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Protein

Small integral membrane protein 11A

Gene

SMIM11A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Small integral membrane protein 11AImported
Gene namesi
Name:SMIM11AImported
Synonyms:C21orf51Imported, FAM165BImported, SMIM11Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

EuPathDBiHostDB:ENSG00000205670.10.
HostDB:ENSG00000273590.4.
HGNCiHGNC:1293. SMIM11A.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei10 – 32HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi54065.
PharmGKBiPA162387008.

Polymorphism and mutation databases

BioMutaiSMIM11.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000795171 – 58Small integral membrane protein 11AAdd BLAST58

Proteomic databases

EPDiP58511.
MaxQBiP58511.
PaxDbiP58511.
PeptideAtlasiP58511.
PRIDEiP58511.
TopDownProteomicsiP58511.

PTM databases

iPTMnetiP58511.
PhosphoSitePlusiP58511.

Expressioni

Tissue specificityi

Expressed in heart, spleen, liver, stomach, muscle, lung, testis, skin, PBL and bone marrow.

Gene expression databases

BgeeiENSG00000205670.
CleanExiHS_FAM165B.
GenevisibleiP58511. HS.

Organism-specific databases

HPAiHPA051321.

Interactioni

Protein-protein interaction databases

BioGridi119872. 8 interactors.
IntActiP58511. 2 interactors.
STRINGi9606.ENSP00000382231.

Structurei

3D structure databases

ProteinModelPortaliP58511.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili29 – 58Sequence analysisAdd BLAST30

Sequence similaritiesi

Belongs to the SMIM11 family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J75V. Eukaryota.
ENOG410Z6JA. LUCA.
GeneTreeiENSGT00640000091610.
HOGENOMiHOG000060330.
HOVERGENiHBG107872.
InParanoidiP58511.
OMAiKVYQRKR.
PhylomeDBiP58511.
TreeFamiTF330784.

Family and domain databases

InterProiView protein in InterPro
IPR028023. SMIM11A.
PfamiView protein in Pfam
PF14981. FAM165. 1 hit.

Sequencei

Sequence statusi: Complete.

P58511-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNWKVLEHVP LLLYILAAKT LILCLTFAGV KMYQRKRLEA KQQKLEAERK

KQSEKKDN
Length:58
Mass (Da):6,886
Last modified:January 23, 2002 - v1
Checksum:i902E0799AD6E5854
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05406651K → R. Corresponds to variant dbSNP:rs34016792Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY033902 mRNA. Translation: AAK68720.1.
AY081144 mRNA. Translation: AAL91138.1.
AP000320 Genomic DNA. No translation available.
AP000321 Genomic DNA. No translation available.
AP000322 Genomic DNA. No translation available.
BC015596 mRNA. Translation: AAH15596.1.
CCDSiCCDS33550.1.
RefSeqiNP_001300621.1. NM_001313692.1.
NP_478062.1. NM_058182.4.
XP_016883692.1. XM_017028203.1.
XP_016883693.1. XM_017028204.1.
XP_016883694.1. XM_017028205.1.
XP_016883886.1. XM_017028397.1.
XP_016883887.1. XM_017028398.1.
XP_016883888.1. XM_017028399.1.
UniGeneiHs.656195.

Genome annotation databases

EnsembliENST00000399292; ENSP00000382231; ENSG00000205670.
ENST00000399295; ENSP00000382234; ENSG00000205670.
GeneIDi102723553.
54065.
KEGGihsa:102723553.
hsa:54065.
UCSCiuc002ytu.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSI11A_HUMAN
AccessioniPrimary (citable) accession number: P58511
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: January 23, 2002
Last modified: September 27, 2017
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families