Reviewed, UniProtKB/Swiss-Prot P58505 (CU058_HUMAN)

Names and origin

Protein names

Recommended name:
    Uncharacterized protein C21orf58

Gene names

Name:

C21orf58

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	322 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Tissue specificity

Expressed in skin and fetal lung.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Technical term	Complete proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform A (identifier: P58505-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform B (identifier: P58505-2)

The sequence of this isoform differs from the canonical sequence as follows:
     273-277: PPHVP → RFFHS
     278-322: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 322	322	Uncharacterized protein C21orf58		PRO_0000079521
Regions
	Compositional bias	292 – 299	8	Poly-His
Natural variations
	Alternative sequence	273 – 277	5	PPHVP → RFFHS in isoform B.		VSP_003827
	Alternative sequence	278 – 322	45	Missing in isoform B.		VSP_003828
Experimental info
	Sequence conflict	111	1	N → D in BAG51693. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform A [UniParc]. Last modified November 25, 2008. Version 2. Checksum: 06DB0577FFAD57D6	FASTA	322	35,003
	10 20 30 40 50 60 MARSRLPATS LRKPWKLDRQ KLPSPDSGHS LLCGWSPGGK ARPAGNTGAW APAEQFFPAS 70 80 90 100 110 120 NRTREGGGLW PPLPLQSSPA APTMLDSSAA EQVTRLTLKL LGQKLEQERQ NVEGGPEGLH 130 140 150 160 170 180 LEPGNEDRPD DALQTALKRR RDLLQRLREQ HLLDELSRAQ AWSGPSRGAL GSALPPELPP 190 200 210 220 230 240 TGILPTASPS PLAPDPPRII LPTVPQPPAT IIQQLPQQPL IAQIPPPQAF PTQRSGSIKE 250 260 270 280 290 300 DMVELLLLQN AQVHQLVLQN WMLKALPPAL QDPPHVPPRV PRAARPRLPA VHHHHHHHHA 310 320 VWPPGAATVL QPAPSLWTPG PP
	Isoform B. Checksum: 0897697CD10B644F	FASTA	277	30,223
	10 20 30 40 50 60 MARSRLPATS LRKPWKLDRQ KLPSPDSGHS LLCGWSPGGK ARPAGNTGAW APAEQFFPAS 70 80 90 100 110 120 NRTREGGGLW PPLPLQSSPA APTMLDSSAA EQVTRLTLKL LGQKLEQERQ NVEGGPEGLH 130 140 150 160 170 180 LEPGNEDRPD DALQTALKRR RDLLQRLREQ HLLDELSRAQ AWSGPSRGAL GSALPPELPP 190 200 210 220 230 240 TGILPTASPS PLAPDPPRII LPTVPQPPAT IIQQLPQQPL IAQIPPPQAF PTQRSGSIKE 250 260 270 DMVELLLLQN AQVHQLVLQN WMLKALPPAL QDRFFHS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A).
[2]	"The DNA sequence of human chromosome 21." Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A. , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L. Nature 405:311-319(2000) [PubMed: 10830953] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"From PREDs and open reading frames to cDNA isolation: revisiting the human chromosome 21 transcription map." Reymond A., Friedli M., Neergaard Henrichsen C., Chapot F., Deutsch S., Ucla C., Rossier C., Lyle R., Guipponi M., Antonarakis S.E. Genomics 78:46-54(2001) [PubMed: 11707072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 39-322 (ISOFORMS A AND B).

Cross-references

Sequence databases
EMBLGenBankDDBJ	AK056387 mRNA. Translation: BAG51693.1. AP000471 Genomic DNA. No translation available. AY039243 mRNA. Translation: AAK72408.1. Different initiation. AY039244 mRNA. Translation: AAK72409.1. Different initiation.
IPI	IPI00291921. IPI00396359.
RefSeq	NP_478060.2.
UniGene	Hs.236572
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	P58505. 1 interaction.
STRING	P58505.
Genome annotation databases
Ensembl	ENST00000291691; ENSP00000291691; ENSG00000160298; Homo sapiens. [Genome view]
GeneID	54058.
KEGG	hsa:54058.
UCSC	uc002ziz.2. human. uc002zjf.1. human.
Organism-specific databases
CTD	54058.
GeneCards	GC21M046545.
HGNC	HGNC:1300. C21orf58.
PharmGKB	PA25853.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	P58505.
HOVERGEN	P58505.
OMA	HQILMQN
Enzyme and pathway databases
BioCyc	CATTLE:ENSBTAG00000021984-MON.
Gene expression databases
ArrayExpress	P58505.
Bgee	P58505.
CleanEx	HS_C21orf58.
Genevestigator	P58505.
GermOnline	ENSG00000160298. Homo sapiens.
Family and domain databases
ProtoNet	Search...
Other Resources
NextBio	56364.

Entry information

Entry name

CU058_HUMAN

Accession

Primary (citable) accession number: P58505
Secondary accession number(s): B3KPI1

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 19, 2001
Last sequence update:	November 25, 2008
Last modified:	November 24, 2009
This is version 52 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.