P58499 (FAM3B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein FAM3B

Alternative name(s):
Cytokine-like protein 2-21
Pancreatic-derived factor
Short name=PANDER

Gene names

Name:	FAM3B
Synonyms:	C21orf11, C21orf76
ORF Names:	PRED44, UNQ320/PRO365

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	235 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Induces apoptosis of alpha and beta cells in a dose- and time-dependent manner. Present in insulin secretory granules and likely cosecreted with insulin. Ref.5
Subcellular location	Secreted. Note: Localized in discrete vesicular and perinuclear structure.
Tissue specificity	Highly expressed in the pancreas. Also found in the colon, kidney, prostate, small intestine and testis. Ref.5
Post-translational modification	2 N-termini have been observed in the mature protein: the first at Glu-30, resulting from signal peptide cleavage, the second at Ser-46.
Sequence similarities	Belongs to the FAM3 family.

Ontologies

Keywords
Biological process	Apoptosis
Cellular component	Secreted
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Signal
Molecular function	Cytokine
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological process	apoptotic process Inferred from electronic annotation. Source: UniProtKB-KW insulin secretion Inferred from direct assay Ref.2. Source: UniProtKB
Cellular component	extracellular space Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	cytokine activity Non-traceable author statement Ref.2. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform B (identifier: P58499-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform A (identifier: P58499-2)

The sequence of this isoform differs from the canonical sequence as follows:
     7-7: G → GSRWACWLTRCLISCFDINVQGRLLVKLRPKPTANTTCPG

Isoform C (identifier: P58499-3)

The sequence of this isoform differs from the canonical sequence as follows:
     7-54: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 29	29
	Chain	30 – 235	206	Protein FAM3B		PRO_0000008750
Amino acid modifications
	Glycosylation	120	1	N-linked (GlcNAc...) Potential
	Glycosylation	208	1	N-linked (GlcNAc...) Potential
	Disulfide bond	63 ↔ 69		Potential
	Disulfide bond	91 ↔ 229		Ref.5
Natural variations
	Alternative sequence	7 – 54	48	Missing in isoform C.		VSP_001505
	Alternative sequence	7	1	G → GSRWACWLTRCLISCFDINV QGRLLVKLRPKPTANTTCPG in isoform A.		VSP_001504
	Natural variant	14	1	V → M. Corresponds to variant rs2838012 [ dbSNP | Ensembl ].		VAR_021953

Sequences

	Sequence		Length	Mass (Da)
	Isoform B [UniParc]. Last modified October 10, 2002. Version 2. Checksum: 05B74722D03155FF	FASTA	235	25,982
	10 20 30 40 50 60 MRPLAGGLLK VVFVVFASLC AWYSGYLLAE LIPDAPLSSA AYSIRSIGER PVLKAPVPKR 70 80 90 100 110 120 QKCDHWTPCP SDTYAYRLLS GGGRSKYAKI CFEDNLLMGE QLGNVARGIN IAIVNYVTGN 130 140 150 160 170 180 VTATRCFDMY EGDNSGPMTK FIQSAAPKSL LFMVTYDDGS TRLNNDAKNA IEALGSKEIR 190 200 210 220 230 NMKFRSSWVF IAAKGLELPS EIQREKINHS DAKNNRYSGW PAEIQIEGCI PKERS
	Isoform A [UniParc]. Checksum: 4727D6EC48D2AD7A	FASTA	274	30,383
	10 20 30 40 50 60 MRPLAGGSRW ACWLTRCLIS CFDINVQGRL LVKLRPKPTA NTTCPGLLKV VFVVFASLCA 70 80 90 100 110 120 WYSGYLLAEL IPDAPLSSAA YSIRSIGERP VLKAPVPKRQ KCDHWTPCPS DTYAYRLLSG 130 140 150 160 170 180 GGRSKYAKIC FEDNLLMGEQ LGNVARGINI AIVNYVTGNV TATRCFDMYE GDNSGPMTKF 190 200 210 220 230 240 IQSAAPKSLL FMVTYDDGST RLNNDAKNAI EALGSKEIRN MKFRSSWVFI AAKGLELPSE 250 260 270 IQREKINHSD AKNNRYSGWP AEIQIEGCIP KERS
	Isoform C [UniParc]. Checksum: 49124303689B545F	FASTA	187	20,815
	10 20 30 40 50 60 MRPLAGAPVP KRQKCDHWTP CPSDTYAYRL LSGGGRSKYA KICFEDNLLM GEQLGNVARG 70 80 90 100 110 120 INIAIVNYVT GNVTATRCFD MYEGDNSGPM TKFIQSAAPK SLLFMVTYDD GSTRLNNDAK 130 140 150 160 170 180 NAIEALGSKE IRNMKFRSSW VFIAAKGLEL PSEIQREKIN HSDAKNNRYS GWPAEIQIEG CIPKERS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"From PREDs and open reading frames to cDNA isolation: revisiting the human chromosome 21 transcription map." Reymond A., Friedli M., Neergaard Henrichsen C., Chapot F., Deutsch S., Ucla C., Rossier C., Lyle R., Guipponi M., Antonarakis S.E. Genomics 78:46-54(2001) [PubMed: 11707072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A; B AND C).
[2]	"Cloning, expression, and initial characterization of a novel cytokine-like gene family." Zhu Y., Xu G., Patel A., McLaughlin M.M., Silverman C., Knecht K.A., Sweitzer S., Li X., McDonnell P., Mirabile R., Zimmerman D., Boyce R., Tierney L.A., Hu E., Livi G.P., Wolf B.A., Abdel-Meguid S.S., Rose G.D. , Aurora R., Hensley P., Briggs M., Young P.R. Genomics 80:144-150(2002) [PubMed: 12160727] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM B), PARTIAL PROTEIN SEQUENCE, CHARACTERIZATION.
[3]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed: 12975309] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B).
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B). Tissue: Placenta.
[5]	"Structure-function studies of PANDER, an islet specific cytokine inducing cell death of insulin-secreting beta cells." Yang J., Gao Z., Robert C.E., Burkhardt B.R., Gaweska H., Wagner A., Wu J., Greene S.R., Young R.A., Wolf B.A. Biochemistry 44:11342-11352(2005) [PubMed: 16114871] [Abstract] Cited for: FUNCTION, TISSUE SPECIFICITY, DISULFIDE BONDS.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ409094 mRNA. Translation: CAC83974.1. AF375989 mRNA. Translation: AAL34495.1. AY040086 mRNA. Translation: AAK74134.1. AF494379 mRNA. Translation: AAM94280.1. AY358459 mRNA. Translation: AAQ88824.1. BC057829 mRNA. Translation: AAH57829.1.
IPI	IPI00067738. IPI00219788. IPI00219789.
RefSeq	NP_478066.3. NM_058186.3. NP_996847.1. NM_206964.1.
UniGene	Hs.473877. Hs.670704.
3D structure databases
ProteinModelPortal	P58499.
ModBase	Search...
Protein-protein interaction databases
STRING	P58499.
Polymorphism databases
DMDM	23821535.
Proteomic databases
PRIDE	P58499.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000357985; ENSP00000350673; ENSG00000183844.
GeneID	54097.
KEGG	hsa:54097.
UCSC	uc002yzb.1. human. uc002yzc.1. human.
Organism-specific databases
CTD	54097.
GeneCards	GC21P042676.
H-InvDB	HIX0203130.
HGNC	HGNC:1253. FAM3B.
HPA	HPA015885.
MIM	608617. gene.
neXtProt	NX_P58499.
PharmGKB	PA27979.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG09340.
GeneTree	ENSGT00530000063020.
HOVERGEN	HBG099991.
InParanoid	P58499.
OrthoDB	EOG48WC2S.
Gene expression databases
ArrayExpress	P58499.
Bgee	P58499.
CleanEx	HS_FAM3B.
Genevestigator	P58499.
GermOnline	ENSG00000183844. Homo sapiens.
Family and domain databases
ProtoNet	Search...
Other
NextBio	56442.
SOURCE	Search...

Entry information

Entry name

FAM3B_HUMAN

Accession

Primary (citable) accession number: P58499

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 19, 2001
Last sequence update:	October 10, 2002
Last modified:	January 25, 2012
This is version 89 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.