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P58474

- PEPB_HAEIN

UniProt

P58474 - PEPB_HAEIN

Protein

Putative peptidase B

Gene

pepB

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 3 out of 5- Protein uncertaini
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 1 (13 Dec 2001)
      Previous versions | rss
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    • Comment

    Functioni

    Probably plays an important role in intracellular peptide degradation.UniRule annotation

    Catalytic activityi

    Release of an N-terminal amino acid, Xaa, from a peptide or arylamide. Xaa is preferably Glu or Asp but may be other amino acids, including Leu, Met, His, Cys and Gln.UniRule annotation

    Cofactori

    Binds 2 manganese ions per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi198 – 1981Manganese 2UniRule annotation
    Metal bindingi203 – 2031Manganese 1UniRule annotation
    Metal bindingi203 – 2031Manganese 2UniRule annotation
    Active sitei210 – 2101UniRule annotation
    Metal bindingi221 – 2211Manganese 2UniRule annotation
    Metal bindingi280 – 2801Manganese 1UniRule annotation
    Metal bindingi282 – 2821Manganese 1UniRule annotation
    Metal bindingi282 – 2821Manganese 2UniRule annotation
    Active sitei284 – 2841UniRule annotation

    GO - Molecular functioni

    1. aminopeptidase activity Source: UniProtKB-HAMAP
    2. manganese ion binding Source: UniProtKB-HAMAP
    3. metalloexopeptidase activity Source: InterPro

    Keywords - Molecular functioni

    Aminopeptidase, Hydrolase, Protease

    Keywords - Ligandi

    Manganese, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative peptidase B (EC:3.4.11.23UniRule annotation)
    Alternative name(s):
    Aminopeptidase BUniRule annotation
    Gene namesi
    Name:pepBUniRule annotation
    Ordered Locus Names:HI_0875
    OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
    Taxonomic identifieri71421 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
    ProteomesiUP000000579: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 434434Putative peptidase BPRO_0000165836Add
    BLAST

    Interactioni

    Subunit structurei

    Homohexamer.UniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliP58474.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase M17 family.UniRule annotation

    Phylogenomic databases

    OMAiWGEKATL.

    Family and domain databases

    HAMAPiMF_00504. Aminopeptidase_M17.
    InterProiIPR011356. Leucine_aapep/pepB.
    IPR008330. Pept_M17_PepB.
    IPR000819. Peptidase_M17_C.
    [Graphical view]
    PfamiPF12404. DUF3663. 1 hit.
    PF00883. Peptidase_M17. 1 hit.
    [Graphical view]
    PIRSFiPIRSF036388. Ctsl_amnpptdse_B. 1 hit.
    PRINTSiPR00481. LAMNOPPTDASE.
    PROSITEiPS00631. CYTOSOL_AP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P58474-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQITLSNTLA NDAWGKNAIL SFDSNKAMIH LKNNGKTDRT LVQQAARKLR    50
    GQGIKEVELV GEKWDLEFCW AFYQGFYTAK QDYAIEFPHL DDEPQDELLA 100
    RIECGDFVRG IINEPAQSLT PVKLVERAAE FILNQADIYN EKSAVSFKII 150
    SGEELEQQGY HGIWTVGKGS ANLPAMLQLD FNPTQDSNAP VLACLVGKGI 200
    TFDSGGYSIK PSDGMSTMRT DMGGAALLTG ALGFAIARGL NQRVKLYLCC 250
    AENLVSNNAF KLGDIITYKN GVSAEVLNTD AEGRLVLADG LIEADNQNPG 300
    FIIDCATLTG AAKSAVGNDY HSVLSMDDEL VKNLFQSAQA ENEPFWRLPF 350
    EDFHRSQINS SFADIANIGS VPVGAGASTA TAFLSYFVKN YKQNWLHIDC 400
    SATYRKSGSD LWSVGATGIG VQTLANLMLS RSLK 434
    Length:434
    Mass (Da):47,285
    Last modified:December 13, 2001 - v1
    Checksum:iA5A592E51EB18B58
    GO

    Sequence cautioni

    The sequence L42023 differs from that shown. Reason: Frameshift at position 340. This may be a natural frameshift.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. No translation available.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. No translation available.

    3D structure databases

    ProteinModelPortali P58474.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    OMAi WGEKATL.

    Family and domain databases

    HAMAPi MF_00504. Aminopeptidase_M17.
    InterProi IPR011356. Leucine_aapep/pepB.
    IPR008330. Pept_M17_PepB.
    IPR000819. Peptidase_M17_C.
    [Graphical view ]
    Pfami PF12404. DUF3663. 1 hit.
    PF00883. Peptidase_M17. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF036388. Ctsl_amnpptdse_B. 1 hit.
    PRINTSi PR00481. LAMNOPPTDASE.
    PROSITEi PS00631. CYTOSOL_AP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

    Entry informationi

    Entry nameiPEPB_HAEIN
    AccessioniPrimary (citable) accession number: P58474
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 13, 2001
    Last sequence update: December 13, 2001
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Caution

    Could be the product of a pseudogene.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Haemophilus influenzae
      Haemophilus influenzae (strain Rd): entries and gene names
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3