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Protein

Potassium channel toxin alpha-KTx 6.4

Gene
N/A
Organism
Pandinus imperator (Emperor scorpion)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Potently, completely and reversibly blocks voltage-gated potassium channel Kv1.2/KCNA2 and Shaker B (Sh). Also blocks small conductance (SK) calcium-activated potassium channel (KCNN).1 Publication

Miscellaneous

This toxin has no effect on voltage-gated potassium channel Kv1.1/KCNA1 and Kv1.3/KCNA3.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei10Important for the interaction with Kv1.2/KCNA2 channel1 Publication1
Sitei19Important for the interaction with Kv1.2/KCNA2 channel1 Publication1
Sitei26Basic residue of the functional dyad, important for the interaction with Kv1.2/KCNA2 channel1 Publication1
Sitei28Important for the interaction with Kv1.2/KCNA2 channel1 Publication1
Sitei30Important for the interaction with Kv1.2/KCNA2 channel1 Publication1
Sitei33Important for the interaction with Kv1.2/KCNA2 channel1 Publication1
Sitei35Aromatic residue of the functional dyad, important for the interaction with Kv1.2/KCNA2 channel1 Publication1

GO - Molecular functioni

Keywordsi

Molecular functionCalcium-activated potassium channel impairing toxin, Ion channel impairing toxin, Potassium channel impairing toxin, Toxin, Voltage-gated potassium channel impairing toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium channel toxin alpha-KTx 6.4
Alternative name(s):
Potassium channel-blocking toxin 4
Short name:
Pi-4
Short name:
Pi4
OrganismiPandinus imperator (Emperor scorpion)
Taxonomic identifieri55084 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesIuridaScorpionoideaScorpionidaeScorpioninaePandinus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Toxic dosei

LD50 is 10 µg/kg by intracerebroventricular injection into mice.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PeptideiPRO_00000449131 – 38Potassium channel toxin alpha-KTx 6.41 PublicationAdd BLAST38

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi6 ↔ 272 Publications
Disulfide bondi12 ↔ 322 Publications
Disulfide bondi16 ↔ 342 Publications
Disulfide bondi22 ↔ 372 Publications

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.1 Publication

Structurei

Secondary structure

138
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi10 – 20Combined sources11
Beta strandi25 – 28Combined sources4
Beta strandi31 – 34Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1N8MNMR-A1-38[»]
ProteinModelPortaliP58498
SMRiP58498
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP58498

Family & Domainsi

Domaini

Has the structural arrangement of an alpha-helix connected to a beta-sheet by disulfide bonds (CSalpha/beta).1 Publication

Sequence similaritiesi

Family and domain databases

Gene3Di3.30.30.10, 1 hit
InterProiView protein in InterPro
IPR036574 Scorpion_toxin-like_sf
IPR001947 Scorpion_toxinS_K_inh
PfamiView protein in Pfam
PF00451 Toxin_2, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD003586 Scorpion_toxinS, 1 hit
SUPFAMiSSF57095 SSF57095, 1 hit
PROSITEiView protein in PROSITE
PS01138 SCORP_SHORT_TOXIN, 1 hit

Sequencei

Sequence statusi: Complete.

P58498-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30 
IEAIRCGGSR DCYRPCQKRT GCPNAKCINK TCKCYGCS
Length:38
Mass (Da):4,188
Last modified:December 19, 2001 - v1
Checksum:i1C1F402B8DF2EEFF
GO

Similar proteinsi

Entry informationi

Entry nameiKAX64_PANIM
AccessioniPrimary (citable) accession number: P58498
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 19, 2001
Last sequence update: December 19, 2001
Last modified: May 23, 2018
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Scorpion potassium channel toxins
    Nomenclature of scorpion potassium channel toxins and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

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