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Protein

Putative peptidase B

Gene

pepB

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed-Annotation score: -Protein uncertaini

Functioni

Probably plays an important role in intracellular peptide degradation.UniRule annotation

Caution

Could be the product of a pseudogene.Curated

Catalytic activityi

Release of an N-terminal amino acid, Xaa, from a peptide or arylamide. Xaa is preferably Glu or Asp but may be other amino acids, including Leu, Met, His, Cys and Gln.UniRule annotation

Cofactori

Mn2+UniRule annotationNote: Binds 2 manganese ions per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi198Manganese 2UniRule annotation1
Metal bindingi203Manganese 1UniRule annotation1
Metal bindingi203Manganese 2UniRule annotation1
Active sitei210UniRule annotation1
Metal bindingi221Manganese 2UniRule annotation1
Metal bindingi280Manganese 1UniRule annotation1
Metal bindingi282Manganese 1UniRule annotation1
Metal bindingi282Manganese 2UniRule annotation1
Active sitei284UniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionAminopeptidase, Hydrolase, Protease
LigandManganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Putative peptidase B (EC:3.4.11.23UniRule annotation)
Alternative name(s):
Aminopeptidase BUniRule annotation
Gene namesi
Name:pepBUniRule annotation
Ordered Locus Names:HI_0875
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
Proteomesi
  • UP000000579 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001658361 – 434Putative peptidase BAdd BLAST434

Proteomic databases

PRIDEiP58474

Interactioni

Subunit structurei

Homohexamer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliP58474
SMRiP58474
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M17 family.UniRule annotation

Phylogenomic databases

OMAiEKSWAFW

Family and domain databases

CDDicd00433 Peptidase_M17, 1 hit
HAMAPiMF_00504 Aminopeptidase_M17, 1 hit
InterProiView protein in InterPro
IPR001346 Interferon_reg_fact_DNA-bd_dom
IPR011356 Leucine_aapep/pepB
IPR008330 Pept_M17_PepB
IPR000819 Peptidase_M17_C
PANTHERiPTHR11963 PTHR11963, 1 hit
PTHR11963:SF20 PTHR11963:SF20, 1 hit
PfamiView protein in Pfam
PF12404 DUF3663, 1 hit
PF00883 Peptidase_M17, 1 hit
PIRSFiPIRSF036388 Ctsl_amnpptdse_B, 1 hit
PRINTSiPR00481 LAMNOPPTDASE
PROSITEiView protein in PROSITE
PS00631 CYTOSOL_AP, 1 hit

Sequencei

Sequence statusi: Complete.

P58474-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQITLSNTLA NDAWGKNAIL SFDSNKAMIH LKNNGKTDRT LVQQAARKLR
60 70 80 90 100
GQGIKEVELV GEKWDLEFCW AFYQGFYTAK QDYAIEFPHL DDEPQDELLA
110 120 130 140 150
RIECGDFVRG IINEPAQSLT PVKLVERAAE FILNQADIYN EKSAVSFKII
160 170 180 190 200
SGEELEQQGY HGIWTVGKGS ANLPAMLQLD FNPTQDSNAP VLACLVGKGI
210 220 230 240 250
TFDSGGYSIK PSDGMSTMRT DMGGAALLTG ALGFAIARGL NQRVKLYLCC
260 270 280 290 300
AENLVSNNAF KLGDIITYKN GVSAEVLNTD AEGRLVLADG LIEADNQNPG
310 320 330 340 350
FIIDCATLTG AAKSAVGNDY HSVLSMDDEL VKNLFQSAQA ENEPFWRLPF
360 370 380 390 400
EDFHRSQINS SFADIANIGS VPVGAGASTA TAFLSYFVKN YKQNWLHIDC
410 420 430
SATYRKSGSD LWSVGATGIG VQTLANLMLS RSLK
Length:434
Mass (Da):47,285
Last modified:December 13, 2001 - v1
Checksum:iA5A592E51EB18B58
GO

Sequence cautioni

The sequence L42023 differs from that shown. Reason: Frameshift at position 340. This may be a natural frameshift.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA No translation available.

Similar proteinsi

Entry informationi

Entry nameiPEPB_HAEIN
AccessioniPrimary (citable) accession number: P58474
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 13, 2001
Last sequence update: December 13, 2001
Last modified: May 23, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health