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Protein

Uncharacterized protein C21orf58

Gene

C21orf58

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein C21orf58
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

HGNCiHGNC:1300. C21orf58.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25853.

Polymorphism and mutation databases

BioMutaiC21orf58.
DMDMi215274005.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 322322Uncharacterized protein C21orf58PRO_0000079521Add
BLAST

Proteomic databases

EPDiP58505.
PaxDbiP58505.
PRIDEiP58505.

Expressioni

Tissue specificityi

Expressed in skin and fetal lung.

Gene expression databases

BgeeiP58505.
CleanExiHS_C21orf58.
ExpressionAtlasiP58505. baseline and differential.
GenevisibleiP58505. HS.

Organism-specific databases

HPAiHPA035110.
HPA035111.

Interactioni

Protein-protein interaction databases

BioGridi119868. 3 interactions.
IntActiP58505. 1 interaction.
STRINGi9606.ENSP00000291691.

Structurei

3D structure databases

ProteinModelPortaliP58505.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi292 – 2998Poly-His

Phylogenomic databases

eggNOGiENOG410IXTF. Eukaryota.
ENOG4111KPW. LUCA.
GeneTreeiENSGT00390000011514.
HOGENOMiHOG000116176.
HOVERGENiHBG051235.
InParanoidiP58505.
OMAiRKPWKLD.
PhylomeDBiP58505.
TreeFamiTF336319.

Family and domain databases

InterProiIPR027904. DUF4587.
[Graphical view]
PfamiPF15248. DUF4587. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P58505-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MARSRLPATS LRKPWKLDRQ KLPSPDSGHS LLCGWSPGGK ARPAGNTGAW
60 70 80 90 100
APAEQFFPAS NRTREGGGLW PPLPLQSSPA APTMLDSSAA EQVTRLTLKL
110 120 130 140 150
LGQKLEQERQ NVEGGPEGLH LEPGNEDRPD DALQTALKRR RDLLQRLREQ
160 170 180 190 200
HLLDELSRAQ AWSGPSRGAL GSALPPELPP TGILPTASPS PLAPDPPRII
210 220 230 240 250
LPTVPQPPAT IIQQLPQQPL IAQIPPPQAF PTQRSGSIKE DMVELLLLQN
260 270 280 290 300
AQVHQLVLQN WMLKALPPAL QDPPHVPPRV PRAARPRLPA VHHHHHHHHA
310 320
VWPPGAATVL QPAPSLWTPG PP
Length:322
Mass (Da):35,003
Last modified:November 25, 2008 - v2
Checksum:i06DB0577FFAD57D6
GO
Isoform 2 (identifier: P58505-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     273-277: PPHVP → RFFHS
     278-322: Missing.

Show »
Length:277
Mass (Da):30,223
Checksum:i0897697CD10B644F
GO
Isoform 3 (identifier: P58505-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-148: MARSRLPATS...RRRDLLQRLR → MAILPGEAPV...VCSSSASALQ

Note: No experimental confirmation available.
Show »
Length:216
Mass (Da):22,742
Checksum:i4DB52066639EBCAC
GO

Sequence cautioni

The sequence AAK72408.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAK72409.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti111 – 1111N → D in BAG51693 (PubMed:14702039).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 148148MARSR…LQRLR → MAILPGEAPVPGPGWPEPDA GGASVALGLPVPVCSSSASA LQ in isoform 3. VSP_057984Add
BLAST
Alternative sequencei273 – 2775PPHVP → RFFHS in isoform 2. 1 PublicationVSP_003827
Alternative sequencei278 – 32245Missing in isoform 2. 1 PublicationVSP_003828Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK098098 mRNA. Translation: BAC05232.1.
AK056387 mRNA. Translation: BAG51693.1.
AP000471 Genomic DNA. No translation available.
AY039243 mRNA. Translation: AAK72408.1. Different initiation.
AY039244 mRNA. Translation: AAK72409.1. Different initiation.
CCDSiCCDS13735.1. [P58505-1]
CCDS68229.1. [P58505-3]
RefSeqiNP_001273391.1. NM_001286462.1. [P58505-3]
NP_001273392.1. NM_001286463.1. [P58505-3]
NP_001273405.1. NM_001286476.1. [P58505-3]
NP_001273406.1. NM_001286477.1. [P58505-3]
NP_478060.2. NM_058180.4. [P58505-1]
XP_005261205.1. XM_005261148.3. [P58505-1]
XP_006724081.1. XM_006724018.2. [P58505-2]
XP_011527921.1. XM_011529619.1. [P58505-1]
XP_011527922.1. XM_011529620.1. [P58505-1]
XP_011527927.1. XM_011529625.1.
XP_011527928.1. XM_011529626.1. [P58505-3]
XP_011527929.1. XM_011529627.1. [P58505-3]
UniGeneiHs.236572.
Hs.744525.

Genome annotation databases

EnsembliENST00000291691; ENSP00000291691; ENSG00000160298. [P58505-1]
ENST00000397679; ENSP00000380796; ENSG00000160298. [P58505-3]
ENST00000397680; ENSP00000380797; ENSG00000160298. [P58505-3]
ENST00000397682; ENSP00000380798; ENSG00000160298. [P58505-3]
ENST00000397683; ENSP00000380799; ENSG00000160298. [P58505-3]
GeneIDi54058.
KEGGihsa:54058.
UCSCiuc002zja.3. human.
uc002zjf.5. human. [P58505-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK098098 mRNA. Translation: BAC05232.1.
AK056387 mRNA. Translation: BAG51693.1.
AP000471 Genomic DNA. No translation available.
AY039243 mRNA. Translation: AAK72408.1. Different initiation.
AY039244 mRNA. Translation: AAK72409.1. Different initiation.
CCDSiCCDS13735.1. [P58505-1]
CCDS68229.1. [P58505-3]
RefSeqiNP_001273391.1. NM_001286462.1. [P58505-3]
NP_001273392.1. NM_001286463.1. [P58505-3]
NP_001273405.1. NM_001286476.1. [P58505-3]
NP_001273406.1. NM_001286477.1. [P58505-3]
NP_478060.2. NM_058180.4. [P58505-1]
XP_005261205.1. XM_005261148.3. [P58505-1]
XP_006724081.1. XM_006724018.2. [P58505-2]
XP_011527921.1. XM_011529619.1. [P58505-1]
XP_011527922.1. XM_011529620.1. [P58505-1]
XP_011527927.1. XM_011529625.1.
XP_011527928.1. XM_011529626.1. [P58505-3]
XP_011527929.1. XM_011529627.1. [P58505-3]
UniGeneiHs.236572.
Hs.744525.

3D structure databases

ProteinModelPortaliP58505.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119868. 3 interactions.
IntActiP58505. 1 interaction.
STRINGi9606.ENSP00000291691.

Polymorphism and mutation databases

BioMutaiC21orf58.
DMDMi215274005.

Proteomic databases

EPDiP58505.
PaxDbiP58505.
PRIDEiP58505.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000291691; ENSP00000291691; ENSG00000160298. [P58505-1]
ENST00000397679; ENSP00000380796; ENSG00000160298. [P58505-3]
ENST00000397680; ENSP00000380797; ENSG00000160298. [P58505-3]
ENST00000397682; ENSP00000380798; ENSG00000160298. [P58505-3]
ENST00000397683; ENSP00000380799; ENSG00000160298. [P58505-3]
GeneIDi54058.
KEGGihsa:54058.
UCSCiuc002zja.3. human.
uc002zjf.5. human. [P58505-1]

Organism-specific databases

CTDi54058.
GeneCardsiC21orf58.
H-InvDBHIX0203120.
HGNCiHGNC:1300. C21orf58.
HPAiHPA035110.
HPA035111.
neXtProtiNX_P58505.
PharmGKBiPA25853.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IXTF. Eukaryota.
ENOG4111KPW. LUCA.
GeneTreeiENSGT00390000011514.
HOGENOMiHOG000116176.
HOVERGENiHBG051235.
InParanoidiP58505.
OMAiRKPWKLD.
PhylomeDBiP58505.
TreeFamiTF336319.

Miscellaneous databases

ChiTaRSiC21orf58. human.
GenomeRNAii54058.
NextBioi56364.
PROiP58505.

Gene expression databases

BgeeiP58505.
CleanExiHS_C21orf58.
ExpressionAtlasiP58505. baseline and differential.
GenevisibleiP58505. HS.

Family and domain databases

InterProiIPR027904. DUF4587.
[Graphical view]
PfamiPF15248. DUF4587. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
  2. "The DNA sequence of human chromosome 21."
    Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A.
    , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.
    Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "From PREDs and open reading frames to cDNA isolation: revisiting the human chromosome 21 transcription map."
    Reymond A., Friedli M., Neergaard Henrichsen C., Chapot F., Deutsch S., Ucla C., Rossier C., Lyle R., Guipponi M., Antonarakis S.E.
    Genomics 78:46-54(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 39-322 (ISOFORMS 1 AND 2).

Entry informationi

Entry nameiCU058_HUMAN
AccessioniPrimary (citable) accession number: P58505
Secondary accession number(s): B3KPI1, Q8N7N9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 19, 2001
Last sequence update: November 25, 2008
Last modified: May 11, 2016
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.