Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

CTD small phosphatase-like protein

Gene

Ctdspl

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells (By similarity).By similarity

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mg2+By similarityNote: Binds 1 Mg2+ ion per monomer.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei1124-aspartylphosphate intermediateBy similarity1
Metal bindingi112MagnesiumBy similarity1
Active sitei114Proton donorBy similarity1
Metal bindingi114Magnesium; via carbonyl oxygenBy similarity1
Sitei168Transition state stabilizerBy similarity1
Sitei206Transition state stabilizerBy similarity1
Metal bindingi223MagnesiumBy similarity1

GO - Molecular functioni

GO - Biological processi

  • negative regulation of G1/S transition of mitotic cell cycle Source: MGI
  • negative regulation of protein phosphorylation Source: MGI

Keywordsi

Molecular functionHydrolase, Protein phosphatase
LigandMagnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
CTD small phosphatase-like protein (EC:3.1.3.16)
Short name:
CTDSP-like
Alternative name(s):
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 3
NIF-like protein
Nuclear LIM interactor-interacting factor 1
Short name:
NLI-interacting factor 1
Small C-terminal domain phosphatase 3
Short name:
SCP3
Short name:
Small CTD phosphatase 3
Gene namesi
Name:Ctdspl
Synonyms:Nif1, Nifl
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1916524 Ctdspl

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002125701 – 276CTD small phosphatase-like proteinAdd BLAST276

Proteomic databases

PaxDbiP58465
PRIDEiP58465

PTM databases

iPTMnetiP58465
PhosphoSitePlusiP58465
SwissPalmiP58465

Expressioni

Gene expression databases

BgeeiENSMUSG00000047409
ExpressionAtlasiP58465 baseline and differential
GenevisibleiP58465 MM

Interactioni

Subunit structurei

Monomer. Interacts with REST.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000072852

Structurei

3D structure databases

ProteinModelPortaliP58465
SMRiP58465
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini102 – 260FCP1 homologyPROSITE-ProRule annotationAdd BLAST159

Phylogenomic databases

eggNOGiKOG1605 Eukaryota
COG5190 LUCA
GeneTreeiENSGT00390000017194
HOGENOMiHOG000236379
HOVERGENiHBG053298
InParanoidiP58465
KOiK15731
OMAiSMRAYCD
OrthoDBiEOG091G0J49
TreeFamiTF313556

Family and domain databases

Gene3Di3.40.50.1000, 1 hit
InterProiView protein in InterPro
IPR011948 Dullard_phosphatase
IPR004274 FCP1_dom
IPR036412 HAD-like_sf
IPR023214 HAD_sf
PfamiView protein in Pfam
PF03031 NIF, 1 hit
SMARTiView protein in SMART
SM00577 CPDc, 1 hit
SUPFAMiSSF56784 SSF56784, 1 hit
TIGRFAMsiTIGR02251 HIF-SF_euk, 1 hit
PROSITEiView protein in PROSITE
PS50969 FCP1, 1 hit

Sequencei

Sequence statusi: Complete.

P58465-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDGPAIITQV TNPKEDEARS PVAGEKASQR NISLKKQRGR SILSSFFCCF
60 70 80 90 100
RDYNVEAPPA NSPSVLPPLV EENGGLQKGD QRQVIPVPSP PAKYLLPEVT
110 120 130 140 150
VLDYGKKCVV IDLDETLVHS SFKPISNADF IVPVEIDGTI HQVYVLKRPH
160 170 180 190 200
VDEFLQRMGQ LFECVLFTAS LAKYADPVAD LLDRWGVFRA RLFRESCVFH
210 220 230 240 250
RGNYVKDLSR LGRELSKVII VDNSPASYIF HPENAVPVQS WFDDMTDTEL
260 270
LDLIPFFEGL SREDDVYSML HRLCSR
Length:276
Mass (Da):31,156
Last modified:October 3, 2012 - v3
Checksum:i3989E5B2E57EEC75
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti37Q → E in CAC69078 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ344340 mRNA Translation: CAC69078.2
AC055818 Genomic DNA No translation available.
AC156800 Genomic DNA No translation available.
BC094289 mRNA Translation: AAH94289.1
CCDSiCCDS23605.1
RefSeqiNP_598471.3, NM_133710.3
UniGeneiMm.439928

Genome annotation databases

EnsembliENSMUST00000073109; ENSMUSP00000072852; ENSMUSG00000047409
GeneIDi69274
KEGGimmu:69274
UCSCiuc009rzz.2 mouse

Similar proteinsi

Entry informationi

Entry nameiCTDSL_MOUSE
AccessioniPrimary (citable) accession number: P58465
Secondary accession number(s): Q52KL5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 13, 2001
Last sequence update: October 3, 2012
Last modified: March 28, 2018
This is version 106 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health