P58478 (HTPG_RICCN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Chaperone protein HtpG

Alternative name(s):
Heat shock protein HtpG
High temperature protein G

Gene names

Name:	htpG
Ordered Locus Names:	RC1302

Organism

Rickettsia conorii (strain ATCC VR-613 / Malish 7) [Complete proteome] [HAMAP]

Taxonomic identifier

272944 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › spotted fever group › Rickettsia conorii

Protein attributes

Sequence length	621 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Molecular chaperone. Has ATPase activity By similarity. HAMAP-Rule MF_00505
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the heat shock protein 90 family.

Ontologies

Keywords
Biological process	Stress response
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Chaperone
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	protein folding Inferred from electronic annotation. Source: HAMAP response to stress Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 621	621	Chaperone protein HtpG HAMAP-Rule MF_00505		PRO_0000063010
Regions
	Region	1 – 328	328	A; substrate-binding By similarity
	Region	329 – 544	216	B By similarity
	Region	545 – 621	77	C By similarity

Sequences

	Sequence		Length	Mass (Da)
	P58478 [UniParc]. Last modified December 13, 2001. Version 1. Checksum: FF6E5B352DD8F017	FASTA	621	70,804
	10 20 30 40 50 60 MIQEKKKFDA EVGKILNLMI HSLYSNKEIF MRELISNASD ACDKLRYLSQ SNSELVAGDS 70 80 90 100 110 120 NFKITVKVDK DHRQIIIRDN GIGMNKDDLI ENLGTIARSG TANFLKSLSG DSKKDNMLIG 130 140 150 160 170 180 QFGVGFYSSF MVADKVTVTS RKAGEDKVHI WESDGLGEYT VSDSDKEFTR GTEIVLHIKK 190 200 210 220 230 240 EEDTFLDHFR LKHIVKSYSD HIAVPIYFFD EAGNNEIQLN SASALWTRPK SEITEEQYKE 250 260 270 280 290 300 FYKSLSYAID DPWITMHNKN EGAIEFTNLL FIPSSKTFDL FHPDRKRRVK LYIKRVFISD 310 320 330 340 350 360 ENIDLIPSYL RFLRGVVDSE DLPLNISRES LQHNSVLEKI KNAITKRVLG ELRKKKEESP 370 380 390 400 410 420 EEYNKFWANF GGALKEGLCE ATTNHEKLLE VCIFRSALHN KMISLDEYIA NFKEGQSTIY 430 440 450 460 470 480 YLSGDNPDKL LSSPQIEGLL SKKIDVLLFT DTVDDFWVNV NSKYKEHAIK SATRSDIDVE 490 500 510 520 530 540 QTTSQSEEKN TDSTKSNDEY KLLTDYFKET LGELVKEVKI SKKLTSSPAC LAVSDAAMDI 550 560 570 580 590 600 RMERFLIEQK QIANASAKNL ELNPKNKIIE KIFNDLKANN KNNEELVNLI FDQACILEGE 610 620 PVADTGAFSK RLNDIVQKAI L

References

[1]

"Mechanisms of evolution in Rickettsia conorii and R. prowazekii." Ogata H., Audic S., Renesto-Audiffren P., Fournier P.-E., Barbe V., Samson D., Roux V., Cossart P., Weissenbach J., Claverie J.-M., Raoult D. Science 293:2093-2098(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC VR-613 / Malish 7.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE006914 Genomic DNA. Translation: AAL03840.1.
PIR	F97862.
RefSeq	NP_360939.1. NC_003103.1.
3D structure databases
ProteinModelPortal	P58478.
ModBase	Search...
Protein-protein interaction databases
STRING	272944.RC1302.
Proteomic databases
PRIDE	P58478.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAL03840; AAL03840; RC1302.
GeneID	928452.
KEGG	rco:RC1302.
PATRIC	17890131. VBIRicCon45613_1494.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0326.
HOGENOM	HOG000031989.
KO	K04079.
OMA	LTDSPAC.
ProtClustDB	PRK05218.
Family and domain databases
Gene3D	3.30.565.10. 1 hit.
HAMAP	MF_00505. HSP90.
InterPro	IPR003594. HATPase_ATP-bd. IPR019805. Heat_shock_protein_90_CS. IPR001404. Hsp90. IPR020575. Hsp90_N. IPR020568. Ribosomal_S5_D2-typ_fold. [Graphical view]
PANTHER	PTHR11528. PTHR11528. 1 hit.
Pfam	PF00183. HSP90. 1 hit. [Graphical view]
PIRSF	PIRSF002583. Hsp90. 1 hit.
PRINTS	PR00775. HEATSHOCK90.
SMART	SM00387. HATPase_c. 1 hit. [Graphical view]
SUPFAM	SSF55874. ATP_bd_ATPase. 1 hit. SSF54211. Ribosomal_S5_D2-typ_fold. 1 hit.
PROSITE	PS00298. HSP90. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HTPG_RICCN

Accession

Primary (citable) accession number: P58478

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 13, 2001
Last sequence update:	December 13, 2001
Last modified:	May 1, 2013
This is version 74 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program