P58504 (KA102_CENNO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Potassium channel toxin alpha-KTx 10.2 Alternative name(s): Cobatoxin-2 Short name=CoTx2
Organism	Centruroides noxius (Mexican scorpion)
Taxonomic identifier	6878 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Arthropoda › Chelicerata › Arachnida › Scorpiones › Buthida › Buthoidea › Buthidae › Centruroides

Protein attributes

Sequence length	32 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Blocks Shaker B potassium-channels (Kv1.1/KCNA1 sub-family). Ref.1
Subcellular location	Secreted.
Tissue specificity	Expressed by the venom gland.
Sequence similarities	Belongs to the short scorpion toxin superfamily. Potassium channel inhibitor family. Alpha-KTx 10 subfamily.

Ontologies

Keywords
Cellular component	Secreted
Molecular function	Ionic channel inhibitor Neurotoxin Potassium channel inhibitor Toxin
PTM	Disulfide bond
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	pathogenesis Inferred from electronic annotation. Source: InterPro
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	potassium channel inhibitor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Peptide	1 – 32	32	Potassium channel toxin alpha-KTx 10.2		PRO_0000044907
Sites
	Site	21	1	Basic residue of the functional dyad By similarity
	Site	30	1	Aromatic residue of the functional dyad By similarity
Amino acid modifications
	Disulfide bond	3 ↔ 22		By similarity
	Disulfide bond	8 ↔ 12		By similarity
	Disulfide bond	27 ↔ 29		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P58504 [UniParc]. Last modified December 19, 2001. Version 1. Checksum: A390616E150839EF	FASTA	32	3,713
	10 20 30 VACVYRTCDK DCTSRKYRSG KCINNACKCY PY

References

[1]

"Cobatoxins 1 and 2 from Centruroides noxius Hoffmann constitute a new subfamily of potassium-channel-blocking scorpion toxins." Selisko B., Garcia C., Becerril B., Gomez-Lagunas F., Garay C., Possani L.D. Eur. J. Biochem. 254:468-479(1998) [PubMed: 9688256] [Abstract] Cited for: PROTEIN SEQUENCE, FUNCTION. Tissue: Venom.

Cross-references

3D structure databases
ProteinModelPortal	P58504.
SMR	P58504. Positions 2-32.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR001947. Scorpion_toxinS. [Graphical view]
PROSITE	PS01138. SCORP_SHORT_TOXIN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KA102_CENNO

Accession

Primary (citable) accession number: P58504

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 19, 2001
Last sequence update:	December 19, 2001
Last modified:	November 16, 2011
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Animal Toxin Annotation Program