum:i902E0799AD6E5854
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti51 – 511K → R.
Corresponds to variant rs34016792 [ dbSNP | Ensembl ].
VAR_054066

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY033902 mRNA. Translation: AAK68720.1.
AY081144 mRNA. Translation: AAL91138.1.
AP000320 Genomic DNA. No translation available.
AP000321 Genomic DNA. No translation available.
AP000322 Genomic DNA. No translation available.
BC015596 mRNA. Translation: AAH15596.1.
CCDSiCCDS33550.1.
RefSeqiNP_001300621.1. NM_001313692.1.
NP_478062.1. NM_058182.4.
UniGeneiHs.656195.

Genome annotation databases

EnsembliENST00000399292; ENSP00000382231; ENSG00000205670.
ENST00000399295; ENSP00000382234; ENSG00000205670.
GeneIDi102723553.
54065.
KEGGihsa:102723553.
hsa:54065.
UCSCiuc002ytu.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY033902 mRNA. Translation: AAK68720.1.
AY081144 mRNA. Translation: AAL91138.1.
AP000320 Genomic DNA. No translation available.
AP000321 Genomic DNA. No translation available.
AP000322 Genomic DNA. No translation available.
BC015596 mRNA. Translation: AAH15596.1.
CCDSiCCDS33550.1.
RefSeqiNP_001300621.1. NM_001313692.1.
NP_478062.1. NM_058182.4.
UniGeneiHs.656195.

3D structure databases

ProteinModelPortaliP58511.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119872. 2 interactions.
STRINGi9606.ENSP00000382231.

PTM databases

iPTMnetiP58511.
PhosphoSiteiP58511.

Polymorphism and mutation databases

BioMutaiSMIM11.

Proteomic databases

EPDiP58511.
MaxQBiP58511.
PaxDbiP58511.
PRIDEiP58511.
TopDownProteomicsiP58511.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000399292; ENSP00000382231; ENSG00000205670.
ENST00000399295; ENSP00000382234; ENSG00000205670.
GeneIDi102723553.
54065.
KEGGihsa:102723553.
hsa:54065.
UCSCiuc002ytu.5. human.

Organism-specific databases

CTDi102723553.
54065.
GeneCardsiSMIM11.
H-InvDBHIX0016088.
HGNCiHGNC:1293. SMIM11A.
HPAiHPA051321.
neXtProtiNX_P58511.
PharmGKBiPA162387008.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J75V. Eukaryota.
ENOG410Z6JA. LUCA.
GeneTreeiENSGT00620000089398.
ENSGT00640000091610.
HOGENOMiHOG000060330.
HOVERGENiHBG107872.
InParanoidiP58511.
OMAiKVYQRKR.
OrthoDBiEOG715Q7C.
PhylomeDBiP58511.
TreeFamiTF330784.

Miscellaneous databases

PROiP58511.

Gene expression databases

BgeeiP58511.
CleanExiHS_FAM165B.
ExpressionAtlasiP58511. baseline and differential.
GenevisibleiP58511. HS.

Family and domain databases

InterProiIPR028023. SMIM11A/B.
[Graphical view]
PfamiPF14981. FAM165. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "From PREDs and open reading frames to cDNA isolation: revisiting the human chromosome 21 transcription map."
    Reymond A., Friedli M., Neergaard Henrichsen C., Chapot F., Deutsch S., Ucla C., Rossier C., Lyle R., Guipponi M., Antonarakis S.E.
    Genomics 78:46-54(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Annotation of human chromosome 21 for relevance to Down syndrome: gene structure and expression analysis."
    Gardiner K., Slavov D., Bechtel L., Davisson M.
    Genomics 79:833-843(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The DNA sequence of human chromosome 21."
    Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A.
    , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.
    Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.

Entry informationi

Entry nameiSI11A_HUMAN
AccessioniPrimary (citable) accession number: P58511
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: January 23, 2002
Last modified: June 8, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.