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P58465

- CTDSL_MOUSE

UniProt

P58465 - CTDSL_MOUSE

Protein

CTD small phosphatase-like protein

Gene

Ctdspl

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 3 (03 Oct 2012)
      Previous versions | rss
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    Functioni

    Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells By similarity.By similarity

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Cofactori

    Binds 1 magnesium ion per monomer.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei112 – 11214-aspartylphosphate intermediateBy similarity
    Metal bindingi112 – 1121MagnesiumBy similarity
    Active sitei114 – 1141Proton donorBy similarity
    Metal bindingi114 – 1141Magnesium; via carbonyl oxygenBy similarity
    Sitei168 – 1681Transition state stabilizerBy similarity
    Sitei206 – 2061Transition state stabilizerBy similarity
    Metal bindingi223 – 2231MagnesiumBy similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. phosphoprotein phosphatase activity Source: UniProtKB-KW

    GO - Biological processi

    1. negative regulation of G1/S transition of mitotic cell cycle Source: MGI
    2. negative regulation of protein phosphorylation Source: MGI

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Ligandi

    Magnesium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    CTD small phosphatase-like protein (EC:3.1.3.16)
    Short name:
    CTDSP-like
    Alternative name(s):
    Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 3
    NIF-like protein
    Nuclear LIM interactor-interacting factor 1
    Short name:
    NLI-interacting factor 1
    Small C-terminal domain phosphatase 3
    Short name:
    SCP3
    Short name:
    Small CTD phosphatase 3
    Gene namesi
    Name:Ctdspl
    Synonyms:Nif1, Nifl
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 9

    Organism-specific databases

    MGIiMGI:1916524. Ctdspl.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 276276CTD small phosphatase-like proteinPRO_0000212570Add
    BLAST

    Proteomic databases

    PaxDbiP58465.
    PRIDEiP58465.

    PTM databases

    PhosphoSiteiP58465.

    Expressioni

    Gene expression databases

    ArrayExpressiP58465.
    GenevestigatoriP58465.

    Interactioni

    Subunit structurei

    Monomer. Interacts with REST.By similarity

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000072852.

    Structurei

    3D structure databases

    ProteinModelPortaliP58465.
    SMRiP58465. Positions 92-263.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini102 – 260159FCP1 homologyPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 FCP1 homology domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5190.
    GeneTreeiENSGT00390000017194.
    HOGENOMiHOG000236379.
    HOVERGENiHBG053298.
    InParanoidiP58465.
    KOiK15731.
    OMAiHMSIITQ.
    OrthoDBiEOG71P2C3.
    TreeFamiTF313556.

    Family and domain databases

    Gene3Di3.40.50.1000. 1 hit.
    InterProiIPR011948. Dullard_phosphatase.
    IPR023214. HAD-like_dom.
    IPR004274. NIF.
    [Graphical view]
    PfamiPF03031. NIF. 1 hit.
    [Graphical view]
    SMARTiSM00577. CPDc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56784. SSF56784. 1 hit.
    TIGRFAMsiTIGR02251. HIF-SF_euk. 1 hit.
    PROSITEiPS50969. FCP1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P58465-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDGPAIITQV TNPKEDEARS PVAGEKASQR NISLKKQRGR SILSSFFCCF    50
    RDYNVEAPPA NSPSVLPPLV EENGGLQKGD QRQVIPVPSP PAKYLLPEVT 100
    VLDYGKKCVV IDLDETLVHS SFKPISNADF IVPVEIDGTI HQVYVLKRPH 150
    VDEFLQRMGQ LFECVLFTAS LAKYADPVAD LLDRWGVFRA RLFRESCVFH 200
    RGNYVKDLSR LGRELSKVII VDNSPASYIF HPENAVPVQS WFDDMTDTEL 250
    LDLIPFFEGL SREDDVYSML HRLCSR 276
    Length:276
    Mass (Da):31,156
    Last modified:October 3, 2012 - v3
    Checksum:i3989E5B2E57EEC75
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti37 – 371Q → E in CAC69078. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ344340 mRNA. Translation: CAC69078.2.
    AC055818 Genomic DNA. No translation available.
    AC156800 Genomic DNA. No translation available.
    BC094289 mRNA. Translation: AAH94289.1.
    CCDSiCCDS23605.1.
    RefSeqiNP_598471.3. NM_133710.3.
    UniGeneiMm.439928.

    Genome annotation databases

    EnsembliENSMUST00000073109; ENSMUSP00000072852; ENSMUSG00000047409.
    GeneIDi69274.
    KEGGimmu:69274.
    UCSCiuc009rzz.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ344340 mRNA. Translation: CAC69078.2 .
    AC055818 Genomic DNA. No translation available.
    AC156800 Genomic DNA. No translation available.
    BC094289 mRNA. Translation: AAH94289.1 .
    CCDSi CCDS23605.1.
    RefSeqi NP_598471.3. NM_133710.3.
    UniGenei Mm.439928.

    3D structure databases

    ProteinModelPortali P58465.
    SMRi P58465. Positions 92-263.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000072852.

    PTM databases

    PhosphoSitei P58465.

    Proteomic databases

    PaxDbi P58465.
    PRIDEi P58465.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000073109 ; ENSMUSP00000072852 ; ENSMUSG00000047409 .
    GeneIDi 69274.
    KEGGi mmu:69274.
    UCSCi uc009rzz.2. mouse.

    Organism-specific databases

    CTDi 10217.
    MGIi MGI:1916524. Ctdspl.

    Phylogenomic databases

    eggNOGi COG5190.
    GeneTreei ENSGT00390000017194.
    HOGENOMi HOG000236379.
    HOVERGENi HBG053298.
    InParanoidi P58465.
    KOi K15731.
    OMAi HMSIITQ.
    OrthoDBi EOG71P2C3.
    TreeFami TF313556.

    Miscellaneous databases

    NextBioi 329009.
    PROi P58465.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P58465.
    Genevestigatori P58465.

    Family and domain databases

    Gene3Di 3.40.50.1000. 1 hit.
    InterProi IPR011948. Dullard_phosphatase.
    IPR023214. HAD-like_dom.
    IPR004274. NIF.
    [Graphical view ]
    Pfami PF03031. NIF. 1 hit.
    [Graphical view ]
    SMARTi SM00577. CPDc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56784. SSF56784. 1 hit.
    TIGRFAMsi TIGR02251. HIF-SF_euk. 1 hit.
    PROSITEi PS50969. FCP1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Refined physical mapping and genomic structure of a 4-Mb region (AP-20) on human chromosome 3p22-p21.33 implicated in lung and kidney cancerogenesis."
      Protopopov A., Kashuba V., Zabarovsky E.
      Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Colon.

    Entry informationi

    Entry nameiCTDSL_MOUSE
    AccessioniPrimary (citable) accession number: P58465
    Secondary accession number(s): Q52KL5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 13, 2001
    Last sequence update: October 3, 2012
    Last modified: October 1, 2014
    This is version 82 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3