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P58465

- CTDSL_MOUSE

UniProt

P58465 - CTDSL_MOUSE

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Protein

CTD small phosphatase-like protein

Gene

Ctdspl

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells (By similarity).By similarity

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mg2+By similarityNote: Binds 1 Mg(2+) ion per monomer.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei112 – 11214-aspartylphosphate intermediateBy similarity
Metal bindingi112 – 1121MagnesiumBy similarity
Active sitei114 – 1141Proton donorBy similarity
Metal bindingi114 – 1141Magnesium; via carbonyl oxygenBy similarity
Sitei168 – 1681Transition state stabilizerBy similarity
Sitei206 – 2061Transition state stabilizerBy similarity
Metal bindingi223 – 2231MagnesiumBy similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. phosphoprotein phosphatase activity Source: UniProtKB-KW

GO - Biological processi

  1. negative regulation of G1/S transition of mitotic cell cycle Source: MGI
  2. negative regulation of protein phosphorylation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Magnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
CTD small phosphatase-like protein (EC:3.1.3.16)
Short name:
CTDSP-like
Alternative name(s):
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 3
NIF-like protein
Nuclear LIM interactor-interacting factor 1
Short name:
NLI-interacting factor 1
Small C-terminal domain phosphatase 3
Short name:
SCP3
Short name:
Small CTD phosphatase 3
Gene namesi
Name:Ctdspl
Synonyms:Nif1, Nifl
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:1916524. Ctdspl.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. extracellular vesicular exosome Source: Ensembl
  2. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 276276CTD small phosphatase-like proteinPRO_0000212570Add
BLAST

Proteomic databases

PaxDbiP58465.
PRIDEiP58465.

PTM databases

PhosphoSiteiP58465.

Expressioni

Gene expression databases

ExpressionAtlasiP58465. baseline and differential.
GenevestigatoriP58465.

Interactioni

Subunit structurei

Monomer. Interacts with REST.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000072852.

Structurei

3D structure databases

ProteinModelPortaliP58465.
SMRiP58465. Positions 92-263.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini102 – 260159FCP1 homologyPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 FCP1 homology domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5190.
GeneTreeiENSGT00390000017194.
HOGENOMiHOG000236379.
HOVERGENiHBG053298.
InParanoidiP58465.
KOiK15731.
OMAiHMSIITQ.
OrthoDBiEOG71P2C3.
TreeFamiTF313556.

Family and domain databases

Gene3Di3.40.50.1000. 1 hit.
InterProiIPR011948. Dullard_phosphatase.
IPR023214. HAD-like_dom.
IPR004274. NIF.
[Graphical view]
PfamiPF03031. NIF. 1 hit.
[Graphical view]
SMARTiSM00577. CPDc. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR02251. HIF-SF_euk. 1 hit.
PROSITEiPS50969. FCP1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P58465-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDGPAIITQV TNPKEDEARS PVAGEKASQR NISLKKQRGR SILSSFFCCF
60 70 80 90 100
RDYNVEAPPA NSPSVLPPLV EENGGLQKGD QRQVIPVPSP PAKYLLPEVT
110 120 130 140 150
VLDYGKKCVV IDLDETLVHS SFKPISNADF IVPVEIDGTI HQVYVLKRPH
160 170 180 190 200
VDEFLQRMGQ LFECVLFTAS LAKYADPVAD LLDRWGVFRA RLFRESCVFH
210 220 230 240 250
RGNYVKDLSR LGRELSKVII VDNSPASYIF HPENAVPVQS WFDDMTDTEL
260 270
LDLIPFFEGL SREDDVYSML HRLCSR
Length:276
Mass (Da):31,156
Last modified:October 3, 2012 - v3
Checksum:i3989E5B2E57EEC75
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti37 – 371Q → E in CAC69078. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ344340 mRNA. Translation: CAC69078.2.
AC055818 Genomic DNA. No translation available.
AC156800 Genomic DNA. No translation available.
BC094289 mRNA. Translation: AAH94289.1.
CCDSiCCDS23605.1.
RefSeqiNP_598471.3. NM_133710.3.
UniGeneiMm.439928.

Genome annotation databases

EnsembliENSMUST00000073109; ENSMUSP00000072852; ENSMUSG00000047409.
GeneIDi69274.
KEGGimmu:69274.
UCSCiuc009rzz.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ344340 mRNA. Translation: CAC69078.2 .
AC055818 Genomic DNA. No translation available.
AC156800 Genomic DNA. No translation available.
BC094289 mRNA. Translation: AAH94289.1 .
CCDSi CCDS23605.1.
RefSeqi NP_598471.3. NM_133710.3.
UniGenei Mm.439928.

3D structure databases

ProteinModelPortali P58465.
SMRi P58465. Positions 92-263.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000072852.

PTM databases

PhosphoSitei P58465.

Proteomic databases

PaxDbi P58465.
PRIDEi P58465.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000073109 ; ENSMUSP00000072852 ; ENSMUSG00000047409 .
GeneIDi 69274.
KEGGi mmu:69274.
UCSCi uc009rzz.2. mouse.

Organism-specific databases

CTDi 10217.
MGIi MGI:1916524. Ctdspl.

Phylogenomic databases

eggNOGi COG5190.
GeneTreei ENSGT00390000017194.
HOGENOMi HOG000236379.
HOVERGENi HBG053298.
InParanoidi P58465.
KOi K15731.
OMAi HMSIITQ.
OrthoDBi EOG71P2C3.
TreeFami TF313556.

Miscellaneous databases

NextBioi 329009.
PROi P58465.
SOURCEi Search...

Gene expression databases

ExpressionAtlasi P58465. baseline and differential.
Genevestigatori P58465.

Family and domain databases

Gene3Di 3.40.50.1000. 1 hit.
InterProi IPR011948. Dullard_phosphatase.
IPR023214. HAD-like_dom.
IPR004274. NIF.
[Graphical view ]
Pfami PF03031. NIF. 1 hit.
[Graphical view ]
SMARTi SM00577. CPDc. 1 hit.
[Graphical view ]
SUPFAMi SSF56784. SSF56784. 1 hit.
TIGRFAMsi TIGR02251. HIF-SF_euk. 1 hit.
PROSITEi PS50969. FCP1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Refined physical mapping and genomic structure of a 4-Mb region (AP-20) on human chromosome 3p22-p21.33 implicated in lung and kidney cancerogenesis."
    Protopopov A., Kashuba V., Zabarovsky E.
    Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Colon.

Entry informationi

Entry nameiCTDSL_MOUSE
AccessioniPrimary (citable) accession number: P58465
Secondary accession number(s): Q52KL5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 13, 2001
Last sequence update: October 3, 2012
Last modified: November 26, 2014
This is version 84 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3