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Protein

Forkhead box protein P2

Gene

Foxp2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Plays a role in synapse formation by regulating SRPX2 levels.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri345 – 370C2H2-typeAdd BLAST26
DNA bindingi503 – 593Fork-headPROSITE-ProRule annotationAdd BLAST91

GO - Molecular functioni

  • androgen receptor binding Source: Ensembl
  • DNA binding Source: MGI
  • DNA binding transcription factor activity Source: MGI
  • metal ion binding Source: UniProtKB-KW
  • protein heterodimerization activity Source: MGI
  • protein homodimerization activity Source: MGI
  • RNA polymerase II proximal promoter sequence-specific DNA binding Source: NTNU_SB
  • transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding Source: NTNU_SB

GO - Biological processi

  • camera-type eye development Source: MGI
  • caudate nucleus development Source: UniProtKB
  • cell differentiation Source: GO_Central
  • cerebellum development Source: MGI
  • cerebral cortex development Source: Ensembl
  • growth Source: MGI
  • innate vocalization behavior Source: Ensembl
  • lung alveolus development Source: MGI
  • lung development Source: MGI
  • negative regulation of transcription, DNA-templated Source: MGI
  • negative regulation of transcription by RNA polymerase II Source: MGI
  • positive regulation of epithelial cell proliferation Source: MGI
  • positive regulation of epithelial cell proliferation involved in lung morphogenesis Source: MGI
  • positive regulation of mesenchymal cell proliferation Source: MGI
  • post-embryonic development Source: MGI
  • putamen development Source: UniProtKB
  • response to testosterone Source: Ensembl
  • righting reflex Source: MGI
  • skeletal muscle tissue development Source: MGI
  • smooth muscle tissue development Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW
  • vocal learning Source: MGI

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein P2
Gene namesi
Name:Foxp2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:2148705 Foxp2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi399Missing : Loss of dimerization. Almost complete loss of DNA-binding. Reduced transcriptional repression activity. 1 Publication1
Mutagenesisi407 – 408HL → AA: Severely reduced transcriptional repression activity. 1 Publication2
Mutagenesisi408L → A: Severely reduced transcriptional repression activity. 1 Publication1
Mutagenesisi421 – 425PLNLV → AANAA: No significant effect on transcriptional repression activity. 1 Publication5
Mutagenesisi552R → H: No change in synaptic density. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000918821 – 714Forkhead box protein P2Add BLAST714

Proteomic databases

MaxQBiP58463
PaxDbiP58463
PRIDEiP58463

PTM databases

iPTMnetiP58463
PhosphoSitePlusiP58463

Expressioni

Tissue specificityi

Highest expression in lung. Lower expression in spleen, skeletal muscle, brain, kidney and small intestine.

Developmental stagei

Expressed in developing lung, neural, intestinal and cardiovascular tissues. Expressed at a high level in the distal airway epithelium and at a low level in the proximal airway epithelium at 12.5 dpc, and restricted to the distal airway epithelium by 14.5 dpc. In the spinal cord, at 12.5 dpc, expressed in a subset of interneurons dorsal to motor neurons. At 16.5 dpc, expression in the brain is observed in the inner intermediate zone of the neopallial cortex and in the developing cerebral hemispheres. In the gastrointestinal system, at 12.5 expressed in the outer mesodermal layer and in the intestinal epithelium. By 16.5 dpc, expression is restricted to the outer longitudinal muscle layer of the intestine and stomach. In the cardiovascular system, at 14.5 dpc, expressed in the outflow tract region of the developing heart. By 16.5 dpc, observed in the outflow tract and atrium, but not in the ventricles.2 Publications

Gene expression databases

BgeeiENSMUSG00000029563
CleanExiMM_FOXP2
ExpressionAtlasiP58463 baseline and differential
GenevisibleiP58463 MM

Interactioni

Subunit structurei

Forms homodimers and heterodimers with FOXP1 and FOXP4. Dimerization is required for DNA-binding (By similarity). Interacts with CTBP1 (PubMed:14701752). Interacts with FOXP1 (By similarity).By similarity1 Publication

GO - Molecular functioni

  • androgen receptor binding Source: Ensembl
  • protein heterodimerization activity Source: MGI
  • protein homodimerization activity Source: MGI

Protein-protein interaction databases

BioGridi227578, 2 interactors
IntActiP58463, 1 interactor
STRINGi10090.ENSMUSP00000031545

Structurei

3D structure databases

ProteinModelPortaliP58463
SMRiP58463
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni387 – 408Leucine-zipperAdd BLAST22
Regioni421 – 425CTBP1-binding5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi53 – 267Gln-richAdd BLAST215

Domaini

The leucine-zipper is required for dimerization and transcriptional repression.1 Publication

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri345 – 370C2H2-typeAdd BLAST26

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG4385 Eukaryota
COG5025 LUCA
GeneTreeiENSGT00910000144016
HOGENOMiHOG000092089
HOVERGENiHBG051657
InParanoidiP58463
KOiK09409
PhylomeDBiP58463
TreeFamiTF326978

Family and domain databases

CDDicd00059 FH, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR001766 Fork_head_dom
IPR032354 FOXP-CC
IPR030456 TF_fork_head_CS_2
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00250 Forkhead, 1 hit
PF16159 FOXP-CC, 1 hit
PRINTSiPR00053 FORKHEAD
SMARTiView protein in SMART
SM00339 FH, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS00658 FORK_HEAD_2, 1 hit
PS50039 FORK_HEAD_3, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P58463-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMQESATETI SNSSMNQNGM STLSSQLDAG SRDGRSSGDT SSEVSTVELL
60 70 80 90 100
HLQQQQALQA ARQLLLQQQT SGLKSPKSSE KQRPLQVPVS VAMMTPQVIT
110 120 130 140 150
PQQMQQILQQ QVLSPQQLQA LLQQQQAVML QQQQLQEFYK KQQEQLHLQL
160 170 180 190 200
LQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ QHPGKQAKEQ
210 220 230 240 250
QQQQQQQQLA AQQLVFQQQL LQMQQLQQQQ HLLSLQRQGL ISIPPGQAAL
260 270 280 290 300
PVQSLPQAGL SPAEIQQLWK EVTGVHSMED NGIKHGGLDL TTNNSSSTTS
310 320 330 340 350
STTSKASPPI THHSIVNGQS SVLNARRDSS SHEETGASHT LYGHGVCKWP
360 370 380 390 400
GCESICEDFG QFLKHLNNEH ALDDRSTAQC RVQMQVVQQL EIQLSKERER
410 420 430 440 450
LQAMMTHLHM RPSEPKPSPK PLNLVSSVTM SKNMLETSPQ SLPQTPTTPT
460 470 480 490 500
APVTPITQGP SVITPASVPN VGAIRRRHSD KYNIPMSSEI APNYEFYKNA
510 520 530 540 550
DVRPPFTYAT LIRQAIMESS DRQLTLNEIY SWFTRTFAYF RRNAATWKNA
560 570 580 590 600
VRHNLSLHKC FVRVENVKGA VWTVDEVEYQ KRRSQKITGS PTLVKNIPTS
610 620 630 640 650
LGYGAALNAS LQAALAESSL PLLSNPGLIN NASSGLLQAV HEDLNGSLDH
660 670 680 690 700
IDSNGNSSPG CSPQPHIHSI HVKEEPVIAE DEDCPMSLVT TANHSPELED
710
DREIEEEPLS EDLE
Length:714
Mass (Da):79,819
Last modified:August 31, 2004 - v2
Checksum:iEB02D66B5AA452D0
GO
Isoform 2 (identifier: P58463-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     134-154: Missing.

Note: May be due to a competing acceptor splice site. No experimental confirmation available.
Show »
Length:693
Mass (Da):77,138
Checksum:i5A9582A3C4DB2E09
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti6A → V in AAK69651 (PubMed:11358962).Curated1
Sequence conflicti543N → S in AAK69651 (PubMed:11358962).Curated1
Sequence conflicti663P → R in BAC38477 (PubMed:16141072).Curated1
Sequence conflicti675E → D in BAC38477 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_011540134 – 154Missing in isoform 2. 1 PublicationAdd BLAST21

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF339106 mRNA Translation: AAK69651.1
AY079003 mRNA Translation: AAL85482.1
AK082361 mRNA Translation: BAC38477.1
BC058960 mRNA Translation: AAH58960.1
BC062926 mRNA Translation: AAH62926.1
CCDSiCCDS19918.1 [P58463-1]
CCDS71726.1 [P58463-2]
RefSeqiNP_001273536.1, NM_001286607.1 [P58463-2]
NP_444472.2, NM_053242.4 [P58463-1]
NP_997600.1, NM_212435.1 [P58463-1]
UniGeneiMm.332919

Genome annotation databases

EnsembliENSMUST00000031545; ENSMUSP00000031545; ENSMUSG00000029563 [P58463-1]
ENSMUST00000115472; ENSMUSP00000111132; ENSMUSG00000029563 [P58463-2]
ENSMUST00000115477; ENSMUSP00000111137; ENSMUSG00000029563 [P58463-1]
GeneIDi114142
KEGGimmu:114142
UCSCiuc009ayy.1 mouse [P58463-1]
uc012eie.1 mouse [P58463-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiFOXP2_MOUSE
AccessioniPrimary (citable) accession number: P58463
Secondary accession number(s): Q6PD37, Q8C4F0, Q8R441
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: August 31, 2004
Last modified: March 28, 2018
This is version 149 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health