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Protein

Putative peptidase B

Gene

pepB

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein uncertaini

Functioni

Probably plays an important role in intracellular peptide degradation.UniRule annotation

Catalytic activityi

Release of an N-terminal amino acid, Xaa, from a peptide or arylamide. Xaa is preferably Glu or Asp but may be other amino acids, including Leu, Met, His, Cys and Gln.UniRule annotation

Cofactori

Mn2+UniRule annotationNote: Binds 2 manganese ions per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi198 – 1981Manganese 2UniRule annotation
Metal bindingi203 – 2031Manganese 1UniRule annotation
Metal bindingi203 – 2031Manganese 2UniRule annotation
Active sitei210 – 2101UniRule annotation
Metal bindingi221 – 2211Manganese 2UniRule annotation
Metal bindingi280 – 2801Manganese 1UniRule annotation
Metal bindingi282 – 2821Manganese 1UniRule annotation
Metal bindingi282 – 2821Manganese 2UniRule annotation
Active sitei284 – 2841UniRule annotation

GO - Molecular functioni

  1. aminopeptidase activity Source: UniProtKB-HAMAP
  2. manganese ion binding Source: UniProtKB-HAMAP
  3. metalloexopeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Protease

Keywords - Ligandi

Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Putative peptidase B (EC:3.4.11.23UniRule annotation)
Alternative name(s):
Aminopeptidase BUniRule annotation
Gene namesi
Name:pepBUniRule annotation
Ordered Locus Names:HI_0875
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 434434Putative peptidase BPRO_0000165836Add
BLAST

Interactioni

Subunit structurei

Homohexamer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliP58474.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M17 family.UniRule annotation

Phylogenomic databases

OMAiKQGWLHI.

Family and domain databases

HAMAPiMF_00504. Aminopeptidase_M17.
InterProiIPR011356. Leucine_aapep/pepB.
IPR008330. Pept_M17_PepB.
IPR000819. Peptidase_M17_C.
[Graphical view]
PfamiPF12404. DUF3663. 1 hit.
PF00883. Peptidase_M17. 1 hit.
[Graphical view]
PIRSFiPIRSF036388. Ctsl_amnpptdse_B. 1 hit.
PRINTSiPR00481. LAMNOPPTDASE.
PROSITEiPS00631. CYTOSOL_AP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P58474-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQITLSNTLA NDAWGKNAIL SFDSNKAMIH LKNNGKTDRT LVQQAARKLR
60 70 80 90 100
GQGIKEVELV GEKWDLEFCW AFYQGFYTAK QDYAIEFPHL DDEPQDELLA
110 120 130 140 150
RIECGDFVRG IINEPAQSLT PVKLVERAAE FILNQADIYN EKSAVSFKII
160 170 180 190 200
SGEELEQQGY HGIWTVGKGS ANLPAMLQLD FNPTQDSNAP VLACLVGKGI
210 220 230 240 250
TFDSGGYSIK PSDGMSTMRT DMGGAALLTG ALGFAIARGL NQRVKLYLCC
260 270 280 290 300
AENLVSNNAF KLGDIITYKN GVSAEVLNTD AEGRLVLADG LIEADNQNPG
310 320 330 340 350
FIIDCATLTG AAKSAVGNDY HSVLSMDDEL VKNLFQSAQA ENEPFWRLPF
360 370 380 390 400
EDFHRSQINS SFADIANIGS VPVGAGASTA TAFLSYFVKN YKQNWLHIDC
410 420 430
SATYRKSGSD LWSVGATGIG VQTLANLMLS RSLK
Length:434
Mass (Da):47,285
Last modified:December 13, 2001 - v1
Checksum:iA5A592E51EB18B58
GO

Sequence cautioni

The sequence L42023 differs from that shown. Reason: Frameshift at position 340. This may be a natural frameshift.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. No translation available.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliP58474.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

OMAiKQGWLHI.

Family and domain databases

HAMAPiMF_00504. Aminopeptidase_M17.
InterProiIPR011356. Leucine_aapep/pepB.
IPR008330. Pept_M17_PepB.
IPR000819. Peptidase_M17_C.
[Graphical view]
PfamiPF12404. DUF3663. 1 hit.
PF00883. Peptidase_M17. 1 hit.
[Graphical view]
PIRSFiPIRSF036388. Ctsl_amnpptdse_B. 1 hit.
PRINTSiPR00481. LAMNOPPTDASE.
PROSITEiPS00631. CYTOSOL_AP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Entry informationi

Entry nameiPEPB_HAEIN
AccessioniPrimary (citable) accession number: P58474
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 13, 2001
Last sequence update: December 13, 2001
Last modified: January 7, 2015
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Caution

Could be the product of a pseudogene.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.